367 results on '"Milinkovic, A"'
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2. Sleep disturbances and their correlation with cardiovascular risk, obesity, and mood disorders in people with HIV
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Maria Mazzitelli, Mattia Trunfio, Ana Milinkovic, Eleonora Castelli, Lolita Sasset, Davide Leoni, Margherita Salvucci, Riccardo Cazzaro, Ilaria Calcinoni, Pietro Balducci, Gustavo Coelho Quirino Ribeiro, Giacomo Filagrana, Vincenzo Scaglione, and Anna M. Cattelan
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Infectious Diseases ,Immunology ,Immunology and Allergy - Published
- 2023
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3. Layer-by-Layer siRNA Particle Assemblies for Localized Delivery of siRNA to Epithelial Cells through Surface-Mediated Particle Uptake
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Aaron Lee, Natalia Gosnell, Daela Milinkovic, Patricia Taladriz-Blanco, Barbara Rothen-Rutishauser, and Alke Petri-Fink
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Biomaterials ,Biochemistry (medical) ,Biomedical Engineering ,General Chemistry - Abstract
Localized delivery of small interfering RNA (siRNA) is a promising approach for spatial control of cell responses at biomaterial interfaces. Layer-by-layer (LbL) assembly of siRNA with cationic polyelectrolytes has been used in film and nanoparticle vectors for transfection. Herein, we combine the ability of particles to efficiently deliver siRNA with the ability of film polyelectrolyte multilayers to act locally. LbL particles were prepared with alternating layers of poly(l-arginine) and siRNA and capped with hyaluronic acid. Negatively charged LbL particles were subsequently assembled on the poly(l-lysine)-functionalized substrate to form a LbL particle-decorated surface. Cells grown in contact with the particle-decorated surface were able to survive, internalize particles, and undergo gene silencing. This work shows that particle-decorated surfaces can be engineered by using electrostatic interactions and used to deliver therapeutic payloads for cell-instructive biointerfaces.
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- 2023
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4. Limited Weight Impact After Switching From Boosted Protease Inhibitors to Dolutegravir in Persons With Human Immunodeficiency Virus With High Cardiovascular Risk: A Post Hoc Analysis of the 96-Week NEAT-022 Randomized Trial
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Waters, Laura, Assoumou, Lambert, González-Cordón, Ana, Rusconi, Stefano, Domingo, Pere, Gompels, Mark, de Wit, Stephane, Raffi, François, Stephan, Christoph, Masiá, Mar, Rockstroh, Jürgen, Katlama, Christine, Behrens, Georg M N, Moyle, Graeme, Johnson, Margaret, Fox, Julie, Stellbrink, Hans-Jürgen, Guaraldi, Giovanni, Florence, Eric, Esser, Stefan, Gatell, José M, Pozniak, Anton, Martínez, Esteban, Vandekerckhove, Linos, Caluwé, Els, Necsoi, Coca, Frankenhuijsen, Maartje Van, Allavena, Clotilde, Reliquet, Véronique, Boutoille, David, Cavellec, Morane, André-Garnier, Elisabeth, Rodallec, Audrey, Tourneau, Thierry Le, Connault, Jérôme, Molina, Jean-Michel, Ferret, Samuel, Previlon, Miresta, Yazdanpanah, Yazdan, Landman, Roland, Joly, Véronique, Pinto, Adriana, Caby, Fabienne, Ktorza, Nadine, Schneider, Luminita, Wolf, Timo, Schüttfort, Gundolf, Wasmuth, Jan-Christian, Schwarze-Zander, Carolynne, Boesecke, Christoph, Hoffmann, Christian, Sabranski, Michael, Esser, Stephan, Jablonka, Robert, Wiehler, Heidi, Stoll, Matthias, Ahrenstorf, Gerrit, Nardini, Giulia, Beghetto, Barbara, Montforte, Antonella D’Arminio, Bini, Teresa, Cogliandro, Viola, Di Pietro, Massimo, Fusco, Francesco Maria, Galli, Massimo, Giacomelli, Andrea, Meraviglia, Paola, Torres, Berta, Mateo, Gracia, Gutierrez, Mar, Portilla, Joaquin, Merino, Esperanza, Reus, Sergio, Boix, Vicente, Gutiérrez, Félix, Padilla, Sergio, Clotet, Bonaventura, Negredo, Eugenia, Bonjoch, Anna, Casado, José L, Bañón-Escandell, Sara, Saban, Jose, Duque, Africa, Podzamczer, Daniel, Saumoy, Maria, Acerete, Laura, Gonzalez-Garcia, Juan, Bernardino, José Ignacio, Arribas, José Ramón, Hontañón, Victor, Pagani, Nicole, Bracchi, Margherita, Vera, Jaime, Clarke, Amanda, Adams, Tanya, Richardson, Celia, Winston, Alan, Mora-Peris, Borja, Mullaney, Scott, Esteban, Nahum de, Milinkovic, Ana, Pett, Sarah, Tiraboschi, Juan Manuel, Youle, Mike, Orkin, Chloe, Rackstraw, Simon, Hand, James, Jennings, Louise, Nicholls, Jane, and Johnston, Sarah
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Microbiology (medical) ,Infectious Diseases ,Medizin - Abstract
BackgroundIn the NEAT022 trial, virologically suppressed persons with human immunodeficiency virus (HIV) at high cardiovascular risk switching from protease inhibitors to dolutegravir either immediately (DTG-I) or after 48 weeks (DTG-D) showed noninferior virological suppression and significant lipid and cardiovascular disease risk reductions on switching to dolutegravir relative to continuing protease inhibitors.MethodsIn post hoc analysis, major endpoints were 48-week and 96-week weight and body mass index (BMI) changes. Factors associated with weight/BMI changes within the first 48 weeks of DTG exposure, proportion of participants by category of percentage weight change, proportions of BMI categories over time, and impact on metabolic outcomes were also assessed.ResultsBetween May 2014 and November 2015, 204 (DTG-I) and 208 (DTG-D) participants were included. Weight significantly increased (mean, +0.810 kg DTG-I arm, and +0.979 kg DTG-D arm) in the first 48 weeks postswitch, but remained stable from 48 to 96 weeks in DTG-I arm. Switching from darunavir, White race, total to high-density lipoprotein cholesterol ratio ConclusionsSwitching from protease inhibitors to dolutegravir in persons with HIV with high cardiovascular risk led to modest weight gain limited to the first 48 weeks, which involved preferentially normal-weight or underweight persons and was not associated with negative metabolic outcomes.Clinical Trials RegistrationNCT02098837 and EudraCT 2013-003704-39.
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- 2022
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5. Guanidinoacetic acid provides superior cardioprotection to its combined use with betaine and (or) creatine in HIIT-trained rats
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Veljko Z. Prokic, Marina R. Rankovic, Nevena D. Draginic, Marijana M. Andjic, Jasmina Z. Sretenovic, Vladimir I. Zivkovic, Jovana N. Jeremic, Milica V. Milinkovic, Sergey Bolevich, Vladimir L.J. Jakovljevic, and Suzana B. Pantovic
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Betaine ,Male ,Pharmacology ,Physiology ,Physiology (medical) ,Glycine ,Animals ,Hydrogen Peroxide ,General Medicine ,High-Intensity Interval Training ,Rats, Wistar ,Creatine ,Rats - Abstract
This study aimed to determine how guanidinoacetic acid (GAA) or its combined administration with betaine (B) or creatine (C) influences the cardiac function, morphometric parameters, and redox status of rats subjected to high-intensity interval training (HIIT). This research was conducted on male Wistar albino rats exposed to HIIT for 4 weeks. The animals were randomly divided into five groups: HIIT, HIIT + GAA, HIIT + GAA + C, HIIT + GAA + B, and HIIT + GAA + C + B. After completing the training protocol, GAA (300 mg/kg), C (280 mg/kg), and B (300 mg/kg) were applied daily per os for 4 weeks. GAA supplementation in combination with HIIT significantly decreased the level of both systemic and cardiac prooxidants ([Formula: see text], H2O2, [Formula: see text], and thiobarbituric acid reactive substances) compared with nontreated HIIT ( p
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- 2022
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6. The 'Bankart knee': high-grade impression fractures of the posterolateral tibial plateau lead to increased translational and anterolateral rotational instability of the ACL-deficient knee
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Danko Dan Milinkovic, Christoph Kittl, Elmar Herbst, Christian Fink, Friedrich Greis, Michael J. Raschke, Robert Śmigielski, and Mirco Herbort
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Orthopedics and Sports Medicine ,Surgery - Abstract
Purpose The aim of this biomechanical cadaver study was to evaluate the effects of high-grade posterolateral tibia plateau fractures on the kinematics of anterior cruciate ligament (ACL)-deficient joints; it was hypothesized that, owing to the loss of the integrity of the osseous support of the posterior horn of the lateral meniscus (PHLM), these fractures would influence the biomechanical function of the lateral meniscus (LM) and consequently lead to an increase in anterior translational and anterolateral rotational (ALR) instability. Methods Eight fresh-frozen cadaveric knees were tested using a six-degree-of-freedom robotic setup (KR 125, KUKA Robotics, Germany) with an attached optical tracking system (Optotrack Certus Motion Capture, Northern Digital, Canada). After the passive path from 0 to 90° was established, a simulated Lachman test and pivot-shift test as well as external rotation (ER) and internal rotation (IR) were applied at 0°, 30°, 60° and 90° of flexion under constant 200 N axial loading. All of the parameters were initially tested in the intact and ACL-deficient states, followed by two different types of posterolateral impression fractures. The dislocation height was 10 mm, and the width was 15 mm in both groups. The intraarticular depth of the fracture corresponded to half of the width of the posterior horn of the lateral meniscus in the first group (Bankart 1) and 100% of the meniscus width in the second group (Bankart 2). Results There was a significant decrease in knee stability after both types of posterolateral tibial plateau fractures in the ACL-deficient specimens, with increased anterior translation in the simulated Lachman test at 0° and 30° of knee flexion (p = 0.012). The same effect was seen with regard to the simulated pivot-shift test and IR of the tibia (p = 0.0002). In the ER and posterior drawer tests, ACL deficiency and concomitant fractures did not influence knee kinematics (n.s.). Conclusion This study demonstrates that high-grade impression fractures of the posterolateral aspect of the tibial plateau increase the instability of ACL-deficient knees and result in an increase in translational and anterolateral rotational instability.
