1. Topology predicts long-term functional outcome in early psychosis
- Author
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Margot Fournier, Michel Cuenod, Martine Cleusix, Philippe Conus, Philippe Golay, Mehdi Gholam-Rezaee, Philipp S. Baumann, Raoul Jenni, Kathryn Hess, Martina Scolamiero, Carina Ferrari, and Kim Q. Do
- Subjects
Predictive markers ,Topology ,Affect (psychology) ,Outcome (game theory) ,Article ,law.invention ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,n-acetylcysteine ,0302 clinical medicine ,1st-episode psychosis ,Quality of life ,Randomized controlled trial ,law ,epidemiologic cohort ,medicine ,Humans ,Molecular Biology ,negative symptoms ,business.industry ,medicine.disease ,base-line ,030227 psychiatry ,Early intervention in psychosis ,early intervention ,Psychiatry and Mental health ,young-people ,Psychotic Disorders ,Schizophrenia ,controlled-trial ,Cohort ,Quality of Life ,double-blind ,business ,Psychosocial ,030217 neurology & neurosurgery - Abstract
Early intervention in psychosis is crucial to improving patient response to treatment and the functional deficits that critically affect their long-term quality of life. Stratification tools are needed to personalize functional deficit prevention strategies at an early stage. In the present study, we applied topological tools to analyze symptoms of early psychosis patients, and detected a clear stratification of the cohort into three groups. One of the groups had a significantly better psychosocial outcome than the others after a 3-year clinical follow-up. This group was characterized by a metabolic profile indicative of an activated antioxidant response, while that of the groups with poorer outcome was indicative of oxidative stress. We replicated in a second cohort the finding that the three distinct clinical profiles at baseline were associated with distinct outcomes at follow-up, thus validating the predictive value of this new stratification. This approach could assist in personalizing treatment strategies.
- Published
- 2020