1. Distribution and volume analysis of early hemorrhagic contusions by MRI after traumatic brain injury: a preliminary report of the Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx)
- Author
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La Rocca, Marianna, Barisano, Giuseppe, Bennett, Alexis, Garner, Rachael, Engel, Jerome, Gilmore, Emily J, McArthur, David L, Rosenthal, Eric, Stanis, James, Vespa, Paul, Willyerd, Frederick, Zimmermann, Lara L, Toga, Arthur W, Duncan, Dominique, and EpiBioS4Rx Study Group
- Subjects
Traumatic ,Epilepsy ,Physical Injury - Accidents and Adverse Effects ,Contusions ,Psychology and Cognitive Sciences ,Neurosciences ,Computational Biology ,Experimental Psychology ,Traumatic Brain Injury (TBI) ,Neurodegenerative ,Magnetic Resonance Imaging ,Medical and Health Sciences ,Brain Disorders ,EpiBioS4Rx Study Group ,Traumatic brain injury ,Posttraumatic late seizures ,Brain Injuries ,Neurological ,Lesion volume analysis ,Humans ,Biomedical Imaging ,Lesion segmentation ,Traumatic Head and Spine Injury - Abstract
Traumatic brain injury (TBI) can produce heterogeneous injury patterns including a variety of hemorrhagic and non-hemorrhagic lesions. The impact of lesion size, location, and interaction between total number and location of contusions may influence the occurrence of seizures after TBI. We report our methodologic approach to this question in this preliminary report of the Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx). We describe lesion identification and segmentation of hemorrhagic contusions by early posttraumatic magnetic resonance imaging (MRI). We describe the preliminary methods of manual lesion segmentation in an initial cohort of 32 TBI patients from the EpiBioS4Rx cohort and the preliminary association of hemorrhagic contusion and edema location and volume to seizure incidence.
- Published
- 2021