262 results on '"Marek L. Kowalski"'
Search Results
2. Allergy clinic patients’ drug hypersensitivity
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Karolina Frachowicz-Guerreiro, Aleksandra Wardzyńska, and Marek L. Kowalski
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Drug Hypersensitivity ,Pulmonary and Respiratory Medicine ,Anti-Inflammatory Agents, Non-Steroidal ,Immunology ,Humans ,Immunology and Allergy ,General Medicine ,beta-Lactams ,Ambulatory Care Facilities ,Anti-Bacterial Agents ,Retrospective Studies ,Skin Tests - Abstract
Background: Drug hypersensitivity reaction (DHR) is a common reason for an allergology consultation, during which it is not only necessary to gather a thorough medical history, but also to propose and perform diagnostic tests. Objectives: The aim of the study was to retrospectively assess the patients with a profile of preliminary drug hypersensitivity diagnosis, the usefulness of NSAID hypersensitivity classification in outpatient practice, and to analyze the results of skin, provocation, and drug tolerance tests performed in Immunology and Allergy Clinic patients. Methods: Around 501 medical records of patients referred to the academic allergy outpatient clinic from 2011 to 2019, and had a preliminary drug hypersensitivity diagnosis were analyzed. The diagnostic and drug tolerance tests results carried out in 269 patients of the Clinic from 2009 to 2019 were then evaluated. Results: Among the patients referred due to suspected drug hypersensitivity, the majority (n=338, 67.5%) were believed to be hypersensitive to NSAIDs and antibiotics (n=272, 54.3%). In patients with hypersensitivity to NSAIDs, the mixed pattern was the most prevalent (n=73, 21.6%), followed by NECD (n=64, 18.9%) and NIUA (n=55, 16.3%). The second most common drug causing DHR were the antibiotics, mainly β-lactams (n=160, 58.8%), followed by macrolides (n=35, 12.9%). In hypersensitivity caused due to β-lactams, the delayed form was predominant (n=24, 15%) with manifested skin symptoms (n=74, 46.3%). Non-steroidal anti-inflammatory drugs (n=21, 42.9%), followed by antibiotics (n=11, 22.5%) were the commonest causes of anaphylaxis, as reported by 49 patients. Conclusion: The study shows that a majority of patients with suspected drug hypersensitivity can be classified under the hypersensitivity umbrella based on their medical history, which is the basis for further diagnostic process.
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- 2022
3. MicroRNA expression profile in peripheral blood mononuclear cells of asthmatic patients and healthy individuals: The effect of age and ex vivo rhinovirus exposure
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Maciej Chałubiński, Marek L. Kowalski, Joanna Rywaniak, Małgorzata Pawełczyk, Joanna Makowska, Joanna Jamroz-Brzeska, and Aleksandra Wardzyńska
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Picornaviridae Infections ,Rhinovirus ,business.industry ,Immunology ,Disease ,Immunosenescence ,medicine.disease_cause ,Peripheral blood mononuclear cell ,Asthma ,Proinflammatory cytokine ,MicroRNAs ,Immune system ,Ageing ,Leukocytes, Mononuclear ,Humans ,Immunology and Allergy ,Medicine ,business ,Ex vivo - Abstract
Ageing of the immune system (or 'immunosenescence') is associated with higher mortality due to infectious diseases and reduced response to vaccines. Dysregulation of the cellular response may be associated with an increased incidence of neoplasms, while an elevated level of proinflammatory cytokines, produced mostly by innate cells, contributes to age-related inflammatory diseases including osteoporosis, type 2 diabetes, atherosclerosis or Alzheimer's disease [1].
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- 2021
4. Human rhinovirus 16 induces antiviral and inflammatory response in the human vascular endothelium
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Adrian Gajewski, Aleksandra Likońska, Maciej Chałubiński, Marek L. Kowalski, Aleksandra Szulc, Mateusz Gawrysiak, and Małgorzata Pawełczyk
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0301 basic medicine ,Microbiology (medical) ,Rhinovirus ,Endothelium ,viruses ,Inflammation ,medicine.disease_cause ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,Human Umbilical Vein Endothelial Cells ,medicine ,Humans ,Immunology and Allergy ,Receptors, Immunologic ,Receptor ,Chemokine CCL5 ,Picornaviridae Infections ,Chemistry ,virus diseases ,MDA5 ,Interferon-beta ,General Medicine ,Protein kinase R ,Toll-Like Receptor 3 ,030104 developmental biology ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,TLR3 ,Immunology ,DEAD Box Protein 58 ,Respiratory epithelium ,Endothelium, Vascular ,medicine.symptom - Abstract
The effect of rhinovirus on airway epithelium is very well described. However, its influence on the vascular endothelium is unknown. The current study assesses the effect of rhinovirus HRV16 on the antiviral and inflammatory response in the human vascular endothelial cells (ECs). HRV16 increased IFN-β, RANTES, and IP-10 mRNA expression and protein release. HRV16 copy number in ECs reached maximal value 10 h after incubation. Increase in virus copies was accompanied by the enhancement of Toll- and RIG-I-like receptors: TLR3, RIG-I, and MDA5. Additionally, HRV16 increased OAS-1 and PKR mRNA expression, enzymes responsible for virus degradation and inhibition of replication. ICAM-1 blockade decreased HRV16 copy number in ECs and inhibited IFN-β, RANTES, IP-10, OAS1, PKR, TLR3, RIG-I, and MDA5 mRNA expression increase upon subsequent induction with HRV16. The vascular endothelium may be infected by human rhinovirus and generate antiviral and inflammatory innate response. Results of the study indicate the possible involvement of the vascular endothelium in the immunopathology of rhinoviral airway infections.
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- 2020
5. Human rhinovirus HRV16 impairs barrier functions and regeneration of human lung vascular endothelium
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Sylwia Michlewska, Adrian Gajewski, Aleksandra Likońska, Marek L. Kowalski, Robert Szewczyk, Maciej Chałubiński, Magdalena Chmiela, and Mateusz Gawrysiak
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Lung ,Rhinovirus ,Endothelium ,business.industry ,Regeneration (biology) ,Immunology ,medicine.disease_cause ,Human lung ,Vascular endothelium ,medicine.anatomical_structure ,medicine ,Cancer research ,Humans ,Regeneration ,Immunology and Allergy ,Endothelium, Vascular ,business - Published
- 2020
6. Physical exercise, immune response, and susceptibility to infections-current knowledge and growing research areas
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Marcin Kurowski, Sven Seys, Matteo Bonini, Stefano Del Giacco, Luis Delgado, Zuzana Diamant, Marek L. Kowalski, André Moreira, Maia Rukhadze, and Mariana Couto
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Inflammation ,Immunity, Cellular ,SARS-CoV-2 ,Immunology ,Immunology and Allergy ,COVID-19 ,Humans ,Exercise ,Respiratory Tract Infections - Abstract
This review presents state-of-the-art knowledge and identifies knowledge gaps for future research in the area of exercise-associated modifications of infection susceptibility. Regular moderate-intensity exercise is believed to have beneficial effects on immune health through lowering inflammation intensity and reducing susceptibility to respiratory infections. However, strenuous exercise, as performed by professional athletes, may promote infection: in about half of athletes presenting respiratory symptoms, no causative pathogen can be identified. Acute bouts of exercise enhance the release of pro-inflammatory mediators, which may induce infection-like respiratory symptoms. Relatively few studies have assessed the influence of regularly repeated exercise on the immune response and systemic inflammation compared to the effects of acute exercise. Additionally, ambient and environmental conditions may modify the systemic inflammatory response and infection susceptibility, particularly in outdoor athletes. Both acute and chronic regular exercise influence humoral and cellular immune response mechanisms, resulting in decreased specific and non-specific response in competitive athletes. The most promising areas of further research in exercise immunology include detailed immunological characterization of infection-prone and infection-resistant athletes, examining the efficacy of nutritional and pharmaceutical interventions as countermeasures to infection symptoms, and determining the influence of various exercise loads on susceptibility to infections with respiratory viruses, including SARS-CoV-2. By establishing a uniform definition of an "elite athlete," it will be possible to make a comparable and straightforward interpretation of data from different studies and settings.