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- 2023
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7. Combined distal femoral osteotomy and tibial tuberosity distalization is effective in patients presenting with patellar instability and patellofemoral pain due to patella alta and femoral malalignment
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Julian Fluegel, Felix Zimmermann, Sebastian Gebhardt, Danko Dan Milinkovic, and Peter Balcarek
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Orthopedics and Sports Medicine ,Surgery ,General Medicine - Abstract
Patellar malalignment has been considered one of the major pathomechanical causes of patellofemoral instability and pain. The results have been reported after femoral varization/torsional osteotomy and tibial tuberosity distalization osteotomy (TTD-O). However, the combination of a femoral deformity (genu valgum/increased femur antetorsion) and patella alta remains underreported. Therefore, the aim of this study was to investigate the clinical outcomes of patients simultaneously treated by distal femoral osteotomy and TTD-O. The hypothesis was that restoration of patellofemoral (PF) alignment via the abovementioned osteotomies would achieve good patient-reported outcome measures.Between 2016 and 2019, a series of 25 knees in 20 patients were treated by a distal femoral osteotomy combined with a TTD-O aiming to correct patellofemoral malalignment consisting of genu valgum and/or increased femur antetorsion and patella alta. Six patients were lost to follow-up, and one patient refused to participate. Thus, 17 knees in 13 patients (male/female 1/12; age 27.4 ± 5.4 years) were included and comprised the study group for this investigation. Patients were evaluated after a mean of 3.1 ± 0.9 years postoperatively. The Kujala anterior knee pain scale and the PF-subscale of the Knee Osteoarthritis and Outcome score (KOOS-PF) were used to assess patients' reported outcome measures from pre- to postoperatively.The mean amount of torsional correction, valgus correction, and tibial tuberosity distalization averaged 14° (10°-18°), 5.2° (3.8°-8°), and 9 mm (6°-15 mm), respectively. The Kujala score increased by an average of 24.18 points from a mean of 66.6 ± 18.3 points (34-93 points) preoperatively to 90.8 ± 14.2 points (44-100 points) postoperatively (95% CI - 33.0 to - 15.3; p 0.0001). The KOOS-PF score increased by an average of 33.7 points from a mean of 49.5 ± 24.5 points (9.1-88.6 points) preoperatively to 83.2 ± 21.6 points (15.9 -100 points) postoperatively (95% CI - 47.5 to - 19.9; p 0.0001).The findings of this study indicate that the combination of a distal femoral osteotomy and a tibial tuberosity distalization osteotomy is effective in patients presenting with patellar instability and patellofemoral pain due to patella alta and femoral malalignment.
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- 2022
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8. Changes in body mass index and clinical outcomes after initiation of contemporary antiretroviral regimens
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Wendy P. Bannister, T. Christopher Mast, Stéphane de Wit, Jan Gerstoft, Lothar Wiese, Ana Milinkovic, Vesna Hadziosmanovic, Amanda Clarke, Line D. Rasmussen, Karine Lacombe, Philipp Schommers, Thérèse Staub, Alexandra Zagalo, Joseba J. Portu, Luba Tau, Alexandra Calmy, Matthias Cavassini, Martin Gisinger, Elena Borodulina, Amanda Mocroft, Joanne Reekie, and Lars Peters
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Male ,Adult ,Adolescent ,Immunology ,HIV Infections ,Middle Aged ,Overweight ,Body Mass Index ,Infectious Diseases ,Anti-Retroviral Agents ,Cardiovascular Diseases ,Risk Factors ,Neoplasms ,Diabetes Mellitus ,Humans ,Immunology and Allergy ,Female ,Obesity - Abstract
Weight gain is becoming increasingly prevalent amongst people with HIV (PWH) receiving contemporary antiretroviral treatment. We investigated BMI changes and clinical impact in a large prospective observational study.PWH aged ≥18 years were included who started a new antiretroviral (baseline) during 2010-2019 with baseline and ≥1 follow-up BMI assessment available. Rates of clinical outcomes (cardiovascular disease [CVD], malignancies, diabetes mellitus [DM] and all-cause mortality) were analysed using Poisson regression to assess effect of time-updated BMI changes (gt;1 kg/m 2 decrease, ±1 kg/m 2 stable,gt;1 kg/m 2 increase), lagged by 1-year to reduce reverse causality. Analyses were adjusted for baseline BMI plus key confounders including antiretroviral exposure.6721 PWH were included; 72.3% were male, median age 48 years (interquartile range [IQR] 40-55). At baseline, 8.4% were antiretroviral-naive, and 5.0% were underweight, 59.7% healthy weight, 27.5% overweight, and 7.8% were living with obesity. There was an 8.2% increase in proportion of overweight and 4.8% in obesity over the study period (median follow-up 4.4 years [IQR 2.6-6.7]).100 CVDs, 149 malignancies, 144 DMs, and 257 deaths were observed with incidence rates 4.4, 6.8, 6.6, 10.6 per 1000 person-years of follow-up, respectively. Compared to stable BMI,gt;1 kg/m 2 increase was associated with increased risk of DM (adjusted incidence rate ratio [IRR]: 1.96, 95% confidence interval [CI]: 1.36-2.80) andgt;1 kg/m 2 decrease with increased risk of death (adjusted IRR: 2.33, 95% CI: 1.73-3.13). No significant associations were observed between BMI changes and CVD or malignancies.A BMI increase was associated with DM and a decrease associated with death.
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- 2022
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9. Multi-tablet, Single-Tablet, or Long-Acting Antiretroviral Treatment for HIV: A Cross-sectional Study of Patient Preferences in the United States and Spain
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Alfredo Soler, Carracedo, Vitor, Oliveira, Jorge, Saz, Ferran, Pujol, Ana, Milinkovic, and Allison, Webel
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Advanced and Specialized Nursing - Published
- 2022
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10. Economic Evaluation of Early Psychosis Interventions From A Canadian Perspective
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Jean-Eric Tarride, Gord Blackhouse, Amal Abdel-Baki, Eric Latimer, Gillian Mulvale, Brian Cooper, Gord Langill, Deborah Milinkovic, Rosain Stennett, and Jeremiah Hurley
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Canada ,Psychiatry and Mental health ,Psychotic Disorders ,Cost-Benefit Analysis ,Humans ,Quality-Adjusted Life Years ,Original Research - Abstract
Background Compared to treatment as usual (TAU), early psychosis intervention programs (EPI) have been shown to reduce mortality, hospitalizations and days of assisted living while improving employment status. Aims The study aim was to conduct a cost-benefit analysis (CBA) and a cost-effectiveness analysis (CEA) to compare EPI and TAU in Canada. Methods A decision-analytic model was used to estimate the 5-year costs and benefits of treating patients with a first episode of psychosis with EPI or TAU. EPI benefits were derived from randomized controlled trials (RCTs) and Canadian administrative data. The cost of EPI was based on a published survey of 52 EPI centers in Canada while hospitalizations, employment and days of assisted living were valued using Canadian unit costs. The outcomes of the CBA and CEA were expressed in terms of net benefit (NB) and incremental cost per life year gained (LYG), respectively. Scenario analyses were conducted to examine the impact of key assumptions. Costs are reported in 2019 Canadian dollars. Results Base case results indicated that EPI had a NB of $85,441 (95% CI: $41,140; $126,386) compared to TAU while the incremental cost per LYG was $26,366 (95% CI: EPI dominates TAU (less costs, more life years); $102,269). In all sensitivity analyses the NB of EPI remained positive and the incremental cost per LYG was less than $50,000. Conclusions In addition to EPI demonstrated clinical benefits, our results suggest that large-scale implementation of EPI in Canada would be desirable from an economic point of view .
