Search

JCTCV:21(4), Introduction: Cytokines play an important role in the inflammatory response associated with cardiopulmonary bypass (CPB) and may contribute to postoperative complications. The aim of our work was to compare the efficacy of myocardial protection of two blood temperatures (warm and cold) on myocardial protection and to study the different inflammatory responses following CPB. Methods: Our prospective, randomized study involving 30 patients (2 groups: cold cardioplegia [ccp] group [n = 15 patients] and warm cardioplegia [wcp] group [n = 15 patients]) undergoing complete revascularization with coronary artery bypass grafting between March 2012 and February 2013. All clinical and biological data (troponin Ic, interleukins [IL-1, IL-6, IL-8, IL-10], and TNF-α) were collected before and after surgery in order to compare the blood concentrations and the kinetics of five cytokines (TNF-α, IL-1, IL-6, IL-8, and IL-10) in these two groups of patients. Results: There were no differences between the 2 groups in terms of age, sex ratio, clinical data, echocardiographic and angiographic findings, number of grafts, and duration of CPB and aortic cross-clamping. The quality of myocardial protection was identical in both groups, and this quality of protection remained identical in the subgroups (i.e., diabetic, left ventricular dysfunction, tri-troncular coronary lesions, and patients with stenosis of the main left coronary). Conclusion: The type of cardioplegia did not seem to influence the postoperative levels and kinetics of interleukins and TNF-α between the two groups. Thus, our data suggest that the use of warm blood cardioplegia or cold crystalloid cardioplegia is followed by the same inflammatory response to CPB.