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- 2022
7. IL-33 prevents the enhancement of AP-N, DPP4, and ACE2 expression induced by rhinovirus HRV16 in the human lung endothelium-potential implications for coronaviral airway infections
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Izabela Gulbas, Adrian Gajewski, Mateusz Gawrysiak, Robert Szewczyk, Aleksandra Likońska, Sylwia Michlewska, Marek L. Kowalski, and Maciej Chałubiński
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Rhinovirus ,Dipeptidyl Peptidase 4 ,Immunology ,Immunology and Allergy ,Humans ,Angiotensin-Converting Enzyme 2 ,Endothelium ,Interleukin-33 ,Lung - Published
- 2022
8. Cutaneous Hypersensitivity Reactions to Analgesics and Nonsteroidal Anti-Inflammatory Drugs
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Marek L. Kowalski and Aleksandra Wardzynska
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- 2022
9. Predicting food allergy: The value of patient history reinforced
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Ronald van Ree, Paraskevi Xepapadaki, L. Barreales, Peter Burney, Marek L. Kowalski, Paco M J Welsing, Monika Jedrzejczak-Czechowicz, Tihomir B. Mustakov, Michael Clausen, Todor A. Popov, E. N. Clare Mills, André C. Knulst, Nikolaos G. Papadopoulos, Serge A. Versteeg, Tanya Kralimarkova, Ruta Dubakiene, James Potts, Barbara Ballmer-Weber, Cristina Fernández-Pérez, Harmieke van Os-Medendorp, Ischa Kummeling, Christian Bieli, Montserrat Fernandez-Rivas, Sarah A. Lyons, Thuy-My Le, University of Zurich, Lyons, Sarah A, Experimental Immunology, APH - Global Health, APH - Personalized Medicine, Ear, Nose and Throat, and AII - Inflammatory diseases
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Adult ,Male ,food sensitization ,0301 basic medicine ,medicine.medical_specialty ,Allergy ,Demographics ,Immunology ,Population ,610 Medicine & health ,Plant foods ,Food Allergy and Gastrointestinal Disease ,03 medical and health sciences ,0302 clinical medicine ,Food allergy ,Internal medicine ,Prevalence ,Humans ,Immunology and Allergy ,Medicine ,Medical history ,Child ,education ,Asthma ,food allergy ,2403 Immunology ,education.field_of_study ,business.industry ,Reproducibility of Results ,10177 Dermatology Clinic ,prediction ,Allergens ,medicine.disease ,Comorbidity ,Europe ,030104 developmental biology ,030228 respiratory system ,patient history ,10036 Medical Clinic ,2723 Immunology and Allergy ,Original Article ,ORIGINAL ARTICLES ,business ,Food Hypersensitivity - Abstract
Background EAACI guidelines emphasize the importance of patient history in diagnosing food allergy (FA) and the need for studies investigating its value using standardized allergy‐focused questionnaires. Objective To determine the contribution of reaction characteristics, allergic comorbidities and demographics to prediction of FA in individuals experiencing food‐related adverse reactions. Methods Adult and school‐age participants in the standardized EuroPrevall population surveys, with self‐reported FA, were included. Penalized multivariable regression was used to assess the association of patient history determinants with “probable” FA, defined as a food‐specific case history supported by relevant IgE sensitization. Results In adults (N = 844), reproducibility of reaction (OR 1.35 [95% CI 1.29‐1.41]), oral allergy symptoms (OAS) (4.46 [4.19‐4.75]), allergic rhinitis (AR) comorbidity (2.82 [2.68‐2.95]), asthma comorbidity (1.38 [1.30‐1.46]) and male sex (1.50 [1.41‐1.59]) were positively associated with probable FA. Gastrointestinal symptoms (0.88 [0.85‐0.91]) made probable FA less likely. The AUC of a model combining all selected predictors was 0.85 after cross‐validation. In children (N = 670), OAS (2.26 [2.09‐2.44]) and AR comorbidity (1.47 [CI 1.39‐1.55]) contributed most to prediction of probable FA, with a combined cross‐validation‐based AUC of 0.73. When focusing on plant foods, the dominant source of FA in adults, the pediatric model also included gastrointestinal symptoms (inverse association), and the AUC increased to 0.81. Conclusions In both adults and school‐age children from the general population, reporting of OAS and of AR comorbidity appear to be the strongest predictors of probable FA. Patient history particularly allows for good discrimination between presence and absence of probable plant FA., In support of expert opinion, data collected in a standardized manner all across Europe reveal that information available from patient history can accurately predict IgE sensitization corresponding to a food‐specific case history (probable FA). OAS and AR comorbidity are strongly associated with presence of FA and GI symptoms with absence of FA (particularly plant FA) in adults and children. Abbreviations: AA, allergic asthma; AR, allergic rhinitis; FA, food allergy; GI, gastrointestinal; OAS, oral allergy symptoms
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- 2020
10. Toward personalization of asthma treatment according to trigger factors
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Luis Caraballo, Susanne Greber-Platzer, W. Pohl, Bulent Enis Sekerel, Valérie Siroux, Elena S. Fedenko, Natalia Ilina, Paolo Maria Matricardi, Harald Renz, Petra Pazderova, Zhanat Ispayeva, Elopy Sibanda, Kian Fan Chung, Nikolaos G. Papadopoulos, Hugo Van Bever, Marianne van Hage, Alexander Emelyanov, S. G. Makarova, Roxana S. Bumbacea, Carmen Panaitescu, Erika von Mutius, Faith H. A. Osier, Sebastian L. Johnston, Jin Lyu Sun, Gary W.K. Wong, R S Fassakhov, Ludmila P. Sizyakina, Kristina Borochova, Jiu-Yao Wang, Evgeny Beltyukov, Zhongshan Gao, Kari C. Nadeau, Antonina Karsonova, Marco Idzko, Snezhana Bychkovskaya, A.N. Pampura, Katarzyna Niespodziana, Peter Errhalt, Tatiana Baranovskaya, Dmitry Kudlay, M. Gotua, Natalia Astafyeva, Thomas Schlederer, Marek L. Kowalski, Rezeda Fayzullina, Musa Khaitov, Tetiana Umanets, Ksenja Riabova, Leyla Namazova-Baranova, Pedro Giavina-Bianchi, Ruby Pawankar, Mohamed-Ridha Barbouche, Zsolt Szépfalusi, Sergii Zaikov, Hae-Sim Park, Guillermo Horacio Docena, Irina Evsegneeva, Mihaela Zidarn, Michael Levin, Adnan Custovic, Jean Bousquet, Elena Kovzel, Paul M. O'Byrne, Daria Fomina, Oleksandr Nazarenko, Elena Borzova, Thomas Eiwegger, Olga Naumova, Gunilla Hedlin, Omer Kalayci, Rudolf Valenta, Vanitha Sampath, Angelika Berger, Margarita Vasileva, Alexander Karaulov, Graduate School, Medical Microbiology and Infection Prevention, AII - Inflammatory diseases, Salvy-Córdoba, Nathalie, Medizinische Universität Wien = Medical University of Vienna, Saratov State Medical University, Partenaires INRAE, Belarusian Medical Academy of Post-Graduate Education [Minsk] (BelMAPGE), Laboratoire d'immunologie clinique [Institut Pasteur de Tunis], Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), South Ural State Medical University, Russian Medical Academy for Continuous Medical Education [Moscow], Pirogov Russian National Research Medical University, Sechenov First Moscow State Medical University, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Humboldt University Of Berlin, Berlin Institute of Health (BIH), University of Medicine and Pharmacy 'Carol Davila' Bucharest (UMPCD), Krasnoyarsk State Medical University (KrasSMU), Universidad de Cartagena [Cartagena de Indias], National Heart and Lung Institute [London] (NHLI), Imperial College London-Royal Brompton and Harefield NHS Foundation Trust, Universidad Nacional de la Plata [Argentine] (UNLP), The Hospital for sick children [Toronto] (SickKids), North-Western State Medical University [St Petersburg, Russia], Krems University Hospital, Kazan Federal University (KFU), Bashkir State University (BASHEDU), NRC Institute of immunology FMBA, Moscow Russian federation, Zhejiang Gongshang University [Hangzhou] (ZJSU), Universidade de São Paulo = University of São Paulo (USP), Tbilisi State University, Astrid Lindgren Children's Hospital, Karolinska University Hospital [Stockholm], Karolinska Institutet [Stockholm], Al-Farabi Kazakh National University [Almaty] (KazNU), Faculty of Medicine [Hacettepe University], Hacettepe University = Hacettepe Üniversitesi, Nazarbayev University [Kazakhstan], Medical University of Łódź (MUL), University of Cape Town, Dmitry Rogachev National Research Center of Pediatric Hematology, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Sean N. Parker Center for Allergy and Asthma Research [Stanford], Stanford Medicine, Stanford University-Stanford University, Pirogov Russian National Reasearch Medical University Moscow, National Academy of Medical Sciences of Ukraine, Shupyk National Medical Academy of Postgraduate Education [Kiev] (SNMAPE), Michael DeGroote School of Medicine [Hamilton, ON, Canada], Faculty of Health Sciences [Hamilton, ON, Canada], McMaster University [Hamilton, Ontario]-McMaster University [Hamilton, Ontario], KEMRI-Wellcome Trust Research Programme (KWTRP), Pius Branzeu Clinical Emergency Hospital (OncoGen), University of Manchester [Manchester], National and Kapodistrian University of Athens (NKUA), Ajou University, Nippon Medical School [Tokyo, Japon], Hietzing Hospital, Karl Landsteiner Institute for Dermatological Research, Landesklinikum St. Poelten, University of Giessen and Marburg Lung Center [Gießen, Germany] (UGMLC), German Center for Lung Research, University of Zimbawe [Harare] (UZ), University of Zimbawe, National University of Science and Technology [Bulawayo], Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Southern Federal University [Rostov-on-Don] (SFEDU), Peking Union Medical College Hospital [Beijing] (PUMCH), Chinese Academy of Medical Sciences and Peking Union Medical College, National University of Singapore (NUS), Center of Allergology and Clinical Immunology, Dr von Hauner Children's Hospital [Munich, Germany], Ludwig-Maximilians-Universität München (LMU), Helmholtz Centre Munich, German Centre for Lung Research, National Cheng Kung University Hospital [Tainan], The Chinese University of Hong Kong [Hong Kong], Respiratory and Allergic Diseases [Golnik, Slovenia], University Clinic of Respiratory and Allergic Diseases Golnik, University of Ljubljana, and Karl Landsteiner University of Health Sciences - Karl Landsteiner Privatuniversität für Gesundheitswissenschaften [Krems an der Donau, Austria]
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0301 basic medicine ,Allergy ,MESH: Asthma ,Rhinovirus ,Asthma treatment ,CHILDREN ,EPITOPE ,Disease ,Microarray ,medicine.disease_cause ,sopenje ,alergeni ,Personalization ,Atopy ,0302 clinical medicine ,immune system diseases ,astma ,Immunology and Allergy ,MESH: Animals ,Precision Medicine ,RISK ,MESH: Rhinovirus ,respiratorni znaki in simptomi ,analiza mikromrež ,Allergen ,alergija in imunologija ,SENSITIZATION ,personalizirana medicina ,Wheeze ,rhinovirus ,allergy and immunology ,INFECTIONS ,1107 Immunology ,wheeze ,ATOPY ,[SDV.IMM]Life Sciences [q-bio]/Immunology ,medicine.symptom ,Life Sciences & Biomedicine ,Bioquímica ,medicine.medical_specialty ,MESH: Allergens ,[SDV.IMM] Life Sciences [q-bio]/Immunology ,precision medicine ,Immunology ,udc:616-097 ,MESH: Precision Medicine ,03 medical and health sciences ,[SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics ,rinovirus ,medicine ,Animals ,Humans ,allergens ,IMMUNOTHERAPY ,Intensive care medicine ,Asthma ,[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics ,MESH: Humans ,Science & Technology ,business.industry ,Allergens ,asthma ,respiratory ,medicine.disease ,respiratory tract diseases ,signs and symptoms ,030104 developmental biology ,ANTIBODY ,030228 respiratory system ,Ciencias Médicas ,MESH: Biomarkers ,microarray analysis ,business ,Biomarkers ,RESPONSES - Abstract
Asthma is a severe and chronic disabling disease affecting more than 300 million people worldwide. Although in the past few drugs for the treatment of asthma were available, new treatment options are currently emerging, which appear to be highly effective in certain subgroups of patients. Accordingly, there is a need for biomarkers that allow selection of patients for refined and personalized treatment strategies. Recently, serological chip tests based on microarrayed allergen molecules and peptides derived from the most common rhinovirus strains have been developed, which may discriminate 2 of the most common forms of asthma, that is, allergen- and virus-triggered asthma. In this perspective, we argue that classification of patients with asthma according to these common trigger factors may open new possibilities for personalized management of asthma., La lista completa de autores que integran el documento puede consultarse en el archivo., Facultad de Ciencias Exactas
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- 2020
11. Position statement of expert panel of the Polish Allergology Society on the management of patients with bronchial asthma and allergic diseases during SARS-Cov-2 pandemics