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- 2022
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11. Short Communication: Predictive Value of HIV-Related Versus Traditional Risk Factors for Coronary Atherosclerosis in People Aging with HIV
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Branca Pereira, Ana Milinkovic, Marta Boffito, Graeme Moyle, Sundhiya Mandalia, Abtehale Al-hussaini, and Maria Mazzitelli
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Male ,Aging ,medicine.medical_specialty ,Immunology ,Population ,HIV Infections ,Coronary Artery Disease ,Disease ,Logistic regression ,Risk Factors ,Virology ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,education ,Coronary atherosclerosis ,Subclinical infection ,education.field_of_study ,business.industry ,Odds ratio ,Middle Aged ,medicine.disease ,Confidence interval ,Cross-Sectional Studies ,Infectious Diseases ,Female ,business ,Calcification - Abstract
BACKGROUND Cardiovascular disease (CVD) is an important cause of morbidity in people living with HIV (PLWH). We compared the predictive value of HIV-related and traditional CVD risk factors to assess which factors best predict the presence of subclinical coronary atherosclerosis in PLWH. METHODS Cross-sectional study in PLWH over 50 years of age who performed CT coronary artery calcium (CAC) scoring between 2009-2019 at Chelsea and Westminster Hospital. The following outcomes were analyzed: CAC=0 (no calcification), CAC >0 (any calcification), CAC >100 (moderate calcification) and CAC >400 (severe calcification). Univariate and multivariate logistic regression analyses were performed to assess predictors of coronary calcification. RESULTS A total of 744 patients were included (mean age 56 ± 5.7 years, 94.8% male, 84% white). A CAC >0 was found in 392 (52.7%), CAC >100 in 90 (12.1%) and CAC >400 in 42 (5.6%) subjects. CAC >100 was strongly associated with hypertension [odds ratio OR: 2.91, (95% confidence interval CI: 1.93-4.36), P 6 years) to protease inhibitors [1.67 (1.06-2.61), P =0.05] whereas exposure to tenofovir (> 8 years) was negatively associated with CAC >100 [0.54 (0.30-0.98), P =0.05]. Despite the high prevalence of hypertension (45.4%), only 21.5% were on anti-hypertensives whereas only 29.2% of eligible candidates were receiving lipid lowering drugs for primary prevention of CVD. CONCLUSIONS Traditional cardio-metabolic risk factors remain the strongest predictors of coronary atherosclerosis in PLWH as in the general population. These results underscore the importance of optimizing treatment of hypertension and promoting primary prevention strategies that may be underused in PLWH.
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- 2022
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12. Safety, immunogenicity, and efficacy of a COVID-19 vaccine (NVX-CoV2373) co-administered with seasonal influenza vaccines: an exploratory substudy of a randomised, observer-blinded, placebo-controlled, phase 3 trial
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Seth Toback, Eva Galiza, Catherine Cosgrove, James Galloway, Anna L Goodman, Pauline A Swift, Sankarasubramanian Rajaram, Alison Graves-Jones, Jonathan Edelman, Fiona Burns, Angela M Minassian, Iksung Cho, Lakshmi Kumar, Joyce S Plested, E Joy Rivers, Andreana Robertson, Filip Dubovsky, Greg Glenn, Paul T Heath, Roy L. Soiza, Robin Brittain-Long, Chiara Scicluna, Carole Edwards, Lynn Mackay, Mariella D'Allesandro, Amy Nicol, Karen Norris, Sandra Mann, Heather Lawrence, Ruth Valentine, Marianne Elizabeth Viljoen, Carol H. Pretswell, Helen Nicholls, Imrozia Munsoor, Agnieszka Meyrick, Christina Kyriakidou, Shalini Iyengar, Arham Jamal, Nick Richards, Helen Price, Bridie Rowbotham, Danielle Bird, Karen Smith, Olga Littler, Kirsty Fielding, Anna Townsend-Rose, Karen Miller, Jessica Davis, Alison Elliot-Garwood, Lauren Trottier, Paul Edwards, Margaret McFarland, Orod Osanlou, Laura Longshaw, Jane Stockport, Lynne Grundy, Katharine Lucy Broad, Karen Regan, Kim Storton, Declan Ryan-Wakeling, Brad Wilson, Malathy Munisamy, John Wright, Anil Shenoy, Beverley English, Lucy Brear, Paola Cicconi, Marta Boffito, Ana Milinkovic, Ruth Byrne, Roya Movahedi, Rosalie Housman, Naveed Kara, Ellen Brown, Andrea Cipriani, Mary-Jane Attenburrow, Katharine A. Smith, Jonathan Packham, Geoff Sparrow, Richard Smith, Josephine M. Rosier, Khalid Saja, Nyasha Nago, Brian Camilleri, Anita Immanuel, Mike Hamblin, Rawlings Osagie, Mahalakshmi Mohan, Hilary Floyd, Suzanne Goddard, Sanjay Mutgi, John Evans, Sean McKeon, Neringa Vilimiene, Rosavic Chicano, Rachel Hayre, Alice Pandaan, Catherine Henshall, Sonia Serrano, Andrea Mazzella, Thurkka Rajeswaran, Moncy Mathew, Karen Bisnauthsing, Laura Bremner, Henry Fok, Franca Morselli, Paola Cinardo, Blair Merrick, Lucy Sowole, Samantha Broadhead, Natalie Palmer, Jessica Cordle, Jaimie Wilson Goldsmith, Enya Cooney, Beth Jackson, Thilina Jayatilleke, Zelda Cheng, Toby Helliwell, Adrian Chudyk, Rafaela Giemza, John Lord Villajin, Noah Yogo, Esther Makanju, Pearl Dulawan, Deepak Nagra, April Buazon, Alice Russell, Georgie Bird, Amardeep Heer, Rex Sarmiento, Balraj Sanghera, Melanie Mullin, Adam Champion, Aisling Bevan, Kinzah Iqbal, Alshia Johnson, Rebecca Clark, Sarah Shaw, Steven Shaw, Amanda Chalk, Martin Lovatt, Caroline Lillicrap, Angela Parker, Jan Hansel, Zhi Wong, Galvin Gan, Eyad Tuma, Jane Minton, Jennifer Murira, Razan Saman, Alistair Hall, Kyra Holliday, Zara Khan, James Calderwood, George Twigg, Helena Baker, Julie Corrigan, Katy Houseman, Subhra Raguvanshi, Dominic Heining, Jake Weddell, Liz Glaves, Kim Thompson, Francis Davies, Ruth Lambley Burke, Emma C. Thomson, Dinesh Saralaya, Lisa Berry, Nancy Hopewell, Leigh Gerdes, Mihaela Pacurar, Saul N. Faust, Jeremy Turner, Christopher Jeanes, Adele Cooper, Jocelyn Keshet-Price, Lou Coke, Melissa Cambell-Kelly, Ketan Dhatariya, Claire Williams, Georgina Marks, James Sudbury, Lisa Rodolico, Judy Bradley, Sharon Carr, Roisin Martin, Angelina Madden, Paul Biagioni, Sonia McKenna, Alison Clinton, Maurice O'Kane, Justin Carter, Matthew Dewhurst, Bill Wetherill, Thandiwe Hoggarth, Katrina Lennon Collins, Marie Chowdhury, Adil Nathoo, Anna Heinen, Orla MacDonald, Claudia Hurducas, Liliana Cifuentes, Harjeevan Gill, Andy Gibson, Raha West, Jane Ewing, Rachel Blacow, John Haughney, Jonathan MacDonald, John Paul Seenan, Stewart Webb, Colin O'Leary, Scott Muir, Beth White, Neil Ritchie, Daniel F. McAuley, Jonathan Stewart, Mariella D'Alessandro, Nicki Lakeman, Laura Purandare, Duncan Browne, David Tucker, Peter Luck, Angharad Everden, Lisa Trembath, Michael Visick, Nick Morley, Laura Reid, Helen Chenoweth, Kirsty Maclean, Ray P. Sheridan, Tom Burden, Craig Francis Lunt, Shirley Todd, Stephanie Estcourt, Jasmine Marie Pearce, Suzanne Wilkins, Cathryn Love-Rouse, Eva Torok-Pollok, Mike Youle, Sara Madge, Danielle Solomon, Aarti Nandani, Janet M. North, Nargis Hemat, Rachel Newport, Philip A. Kalra, Chukwuma Chukwu, Olivia Wickens, Vikki O'Loughlin, Hema Mistry, Louise Harrison, Robert Oliver, Anne-Marie Peers, Jess Zadik, Katie Doyle, David R. Chadwick, Kerry Colling, Caroline Wroe, Marie Branch, Alison Chilvers, Sarah Essex, Mark Stone, Alberto San Francisco Ramos, Emily Beales, Olivia Bird, Zsofia Danos, Hazel Fofie, Cecilia Hultin, Sabina Ikram, Fran Mabesa, Aoife Mescall, Josyanne Pereira, Jennifer Pearce, Natalina Sutton, Emma Snashall, David Neil Baxter, Sara Bennett, Debbie Suggitt, Kerry Hughes, Wiesia Woodyatt, Lynsey Beacon, Alissa Kent, Chris Cooper, Milan Rudic, Simon Tunstall, Matthew Jackson, Claire Hombersley, Patrick Moore, Rebecca Cutts, Andrew Higham, Marwan Bukhari, Mohamed Elnaggar, Michelle Glover, Fiona Richardson, Alexandra Dent, Shahzeb Mirza, Rajiv Ark, Jennie Han, Suzy V. Hope, Philip J. Mitchelmore, Rostam Osanlou, Andrew Freedman, Alison Cooper, Katherine Burton, Kashyap Katechia, Michael Barrett, Jo Salkeld, Natalie Hill, Nathaniel Lee, Jon Perkins, and Polly Fox
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Adult ,Pulmonary and Respiratory Medicine ,Trivalent influenza vaccine ,medicine.medical_specialty ,COVID-19 Vaccines ,Adolescent ,Influenza vaccine ,Population ,Placebo ,Young Adult ,Immunogenicity, Vaccine ,Double-Blind Method ,Internal medicine ,Humans ,Medicine ,education ,Adverse effect ,Aged ,education.field_of_study ,Reactogenicity ,SARS-CoV-2 ,business.industry ,COVID-19 ,Articles ,Middle Aged ,Vaccine efficacy ,Vaccination ,Influenza Vaccines ,Seasons ,business - Abstract
