1. Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS)
- Author
-
Wenning, Gregor K., Tison, François, Seppi, Klaus, Sampiao, Cristina, Diem, Anja, Yekhlef, Farid, Ghorayeb, Imad, Ory, Fabienne, Galitzky, Monique, Scaravilli, Tommaso, Bozi, Maria, Colosimo, Carlo, Gilman, Sid, Shults, Clifford W., Quinn, Niall P., Rascol, Olivier, Poewe, Werner, Dupont, Erik, Ostergaard, Karen, Tolosa, Eduardo, Klockgether, Thomas, Dodel, Richard, Abele, Michael, Pollak, Pierre, Geser, Felix, Stamfer, Michaela, Deuschl, Günther, Daniels, Christine, Coelho, Miguel, Pirtosek, Zvezdan, Brooks, David J., Fowler, Claire, Lees, Andrew, Mathias, Christopher J., Revesz, Tamas, Gerhard, Alexander, Holton, Janice, Schrag, Anette, Wood, Nick, Lindvall, Olle, Widner, Håkan, Grabowski, Martin, Nilsson, Christer F., Oertel, Wolfgang, Eggert, Karla Maria, Schimke, Nicole, Albanese, Alberto, del Sorbo, Francesco, Barone, Paolo, Carella, Francesco, Djaljetti, Ruth, Meco, Giuseppe, Berciano, Jose, Gonzalez-Mandly, Andres, Giladi, Nir, Gurevich, Tanya, Gasser, Thomas, Kamm, Christoph, Aquilonius, Sten Magnus, and Bergquist, Jonas
- Subjects
Male ,Gerontology ,medicine.medical_specialty ,Cerebellar Ataxia ,Scale (ratio) ,education ,Autonomic Nervous System ,Severity of Illness Index ,Speech Disorders ,Part iii ,Disability Evaluation ,Hypotension, Orthostatic ,Atrophy ,Physical medicine and rehabilitation ,Erectile Dysfunction ,Parkinsonian Disorders ,Rating scale ,Surveys and Questionnaires ,Internal consistency ,Activities of Daily Living ,Validation ,medicine ,Humans ,Interrater Reliability ,Age of Onset ,Observer Variation ,Reproducibility of Results ,Multiple System Atrophy ,Urinary Retention ,Unified Multiple System Atrophy Rating Scale ,medicine.disease ,Degree (music) ,Inter-rater reliability ,Urinary Incontinence ,Neurology ,Female ,International Cooperative Ataxia Rating Scale ,Neurology (clinical) ,Psychology - Abstract
We aimed to develop and validate a novel rating scale for multiple system atrophy (Unified Multiple System Atrophy Rating Scale - UMSARS). The scale comprises the following components: Part I, historical, 12 items; Part II, motor examination, 14 items; Part III, autonomic examination; and Part IV, global disability scale. For validation purposes, 40 MSA patients were assessed in four centers by 4 raters per center (2 senior and 2 junior raters). The raters applied the UMSARS, as well as a range of other scales, including the Unified Parkinson's Disease Rating Scale (UPDRS) and the International Cooperative Ataxia Rating Scale (ICARS). Internal consistency was high for both UMSARS-1 (Crohnbach's alpha = 0.84) and UMSARS-II (Crohnbach's alpha = 0.90) sections. The interrater reliability of most of the UMSARS-I and -II items as well as of total UMSARS-I and -II subscores was substantial (k (w) = 0.6-0.8) to excellent (k (w) > 0.8). UMSARS-II correlated well with UPDRS-III and ICARS (rs > 0.8). Depending on the degree of the patient's disability, completion of the entire UMSARS took 30 to 45 minutes. Based on our findings, the UMSARS appears to be a multidimensional, reliable, and valid scale for semiquantitative clinical assessments of MSA patients.
- Published
- 2004