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Marek L. Kowalski, Jerzy Kruszewski, Maciej Chałubiński, Magdalena Czarnecka-Operacz, Marek Niedoszytko, Anna Bręborowicz, Marek Kulus, Roman Nowicki, Zbigniew Bartuzi, Barbara Rogala, Marcin Moniuszko, and Marita Nittner-Marszalska
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Position statement ,Allergen immunotherapy ,medicine.medical_specialty ,Allergy ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Disease ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,030228 respiratory system ,Pandemic ,medicine ,General Earth and Planetary Sciences ,030212 general & internal medicine ,Allergists ,Intensive care medicine ,business ,General Environmental Science ,Asthma - Abstract
The document prepared by the expert panel of allergy/immunology specialists representing Polish Allergy Society intends to provide allergists with recommendations with respect to proper management of allergic patients during SARS-CoV-2 pandemics Allergist should aim at reducing patient’s social interactions by replacing face-to-face visits with communication via telephone or internet In parallel allergist is responsible for assuring that the patient is receiving proper care of underlying allergic disease The experts panel provides eighteen recommendations for management of patients with asthma and allergic diseases during pandemics, indicating that in majority of patients asthma treatment (including inhaled corticosteroids) and allergy treatment should be continued Specific recommendations for treatment with allergen immunotherapy and with biologics are discussed in details
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- 2020
12. IL-33 may augment the effect of rhinovirus HRV16 on the inflammatory activity of human lung vascular endothelium – possible implication for asthma exacerbations
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Robert Szewczyk, Marek L. Kowalski, Maciej Chałubiński, Adrian Gajewski, and Mateusz Gawrysiak
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Interleukin 33 ,Vascular endothelium ,Asthma exacerbations ,medicine.anatomical_structure ,business.industry ,Immunology ,medicine ,Rhinovirus ,Augment ,medicine.disease_cause ,business ,Human lung - Published
- 2021
13. Asthma in elite athletes – a non-Type 2 disease
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Marcin Kurowski, Sergio Bonini, Pekka Malmberg, Katja Radon, Sofia Vakali, Søren Malte Rasmussen, Trine Stensrud, Luís Delgado, Nikos Papadoupolous, Erik Sören Halvard Hansen, Marek L. Kowalski, Tari Haahtela, Mikko Voutilainen, André Moreira, Franchek Drobnik, Christina Gratziou, Matteo Bonini, Vibeke Backer, and Jean Bousquet
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medicine.medical_specialty ,business.industry ,Internal medicine ,medicine ,Elite athletes ,Disease ,business ,medicine.disease ,Asthma - Published
- 2021
14. Interferon-dependant and immune cell-based mechanisms of antiviral resistance of the human lung vascular endothelium infected with rhinovirus HRV16
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Aleksandra Likońska, Mateusz Gawrysiak, Adrian Gajewski, Mateusz Kobierecki, Michał Szymański, Maciej Chałubiński, Izabela Gulbas, Marek L. Kowalski, Robert Szewczyk, and Sylwia Michlewska
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business.industry ,Antiviral resistance ,medicine.disease_cause ,Human lung ,Vascular endothelium ,medicine.anatomical_structure ,Immune system ,Interferon ,Immunology ,medicine ,Rhinovirus ,business ,Cell based ,medicine.drug - Published
- 2021
15. Human rhinovirus causes increase in angiogenetic activity of lung endothelial cells – potential involvement in enhanced vasculature in asthmatics
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Adrian Gajewski, Robert Szewczyk, Maciej Chałubiński, Kinga Klimczak, Mateusz Gawrysiak, Izabela Gulbas, Aleksandra Likońska, and Marek L. Kowalski
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Lung ,medicine.anatomical_structure ,business.industry ,Immunology ,medicine ,Rhinovirus ,business ,medicine.disease_cause - Published
- 2021
16. The effect of IL-33 and IL-25 on the rhinovirus-induced susceptibility of the lung vascular endothelium to SARS-CoV-2, MERS and 229E coronaviral infections
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Mateusz Gawrysiak, Robert Szewczyk, Maciej Chałubiński, Izabela Gulbas, Marek L. Kowalski, and Adrian Gajewski
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Vascular endothelium ,Interleukin 33 ,Lung ,medicine.anatomical_structure ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Immunology ,Medicine ,Rhinovirus ,business ,medicine.disease_cause - Published
- 2021
17. Physical exercise, immune response and susceptibility to infections -- current knowledge and growing research areas
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Matteo Bonini, André Moreira, Zuzana Diamant, Stefano Del Giacco, Sven Seys, Maia Rukhadze, Luís Delgado, Marek L. Kowalski, Marcin Kurowski, and Mariana Couto
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medicine.medical_specialty ,biology ,business.industry ,Research areas ,Athletes ,Strenuous exercise ,Psychological intervention ,Inflammation ,Physical exercise ,Systemic inflammation ,biology.organism_classification ,Immune system ,medicine ,medicine.symptom ,business ,Intensive care medicine - Abstract
This review presents state-of-the-art knowledge and identifies knowledge gaps for future research in the area of exercise-associated modifications of infection susceptibility. Regular moderate-intensity exercise is believed to have beneficial effects on immune health through lowering inflammation intensity and reducing susceptibility to respiratory infections. Infection-promoting consequences are attributed to strenuous exercise as performed by professional athletes. In about half of the athletes presenting respiratory symptoms, no causative pathogen can be identified. Acute bouts of exercise enhance release of proinflammatory mediators thus probably leading to appearance of infection-like respiratory symptoms. Studies assessing influence of regularly repeated exercise on immune response and systemic inflammation are far less numerous than those regarding acute exercise effects. This identifies another knowledge gap requiring further assessment both in recreational and in professional athletes Additionally, ambient and environmental conditions modify systemic inflammatory response and infection susceptibility in particular in outdoor athletes. Both acute and chronic regular exercise influence humoral and cellular immune response mechanisms resulting in decreased specific and non-specific response in competitive athletes. Most promising areas of further research in exercise immunology include: detailed immunological characterization of infection-prone and infection-resistant athletes; efficacy of nutritional and pharmaceutical interventions as countermeasures to infections’ symptoms; and influence of various exercise loads on susceptibility to infections with respiratory viruses, including SARS-CoV-2. Establishing uniform definition of “elite athlete’ shall hopefully allow for comparable and straightforward interpretation of data coming from different studies and settings.
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- 2021
18. Circulating miRNA expression in asthmatics is age-related and associated with clinical asthma parameters, respiratory function and systemic inflammation
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Aleksandra Wardzyńska, Joanna Jamroz-Brzeska, Joanna Rywaniak, Marek L. Kowalski, Joanna Makowska, and Małgorzata Pawełczyk
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Basic immunology ,Male ,0301 basic medicine ,Systemic inflammation ,Pulmonary function testing ,Proinflammatory cytokine ,Pathogenesis ,Diseases of the respiratory system ,03 medical and health sciences ,Elderly ,0302 clinical medicine ,Immune system ,Forced Expiratory Volume ,Humans ,Medicine ,Respiratory function ,Circulating MicroRNA ,miRNA ,Aged ,Asthma ,Innate immunity ,Inflammation ,RC705-779 ,business.industry ,Research ,Middle Aged ,medicine.disease ,030104 developmental biology ,030228 respiratory system ,Immunology ,Cytokines ,Female ,Tumor necrosis factor alpha ,medicine.symptom ,business ,Biomarkers - Abstract
BackgroundThe course of asthma may differ between elderly asthmatics (EA) and non-elderly asthmatics (nEA), which may be partially associated with an age-dependent aberrant immune response. The aim of the study was to determine the influence of serum miRNA expression on asthma characteristics and systemic inflammation markers in EA and nEA.MethodsControl and severity of asthma, pulmonary function and FeNO were assessed in 28 EA and 31 nEA patients. The control group included 59 elderly and non-elderly healthy individuals. The expression of selected miRNAs in serum was measured with rt-PCR, and proinflammatory cytokine activity was assayed by ELISA or flow cytometry.ResultsNo difference in serum miRNA expression was observed between the asthmatics and healthy controls. EA demonstrated lower expression of miRNA-106a and miRNA-126a than nEA (p = 0.003 and p = 0.02) and EC had lower expression of miRNA-146a, -126a, -106a and 19b than nEC (p = 0.001, p = 0.003, p = 0.005 and p ConclusionSerum miRNA expression was found to correlate with clinical characteristics of asthma and systemic inflammation in an age-dependent fashion, suggesting that miRNA may differentially contribute to asthma pathogenesis in elderly and non-elderly patients.
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- 2021
19. Physical activity in asthma control and its immune modulatory effect in asthmatic preschoolers
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Barbara Stanic, Ya-dong Gao, Susetta Finotto, Michael Villiger, Cezmi A. Akdis, Claus Bachert, Debbie J Maurer, Mübeccel Akdis, Luo Zhang, Nikolaos G. Papadopoulos, Nan Zhang, Tuomas Jartti, Heikki Lukkarinen, Walter Kistler, Maria Pasioti, Ge Tan, Anna Graser, Chengyao Liu, Marek L. Kowalski, Paraskevi Xepapadaki, University of Zurich, and Akdis, Cezmi A
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medicine.medical_treatment ,Immunology ,Physical activity ,physical activity ,610 Medicine & health ,EXERCISE ,CHILDREN ,Peripheral blood mononuclear cell ,SPORTS ,Proinflammatory cytokine ,ACTIVATION ,chemistry.chemical_compound ,Immune system ,10183 Swiss Institute of Allergy and Asthma Research ,Asthma control ,Medicine and Health Sciences ,Immunology and Allergy ,Humans ,Medicine ,POSITION STATEMENT ,Child ,Exercise ,Asthma ,2403 Immunology ,immune modulation ,business.industry ,Zymosan ,Attendance ,Immunity ,asthma ,medicine.disease ,cytokines ,PreDicta ,ALLERGY ,Cytokine ,chemistry ,2723 Immunology and Allergy ,Leukocytes, Mononuclear ,Cytokines ,business - Abstract
Background: The impact of physical activity on immune response is a hot topic in exercise immunology, but studies involving asthmatic children are scarce. Our aims were to examine whether there were any differences in the level of physical activity and daily TV attendance, to assess its role on asthma control and immune responses to various immune stimulants. Methods: Weekly physical activity and daily television attendance were obtained from questionnaires at inclusion of the PreDicta study. PBMC cultures were stimulated with phytohemagglutinin (PHA), R848, poly I:C, and zymosan. A panel of cytokines was measured and quantified in cell culture supernatants using luminometric multiplex immunofluorescence beads-based assay. Results: Asthmatic preschoolers showed significantly more TV attendance than their healthy peers (58.6% vs. 41.5% 1–3 h daily and only 25.7% vs. 47.2% ≤1 h daily) and poor asthma control was associated with less frequent physical activity (PA) (75% no or occasional activity in uncontrolled vs. 20% in controlled asthma; 25% ≥3 times weekly vs. 62%). Asthmatics with increased PA exhibited elevated cytokine levels in response to polyclonal stimulants, suggesting a readiness of circulating immune cells for type 1, 2, and 17 cytokine release compared to subjects with low PA and high TV attendance. This may also represent a proinflammatory state in high PA asthmatic children. Low physical activity and high TV attendance were associated with a decrease in proinflammatory cytokines. Proinflammatory cytokines were correlating with each other in in vitro immune responses of asthmatic children, but not healthy controls, this correlation was more pronounced in children with sedentary behavior. Conclusion: Asthmatic children show more sedentary behavior than healthy subjects, while poor asthma control is associated with a substantial decrease in physical activity. Our results suggest that asthmatic children may profit from regular exercise, as elevated cytokine levels in stimulated conditions indicate an immune system prepared for responding strongly in case of different types of infections. However, it has to be considered that a hyperinflammatory state in high PA may not be beneficial in asthmatic children.
