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Motivation is a primary determinant of a student’s academic success, but in many under-resourced educational contexts around the world, opportunities to develop motivation are lacking. In the City of God neighborhood of Rio de Janeiro, Brazil, we (a group of scientists and science educators) enacted brief, interactive interventions targeting teenage students at risk of dropping out of school. Students participated in an immersive 5-day program, followed by a six-month break, before completing the second, 3-day program. Participants learned how to use the scientific method in real-world settings to generate new knowledge. In order to consolidate these knowledge gains and bolster the program’s inspirational power, capstone projects empowered participants to speak with NASA mission managers and, in some cases, acquire never-before-seen images of Mars. While longitudinal study and a more robust sample size are required to bolster conclusions about the efficacy of our approach, initial results suggest that Ad Astra programs significantly enhance self-efficacy and science-oriented career ambitions.