Background The safety and immunogenicity profile of COVID-19 vaccines when administered concomitantly with seasonal influenza vaccines have not yet been reported. We therefore aimed to report the results of a substudy within a phase 3 UK trial, by evaluating the safety, immunogenicity, and efficacy of NVX-CoV2373 when co-administered with licensed seasonal influenza vaccines. Methods We did a planned exploratory substudy as part of the randomised, observer-blinded, placebo-controlled, phase 3 trial of the safety and efficacy of the COVID-19 vaccine (NVX-CoV2373) by co-administrating the influenza vaccine at four study hospitals in the UK. Approximately, the first 400 participants meeting the main study entry criteria—with no contraindications to influenza vaccination—were invited to join the substudy. Participants of the main study were randomly assigned (1:1) to receive two intramuscular injections of either NVX-CoV2373 (5 μg) or placebo (normal saline) 21 days apart; participants enrolled into the substudy were co-vaccinated with a single (0·5 mL) intramuscular, age-appropriate (quadrivalent influenza cell-based vaccine [Flucelvax Quadrivalent; Seqirus UK, Maidenhead] for those aged 18–64 years and adjuvanted trivalent influenza vaccine [Fluad; Seqirus UK, Maidenhead] for those ≥65 years), licensed, influenza vaccine on the opposite deltoid to that of the first study vaccine dose or placebo. The influenza vaccine was administered in an open-label manner and at the same time as the first study injection. Reactogenicity was evaluated via an electronic diary for 7 days after vaccination in addition to monitoring for unsolicited adverse events, medically attended adverse events, and serious adverse events. Immunogenicity was assessed with influenza haemagglutination inhibition and SARS-CoV-2 anti-spike protein IgG assays. Vaccine efficacy against PCR-confirmed, symptomatic COVID-19 was assessed in participants who were seronegative at baseline, received both doses of study vaccine or placebo, had no major protocol deviations affecting the primary endpoint, and had no confirmed cases of symptomatic COVID-19 from the first dose until 6 days after the second dose (per-protocol efficacy population). Immunogenicity was assessed in participants who received scheduled two doses of study vaccine, had a baseline sample and at least one post-vaccination sample, and had no major protocol violations before unmasking (per-protocol immunogenicity population). Reactogenicity was analysed in all participants who received at least one dose of NVX-CoV2373 or placebo and had data collected for reactogenicity events. Safety was analysed in all participants who received at least one dose of NVX-CoV2373 or placebo. Comparisons were made between participants of the substudy and the main study (who were not co-vaccinated for influenza). This study is registered with ClinicalTrials.gov, number NCT04583995. Findings Between Sept 28, 2020, and Nov 28, 2020, a total of 15 187 participants were randomised into the main phase 3 trial, of whom 15 139 received treatment (7569 received dose one of NVX-CoV2373 and 7570 received dose one of placebo). 431 participants were co-vaccinated with a seasonal influenza vaccine in the substudy (217 received NVX-CoV2373 plus the influenza vaccine and 214 received placebo plus the influenza vaccine). In general, the substudy participants were younger, more racially diverse, and had fewer comorbid conditions than those in the main study. Reactogenicity events were more common in the co-administration group than in the NVX-CoV2373 alone group: tenderness (113 [64·9%] of 174 vs 592 [53·3%] of 1111) or pain (69 [39·7%] vs 325 [29·3%]) at injection site, fatigue (48 [27·7%] vs 215 [19·4%]), and muscle pain (49 [28·3%] vs 237 [21·4%]). Incidences of unsolicited adverse events, treatment-related medically attended adverse events, and serious adverse events were low and balanced between the co-administration group and the NVX-CoV2373 alone group. No episodes of anaphylaxis or deaths were reported within the substudy. Co-administration resulted in no change to influenza vaccine immune response although a reduction in antibody responses to the NVX-CoV2373 vaccine was noted. NVX-CoV2373 vaccine efficacy in the substudy (ie, participants aged 18 to
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- 2022
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13. The Effects of Different Drugs with Anti-Inflamatory Potential in Prevention of Pulp Damage During the Teeth Bleaching
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Miona Glisic, Andjela Milojevic, Milica Milinkovic, and Marina Rankovic
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This paper aims to collect all the necessary information and conclusions which deal with the anti-inflammatory drugs within the scope of teeth bleaching, and which are rooted in scientific research. It is a well-known fact that the teeth whiteners / bleachers are at the same time a very aggressive agents, which opened up the question of the safety of their application. The most frequently applied bleaching agents are the hydrogen-peroxide (H2O2) and carbim peroxide (CH6N2O3), therefore this paper will be based on the research which included these two agents. The first studies were directed towards investigating the outcome / impact on the enamel, i.e. if there is direct surface damage of the enamel layer after the use of such agents. However, bearing in mind that the clinical practice has shown that in a number of cases there arises the sensitivity of teeth in the form of painful sensation after the bleaching treatment, some researches were directed towards the estimation of the permeability of the enamel and dentin for the bleaching agent, and later the effect on the pulp tissue. Along with the existing proof about the irritability of these agents to the pulp tissue, the modern research have the idea of looking into the effects of the anti-inflamatory drugs as the accompanying and prevention therapy of any of the irreversible damage of the pulp. On one hand the application of these drugs can reduce the sensitivity and painfulness of the teeth, which makes the intervention pleasant for the patient, but on the other hand the intervention becomes completely justifiable from the aspect of safety and the basic principle primum non nocere. The anti-inflammatory drugs which will be the topic of this study are H hydrocortisone, acetaminophen, ipobruphen and etodolac. Taking into consideration the vasoconstrictive and anti-oxidative effect, the anti-inflammatory effect of the carvedilol will be looked into, which belongs to the group of beta blockers. Based on available informations it can be noticed that the most efficient anti-inflammatory effect in teeth whitening is achived by hydrocortisone.
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- 2023
- Full Text
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14. The utility of serum amyloid A and other acute-phase reactants determination in ambulatory COVID-19 patients
- Author
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Boris Jegorovic, Aleksandra Nikolic, Neda Milinkovic, Svetlana Ignjatovic, and Sandra Sipetic Grujicic
- Subjects
Biochemistry (medical) ,Clinical Biochemistry - Abstract
Background: The unpredictable course of Coronavirus Disease 19 (COVID-19) is making good severity assessment tools crucial. This study aimed to assess the usefulness of serum amyloid A (SAA) and other acute-phase reactants (APRs) in ambulatory COVID-19 patients and identified relationships between these markers and disease outcomes. Methods: From August to November 2020, patients seen in the outpatient department of the Clinic for Infectious and Tropical Diseases (Belgrade, Serbia) with confirmed COVID-19 were included. Based on World Health Organization criteria, patients were classified into mild, moderate, and severe disease groups. SAA, C-reactive protein (CRP), interleukin-6 (IL-6), procalcitonin (PCT), ferritin, fibrinogen, D-dimer, albumin, and transferrin were measured. The Receiver operator characteristic (ROC) curve analysis was used for the classification characteristics assessment of individual APRs for the severity of illness, hospitalization, and survival. The median values of all APRs were compared between COVID-19 severity groups, hospitalized and non-hospitalized patients, and survivors and non-survivors. Results: Higher levels of SAA, CRP, IL-6, PCT, and lower levels of transferrin and albumin were observed in severe cases, hospitalized patients, and non-survivors. Based on ROC curve analysis AUC for SAA has fair classification performance for disease severity (0.794) and death (0.732) and good performance for hospitalization (0.853). Conclusion: SAA is a valuable marker in everyday practice for assessing COVID-19 severity and prognosis in ambulatory patients.
