1. Chemical Composition and Biological Activities of Croton delpyi, Croton decalvatusand Croton caudatus
- Author
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Pompimon Wilart, Pikulthong Suttiporn, Jungsuttiwong Siriporn, Chalaemwongwan Noraset, Meepowpan Puttinan, Nuntasaen Narong, Udomputtimekakul Phansuang, Wongping Jutarut, Hadsadee Sarinya, Kansorn Chidawan, Tidchai Chanika, and Chaibun Sakchai
- Subjects
Croton decalvatus ,Complementary and alternative medicine ,biology ,Traditional medicine ,Drug Discovery ,Croton caudatus ,biology.organism_classification ,Croton ,Chemical composition - Abstract
Background: C. delpyi, C. decalvatus and C. caudatus are in the Euphorbiaceae family. The aerial parts, such as twigs, leaves and barks of these plants are used as traditional medicine such as anti-inflammatory, cytotoxicity, and antifungal properties. Objectives: The aims of this work were 1) to study the chemical composition of C. delpyi, C. decalvatus, and C. caudatus 2) to test the antibacterial, anti-HIV-1 RT, and cytotoxicity activities of crude extracts and pure compounds from these plants. Methods: Extraction, separation and purification of three plants were performed following chromatographic method. The biological activities, including antibacterial, anti-HIV-1 RT and cytotoxicity assay of three plants, were evaluated by the standard methods. Results: Phytochemical investigation of C. delpyi highlighted a new clerodane diterpenoid; crotondelpyitin A (1). The five known compounds were found, such as acetyl aleuritolic acid (2), 5- hydroxy-7,4′-dimethoxyflavone (3), and pilloin (4) in C. decalvatus and 3α-benzoyloxy-D while Afriedo- oleanan-27,16α-lactone (5), and bergenin (6) in C. caudatus. Compound 3 showed the most effective antibacterial activities with MIC in range 5.0 mg/mL. The six compounds were inactive with anti-HIV-1 RT. In addition, compound 4 was active for cytotoxic activities on FaDu and KKU-M213 at Conclusion: The present study reveals that the Croton species are sources of diterpenoid-type compounds and a significant guide for further research of chemical constituents from these plants as potential medicines.
- Published
- 2021