1. Development and validation of an ankle brachial index risk model for the prediction of cardiovascular events
- Author
-
Fowkes, FGR, Murray, GD, Butcher, I, Folsom, AR, Hirsch, AT, Couper, DJ, Debacker, G, Kornitzer, M, Newman, AB, Sutton-Tyrrell, KC, Cushman, M, Lee, AJ, Price, JF, D'Agostino, RB, Murabito, JM, Norman, Pe, Masaki, KH, Bouter, LM, Heine, RJ, Stehouwer, CDA, McDermott, MM, Stoffers, HEJH, Knottnerus, JA, Ogren, M, Hedblad, B, Koenig, W, Meisinger, C, Cauley, JA, Franco, Oh, Hunink, MGM, Hofman, A, Witteman, JC, Criqui, MH, Langer, RD, Hiatt, WR, Hamman, RF, Ankle Brachial Index Collaboration, EMGO+ - Lifestyle, Overweight and Diabetes, Epidemiology and Data Science, Internal medicine, EMGO - Lifestyle, overweight and diabetes, Interne Geneeskunde, Family Medicine, RS: CAPHRI School for Public Health and Primary Care, RS: CARIM - R3 - Vascular biology, RS: CAPHRI - Implementation of Evidence, RS: CAPHRI - Diagnosis and treatment of frequently occuring diseases in general practice, RS: CAPHRI - Clinical epidemiology, RS: CAPHRI - Asthma and COPD, Epidemiology, and Radiology & Nuclear Medicine
- Subjects
Male ,Time Factors ,Epidemiology ,Cardiorespiratory Medicine and Haematology ,Cardiovascular ,Risk model ,Models ,Risk Factors ,80 and over ,Medicine ,LOWER-EXTREMITY ,Young adult ,Aged, 80 and over ,Framingham Risk Score ,PRIMARY-CARE ,Statistical ,Middle Aged ,Prognosis ,Europe ,medicine.anatomical_structure ,Heart Disease ,PRACTICE GUIDELINES ,Cardiovascular Diseases ,Predictive value of tests ,Female ,Cardiology and Cardiovascular Medicine ,Risk assessment ,Adult ,medicine.medical_specialty ,animal structures ,Clinical Sciences ,ALL-CAUSE ,Risk Assessment ,Article ,White People ,Young Adult ,Sex Factors ,SDG 3 - Good Health and Well-being ,Clinical Research ,Predictive Value of Tests ,Humans ,CORONARY-HEART-DISEASE ,Ankle Brachial Index ,cardiovascular diseases ,OLDER-ADULTS ,Aged ,Models, Statistical ,business.industry ,PERIPHERAL ARTERIAL-DISEASE ,Prevention ,Reproducibility of Results ,Coronary heart disease ,United States ,body regions ,Cardiovascular System & Hematology ,Ankle Brachial Index Collaboration ,Physical therapy ,PRESSURE INDEX ,Ankle ,FOLLOW-UP ,business ,TASK-FORCE - Abstract
BackgroundThe ankle brachial index (ABI) is related to risk of cardiovascular events independent of the Framingham risk score (FRS). The aim of this study was to develop and evaluate a risk model for cardiovascular events incorporating the ABI and FRS.DesignAn analysis of participant data from 18 cohorts in which 24,375 men and 20,377 women free of coronary heart disease had ABI measured and were followed up for events.MethodsSubjects were divided into a development and internal validation dataset and an external validation dataset. Two models, comprising FRS and FRS + ABI, were fitted for the primary outcome of major coronary events.ResultsIn predicting events in the external validation dataset, C-index for the FRS was 0.672 (95% CI 0.599 to 0.737) in men and 0.578 (95% CI 0.492 to 0.661) in women. The FRS + ABI led to a small increase in C-index in men to 0.685 (95% CI 0.612 to 0.749) and large increase in women to 0.690 (95% CI 0.605 to 0.764) with net reclassification improvement (NRI) of 4.3% (95% CI 0.0 to 7.6%, p = 0.050) and 9.6% (95% CI 6.1 to 16.4%, p
- Published
- 2014
- Full Text
- View/download PDF