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- 2021
20. High-resolution allele frequencies for NGS based HLA-A, B, C, DQB1 and DRB1 typing of 23,595 bone marrow donors recruited for the Polish central potential unrelated bone marrow donor registry
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Jarosław Czerwiński, Anna Bogacz, Klaudia Nestorowicz, Bogusław Tymoniuk, Łukasz Kniżewski, Mariusz Gronkowski, Sylwia Wróblewska-Kabba, Michał Góralski, Michał Kolasiński, Alicja Bukowska, Mateusz Chraplak, Karol Jopek, Małgorzata Dudkiewicz, Mateusz Sowiński, Marek L. Kowalski, and Jacek Nowak
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0301 basic medicine ,medicine.medical_treatment ,Immunology ,Human leukocyte antigen ,Hematopoietic stem cell transplantation ,03 medical and health sciences ,0302 clinical medicine ,Gene Frequency ,HLA Antigens ,medicine ,Humans ,Immunology and Allergy ,Registries ,Typing ,Allele ,Allele frequency ,Bone Marrow Transplantation ,business.industry ,Histocompatibility Testing ,Haplotype ,High-Throughput Nucleotide Sequencing ,General Medicine ,Tissue Donors ,HLA-A ,Genetics, Population ,030104 developmental biology ,medicine.anatomical_structure ,Haplotypes ,Poland ,Bone marrow ,business ,030215 immunology - Abstract
Next-generation sequencing (NGS)-based typings of HLA-A, B, C, DQB1 and DRB1 loci were performed from 2018 to 2019 in 23 595 newly recruited or re-typed adult potential bone marrow donors registered in Poltransplant Registry to characterize allele and haplotype frequencies of HLA system for loci important for hematopoietic stem cell transplantation. The donors were recruited for registry and not for any other purpose including controls in a disease association study. The population sample was collected in various regions of Poland including all voivodships. The data regarding the degree of relatedness among individuals in the sample were not collected. Typings were supported by public funds as a part of the Polish National Program for Transplant Medicine Development. HLA frequency data are available in the Allele Frequencies Net Database.
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- 2020
21. Management of ocular allergy
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Jean Luc Fauquert, Dermot Ryan, Diana Silva, Banu Bozkurt, Carmen Rondon, Andrea Leonardi, Daniel Perez Formigo, Luís Delgado, Virginia L. Calder, Pia Allegri, Serge Doan, Marek L. Kowalski, Vibha Sharma, Selçuk Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, and Bozkurt, Banu
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medicine.medical_specialty ,Eye Diseases ,Immunology ,MEDLINE ,Primary care ,Disease ,systematic review ,Risk Factors ,Hypersensitivity ,medicine ,Humans ,Immunology and Allergy ,Anti-Asthmatic Agents ,Intensive care medicine ,treatment ,business.industry ,Disease Management ,medicine.disease ,Combined Modality Therapy ,Allergic conjunctivitis ,Ocular allergy ,allergic conjunctivitis ,Calcineurin ,Treatment Outcome ,Systematic review ,ocular allergy ,management ,Disease Susceptibility ,Allergists ,business - Abstract
PubMed: 30887530, The treatment and management of ocular allergy (OA) remain a major concern for different specialties, including allergists, ophthalmologists, primary care physicians, rhinologists, pediatricians, dermatologists, clinical immunologists, and pharmacists. We performed a systematic review of all relevant publications in MEDLINE, Scopus, and Web Science including systematic reviews and meta-analysis. Publications were considered relevant if they addressed treatments, or management strategies of OA. A further wider systematic literature search was performed if no evidence or good quality evidence was found. There are effective drugs for the treatment of OA; however, there is a lack an optimal treatment for the perennial and severe forms. Topical antihistamines, mast cell stabilizers, or double-action drugs are the first choice of treatment. All of them are effective in reducing signs and symptoms of OA. The safety and optimal dosing regimen of the most effective topical anti-inflammatory drugs, corticosteroids, are still a major concern. Topical calcineurin inhibitors may be used in steroid-dependent/resistant cases of severe allergic keratoconjunctivitis. Allergen-specific immunotherapy may be considered in cases of failure of first-line treatments or to modify the natural course of OA disease. Based on the current wealth of publications and on the collective experience, recommendations on management of OA have been proposed. © 2019 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd., Funding information This work was done under the approval of EAACI with a TF budget 2015-18.
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- 2019
22. 2019 ARIA – Care pathways for allergic rhinitis – Poland
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Agnieszka Lipiec, Marek Niedoszytko, Barbara Piekarska, Peter Hellings, Dana Wallace, Filip Raciborski, Wienczyslawa Czarlewski, Piotr Kuna, Edyta Krzych-Fałta, Maciej Kupczyk, Holger J. Schünemann, Jean Bousquet, Marek L. Kowalski, Oliver Pfaar, Bolesław Samoliński, Anna Bedbrook, Marek Jutel, Ewa Jassem, and Claus Bachert
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recommendation ,medicine.medical_specialty ,Allergy ,IMPACT ,CHILDREN ,COST-EFFECTIVENESS ,Medicine and Health Sciences ,medicine ,QUALITY ,integrated care ,General Environmental Science ,Asthma ,EAACI AIT GUIDELINES ,Science & Technology ,allergic rhinitis ,business.industry ,FLUTICASONE FUROATE ,asthma ,medicine.disease ,Integrated care ,URBAN-POPULATION ,SUBLINGUAL IMMUNOTHERAPY ,Family medicine ,General Earth and Planetary Sciences ,AZELASTINE NASAL SPRAY ,business ,Life Sciences & Biomedicine - Abstract
Integrated health care plays a pivotal role in allergic diseases. It identifies key actions (based on guidelines) in the management of allergy patients that are transferred to the local level and implemented in clinical practice. It is particularly important for allergic rhinitis to develop a new generation of guidelines for pharmacotherapy and allergen immunotherapy. Allergen-specific immunotherapy is a parallel therapy that has a preventive (or prophylactic) character and not a method indicated for those who do not respond to pharmacotherapy.
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- 2019
23. Asthma and exercise-induced respiratory disorders in athletes. The position paper of the Polish Society of Allergology and Polish Society of Sports Medicine
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Zbigniew Bartuzi, Radosław Gawlik, Andrzej Pokrywka, Hubert Krysztofiak, Marcin Kurowski, Jarosław Krzywański, Ziemowit Ziętkowski, Marek L. Kowalski, and Andrzej Bugajski
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lcsh:Internal medicine ,medicine.medical_specialty ,Allergy ,Sports medicine ,diagnosis ,Physical examination ,Dermatology ,Atopy ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,lcsh:Dermatology ,medicine ,Immunology and Allergy ,Medical history ,lcsh:RC31-1245 ,Intensive care medicine ,General Environmental Science ,Asthma ,treatment ,medicine.diagnostic_test ,biology ,Athletes ,business.industry ,exercise-induced bronchoconstriction ,lcsh:RL1-803 ,medicine.disease ,biology.organism_classification ,Physical therapy ,General Earth and Planetary Sciences ,Position paper ,Special Paper ,business ,human activities - Abstract
Exercise-induced respiratory symptoms describe acute airway narrowing that occurs as a result of exercise. It includes exercise-induced bronchoconstriction (EIB) and exercise-induced asthma (EIA) issues. To provide clinicians with practical guidelines, a multidisciplinary panel of stakeholders was convened to review the pathogenesis of EIB/EIA and to develop evidence-based guidelines for the diagnosis and treatment. Recommendations for the diagnosis and treatment of EIB were developed. High-intensity exercise in polluted environment (cold air, humidity, contamination, allergens) may increase the risk of EIB and asthma symptoms in athletes. Diagnostic procedures should include history taking, physical examination, atopy assessment and functional tests of the respiratory system. A strong recommendation was made for regular use of inhaled glucocorticosteroids and avoidance of short-acting β2-agonists as the only treatment. The treatment of asthma in athletes should always take into account current anti-doping regulations. This position paper reflects the currently available evidence.
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- 2019
24. Heterogeneity of NSAID-Exacerbated Respiratory Disease
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Marek L Kowalski
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Pulmonary and Respiratory Medicine ,medicine.medical_treatment ,Disease ,Bioinformatics ,03 medical and health sciences ,Nasal Polyps ,0302 clinical medicine ,Eosinophilic ,medicine ,Humans ,Nasal polyps ,030212 general & internal medicine ,Sinusitis ,Rhinitis ,Asthma ,Desensitization (medicine) ,Aspirin ,business.industry ,Anti-Inflammatory Agents, Non-Steroidal ,Respiratory disease ,medicine.disease ,Phenotype ,medicine.anatomical_structure ,030228 respiratory system ,Chronic Disease ,Asthma, Aspirin-Induced ,business ,Biomarkers ,medicine.drug ,Respiratory tract - Abstract
PURPOSE OF REVIEW:NSAID-Exacerbated Disease (N-ERD) is a chronic eosinophilic inflammatory disorder of the respiratory tract occurring in patients with asthma and/or rhinosinusitis with nasal polyps, whose symptoms are exacerbated by NSAIDs. The purpose of this review is to provide an update on clinical characteristics, pathophysiology, and management of N-ERD, and to emphasize heterogeneity of this syndrome. RECENT FINDINGS:Growing evidence indicates that N-ERD, which has been considered a separate asthma phenotype, is heterogenous, and can be divided in several subphenotypes varying in clinical characteristics. Pathophysiology of N-ERD is complex and extends beyond abnormalities in the arachidonic acid metabolism. Heterogeneity of pathophysiological mechanisms underlying development of airway inflammation seems to be associated with variability in response to both anti-inflammatory and disease-specific treatments (e.g., with aspirin after desensitization). SUMMARY:Progress in understanding of the pathophysiology of N-ERD leads to discovery and validation of new biomarkers facilitating diagnosis and predicting the response to treatment of the chronic inflammation underlying upper (CRSwNP) and lower airway (asthma) symptoms. Better characterization of the immunophysiopathological heterogeneity of N-ERD (identification of endotypes) may allow more personalized, endotype-driven approach to treatment in the future.
