75 results on '"Mark W. Holladay"'
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2. Discovery of Highly Potent and Selective Pan-Aurora Kinase Inhibitors with Enhanced in Vivo Antitumor Therapeutic Index
3. Novel series of pyrrolotriazine analogs as highly potent pan-Aurora kinase inhibitors
4. Neuronal nicotinic receptors: A perspective on two decades of drug discovery research
5. Discovery and optimization of a highly efficacious class of 5-aryl-2-aminopyridines as FMS-like tyrosine kinase 3 (FLT3) inhibitors
6. Synthesis and Structure−Activity Studies on N-[5-(1H-Imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an Imidazole-Containing α1A-Adrenoceptor Agonist
7. Synthesis and Structure−Activity Relationships of a Novel Series of 2,3,5,6,7,9-Hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-Dioxide KATP Channel Openers: Discovery of (−)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9- hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-Dioxide (A-278637), a Potent KATP Opener That Selectively Inhibits Spontaneous Bladder Contractions
8. Structure–Activity studies for a novel series of tricyclic dihydropyrimidines as KATP channel openers (KCOs)
9. DNA-Interactive Agents
10. Preface to the Third Edition
11. Drug Resistance and Drug Synergism
12. Prodrugs and Drug Delivery Systems
13. Enzymes
14. The Organic Chemistry of Drug Design and Drug Action
15. Enzyme Inhibition and Inactivation
16. Introduction
17. Lead Discovery and Lead Modification
18. Receptors
19. Solid Phase Heterocyclic Chemistry
20. Efficient asymmetric synthesis of ABT-594; a potent, orally effective analgesic
21. The role of neuronal nicotinic acetylcholine receptors in antinociception: Effects of ABT-594
22. Synthesis and structure-activity relationships of pyridine-modified analogs of 3-[2-((S)-pyrrolidinyl)methoxy]pyridine, A-84543, a potent nicotinic acetylcholine receptor agonist
23. Identification and Initial Structure−Activity Relationships of (R)-5-(2-Azetidinylmethoxy)-2-chloropyridine (ABT-594), a Potent, Orally Active, Non-Opiate Analgesic Agent Acting via Neuronal Nicotinic Acetylcholine Receptors
24. Novel 2-(2′-furo[3,2-b]pyridinyl) pyrrolidines: potent neuronal nicotinic acetylcholine receptor ligands
25. ABT-089 [3-(2(S)-pyrrolidinylmethoxy)-2-methyl-pyridine]: An orally effective cholinergic channel modulator with potential once-a-day dosing and cardiovascular safety
26. 2-(Aryloxymethyl) azacyclic analogues as novel nicotinic acetylcholine receptor (nAChR) ligands
27. Amino acid-derived piperidides as novel CCKB ligands with anxiolytic-like properties
28. Structure - activity relationships of nicotinic acetylcholine receptor agonists as potential treatments for dementia
29. CEP-32496: a novel orally active BRAF(V600E) inhibitor with selective cellular and in vivo antitumor activity
30. Novel Isoxazoles which Interact with Brain Cholinergic Channel Receptors Have Intrinsic Cognitive Enhancing and Anxiolytic Activities
31. N-[3-(1H-Imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1), a Novel α1-Adrenoceptor Ligand with an Enhanced in Vitro and in Vivo Profile Relative to Phenylpropanolamine and Midodrine
32. Identification of 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride (CEP-32496), a highly potent and orally efficacious inhibitor of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF) V600E
33. 4-Quinazolinyloxy-diaryl ureas as novel BRAFV600E inhibitors
34. Double bond isosteres of the peptide bond: Synthesis and biological activity of cholecystokinin (CCK) C-terminal hexapeptide analogs
35. Synthesis and structure–activity relationships of 5-substituted pyridine analogues of 3-[2-((S)-pyrrolidinyl)methoxy]pyridine, A-84543
36. ChemInform Abstract: trans-3-n-Propyl-L-proline is a Highly Favorable, Conformationally Restricted Replacement for Methionine in the C-Terminal Tetrapeptide of Cholecystokinin. Stereoselective Synthesis of 3-Allyl- and 3-n- Propyl-L-proline Derivatives fr
37. ChemInform Abstract: Novel 3-Pyridyl Ethers with Subnanomolar Affinity for Central Neuronal Nicotinic Acetylcholine Receptors (nAChR′s)
38. ChemInform Abstract: Structure-Activity Studies on 2-Methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): An Orally Bioavailable 3-Pyridyl Ether Nicotinic Acetylcholine Receptor Ligand with Cognition-Enhancing Properties
39. ChemInform Abstract: Novel 2-(2′-Furo[3,2-b]pyridinyl) Pyrrolidines: Potent Neuronal Nicotinic Acetylcholine Receptor Ligands
40. ChemInform Abstract: Efficient Asymmetric Synthesis of ABT-594; a Potent, Orally Effective Analgesic
41. ChemInform Abstract: Solid-Phase Heterocyclic Chemistry
42. Synthesis and biological activity of CCK heptapeptide analogs. Effects of conformational constraints and standard modifications on receptor subtype selectivity, functional activity in vitro, and appetite suppression in vivo
43. Synthesis of .alpha.-benzyl .gamma.-lactam, .alpha.-benzyl .delta.-lactam, and .alpha.-benzylproline derivatives as conformationally restricted analogs of phenylalaninamide
44. Conformationally constrained amino acids. Synthesis and optical resolution of 3-substituted proline derivatives
45. Synthesis and structure-activity relationships of a novel series of 2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide K(ATP) channel openers: discovery of (-)-(9S)-9-(3-bromo-4-fluorophenyl)-2,3,5,6,7,9- hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637), a potent K(ATP) opener that selectively inhibits spontaneous bladder contractions
46. N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine
47. Potassium Channel Openers
48. Hypnotics, Sedatives, Anticonvulsants, and Anxiolytics
49. Neuroregulators
50. Convenient preparation of O-linked polymer-bound N-substituted hydroxylamines, intermediates for synthesis of N-substituted hydroxamic acids
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