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- 2023
- Full Text
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15. Validation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery
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Ahmed, W. U. R., Bhatia, S., Mclean, K. A., Khaw, R., Baker, D., Kamarajah, S. K., Bell, S., Nepogodiev, D., Harrison, E. M., Glasbey, J. C., Borakati, A., Burke, J., Drake, T. M., Bath, M. F., Claireaux, H. A., Gundogan, B., Mohan, M., Deekonda, P., Kong, C., Joyce, H., Mcnamee, L., Woin, E., Khatri, C., Fitzgerald, J. E., Bhangu, A., Arulkumaran, N., Duthie, F., Hughes, J., Pinkney, T. D., Prowle, J., Richards, T., Thomas, M., Blanco-Colino, R., Chapman, S. J., Pata, F., Pellino, G., Sgr??, A., Soares, A., van Elst, T., Van Straten, S., Knowles, C. H., Dynes, K., Patel, M., Patel, P., Wigley, C., Suresh, R., Shaw, A., Klimach, S., Jull, P., Evans, D., Preece, R., Ibrahim, I., Manikavasagar, V., Smith, R., Brown, F. S., Teo, R., Sim, D. P. Y., Logan, A. 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E., Kechagias, A., Turunen, A., Katunin, J., Niskakangas, M., Ojak????r, A., Venara, A., Lenaoures, P., Duchalais, E., Vignaud, T., Frey, S., Ricolleau, C., Ioannidis, A., Konstantinidis, M., Antonakopoulos, F., Mathioulaki, A., Chrysoheris, P., Athanasopoulos, P. G., Koutserimpas, C., Tenconi, S. M., Rausei, S., Maioli, D., Marchionini, V., Pasquali, S., Simioni, A., Farina, V., Podda, M., Lorenzon, L., Tirelli, F., Fico, V., Santullo, F., Belia, F., Schaeff, V., Otto, A., Jakubauskas, M., Po??kus, E., Danys, D., Kry??auskas, M., Mikalauskas, S., Rackauskas, R., Drungilas, M., Po??kus, T., Jotautas, V., Strupas, K., Petrulionis, M., van Elst, T. R., Abdulrahman, Z., Chu, M., Fagan, P. V. B., Wells, C. I., Alagoa Jo??o, A., Apar??cio, D. J., Fragoso, M., Guimar??es, J., Cruz, G., Ribeiro, J., Borges da Ponte, I., Almeida, S., Martins, A. R., Juloski, J., Cuk, V. V., Radulovic, R., Milo??evic, K., Bojicic, J., Gencic, M., Jankovic, U., Jovanovic, M., El Kasmy El Kasmi, Y., G??mez Jurado, M. J., Alberti Delgado, P., Bordanova Reverter, A., G??mez del Pulgar, A., Belzunce-Cap??, J. F., Verdaguer Tremolosa, M., Lin, Q., P??rez-Ajates, S., Ramayo D??az, N., Gonz??lez Caraballo, I., Pascual Vicente, T., Orue-Echebarria, M. I., S??nchez-Calvo, L., Wang, D., Trueba-Collado, C., Morales Bernaldo de Quir??s, J. T., Anabitarte Bautista, O., Yebes, A., Espin-Basany, E., Clerc, D., Mignon, G., Vanoni, A., Henkens, A., Jarrar, G., Odovic, M., Willemin, M., Milliet, O., Hahnloser, D., Demartines, N., Curchod, P., Ciubotaru, C., Popescu, S., Popescu, S. S., Piras, K., Ciubotaru, C. I., Yanishev, A., Luzan, R., Lutovinova, E., Gavrilina, A., Barkovskaya, A., Kudelkina, N., Topchubaev, D., Ozkan, B. B., Yagiz Sen, A., Aktas, M. K., Aykun, N., Agca, M. H., Bilen, C., Kilinc, I., Atar, C., Kilic, V., Aktuna, C., Aba, M., Eray, I. C., Baki, B. E., Arslan, E., Alemdag, G., Ulusahin, M., Gul, E. B., Yildirim, R., Semiz, A., Bektur, G., Tomas, K., Bodur, S., Y??ksek, B., Serin, H., Erd??nmez, H., G??rsoy, F., Kara, H., nsal, U., zbek, M., Kasar, P. A., Ipor, A., etin, M. F., Khaw, R. A., Mills, E., Manley, L. R., Vutipongsatorn, K., Thakral, N., Adra, M., Khan, S. M., Badran, A., Ramjeeawon, A., Tan, H. L., Rye, D. S., Rajaraman, N., Norman, J. G., Solomou, G., Baker, D. M., Brandao, B. D., Stainer, B., Onafowokan, O. O., Gharooni, A., Dabab, N., Carlton-Carew, S., Kungwengwe, G., Gabriel, M., Sewart, E., Lawday, S, Pockney, P., Chrimes, A., Agarwal, A., Zhao, J., Jayalath, J. M. S. N., Liebenberg, P., Khor, S., Muddasani, T., Dawson, A., Taylor, N., Stevenson, C., Drane, A., Pahalawatta, U., Lai, L. T., Debiasio, A., Jung, M., Brumfitt, C. D., Beh, Y. Z., Dudi-Venkata, N. N., Lee, Y. D., Stewart, P., Thirugnanasundralingam, V., Muir, K., Ng, B., Mendis, D. M., Robb, P. M., Lee, H. J., Wyche, A. A. B., Davis, L. T., Luong, J. K., Jegathees, T., Coulter-Nile, S. M. C. J., Gosselink, M. P., Wang, Y. L., Maciaszek, M., Chrapko, P. S., White, S., Ivanov, V., Borisova, A., Kuncarov??, K., Ri??ko, J., Ludvik, M., Stercz, M., Treskon, R., Posp????il, M., Hlav??cov??, L., Tomanov??, D., Kolo??ov??, B., Sobotkov??, K., Cha, S., uta Kimle, K., Jirankova, K., Bujda, M., Pacl??k, A., Chrz, K., Antonova, T., Chodora, S., Houdek, O., Novick??, R., Skalick??, A., Farka??ov??, M., Jozaf, V., Klail, T., Prochazka, V., Harbjerg, J. L., Enevoldsen, M., H??jgaard Pedersen, J., Brandsborg, S., Amiri, S., Brinck, S., Jepsen, B. N., Hillgaard, T. K., Erichsen, S. B., Nielsen, C. V., Madsen, C. P., Bjerke, J., Skej??, C. D., Aabling, R. R., Kjaer, M. D., Unbehaun, K. P., Mark-Christensen, A., Dalsgaard, P., Trap, A., J??rgens-Lahnstein, J., Storm, M., Damgaard, I., Olawi, F., Ehlern, F., Raos, M., Ravn, S., Lycke, K. D., Kristensen, F. P., B??nnerup, K., Brigand, C., Dumange, E., Gout, M., Moehwald, C., Prem, M., Krupp, J., Alhalabi, O., Sliwinski, S., Gablenz, E., Seiboldt, T., Beck, L., Pohl, L. J., Zamzow, K., Betge, F., Poncelet, A., Truant, M., Hauschild, H., Neugebauer, N., D??rr-Harim, C., Schmitzer, L., Kopp, A., Steinle, J., Gsenger, J., Riccardi, M., Christodoulou, I. M., Zoikas, A., Machairas, N., Paspala, A., Papaconstantinou, D., Spartalis, E., Arkadopoulos, N., Prodromidou, A., Garoufalia, Z., Balalis, D., Manatakis, D. K., Kalles, V., Spyrou, I., Barkolias, C., Aguilera, M. L., Mendez, D., Rosales, J., Flores, M., Garcia, M., Garcia, A., Noriega, Z., Torselli, D., Rodriguez, J., Argenti, F., Milani, M. S., Malabarba, S., Giambartolomei, G., Vella, I., Gronchi, F., Ruggieri, A., Marano, L., Fleres, F., Lovisetto, F., Barberis, A., Serra, D., Sasia, D., Geretto, P., Pellegrino, L., Borghi, B., Marano, A., Corino, C., Cannata, G., Giuffrida, M. C., Landra, F., Giraudo, G., Segalini, E., Monti, M., Magnoli, M., Pata, G., Lucchi, A., Grassia, M., Cufari, M. E., Sagnotta, A., Di Cintio, A., Gemini, A., Trastulli, S., De Luca, M., Desiderio, J., Gubbiotti, F., Campagnaro, T., Pedrazzani, C., Turri, G., Lazzarini, E., Conti, C., Ruzzenente, A., Petrelli, F., Marziali, I., Mazzocato, S., Vergari, R., Piazzai, F., Kubolli, I., Aggiusti, A., Paolucci, A., Ortenzi, M., Gallo, G., Clerico, G., De Santi, G., Bitonti, M. F., Trompetto, M., Realis Luc, A., Papandrea, M., Cerra, C., Pirillo, M., Cravano, S., Libri, I., Laquatra, N., Isabello, A., De Luca, E., Testa, V., Morino, M., Mistrangelo, M., Sinibaldi, G., Angelucci, G. P., Scaramuzzo, R., Larcinese, A., Fioriti, C., Picone, E., Nardi, M., Di