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To assess the spatial distribution of TB and malaria incidence, as well as their spatial association with each other, regardless of environmental and socio-economic factors commonly reported as determinants of both disease rates among the municipalities of Amazonas State, Brazil between 2012 and 2015.Through an ecological approach considering municipalities of Amazonas, Brazil, as unit of analysis, a negative binomial regression model was used to assess association between malaria and TB rates, in which the dependent variable was the average municipal tuberculosis incidence rate.Positive associations of overall malaria (β = 0.100 [CI = 0.032, 0.168], P = 0.004), P. vivax malaria (β = 0.115 [CI = 0.036, 0.195], P = 0.005), and P. falciparum malaria (β = 0.389 [CI = -0.0124, 0.791], P = 0.057) with TB rates were found, regardless of the sociodemographic factors included in the study.In the Brazilian Amazon, TB and malaria are spatially associated. Therefore, it is very likely that co-infections also occur in this region, regardless of the HIV status.Evaluer la distribution spatiale de l'incidence de la tuberculose (TB) et du paludisme, ainsi que leur association spatiale, indépendamment des facteurs environnementaux et socioéconomiques communément rapportés comme déterminants des taux des deux maladie dans les municipalités de l'Etat d'Amazonas, au Brésil, entre 2012 et 2015. MÉTHODES: Dans le cadre d'une approche écologique prenant en considération les municipalités d'Amazonas, au Brésil, comme unité d'analyse, un modèle de régression binomiale négatif a été utilisé pour évaluer l'association entre les taux de paludisme et de TB, dans laquelle la variable dépendante était le taux moyen d'incidence municipale de la TB. RÉSULTATS: Des associations positives entre le paludisme en général (β = 0,100 [IC= 0,032 à 0,168], p = 0,004), le paludisme à P. vivax (β = 0,115 [IC: 0,036 à 0,195], p = 0,005) et le paludisme à P. falciparum (β = 0,389 [IC: - 0,0124 à 0,791], p = 0,057) avec des taux de TB ont été retrouvées quels que soient les facteurs sociodémographiques inclus dans l’étude.En Amazonie brésilienne, la TB et le paludisme sont associés spatialement. Par conséquent, il est très probable que des coinfections se produisent également dans cette région, quel que soit le statut VIH.

A aprovação da Súmula Vinculante nº 13 pelo STF foi importante passo contra a influência das relações familiares como fator determinante de nomeações para cargos e funções públicos da Administração Pública, favorecimento popularmente conhecido como nepotismo. Certo é que o nepotismo seja favorecimento decorrente das relações parentais por afinidade ou consanguinidade. Ao presente artigo interessa aquele por intermédio do qual uma pessoa é conduzida a determinado cargo ou função de confiança sem o crivo selecionador prévio de um procedimento isonômico, objetivo e pautado pelas qualidades do nomeado e pela impessoalidade, condução esta que não aconteceria em circunstâncias outras que não a relação de parentesco preexistente. Passados alguns anos, novas manifestações de nepotismo podem surgir, ao mesmo tempo em que outras práticas de nepotismo ainda sobreviverão. A propósito, um dos objetivos do presente artigo é o de tirar da obscuridade as formas invisíveis disfarçadas desse favorecimento antirrepublicano e contrário ao interesse público. O favorecimento de parentes no acesso aos cargos públicos deve ser combatido, sejam aqueles alcançados pela Súmula Vinculante sejam outras formas que possam surgir dissimuladamente, apresentando-se como se nepotismo não fosse. É o caso, por exemplo, de uma espécie, que ora se descortina, que pode ser denominada como nepotismo tardio ou póstumo, em que antigos dirigentes se valem, não mais do cargo ocupado, pois que dele já se afastaram, mas da influência que ainda exercem em órgãos ou entidades públicas para aí nomear seus parentes.

Acute leukemias commonly diagnosed in pregnancy include acute myeloid leukemia, acute promyelocytic leukemia, and acute lymphoblastic leukemia. These are aggressive diseases that require urgent treatment. Delaying curative therapy or administering inadequate chemotherapy regimens may adversely affect maternal survival. Pregnant women receiving a diagnosis of acute leukemia during the first trimester should prompt a discussion of medical termination of pregnancy and timely treatment of the underlying disease. After the first trimester, chemotherapy has a decreased risk for fetal malformations and may be administered more safely. For patients diagnosed with acute leukemia from week 33–34 onwards, delivery followed by prompt initiation of leukemia treatment is advisable. Specific aspects of each type of acute leukemia are discussed in this chapter. In turn, chronic myeloid leukemia, chronic lymphocytic leukemia, and less frequently, hairy cell leukemia are chronic leukemias that have also been reported in pregnant women. Different from acute leukemias, watchful waiting or delaying therapy during pregnancy may be safe approaches in this context. Alternative options for patients with chronic leukemia requiring treatment are discussed in detail. Recommendations on transfusion support, delivery preparation, and postpartum care in pregnant women with leukemia are also made in this chapter.

Defende-se, no presente trabalho, que tanto a sanção de ressarcimento ao erário quanto a sanção de multa aplicadas pelos Tribunais de Contas, transmitemse aos sucessores causa mortis do gestor público falecido, nos limites do patrimônio transferido, notadamente em razão do caráter obrigacional de referida condenação. Demonstra-se que a premissa invocada por aqueles que defendem que, em julgamentos proferidos pelos Tribunais de Contas, a sanção de multa “não ultrapassaria a pessoa do condenado”, é equivocada, já que embasados em dispositivos de eminente natureza penal. Demonstra-se ainda que o que ora se defende certamente confere efetividade aos comandos e preceitos constitucionais.

The measurement of inspiratory muscle strength is achieved by static measures of respiratory maximum pressures (inspiratory- MIP and expiratory- MEP) and is an important tool for determining the existence and prognosis of neuromuscular and lung disorders. Aim: To develop predictive equations of inspiratory pressure Maximum and Maximum Expiratory Pressure for healthy people sedentary and active. Materials and Methods: Participants were 177 sedentary healthy and active, aged 20 and 80 years. The volunteers were selected according to the following criteria: a BMI between 18.0 and 29.5 kg / m2 and no history of smoking. Individuals with a history of respiratory or cardiovascular disease were excluded, as well as individuals with any neuromuscular disease that prevented the tests. Maximal respiratory pressures were determined according to a standardized protocol. Results: Two regression models were adjusted: 1 (age- gender) and 2 (gender and physical activity). For the model MEP, there was an increase in the R² 15.91% to 26.18%, indicating that with age and activity can be explained 26.18% of the variability of MEP. For the model of MIP, the R² went from 6.05% to 16.46%, indicating that with age and activity can be explained 16.46% of the variability of MIP. Conclusion: Was checked with the adjusted models, there was a considerable gain in the predictive quality of the models for MEP and MIP add Physical Activity.