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- 2019
25. IL-33 augments the effect of rhinovirus HRV16 on inflammatory activity of human lung vascular endothelium-possible implications for rhinoviral asthma exacerbations
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Izabela Gulbas, Marek L. Kowalski, Robert Szewczyk, Sylwia Michlewska, Adrian Gajewski, Maciej Chałubiński, Aleksandra Likońska, and Mateusz Gawrysiak
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Asthma exacerbations ,Rhinovirus ,business.industry ,Immunology ,medicine.disease_cause ,Interleukin-33 ,Asthma ,Human lung ,Vascular endothelium ,Interleukin 33 ,medicine.anatomical_structure ,medicine ,Immunology and Allergy ,Humans ,Endothelium, Vascular ,business ,Lung - Published
- 2021
26. Estimating the Risk of Severe Peanut Allergy Using Clinical Background and IgE Sensitization Profiles
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Mareen R. Datema, Sarah A. Lyons, Montserrat Fernández-Rivas, Barbara Ballmer-Weber, André C. Knulst, Riccardo Asero, Laura Barreales, Simona Belohlavkova, Frédéric de Blay, Michael Clausen, Ruta Dubakiene, Cristina Fernández-Perez, Philipp Fritsche, David Gislason, Karin Hoffmann-Sommergruber, Monika Jedrzejczak-Czechowicz, Laurian Jongejan, Marek L. Kowalski, Tanya Z. Kralimarkova, Jonas Lidholm, Nikolaos G. Papadopoulos, Todor A. Popov, Nayade del Prado, Ashok Purohit, Isabel Reig, Suranjith L. Seneviratne, Athanassios Sinaniotis, Emilia Vassilopoulou, Serge A. Versteeg, Stefan Vieths, Paco M. J. Welsing, E. N. Clare Mills, Thuy-My Le, Aeilko H. Zwinderman, and Ronald van Ree
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0301 basic medicine ,Allergy ,clinical background ,Peanut allergy ,severity ,Immunoglobulin E ,EuroPrevall ,Atopy ,03 medical and health sciences ,0302 clinical medicine ,medicine ,IgE ,prediction ,peanut allergy ,component-resolved diagnostics ,Lebensmittelallergie ,iFAAM ,Sensitization ,House dust mite ,biology ,business.industry ,food and beverages ,General Medicine ,Atopic dermatitis ,RC581-607 ,medicine.disease ,biology.organism_classification ,030104 developmental biology ,medicine.anatomical_structure ,nervous system ,030228 respiratory system ,Latex allergy ,Immunology ,biology.protein ,Immunologic diseases. Allergy ,business - Abstract
Background:It is not well-understood why symptom severity varies between patients with peanut allergy (PA).Objective:To gain insight into the clinical profile of subjects with mild-to-moderate and severe PA, and investigate individual and collective predictive accuracy of clinical background and IgE to peanut extract and components for PA severity.Methods:Data on demographics, patient history and sensitization at extract and component level of 393 patients with probable PA (symptoms ≤ 2 h + IgE sensitization) from 12 EuroPrevall centers were analyzed. Univariable and penalized multivariable regression analyses were used to evaluate risk factors and biomarkers for severity.Results:Female sex, age at onset of PA, symptoms elicited by skin contact with peanut, family atopy, atopic dermatitis, house dust mite and latex allergy were independently associated with severe PA; birch pollen allergy with mild-to-moderate PA. The cross-validated AUC of all clinical background determinants combined (0.74) was significantly larger than the AUC of tests for sensitization to extract (0.63) or peanut components (0.54–0.64). Although larger skin prick test wheal size, and higher IgE to peanut extract, Ara h 1 and Ara h 2/6, were associated with severe PA, and higher IgE to Ara h 8 with mild-to-moderate PA, addition of these measurements of sensitization to the clinical background model did not significantly improve the AUC.Conclusions:Models combining clinical characteristics and IgE sensitization patterns can help establish the risk of severe reactions for peanut allergic patients, but clinical background determinants are most valuable for predicting severity of probable PA in an individual patient.
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- 2021
27. Glycomics in tears: seeking for new biomarkers for ocular allergy diagnosis
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Jean-Luc Fauquert and Marek L. Kowalski
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medicine.medical_specialty ,business.industry ,Immunology ,MEDLINE ,Dermatology ,Ocular allergy ,Glycomics ,Tears ,Hypersensitivity ,Immunology and Allergy ,Medicine ,Humans ,business ,Biomarkers - Published
- 2021
28. Association between Venom Immunotherapy and Changes in Serum Protein-Peptide Patterns
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Slawomir Kosinski, Ewa Smorawska-Sabanty, Eliza Matuszewska, Joanna Matysiak, Jan Matysiak, and Marek L. Kowalski
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0301 basic medicine ,Immunology ,Hymenoptera venom allergy ,lcsh:Medicine ,Venom ,Peptide ,Protein degradation ,Pharmacology ,Proteomics ,Article ,protein–peptide profiling ,03 medical and health sciences ,0302 clinical medicine ,proteomics ,Immunity ,Drug Discovery ,Protein biosynthesis ,Medicine ,MALDI-TOF MS ,Pharmacology (medical) ,Fibrinogen alpha chain ,chemistry.chemical_classification ,business.industry ,lcsh:R ,Venom immunotherapy ,030104 developmental biology ,Infectious Diseases ,030228 respiratory system ,chemistry ,venom immunotherapy ,business - Abstract
Venom immunotherapy (VIT) is administered to allergic patients to reduce the risk of dangerous systemic reactions following an insect sting. To better understand the mechanism of this treatment and its impact on the human organism, we analysed serum proteomic patterns obtained at five time-points from Hymenoptera-venom-allergic patients undergoing VIT. For statistical analyses, patients were additionally divided into two groups (high responders and low responders) according to serum sIgG4 levels. VIT was found to be associated with changes in seven proteins: the fibrinogen alpha chain, complement C4-A, complement C3, filamin-B, kininogen-1, myosin-9 and inter-alpha-trypsin inhibitor heavy chain H1. The number of discriminative m/z (mass-to-charge ratio) features increased up to the 90th day of VIT, which may be associated with the development of immunity after the administration of increased venom doses. It may also suggest that during VIT, there may occur processes involved not only in protein synthesis but also in protein degradation (caused by proteolytic venom components). The results are consistent with measured serum sIgG4 levels, which increased from 2.04 mgA/I at baseline to 7.25 mgA/I at 90 days. Moreover, the major proteomic changes were detected separately in the high responder group. This may suggest that changes in protein–peptide profiles reflect the actual response to VIT.
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- 2021
29. Predictors of excessive short-acting beta2-agonist use and asthma exacerbations: a retrospective analysis of a Polish prescription database
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Dorota Brzostek, Grazyna Bochenek, Andrzej Dąbrowski, Grzegorz Brożek, Piotr Dąbrowiecki, Maciej Kupczyk, Edyta Zagrajek, Radosław Gawlik, Izabela Kupryś-Lipińska, Agnieszka Mastalerz-Migas, Wojciech Barg, Aleksandra Kucharczyk, Rafał Dobek, and Marek L. Kowalski
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medicine.medical_specialty ,Asthma exacerbations ,Prescription database ,B2 receptor ,business.industry ,Emergency medicine ,Retrospective analysis ,Medicine ,business - Published
- 2020
30. Late Breaking Abstract - Overestimation of asthma control and misperception of short-acting ß2-agonists (SABA) use among physicians in Poland
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Aleksandra Kucharczyk, Agnieszka Mastalerz-Migas, Rafał Dobek, Marek L. Kowalski, Grazyna Bochenek, Maciej Kupczyk, Izabela Kupryś-Lipińska, Radosław Gawlik, Grzegorz Brożek, Dorota Brzostek, Piotr Dąbrowiecki, Wojciech Barg, and Andrzej Dąbrowski
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medicine.medical_specialty ,business.industry ,Asthma control ,Family medicine ,medicine ,Treatment decision making ,Allergists ,medicine.disease ,Asthma management ,business ,Gina guidelines ,Pulmonologists ,Asthma - Abstract
Background: Poland does not currently have a national asthma management policy. Although the global GINA guidelines are regularly translated, they may be adopted differently by physicians. Objective: To investigate, if the real-life assessment of asthma control in Poland meets global management standards. Methods: In total, 70 alergists, 80 pulmonologists and 103 GPs participated in the study. All physicians responded to a qualitative questionnaire and delivered diaries (assessment and decisions) of the 10 consecutive asthma patients. The level of asthma control assessed subjectively by the physicians was matched with the patient-reported symptoms according to the GINA guidelines. We also asked physicians about the frequency of short-acting s2-agonists (SABA) use as a sign of poor asthma control. Results: Data obtained from 253 physicians and 2,482 patients showed, that only 59.1% allergists, 44.1% pulmonologists and 44.1% GPs correctly assessed the level of asthma control according to the GINA guidelines (p=0.05, chi²-test). In terms of the GINA guidelines for SABA consumption, only 27% of allergists, 15% pulmonologists and 12% GPs correctly stated the use 1-2 times per week was indicative of controlled asthma. Meanwhile, 41% allergists, 62% pulmonologists and 59% GPs incorrectly assumed the use of 3 or more SABA canisters per year was a sign of controlled asthma. Conclusions: We found low adoption of the GINA guidelines in terms of the assessment of asthma control in Poland, especially regarding SABA overuse. Incorrect assessment of asthma control may lead to sub-optimal treatment decisions.