Candido, F., Spinelli, A., Marco, M., Bevilacqua, M., Maroli, A., Colombo, F., Cigognini, M., Zaffaroni, G., Maffioli, A., Colombo, S., Bondurri, A., Sampietro, G., Foschi, D., Perrone, G., Bonati, E., Aresu, S., Saba, A., Biancafarina, A., Angelini, M., Andolfi, E., Miranda, E., Scricciolo, M., Provenza, G., Cavallina, G., Frezza, B., Fontani, A., Malatesti, R., Pellican??, G. A., Ceccarelli, G., Canonico, G., Falsetti, E., Pagnanelli, M., De Nardi, P., Rosati, R., Marcocci, G., Vignali, A., Quattromani, R., Curletti, G., Galleano, R., Malerba, M., Percivale, A., Ghazouani, O., Reggiani, L., Spirito, C., Bini, R., de Manzoni Garberini, A., Impellizzeri, H., Moretto, G., Bacchion, M., Casaril, A., Inama, M., Creciun, M., Vitali, M., Cillara, N., Mosino, L., Peddis, M., Melis, S., De Donno, G., Aru, A. C., Loche, G. A., Tutino, R., Licari, L., Campanella, S., Profita, G., Falco, N., Rotolo, G., Venturelli, P., De Marco, P., Marcian??, M., Picciariello, A., Chetta, N., Aquilino, F., Papagni, V., Coletta, D., Cerasari, S., Galiffa, G., Lapolla, P., Del Basso, C., Cirillo, B., De Toma, G., Fazzi, K., Bini, S., De Padua, C., Savino, G., Finotti, E., Ferrara, F., Stella, M., Gobatti, D., Tamini, N., Brenna, R., Giani, A., Tirotta, F., Famularo, S., Angrisani, M., Ceresoli, M., Talamo, G., Sucameli, F., Gennai, A., Moggia, E., Bianchi, C., Bonfante, P., Macina, S., Feleppa, C., Imperatore, M., Berti, S., Parini, D., Lanari, J., Giamundo, P., lo Conte, A., Pagano, G., Manigrasso, M., Danzi, M., Amato, R., Anastasio, L., Mastella, F., Basile, R., Peltrini, R., Marra, E., Luglio, G., Giglio, M., Anoldo, P., Vertaldi, S., Grimaldi, L., Tammaro, N., Ripetti, V., D'Alessio, R., Benvenuto, D., Pesce, A., Menduni, N., Giudicissi, R., Zalla, T., Baraghini, M., Romoli, L., Calussi, M., Vellei, S., Genzano, C., Feroci, F., Vita, M., Giani, I., Goldin, E., Ciccioli, E., Galgano, A., Zuin, M., Bettella, A., Barina, A., Vendramin, E., Palano, G., Schiavone, D., Rega, D., La Manna, V., Migliore, G., Aversano, A., Fares Bucci, A., Belli, A., Andriola, V., Lafranceschina, S., Gordini, L., Erdas, E., Podda, F., Cappellacci, F., Salaris, C., Sanna, S., Marcialis, J., Longheu, A., Foppa, C., Coratti, F., Montanelli, P., Grandi, S., Nelli, T., Ben Khaled, N., Cammelli, F., Ferrini, E., Billo, M. E., Piccolo, G., Romano, S., Gaetano, P., Pilotta, F., Baldassarre, L., Birindelli, A., D'Errico, U., Bianchini, S., Ferrari, C., Franceschi, A., Caristo, G., Ballarini, Z., Romelli, M., Ruggiero, S., Percassi, A., Milone, M., De Rosa, M., Pipitone Federico, N. S., Molteni, B., Magri Piccinini, A., Tilocca, P. L., Marrosu, A. G., Scognamillo, F., Pala, C., Attene, F., Carboni, L., Ruggiu, M. W., Gabbas, G., Sancini, G., Roggiani, A., Balsamo, F., Gori, A., Cuicchi, D., Vittori, L., Piozzi, G. N., Tringali, D., Bevilacqua, E., Panizzo, V., Lauretta, A., Poillucci, G., Mulas, S., Simcikas, D., Samalavicius, N. E., Nutautiene, V., Zeromskas, P., Jurgaitis, J., Aliosin, O., Slepavicius, A., Eismontas, V., Kybransiene, M., Portelli, L., Cachia, C., Cefai, C., Youssef, Y., Degaetano, D., Debono, S., Sammut, M., Cassar, J., Sammut, K., Andrejevic, P., van Wijnbergen, J. W. M., Dinger, T. L., ten Doesschate, S. F. H., van Dalen, A. S. H. M., Looijen, R. C., Becker, M. A. J., Comert, D., Stellingwerf, M. E., Abdulrahman, N., van den Bos, D. D., Gr??ter, A., Vroom, Y., Voeten, D. M., Feenstra, T., de Roy van Zuidewijn, D., Hansmann, M., Nasimi, B., Gerdsen, M., Stijns, R. C. H., Leow, T. Y. S., Penningnieuwland, G., Davids, J., Medina Feliz, J., Kuiper, S. Z., Sluijpers, N. R. F., van de Pas, K. G. H., Pruijssers, S. R., Molenaar, C. J. L., Thomas, G., Farik, S., Chen, S. Y., Kilpatrick, K., Kim, D. H., Ong, H. I., Elliott, B. M., Geneta, V. P., Alsadat, R., Cherry, R., Chapman, D. A., Singh, N., Clucas, A., Gatenby, G., Kelly, B., Ruppeldt, P., Mcintosh, N. D., Li, Y., Wilton, S., Mclaughlin, S. J. P., Kearney, J., Sprosen, H., Kerckhoffs, P., Kandelaki, H., Welman, D., Coulter, J., Morreau, M., Li, E., Rankin, A., Winders, J., Skipworth, C., Peng, S. L., Campbell, S., Lim, Y. K., Yassaie, S. S., Dixon, S., Yassaie, S., Murray, M., Haran, C., Koh, S., Wilms, H., Dalzell, F., Tewhaiti-Smith, J., Kader, T., Yam, S. T., Dahya, D., Hardie Boys, M., Fleischl, W., Desmond, B., Tan, J., Skavysh, A., Castro, J., Orelhas, L., Santos, J., Pacheco, A., Rocha, A. F., Jervis, M. J., Pedro, V., Paix??o, V., Guerreiro, A., Melo, D., Laranjeira, A., Machado, A., Horta, V., Rocha-Melo, M., Patr??cio, J., Pereira, M., Lima, R., Cinza, A. M., Oliveira, J., Velez, C., Senhorinho, R., Catarino, S., Aveiro, D., Couto, M., Loureiro, A. R., Neves-Marques, C., Louro, T., Morgado, M., Ferreira, A. S., Alves, M., Oliveira, N., L??rias, R., Estalagem, I., Botelho, C., Alves-Vale, C., Correia, J. G., Jardim, J. A. M., Domingos, S. P., Bai??o, J. M., Rocha, B. S., Lopes, N. M. R. O., Jord??o, D. M., ngelo, M. D., Caro??o, T., Vieira, B. N., Silva, A. G., Galv??o, D., Mora, A., Bettencourt, R., Quintela, A. C., Alves, D., Dias, B., Costa, C., Gon??alves, J. P., Valente, P., Freire, L., Saraiva, R., Moreira, M., Peixoto, R., Serra, M. L., Santos, T. C., Lages, R. R., Pimentel, A., Martins, M., Maciel, J., B??rtolo, J., Fidalgo Antunes, C., Cabral, F., Brito Silva, F., Dias Matos, A., Santos, M., Cunha, R., Duarte, M., Sousa, M., Cunha, M., Neves, J., M??nica, I., Oliveira, S., Ribeiro, H., Ferreira, M., Guimar??es, N., Azevedo, J., Louro, H., Queiros, T., Castro, B., Fonseca, S., Carvalho, L., Torre, A. P., Amado, A., Leite, M., Romano, M., Gomes, J. R., Monteiro, R. G., Eir??, F., Borges, F., Sim??es, J., Botelho, P., Cismasiu, B., Romano, J., Monteiro, C., Silva, M., Claro, M., Almeida, P., Cruz, A., Vaz Pinto, G., Sousa, D., Costa Santos, D., Silva, A., Silva, F., Almeida, M. R., Parreira, R., Faustino, A., Medeiros, N., Castro, R., Soares, B., Resendes, M., Peyroteo, M., Canotilho, R., Correia, A. M., Martins, P. C., Machado, N. D., S??, T. C., Bernardes, F. M., Saraiva, P., Almeida, J., Mendes, M., Fernandes, V., Ribeiro, A., Soares, D., Capote, H., Fialho, G., Reia, M., Pratas, N., Costa, J., Morais, S., Miranda, P., Cunha, C., Sousa, X., Amado, F., Batista, A., Seabra, J., Praxedes, V., Monteiro, N., Martins, I., Lamas, M., Devesa, H., Miranda, J., Martins, S. F., Cavadas, D., Silva, R., Pina, S., Paix??o, I., Frade, S., Guerreiro, I., Tom??, M., Patrocinio, S., Costa, M., Rosete, M., Senaratne, R., Kakodkar, P., Balasubramanian, I., Hogan, A., Al-Salihi, A., Vyas, V., Vedadi, A., English, C., Mohammed, N., Dervan, L., Kang, S. J., Morrissey, E., Compton, M., Litvin, A., Romanova, E., Ponomarev, N., Savchenko, A., M??sz??rosov??, K., Zubowicz, M., Such??n, P. K., Gerstmeier, J., Brazitikou, E., Fytrou, E., Celik, M., Dubovsk??, M., Schmalenbeck, J., Sautter, S. C., Ceyran, H., Panyko, A., Jaich, R., Fitchat, N., De Lima, H., Withey, K., Piperidis, A., Toyi, Y., Nicolaides, A., Brooks, S., Jaffer, T., Sparke, A., Van