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A visible-light-catalyzed difluoroacetylated spirocyclization of N-arylpropiolamides with ethyl bromodifluoroacetate as a CF2CO2Et radical precursor is described using fac-[Ir(ppy)3] as a photocatalyst.

A practical and efficient synthesis of 11-aryldibenzooxa/thiazepines is achieved, via a late-stage and two-step C11–H arylation of simple dibenzooxa/thiazepines. The adoption of Grignard addition and DDQ dehydrogenation allows for operationally simple and chemically reliable, step-efficient, and high-yielding transformations. The two-step and one-pot procedures provide excellent yields. The gram-scale experiment demonstrates the promising synthetic potentials in large-scale applications, and the advantages of this method are also highlighted in the efficient synthesis of an H460TaxR inhibitor.

1,2,3-Thiadiazoles serve as masked S-electrophilic thia-1,3-dipoles. Under rhodium/racemic BINAP catalysis, they undergo denitrogenative (3 + 2) umpolung transannulations with aryl isothiocyanates with inverse regioselectivity and excellent stereoselectivity, yielding

A site-specific oxidative C–H chalcogenation of quinoxalin-2(1H)-ones with various diaryl diselenides/disulfides is presented by employing Selectfluor reagent as an oxidant. The reaction proceeds selectively at the C6 position of quinoxalin-2(1H)-ones, and enables access to a wide array of chalcogenyl quinoxalin-2(1H)-ones. The merits of the transformation involve excellent substrate and functional compatibility, operational simplicity, and the use of a mild oxidant. The present work offers a fundamental basis for the selective synthesis of functional quinoxalin-2(1H)-ones from readily available feedstocks.

Porcine deltacoronavirus (PDCoV) is a novel coronavirus that causes diarrhea in pigs of various ages, especially in suckling piglets, and there are no effective measures to prevent and control PDCoV currently. In this study, two adjuvants Al(OH)

The reproductive characteristics of plants are likely affected by climate change e.g., changes in precipitation patterns and nitrogen deposition, but few studies have examined the effects of these ecological agents of selection on the seed yield and germination characteristics of perennial grasses. Here, we conducted a multiple-year pot experiment with Leymus chinensis, a common perennial grass in the eastern region of the Eurasian steppe zone, which was grown under three water treatments with and without nitrogen addition. The seed yield of L. chinensis increased with precipitation and was highest (7.0 g/pot) under 747 mm of precipitation with nitrogen addition (10.5 g/m2). Seed yield was positively correlated with heading number, tiller number, and grain number per spike, and the heading number was a critical factor affecting seed yield. Seed germination percentage and the time to obtain 50% germination were affected by environmental cues experienced by the mother plants.

To analyze the rules of acupoints selection for phlegm disorder in treatment with acupuncture and moxibustion in ancient literature so as to provide guidance to clinical treatment of phlegm disorder.The word "phlegm" was taken as the search term and the relevant articles were retrieved from Zhonghuayidian (It was found that in treatment of phlegm disorder, the highest frequently used acupoints were Zusanli (ST36) and Zhongwan (CV12). The use frequency of three yang meridians was higher than that of three yin meridians. The commonly involved meridians were the Conception Vessel, Bladder Meridian of Foot-Ancient medical scholars focus on regulating spleen and stomach functions, as well as qi activity in treatment of phlegm disorder with acupuncture and moxibustion, which is coincident with the treatment principle of phlegm disorder in traditional Chinese medicine. In treatment, acupuncture-moxibusiton is characterized as laying the emphasis on the specific points, the local acupoints and the holistic idea as " regulation of yang for

Correction for ‘Catalytic (3 + 2) umpolung annulations of α-thioacyl carbenes with aryl isothiocyanates’ by Ziyang Dong et al., Chem. Commun., 2022, 58, 7980–7983, https://doi.org/10.1039/D2CC02882D.