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- 2020
31. Subacute Thyroiditis is Associated with
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Magdalena, Stasiak, Bogusław, Tymoniuk, Renata, Michalak, Bartłomiej, Stasiak, Marek L, Kowalski, and Andrzej, Lewiński
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HLA-B*35 ,HLA-C*04:01 ,HLA-DRB1*01 ,HLA-B*18:01 ,subacute thyroiditis ,Article - Abstract
Subacute thyroiditis (SAT) is a thyroid inflammatory disease whose pathogenesis is still not completely defined. Previous viral infection is considered to be a triggering factor in genetically predisposed individuals. In about 70% of patients, susceptibility to SAT is associated with the HLA-B*35 allele. The correlation between SAT and other human leukocyte antigens (HLA) has not yet been unequivocally demonstrated and the genetic background is still unknown in about 30% of patients. The purpose of our study was to perform HLA genotyping using a next-generation sequencing method, to find out whether alleles other than HLA-B*35 are correlated with SAT morbidity. HLA-A, -B, -C, -DQB1, -DRB1 were genotyped using a next-generation sequencing method in 1083 subjects, including 60 SAT patients and 1023 healthy controls. Among 60 patients diagnosed with SAT, 81.7% of subjects were identified as having allele HLA-B*35, 23.3% had HLA-B*18:01, 28.3% had HLA-DRB1*01 and 75.5% had HLA-C*04:01. These alleles occurred in the control group at frequencies of 10.2%, 7.2%, 12.9% and 12.5%, respectively. The differences were statistically significant, with p < 0.05. In addition to its previously described relationship with HLA-B*35, genetic susceptibility to SAT was associated with the presence of HLA-B*18:01, DRB1*01 and C*04:01. The alleles HLA-B*18:01 and DRB1*01 were independent SAT risk factors. The assessment of these four alleles allows the confirmation of genetic predisposition in almost all patients with SAT.
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- 2020
32. ARIA���EAACI statement on asthma and COVID���19 (June 2, 2020)
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Tari Haahtela, Victoria Cardona, Alvaro A. Cruz, Anna Bedbrook, Ken Ohta, Wienczyslawa Czarlewski, Nikos G. Papadopoulos, Marc Humbert, Menachem Rottem, Violeta Kvedariene, Omar S. Usmani, Eric D. Bateman, Helga Kraxner, Ludger Klimek, Hubert Blain, Thomas B. Casale, Mário Morais-Almeida, Aziz Sheikh, Joaquin Sastre, Piotr Kuna, Giovanni Rolla, Nataliya Ilina, Thomas Eiwegger, Seppo Koskinen, Tomas Chivato, Torsten Zuberbier, Nicola Scichilone, De Yun Wang, Luisa Brussino, Désirée Larenas-Linnemann, Manuel Soto-Martínez, Maciej Kupczyk, Karin Hoffmann-Sommergruber, Sharon Chinthrajah, Karl Christian Bergmann, M. Gotua, Sinthia Bosnic-Anticevich, Charlotte Suppli-Ulrik, Marek L. Kowalski, Mübeccel Akdis, Bilun Gemicioglu, Petr Panzner, Giovanni Viegi, Elisabete Nunes, Jürgen Schwarze, Sanna Toppila-Salmi, Ioanna Tsiligianni, Hui Du, Wytske Fokkens, Maria Teresa Ventura, Eckard Hamelmann, Paulo Augusto Moreira Camargos, Dmitry Kudlay, Mateo Bonini, Sian Williams, Mina Gaga, Louis-Philippe Boulet, Ignacio J. Ansotegui, Teresa To, Oliver Pfaar, Ioana Agache, Giorgio Walter Canonica, João Fonseca, Leyla Namazova, K. S. Bennoor, Elena Camelia Berghea, Ya-dong Gao, Roland Buhl, David M.G. Halpin, Gabrielle L. Onorato, Nhân Pham-Thi, Todor A. Popov, Mihaela Zidarn, Stefania Nicola, Branislava Milenkovic, Robyn E O'Hehir, Kari C. Nadeau, Juan Carlos Ivancevich, Luís Taborda-Barata, Florin Mihaltan, Amir Hamzah Abdul Latiff, Rafael Stelmach, Marek Jutel, Frederico S. Regateiro, B. Pigearias, Theodor Vontetsianos, Ruby Pawankar, Mohammad R. Masjedi, Renaud Louis, Musa Khaitov, Manuel E. Soto-Quiros, Lan T. Le, H. Neffen, Yousser Mohammad, Yoshitaka Okamoto, Fanny W.S. Ko, Yehia El-Gamal, Edward F. Knol, Gary W.K. Wong, Guy Joos, Gianni Passalacqua, Jean Bousquet, Paul M. O'Byrne, Arunas Valiulis, Cezmi A. Akdis, George Christoff, Bolesław Samoliński, Claus Bachert, Vincenzo Patella, Josep M. Antó, Arzu Yorgancioglu, Michael Levin, Liam O'Mahony, Mario E. Zernotti, Erik Melén, Joaquim Mullol, Peter Valentin Tomazic, Stefano Del Giacco, Francesca Puggioni, Milan Sova, Bruce Kirenga, UAM. Departamento de Medicina, Ear, Nose and Throat, AII - Inflammatory diseases, Bousquet J., Jutel M., Akdis C.A., Klimek L., Pfaar O., Nadeau K.C., Eiwegger T., Bedbrook A., Ansotegui I.J., Anto J.M., Bachert C., Bateman E.D., Bennoor K.S., Berghea E.C., Bergmann K.-C., Blain H., Bonini M., Bosnic-Anticevich S., Boulet L.-P., Brussino L., Buhl R., Camargos P., Canonica G.W., Cardona V., Casale T., Chinthrajah S., Akdis M., Chivato T., Christoff G., Cruz A.A., Czarlewski W., Del Giacco S., Du H., El-Gamal Y., Fokkens W.J., Fonseca J.A., Gao Y., Gaga M., Gemicioglu B., Gotua M., Haahtela T., Halpin D., Hamelmann E., Hoffmann-Sommergruber K., Humbert M., Ilina N., Ivancevich J.-C., Joos G., Khaitov M., Kirenga B., Knol E.F., Ko F.W., Koskinen S., Kowalski M.L., Kraxner H., Kudlay D., Kuna P., Kupczyk M., Kvedariene V., Abdul Latiff A.H., Le L.T., Levin M., Larenas-Linnemann D., Louis R., Masjedi M.R., Melen E., Mihaltan F., Milenkovic B., Mohammad Y., Morais-Almeida M., Mullol J., Namazova L., Neffen H., Nunes E., O'Byrne P., O'Hehir R., O'Mahony L., Ohta K., Okamoto Y., Onorato G.L., Panzner P., Papadopoulos N.G., Passalacqua G., Patella V., Pawankar R., Pham-Thi N., Pigearias B., Popov T.A., Puggioni F., Regateiro F.S., Rolla G., Rottem M., Samolinski B., Sastre J., Schwarze J., Sheikh A., Scichilone N., Soto-Quiros M., Soto-Martinez M., Sova M., Nicola S., Stelmach R., Suppli-Ulrik C., Taborda-Barata L., To T., Tomazic P.-V., Toppila-Salmi S., Tsiligianni I., Usmani O., Valiulis A., Ventura M.T., Viegi G., Vontetsianos T., Wang D.Y., Williams S., Wong G.W.K., Yorgancioglu A., Zernotti M., Zidarn M., Zuberbier T., and Agache I.
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2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,Allergy ,Statement (logic) ,Medicina ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,viruses ,Immunology ,Settore MED/10 - Malattie Dell'Apparato Respiratorio ,medicine.disease_cause ,03 medical and health sciences ,0302 clinical medicine ,astma ,Medicine and Health Sciences ,medicine ,Humans ,Immunology and Allergy ,030212 general & internal medicine ,Letters to the Editor ,Letter to the Editor ,udc:616.2 ,Asthma ,Coronavirus ,Science & Technology ,business.industry ,SARS-CoV-2 ,virus diseases ,COVID-19 ,asthma ,medicine.disease ,Virology ,3. Good health ,030228 respiratory system ,covid-19 ,1107 Immunology ,Angiotensin-Converting Enzyme 2 ,business ,ARIA-EAACI ,Life Sciences & Biomedicine ,600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit - Abstract
Artículo con numerosos autores sólo se mencionan el primero y el de la UAM, Open access funding enabled and organized by Projekt DEAL
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- 2020
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33. Regulated on Activation, Normal T Cell Expressed and Secreted Drives the Resolution of Allergic Asthma
- Author
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Nina Li, Hoomann Mirzakhani, Alexander Kiefer, Julia Koelle, Tytti Vuorinen, Manfred Rauh, Paraskevi Xepapadaki, Anna Lewandowska-Polak, Heikki Lukkarinen, Nan Zhang, Barbara Stanic, Theodor Zimmermann, Marek L. Kowalski, Tuomas Jiartti, Claus Bachert, Mubeccel Akdis, Nikolaos G. Papadopoulos, Benjamin A. Raby, Scott T. Weiss, and Susetta Finotto
- Published
- 2020
34. A similar pro/anti-inflammatory cytokine balance is present in the airways of competitive athletes and non-exercising asthmatics
- Author
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Janusz Jurczyk, Hubert Krysztofiak, Marzanna Jarzębska, Agnieszka Olszewska-Ziąber, Marek L. Kowalski, and Marcin Kurowski
- Subjects
Adult ,Male ,Adolescent ,medicine.drug_class ,medicine.medical_treatment ,Respiratory System ,Competitive athletes ,Anti-inflammatory ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Humans ,Medicine ,Exhaled breath condensate ,Exercise ,Balance (ability) ,Asthma ,biology ,business.industry ,Athletes ,Airway inflammation ,030229 sport sciences ,General Medicine ,medicine.disease ,biology.organism_classification ,Immunity, Innate ,respiratory tract diseases ,Nasal Mucosa ,Cytokine ,Breath Tests ,030228 respiratory system ,Exhalation ,Immunology ,Cytokines ,Female ,Inflammation Mediators ,business - Abstract
Intensive exercise modifies airway inflammation and infection susceptibility. We aimed to determine the effect of exercise on pro- and anti-inflammatory cytokine (TNF-α, IL-1ra, IL-10) and innate immunity protein (HSPA1, sCD14) levels in exhaled breath condensate (EBC) and nasal secretions of competitive athletes, non-exercising asthmatics and healthy controls (HC).The study group consisted of 15 competitive athletes (five speed skaters and ten swimmers) aged 15-25. The control groups comprised 10 mild-to-moderate asthmatics (AC) and seven HC. Athletes were assessed in- and off-training while asthmatics and controls at one time point. Nasal lavages and EBC were collected before and after a treadmill exercise challenge. Protein levels were assessed using ELISA.TNF-α levels in EBC were significantly higher in athletes than HC, but similar to asthmatic patients. In contrast, IL-1ra EBC concentrations were significantly lower in athletes than in HC, but again similar to asthmatics. Significant positive correlations were seen between baseline concentrations of TNF-α in EBC and fall in FEV1 following exercise challenge in athletes during training period (R=0.74, p0.01) and in asthmatics (R=0.64, p0.05). In nasal secretions, baseline IL-1ra levels were significantly higher in athletes and asthmatics than in HC. Exercise caused a slight, yet significant, increase in EBC HSPA1 in athletes (p=0.02). The exercise challenge did not considerably influence TNF-α, IL-1ra, HSPA1 and sCD14 in EBC or nasal secretions.Dysregulation of the TNF-α/IL-1ra balance in EBC and nasal secretions from athletes may reflect the presence of airway inflammation induced by repeated strenuous exercise.