Staden, N., Mcduling, C. R., Claassen, L., Van Vuuren, S., Marx, M., Kruger, C., Weyers, J., Lecler, J., Nshalati Salvation, M., Mathebula, S., Chauke, J., Mculu, W., Ngwenya, Z., Cardo, J. Garc??a., Mora-Guzm??n, I., Sancho Muriel, J., de Andres Olabarria, U., Casaval Cornejo, L., Vicente Rodr??guez, I., Jim??nez Escovar, F., Calvo Fern??ndez, M., Portugal Mart??nez, A., Badiola Bergara, I., Landaluce Olavarria, A., del Pozo Andr??s, E., Muriel, P., Mestres, N., Cuello, E., Merichal, M., Sierra, J. E., Escoll, J., Rufas, M., Pinillos, A. I., Ortega, J., Cerd??n, C., Jimenez Vi??as, C., Alconchel, F., Mart??nez D??az, J. M., Ruiz Manzanera, J. J., Navarro Barrios, ??., Rodr??guez Pedre??o, L., Moreno, P. Garc??a., G??mez, M. Garc??a., Rodrigues, K., Abrisqueta, J., Esteban Sinovas, O., Oro, C. Fair??n., L??pez Otero, M., Toimil, C. Samart??n., Primo ??lvarez, J. C., Rodriguez Fernandez, L., Paniagua Garcia Se??orans, M., Figueroa Jim??nez, S., Livianos Arias-Camis??n, P., Nieto Arranz, J. M., Mateos Sexmero, M. J., Diego Alonso, E., Gonz??lez Amor, L., Claramonte Bellmunt, O., Mart??nez Caballero, J., Rubio-P??rez, I., Ramos Martin, P., Mate Mate, P., Marcano Chavez, C., Rubio-Perez, I., Ayllon, H., Aguilar-Mart??nez, M. M., Arroyo, A., Segura-Sampedro, J. J., Jer??-McFarlane, S., Soldevila-Verdeguer, C., Pine??o-Flores, C., Ambrona-Zafra, D., Fern??ndez-Vega, L., Gil-Catal??n, A., Craus-Miguel, A., Pujol-Cano, N., Sena-Ruiz, F., Olmedo Moreno, C., Pastor Idoate, C., Negre Parra, D., Soriano Li??bana, M. M., Campo Betancourth, C. F., Sevila Mico, S., Est??vez Diz, A. M., Mart??n-Balbuena, R., Garc??a-Vico, A., Roman-Rando, A., S??nchez-G??lvez, M. ??., Bersabe-Alonso, I. M., Vadillo-Bohorquez, A., Bustamante Recuenco, C., Calzada, M. G., Recuenco, C. B., Martin, M. C., Licardie Bola??os, R. E., Garcia Orozco, J. J., Ferrusola Diaz, D. A., Garcia Jimenez, M. L., Castro Diez, L., Mosquera Fernandez, C., Fern??ndez, P., Platero Diago, J., Veras Lista, M., Rif?? Terricabras, S., Butler Sanz, L., Alberch Camprub??, E., Rico Ferr??ndez, M., Puig Lao, E., De Pablo Mir??, M., D??az Padillo, A., Padilla Zegarra, E. D., Franco, M., Martinez, A., Forero-Torres, A., Alonso-Poza, A., Dieguez, B., Losada, M., Gilsanz, C., Alberdi San Rom??n, I., Ramos Jim??nez, F. A., P??rez Ortega, A., Trujillo Barbadillo, A., Romero Pujana, E., Fernandez Illera, M. V., Salvador Ros??s, H., Delisau Puig, O., Castro, A., Codony Bassols, C., Fernandes, N., damez, J. Garc??a., Caula Freixa, C., G??mez Romeu, N., Merayo ??lvarez, M., Merayo Alvarez, M., Alonso Batanero, E., Canales, I. Cifri??n., Villarejo Campos, P., Alberca-Paramo, A., Alia Verdejo, T., Ca??ete-Manzanares, J., Molina-Florez, M., Hern??ndez, L. C. Garc??a., Orozco Nu??ez, S., Suarez-Sanchez, M., Martin-Fernandez, J., Estaire Gomez, M., Lopes Moreira, C. C., Gutierrez Rios, R. D., Eizaguirre Ubegun, M., Novo Sukia, I., Uribe Isado, M., Iba??ez Alda, M., Enriquez-Navascues, J. M., Uriol Peralta, P., Lima Pinto, F., N????ez O??Sullivan, S., Serrano Navidad, M., Vivas Angeles, P., Vives Figueras, R., Baena Sanfeliu, E., Campillo Alonso, B., Alberich Prats, M., Duran Arrocha, J., Cornell?? Garceso, N., Uribe Galeano, C., Collado-Roura, F., Ripoll??s-Melchor, J., Garcea, A., G??mez Facundo, H., Troncoso Pereira, P., Garcia, J. M., Gil, A., Giordano, H. E., P??rez Guarinos, C. V., Blaser, B., Imadalou, L., Piazza, G., Teixeira, H., Pittet, O., Gaspar, S., Gagliardi, B., Haller, M. L., Huot, A., Yurdaor, S. S., Alim, Y. E., Binbuga, M., K??rkl??, ??., Ceylan, C., Yilmaz, S., alar, S. N., Yildirim, N., Yavuz, G., Biyiklioglu, O., Kopac, O., Baykan, B., Abbasguliyev, H., Mutlu, V., Mahmoudi, Y., Dossa, S. A. A., Mizan, S. R., Demirtas, B., Cavus, T., Yuksek, A., Karabulut, K., Uyanik, A., Kargici, K., Banaz, T., Abdulrahman, S. M. F., Yesilsancak, M., Yanikoglu, E., Karabulut, A., Kuyumcu, O. F., Kutluk, F., Tunc, E., Ozmen, B. B., Kurtoglu, G. K., Sel, E. K., Isler, V. C., Yilmaz, B. S., Adiyaman, C., Kara, M., Demirkaya, H. C., Korkmaz, H. K., Pektas, A. M., Mutlu, D., Tiftik, E., Aksoy, A. B., Karag??z, E., Sabanci, R., T??mer, S. S., Sarig??l, L., Aksoy, B., Emiroglu, B., Mollavelioglu, B., Gereklioglu, D., Guler, M., Toprak, S., Afsar, H. B., Guler, S. E., Alizade, E., Aydin, T., Yalcinkaya, A., Erdem, M., Kayacan, S., Sahin, C., Uysal, M., Karakus, K., Altiner, S., Demirci, Z. S., Eren, E., Yavas, M., Dogan, H., Ozoglu, F., Mazlum, S. S., Yelkenci, C., Baran, T., Satilmisoglu, M., Sahin, A. Z., Kilin??, A., Isik, K., Kocer, M. D., G??ner, B., Islek, E. C., Tombul, H. B., Boztug, C. Y., Tinaz, A., Yilmaz, M., Karaman, Y., Akin, F. A., Dansuk, S., Bas??avus, M., Kaya, M., Kutlu, B., Akyol, C., Bilicen, G., Yarenci, E., Demiroglu, Y., Sunal, A., Cinar, E. N., Tipi, O. U., Benli, G. E., Tasdelen, I., Tura, A., Ucar, A., Ekci, B., Bilgili, A. C., Kiraz, I. N., Aksoy, H., Basak, A., Karip, B., Uslu, ??., Seker, M. C., Erten, V., Memis, U., Ko??ak, Z. B., Karapinar, Y. E., Fakirullahoglu, M., K??seoglu, E., Yeni, M., Uygur, F. A., Kaya, Y., zen, D., lmez, M., Altintas, E., Toklu, R., Sari??i??ek, T., Isik, A. E., Demirci, K., Suresh, G., Anbarasan, J., Rehman, S., Hu, E., Timms, S., Reynolds, W., Hotchkies, A., Misra, V., Finch, B. J., Philip Rajathasan, T., Jeddy, H., Kyaw, H. A., Wong, N., Bhahirathan, Y., Donaldson, C., Sequeira Campos, M., Armitage, M. N., Hussain, A. S., Hardy, B., Hassan Serry, M. Y., Herron, J., Thakrar, C., Rojoa, D., Yeap, B., Iqbal, Z., Rojoa, D. M., Cabaleiro Barciela, C., Ruddy, C. M., Lindwe, S., Qamar, Y., Chuita, S., James, A., Bugelli, M., Chechelnitskaya, Y., Bylinski, T., Findlay, J. M., Skan, O., Kind, C., Tupper, P., Van Rhee, C., Honeyman, S. I., Menon, G., Sloper, W., Burford, C., Coey, J., Akbari, K., Whitehead, T., Dimitriadis, S., Marshall, K., Flint, E. J., Can, B., Cesmeli, E., Kus, D., Kavar, R. C., Cevlik, A. D., Cengiz, U., Turk, E. G., Yilmaz, I., Yumurtaci, ??., Emin, A., Girit, ??. a. g. r. i., Yildirak, M. K., Senyigit, E., G??ldag, A., S??yleyici, B., Aytin, Y. E., Akay, F. E., Iskan, N. G., Mutlu, B., Sunay, A. O., Bell, T., Limnatitou, D., Gormley, S., Taleongpong, P., Patel, V., Macgregor, L., Amini, S., Turner, C., To, N., Laurence, N., Green, C., Frostick, R., Khera, R., Povey, M., Mahapatra, S., Bradbury, M., Osunronbi, T., Tam, L. Y. C., Khanan