- Published
- 2018
35. Serum but not exhaled breath condensate periostin level is increased in competitive athletes
- Author
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Aleksandra Wardzyńska, Hubert Krysztofiak, Marzanna Jarzębska, Janusz Jurczyk, Marek L. Kowalski, and Marcin Kurowski
- Subjects
Male ,0301 basic medicine ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Allergy ,Adolescent ,Stimulation ,Periostin ,Gastroenterology ,Allergic inflammation ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Forced Expiratory Volume ,Internal medicine ,medicine ,Humans ,Immunology and Allergy ,Exhaled breath condensate ,Genetics (clinical) ,Asthma ,biology ,Athletes ,business.industry ,Matricellular protein ,medicine.disease ,biology.organism_classification ,Healthy Volunteers ,Asthma, Exercise-Induced ,030104 developmental biology ,Breath Tests ,030228 respiratory system ,Exhalation ,Exercise Test ,Cytokines ,Female ,business ,Cell Adhesion Molecules ,Biomarkers - Abstract
INTRODUCTION Periostin is a matricellular protein expressed by many tissues. Its release may be enhanced, among others, through mechanical stimulation of muscles and bones as well as by cytokines of allergic inflammation. OBJECTIVES Our aim was to assess periostin levels in serum and exhaled breath condensate (EBC) of professional athletes, asthmatics and healthy controls. We also sought to determine whether acute treadmill exercise influences serum and EBC periostin. METHODS Study groups included 9 competitive swimmers, 10 mild-to-moderate asthmatics and 7 healthy controls. Athletes were assessed twice (in- and off-training period) while asthmatics and controls in one time-point. Data on demographics, allergy symptoms and exercise load were acquired through Allergy Questionnaire for Athletes (AQUA) and International Physical Activity Questionnaire (IPAQ). Serum and EBC were collected before and after treadmill exercise challenge. RESULTS Baseline serum periostin in swimmers during training period was significantly higher (5- to 7-fold) than in asthmatics (P = .01) and controls (P < .05). In EBC, lowest periostin levels were seen in athletes in-training as compared with off-training period (P < .01) and with asthmatics (P < .03). Acute bout of exercise did not induce significant changes neither in serum nor in EBC periostin in any group. CONCLUSION Increased serum, but not EBC, periostin levels in competitive athletes are probably because of permanently increased exercise load leading to stimulation, injury and regeneration of musculoskeletal tissues. Periostin may be considered marker of long-term exercise overload after confirmation in larger groups.
- Published
- 2018
36. Qualifications for allergen specific immunotherapy – an algorithm
- Author
-
Marek L. Kowalski
- Subjects
business.industry ,Immunology ,General Earth and Planetary Sciences ,Specific immunotherapy ,Medicine ,business ,General Environmental Science - Published
- 2018
37. Management of suspected drug hypersensitivity reactions. Guidelines of the Section of Drug Hypersensitivity of the Polish Society of Allergology
- Author
-
Marita Nittner-Marszalska, Grazyna Bochenek, Anna Bodzenta-Łukaszyk, Małgorzata Wiśniewska, Grażyna Sławeta, Barbara Rymarczyk, Marek L. Kowalski, Iwona Poziomkowska-Gęsicka, Joanna Makowska, Michał Kurek, Joanna Glück, and Grzegorz Porebski
- Subjects
Drug ,Allergy ,medicine.medical_specialty ,business.industry ,media_common.quotation_subject ,Section (typography) ,medicine ,General Earth and Planetary Sciences ,medicine.disease ,business ,Dermatology ,General Environmental Science ,media_common - Published
- 2018
38. Winter ambient training conditions are associated with increased bronchial hyperreactivity and with shifts in serum innate immunity proteins in young competitive speed skaters
- Author
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Sylwia Moskwa, Marcin Kurowski, Janusz Jurczyk, Hubert Krysztofiak, Marzanna Jarzębska, and Marek L. Kowalski
- Subjects
Allergy ,meteorological factors ,Physiology ,03 medical and health sciences ,0302 clinical medicine ,Clinical Research ,Medicine ,030212 general & internal medicine ,Respiratory system ,Lung function ,Bronchial hyperreactivity ,Innate immune system ,Lung ,biology ,Respiratory tract infections ,business.industry ,Athletes ,heat shock protein HSPA1 ,General Medicine ,interleukin-1 receptor antagonist protein ,sCD14 ,biology.organism_classification ,medicine.disease ,bronchial hyperreactivity ,medicine.anatomical_structure ,030228 respiratory system ,business ,exercise training - Abstract
Introduction Regular training modulates airway inflammation and modifies susceptibility to respiratory infections. The impact of exercise and ambient conditions on airway hyperreactivity and innate immunity has not been well studied. We aimed to assess exercise-related symptoms, lung function, airway hyperresponsiveness and innate immunity proteins in relation to meteorological conditions and exercise load in competitive athletes. Material and methods Thirty-six speed skaters were assessed during winter (WTP) and summer (STP) periods. The control group comprised 22 non-exercising subjects. An allergy questionnaire for athletes (AQUA) and IPAQ (International Physical Activity Questionnaire) were used to assess symptoms and exercise. Meteorological parameters were acquired from World Meteorological Organization resources. Serum innate immunity proteins were measured by ELISA. Results Exercise-associated respiratory symptoms were reported by 79.4% of skaters. Despite similar exercise load and lung parameters during both periods, positive methacholine challenge was more frequent during winter (p = 0.04). Heat shock protein HSPA1 and IL-1RA were significantly decreased during STP compared to WTP and controls. During WTP, IL-1RA was elevated in skaters reporting exercise-induced symptoms (p = 0.007). sCD14 was elevated in athletes versus controls in both periods (p < 0.05). HSPA1 was significantly higher in WTP compared to STP irrespective of presence of respiratory tract infections (RTIs). IL-1RA in WTP was elevated versus STP (p = 0.004) only in RTI-negative athletes. Serum IL-1RA negatively correlated with most meteorological parameters during WTP. Conclusions Ambient training conditions, but not training load, influence bronchial hyperreactivity and the innate immune response in competitive athletes assessed during winter. The protective effect of regular exercise against respiratory infections is associated with a shift in serum innate immunity proteins.
- Published
- 2018
39. Introduction to management of drug hypersensitivity. Guidelines of the Section of Drug Hypersensitivity of the Polish Society of Allergology
- Author
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Anna Bodzenta-Łukaszyk, Marita Nittner-Marszalska, Grazyna Bochenek, Marek L. Kowalski, Grażyna Sławeta, Małgorzata Wiśniewska, Barbara Rymarczyk, Grzegorz Porebski, Joanna Makowska, Michał Kurek, Iwona Poziomkowska-Gęsicka, and Joanna Glück
- Subjects
Drug ,medicine.medical_specialty ,Allergy ,business.industry ,medicine.medical_treatment ,media_common.quotation_subject ,Section (typography) ,medicine.disease ,Dermatology ,General Earth and Planetary Sciences ,Medicine ,business ,General Environmental Science ,Desensitization (medicine) ,media_common - Published
- 2018
40. Hypersensitivity to nonsteroidal anti-inflammatory drugs. Guidelines of the Section of Drug Hypersensitivity of the Polish Society of Allergology
- Author
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Marita Nittner-Marszalska, Grazyna Bochenek, Barbara Rymarczyk, Grzegorz Porebski, Joanna Makowska, Grażyna Sławeta, Marek L. Kowalski, and Joanna Glück
- Subjects
Drug ,medicine.medical_specialty ,Allergy ,Nonsteroidal ,biology ,business.industry ,medicine.drug_class ,media_common.quotation_subject ,Section (typography) ,medicine.disease ,Dermatology ,Anti-inflammatory ,chemistry.chemical_compound ,chemistry ,biology.protein ,medicine ,General Earth and Planetary Sciences ,Cyclooxygenase ,business ,General Environmental Science ,media_common - Published
- 2018
41. Conjunctival allergen provocation test
- Author
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Marek L. Kowalski and Monika Jedrzejczak-Czechowicz
- Subjects
medicine.medical_specialty ,Allergen ,business.industry ,Provocation test ,General Earth and Planetary Sciences ,Medicine ,business ,medicine.disease_cause ,medicine.disease ,Dermatology ,Allergic conjunctivitis ,General Environmental Science - Published
- 2018
42. Hypersensitivity to iodine contrast media. Guidelines of the Section of Drug Hypersensitivity of the Polish Society of Allergology
- Author
-
Joanna Glück, Marita Nittner-Marszalska, Grazyna Bochenek, Barbara Rymarczyk, Marek L. Kowalski, Anna Bodzenta-Łukaszyk, Grzegorz Porebski, Joanna Makowska, and Grażyna Sławeta
- Subjects
medicine.medical_specialty ,Allergy ,business.industry ,media_common.quotation_subject ,Section (typography) ,chemistry.chemical_element ,medicine.disease ,Iodine ,Dermatology ,chemistry ,General Earth and Planetary Sciences ,Medicine ,Contrast (vision) ,business ,General Environmental Science ,media_common - Published
- 2018
43. Management of drug hypersensitivity. Guidelines of the Section of Drug Hypersensitivity of the Polish Society of Allergology
- Author
-
Marita Nittner-Marszalska, Małgorzata Wiśniewska, Grazyna Bochenek, Barbara Rymarczyk, Michał Kurek, Grzegorz Porebski, Joanna Makowska, Joanna Glück, Grażyna Sławeta, Iwona Poziomkowska-Gęsicka, Marek L. Kowalski, and Anna Bodzenta-Łukaszyk
- Subjects
Drug ,medicine.medical_specialty ,Allergy ,business.industry ,Family medicine ,media_common.quotation_subject ,Section (typography) ,General Earth and Planetary Sciences ,Medicine ,business ,medicine.disease ,General Environmental Science ,media_common - Published
- 2018
44. Hypersensitivity to biological drugs. Guidelines of the Section of Drug Hypersensitivity of the Polish Society of Allergology
- Author
-
Marita Nittner-Marszalska, Grazyna Bochenek, Grażyna Sławeta, Barbara Rymarczyk, Grzegorz Porebski, Joanna Glück, Joanna Makowska, Anna Bodzenta-Łukaszyk, and Marek L. Kowalski
- Subjects
Drug ,Allergy ,medicine.drug_class ,business.industry ,media_common.quotation_subject ,Section (typography) ,medicine.disease ,Monoclonal antibody ,Biological drugs ,Immunology ,medicine ,General Earth and Planetary Sciences ,business ,General Environmental Science ,media_common - Published
- 2018
45. Hypersensitivity to drugs and substances used during anaesthesia. Guidelines of the Section of Drug Hypersensitivity of the Polish Society of Allergology
- Author
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Grażyna Sławeta, Joanna Glück, Joanna Makowska, Barbara Rymarczyk, Marita Nittner-Marszalska, Grazyna Bochenek, Anna Bodzenta-Łukaszyk, Marek L. Kowalski, and Grzegorz Porebski
- Subjects
Drug ,Allergy ,business.industry ,media_common.quotation_subject ,Anesthesia ,Section (typography) ,General Earth and Planetary Sciences ,Medicine ,Neuromuscular Agents ,business ,medicine.disease ,General Environmental Science ,media_common - Published
- 2018
46. Differential effect of human rhinovirus 1B (RV1B) on IL‐4‐primed IgE synthesis by PMBCs from allergic patients and healthy subjects
- Author
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Aleksandra Szulc, Marek L. Kowalski, Klaudia Zelewska-Fichna, Maciej Chałubiński, and Marzanna Jarzębska
- Subjects
Adult ,Male ,Microbiology (medical) ,Allergy ,Rhinovirus ,medicine.disease_cause ,Immunoglobulin E ,Pathology and Forensic Medicine ,Hypersensitivity ,medicine ,Humans ,Immunology and Allergy ,Interleukin 4 ,Aged ,Asthma ,biology ,business.industry ,Healthy subjects ,General Medicine ,Middle Aged ,medicine.disease ,Immunology ,Leukocytes, Mononuclear ,biology.protein ,Female ,Interleukin-4 ,business - Published
- 2019
47. Erratum to 'IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper' [World Allergy Organ J 13/2 (2020) 100080]
- Author
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Victoria Cardona, Oliver Pfaar, Luis Caraballo, Bernard Yu-Hor Thong, Harald Renz, Edgardo Jares, Olga Sánchez, Pascal Demoly, Ignacio J. Ansotegui, Gianenrico Senna, Eleonora Savi, Motohiro Ebisawa, Torsten Zuberbier, John Oppenheimer, Antonino Romano, Giovanni Melioli, Luciana Kase Tanno, Martti Anton Antila, Enrico Scala, Jean Bousquet, Tari Haahtela, Marta Ferrer Puga, Nelson Augusto Rosário Filho, Olga Patricia Monge Ortega, Didier G. Ebo, Elisa Villa, Ruby Pawankar, David A. Fischer, Lanny J. Rosenwasser, Mário Morais-Almeida, Sandra Nora González Díaz, Roy Gerth van Wijk, Giorgio Walter Canonica, Mimi L.K. Tang, Lawrence M. DuBuske, Marek L. Kowalski, Dennis K. Ledford, Lars K. Poulsen, Ayse Fusun Kalpaklioglu, Giovanni Passalacqua, R. Maximiliano Gómez, Wen Chin Chiang, Alexei Gonzalez-Estrada, Juan Carlos Sisul, Robert A. Wood, Rudolf Valenta, Erika Jensen-Jarolim, and Mario Sanchez Borges
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Allergy ,biology ,business.industry ,Immunology ,RC581-607 ,Immunoglobulin E ,medicine.disease ,Dermatology ,Article ,3. Good health ,03 medical and health sciences ,0302 clinical medicine ,030228 respiratory system ,biology.protein ,medicine ,Immunology and Allergy ,Immunologic diseases. Allergy ,030223 otorhinolaryngology ,business - Abstract
The publisher regrets we have been made aware of the below errors: 1) In Table 15, row NOVEOS chemiluminescent assay is written “utilizes 40 μL (0.04 ml) of sample per result”. The correct value would be “4 μL (0.004 ml)" of sample per result.2) In Table 16, is written “NOVEOS menu has 79 available allergens, consisting of 69 extracts and 10 molecular allergens”. It should say “NOVEOS menu continues to increase and it has 152 total allergens with 108 extracts and 44 components".3) In Table 15, row “Euroimmun”, column “Patient's serum”, is written “1000 ml”. The correct value would be “0.1 ml (-0.4 ml)”.The publisher would like to apologise for any inconvenience caused.
- Published
- 2021
48. Innate lymphoid cells: the role in respiratory infections and lung tissue damage
- Author
-
Anna Głobińska and Marek L. Kowalski
- Subjects
0301 basic medicine ,Immunology ,Inflammation ,03 medical and health sciences ,0302 clinical medicine ,Immunity ,medicine ,Animals ,Humans ,Immunology and Allergy ,Lymphocytes ,Molecular Targeted Therapy ,skin and connective tissue diseases ,Lung ,Respiratory Tract Infections ,Tissue homeostasis ,Innate immune system ,Respiratory tract infections ,business.industry ,Innate lymphoid cell ,Immunity, Innate ,body regions ,030104 developmental biology ,medicine.anatomical_structure ,Virus Diseases ,Cytokines ,Respiratory epithelium ,medicine.symptom ,business ,030215 immunology - Abstract
Innate lymphoid cells (ILCs) represent a diverse family of cells of the innate immune system, which play an important role in regulation of tissue homeostasis, immunity and inflammation. Emerging evidence has highlighted the importance of ILCs in both protective immunity to respiratory infections and their pathological roles in the lungs. Therefore, the aim of this review is to summarize the current knowledge, interpret and integrate it into broader perspective, enabling greater insight into the role of ILCs in respiratory diseases. Areas covered: In this review we highlighted the role of ILCs in the lungs, citing the most recent studies in this area. PubMed searches (2004- July 2017) were conducted using the term 'innate lymphoid cells respiratory viral infections' in combination with other relevant terms including various respiratory viruses. Expert commentary: Since studies of ILCs have opened new areas of investigation, understanding the role of ILCs in respiratory infections may help to clarify the mechanisms underlying viral-induced exacerbations of lung diseases, providing the basis for novel therapeutic strategies. Potential therapeutic targets have already been identified. So far, the most promising strategy is cytokine-targeting, although further clinical trials are needed to verify its effectiveness.
- Published
- 2017
49. Mechanisms of exercise‐induced bronchoconstriction in athletes: Current perspectives and future challenges
- Author
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Sven Seys, Luís Delgado, André Moreira, Marcin Kurowski, Dominique Bullens, Marek L. Kowalski, Mariana Couto, and Kai-Håkon Carlsen
- Subjects
medicine.medical_specialty ,Chronic condition ,Time Factors ,Immunology ,Population ,Competitive athletes ,Constriction, Pathologic ,Respiratory Mucosa ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,medicine ,Humans ,Immunology and Allergy ,Elite athletes ,Intensive care medicine ,Bronchial obstruction ,education ,Exercise ,Asthma ,education.field_of_study ,biology ,business.industry ,Athletes ,Bronchial Diseases ,030229 sport sciences ,medicine.disease ,biology.organism_classification ,Asthma, Exercise-Induced ,Gene Expression Regulation ,030228 respiratory system ,Physical therapy ,Bronchoconstriction ,Disease Susceptibility ,medicine.symptom ,business ,Signal Transduction ,Sports - Abstract
The evidence of exercise-induced bronchoconstriction (EIB) without asthma (EIBwA ) occurring in athletes led to speculate about different endotypes inducing respiratory symptoms within athletes. Classical postulated mechanisms for bronchial obstruction in this population include the osmotic and the thermal hypotheses. More recently, the presence of epithelial injury and inflammation in the airways of athletes was demonstrated. In addition, neuronal activation has been suggested as a potential modulator of bronchoconstriction. Investigation of these emerging mechanisms is of major importance as EIB is a significant problem for both recreational and competitive athletes and is the most common chronic condition among Olympic athletes, with obvious implications for their competing performance, health and quality of life. Hereby, we summarize the latest achievements in this area and identify the current gaps of knowledge so that future research heads toward better defining the etiologic factors and mechanisms involved in development of EIB in elite athletes as well as essential aspects to ultimately propose preventive and therapeutic measures.
- Published
- 2017
50. Cytomegalovirus DNA is highly prevalent in the blood of patients with asthma and is associated with age and asthma traits
- Author
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Aleksandra Wardzyńska, Zbigniew J. Lesnikowski, Marek L. Kowalski, Mirosława Studzińska, Edyta Paradowska, and Małgorzata Pawełczyk
- Subjects
Adult ,Male ,0301 basic medicine ,Immunology ,Congenital cytomegalovirus infection ,Cytomegalovirus ,Inflammation ,Nitric oxide ,Pathogenesis ,03 medical and health sciences ,chemistry.chemical_compound ,Quantitative Trait, Heritable ,0302 clinical medicine ,immune system diseases ,Humans ,Immunology and Allergy ,Medicine ,Respiratory system ,Aged ,Asthma ,Aged, 80 and over ,biology ,business.industry ,Eosinophil Cationic Protein ,Age Factors ,virus diseases ,Immunosenescence ,Immunoglobulin E ,Middle Aged ,Viral Load ,medicine.disease ,respiratory tract diseases ,030104 developmental biology ,chemistry ,Cytomegalovirus Infections ,DNA, Viral ,Leukocytes, Mononuclear ,biology.protein ,Female ,medicine.symptom ,Antibody ,business ,Biomarkers ,030215 immunology - Abstract
Cytomegalovirus (CMV) IgG antibodies have been associated with inflammaging and immunosenescence. We aimed to assess the presence of CMV DNA in the blood of adult and elderly patients with bronchial asthma to establish potential association of CMV DNAemia with asthma and asthma characteristics. Eighty-five elderly asthmatics, 74 younger asthma patients, and 114 age-matched controls were recruited. The CMV DNA was detected using commercial artus assay in 10.7% of asthma patients, but was negative in all control individuals. The secondary assay identified CMV DNA in 41.5% of asthmatics and 13.3% of control subjects (P < .001). Presence of CMV DNA was associated with an increased risk of asthma and CMV DNA copy numbers correlated with some asthma traits, including respiratory parameters and exhaled breath nitric oxide. We conclude that CMV infection is associated with asthma and may contribute to the pathogenesis of asthmatic inflammation.
- Published
- 2017
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