Kaabneh, A., Lawther, J., Fisher, P., Tribedi, T., Moosa, A., Ramdin, A., Mcgee, F., Flanagan, S., Tan, Q. J., Anwar, H., Clough, R., Chrisp, B., Cassels, J., Cross, G. W. V., Refalo, A., Hadley, R., Mctighe, A., Farrow, F., Brodie, A., Davis, G., Shah, D. R., Bowers, C., M. P. E., Ng, Wong, R. T. W., Maese, S., Tandon, R., Gray, M., Kumar, A., Ciurleo, C., Nyamali, I., Hiremath, S., Sinha, S., Chowdhary, M., Kirupananthan, P., Boh, Z. Y., Dass, S., Soma, A., Newton, A., Hill, M., Shafiq, Y., Brkljac, M., Martin, H., Mcclarty, C., Sanyal, S., Alsaif, A., Bhopal, S., Muneeb, F., Page, O., Zeb, E., Al-Azzawi, A., Mcintosh, J., Vucicevic, A., Hughes, M., Brooks, L., Fanibi, B., Dixon, M., Njoku, P., Morris, D., Jobson, J., Trussell, S., Chowdhury, H., Alawode, D. O. T., Udayachandran, V., Alsoof, D., Ekert, J., Joseph, N., Zulkefley, N., Hunt, G., Christodoulou, T., Wright, O., Soman, S., Jamal, M., Beqiri, S., Borgas, P., Pereira, F., Browne, S., Yiu, J., Dworkin, A., Mak, J., Patrawala, S., Milinkovic, N., Schofield, R., Chauhan, M., Hartley, L., Hind, J., Heybourne, A., Morgan, H., Wickstone, C., Panagiotou, D., O'Connell, E., Dean, K., Iqbal, R., Walsh, L., Yu, N., Rana, N., Massie, E., Foong, J., Lee, Y. J., Mijalkov, D., Wells, A., Bull, N., Ajmera, A., Warburton, T., Morgan, S., Mahmoud, A., Schachtel, M., Mikhail, B., Fomin, I., Mekaeil, B., Jun, H. J. S., Hengpoonthana, R., Childs, S., Ridgway, S., Blefari, N. D. A., Tam, H., Puchalski, N., Ngai, C., Mackenzie, J., Johnson, N., Holmes, M., Zuzek, R., Saluja, T., Gould, T., Goh, Y. K., Selvaraj, T., Horne, D., Borrow, J. L., Campbell, C., Cousins, G., Jackson, L., Maheepala, K., Zhao, S., Holden, E., Tutt, L., Thompson, B., Collins, H., Louie, F., Buckland, B., Smith, D., Chong, C., Chua, T. H., Nayak, C., Redmond, J., Tan, R. R., Gramlick, M., Teh, J. S., S. Y., Ng, Britten-Jones, P., Mohd Rosli, R., Pham, H. D. V., Harris, M., Salibasic, M., Pavlov, V., Paycheva, T., Lyulenina, E., Kolev, N., Boev, B., Nguen, D., Mitkov, Y., Mitkov, E., Vladova, P., Dimitrov, V., Gabarski, A., Feradova, H., Mladenov, T., P??s, M., Adel, A., Sotona, O., Barto??, M., Amjad, T., Mal??, O., Berec, S., Hanu??ov??, M., Hurn??, M., rhalmi, J., S??rensen, J. S., Chanut, F., Magnin, J., Sch??ning, L., CS Simon, S., Galata, C., Karampinis, I., Th??wel, T., Seckler, A. M., Kerem, C., Durdevic, S., Herrle, F., Artioli, E., Giaccari, S., Nevoso, V., Schimera, A., Marino, S., Resta, G., Ongaro, D., Baronio, G., Raimondo, S., Casiraghi, S., Salvadori, R., Armellini, A., Vulcano, I., Bertilone, E., Pintabona, G., Viscosi, F., Mazzeo, C., Olivieri, M., Belluco, C., Antona, A. D., Basso, S., Frattalone, M., Marino, F., Carbone, F., Incollingo, P., Romano, F. M., Anania, M., Pulighe, F., Cruccu, A., Murru, M. L., Massaiu, C., Balestra, F., Pazzona, M., De Nisco, C., Gusai, G. P., Giannella, A., Santangelo, M., Frangella, F., Magagnano, D., Liberatore, P., Rondelli, F., Castagnoli, G., Bartoli, A., Bellochi, R., Spaziani, A., Conti, D., Poponesi, V., Trippetti, M., Amicucci, S., Tazza, G., Procacci, P., Giovannini, F., Basile, E., Moschetta, G., Cosmi, F., Romeo, G., Gasparrini, M., Virgilio, E., Sparta, C., Mura, F. A., Barmina, M., Lorettu, A., Rettaroli, C., Mastino, G., Ruggiu, G. V., Mura, G. A., Perrone, B. A., De Angelis, M., Mereu, A., Adamo, V., Bianco, C., Ricciardiello, M., Campanaro, C., Panaccio, P., Esposito, L. M., Di Mola, F. F., D'Ascanio, F., Pietroletti, R., Di Marco, F., Amico, A., Schembari, E., Puglisi, S., Tuminello, F., Fig??, F., Caiazzo, A., Selvaggi, L., Capozzolo, A., Braccio, B., Tru??kovs, A., Bartnick, A., Malcevs, E., Machatschek, M. J., Alm, J., Lapsa, S., Delorme, M., Zeynalov, F., Larnovskis, J., Sauka, J., Bodrov, D., Gailumsis, R., Wiemann, A. M., M??ller, N. L., Jelovskis, I., Deksnis, D., Bauermeister Potts, O., Slimbajevs, T., Ancans, G., Dulskas, A., Kuliavas, J., Kavaliauskas, P., Kavaliauskaite, R., te Molder, L., Tromp, J., Matthee, E., Tissen, Y. M., Brinkhuis, E., de Vries, H. S., Hart, E. 't., Beckers, K., Bekker, Y., Kakar, S., van Smaalen, T. C., Veen, O. C., Dingemans, S. A., van den Brink, L. C., Vijgen, G. H. E. J., van de Voort, E. M. F., van der Pool, A., van Rest, K. L. C., Haak, T., Gordinou de Gouberville, M. C., Saleh, S., Mens, M. A., Hoeks, E. M., Nieuwenhuizen, S., Brandsma, A. M., van Praag, E. M., Westerduin, E., Smit, M. P. C. M., van der Lely, S. J., de Ruiter, A., Ribbers, T., Aarts, C. A. M., Tulek, M. S., de Jonge, J., Kocak, S., Alqethami, H. J., Constansia, R., van Elst, P. C., Tissink, M. W., Azzahhafi, J., Bofarid, S., Kip, M., Saleh, W., Franssen, S., Boon, C. L., Franssen, R. J. M., Romaen, I., Jense, M. T. F., D'Souza, J., Pascoe, R., Scott, A., Stark, E., Mulholland, K., Lau, W. K., Smith, B., Adams, S. I. B., Shah, N., Ling, E., Young, J., Hawkins, R., Jacobson, A., Macfater, H., Stanfield, B., Henderson, N., Chuang, A., Maskill, L., Ker, H., Mouldey, K., Hu, R., Matthews, C., Aitken, E., Walker, M., Winstanley, J., Miguel, I., Martins, J., Cunha, M. F., Melo, J., Veiga, D. 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E., Camarero, E., Mart??nez Ill??n, M., Aranda Garc??a, L., L??zaro Cardona, M., Montalvo Olmedo, C., Izquierdo Moreno, A., Cuenca Ram??rez, A., Margarida, A., Pando, B., Liquete Mar??n, L., P??rez Calle, M., Ramos Cordero, M. J., Sagredo Cuartango, A., S??nchez, E., Marcos Rodrigo, A., Fernandez, A., Curtis, C., Bosch, M., Triguero, D., Bosch Ram??rez, M., De La Llave Serralvo, A., S??nchez, M. J., Mart??n-Borreg??n, P., Quevedo, A., Mart??nez, J., Mar??n, J. M., Rodr??guez, P., Esteban Avenda??o, I., Jim??nez Relimpio, C., Lancho Lavilla, P., Blanco Bartolom??, I., G??mez Cano, I., Blasco Andr??s, C., Abad-Motos, A., Mar??nez-Hurtado, E., Salvachua-Fern??ndez, R., Muniesa, C., Avelino, L., Cholewa, H., Sancho-Muriel, J., Navasquillo, M., Nav??o, A., Abell??, D., De Jesus, M., Alvarez, E., Kefleyesus, A., Bugmann, A., Piotet, L. M., Meijers, L., Tonchev, P., Tamosiunas, A., Rottier, S. J., Negoi, I., Bernado, I. R., Eftychiou, S., Psychiatry, Surgery, RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tampere University, Kanta-Häme Central Hospital Hämeenlinna, Ahmed, W, Bhatia, S, Mclean, K, Khaw, R, Baker, D, Kamarajah, S, Bell, S, Nepogodiev, D, Harrison, E, Glasbey, J, Borakati, A, Burke, J, Drake, T, Bath, M, Claireaux, H, Gundogan, B, Mohan, M, Deekonda, P, Kong, C, Joyce, H, Mcnamee, L, Woin, E, Khatri, C, Fitzgerald, J, Bhangu, A, Arulkumaran, N, Duthie, F, Hughes, J, Pinkney, T, Prowle, J, Richards, T, Thomas, M, Blanco-Colino, R, Chapman, S, Pata, F, Pellino, G, Sgro, A, van Elst, T, Van Straten, S, Knowles, C, Dynes, K, Patel, M, Patel, P, Wigley, C, Suresh, R, Shaw, A, Klimach, S, Jull, P, Evans, D, Preece, R, Ibrahim, I, Manikavasagar, V, Smith, R, Brown, F, Teo, R, Sim, D, Logan, A, Barai, I, Amin, H, Suresh, S, Sethi, R, Gul, W, Bolton, W, Corbridge, O, Horne, L, Attalla, M, Morley, R, Robinson, C, Hoskins, T, Mcallister, R, Lee, S, Dennis, Y, Nixon, G, Heywood, E, Wilson, H, Ng, 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A., Tutino, R., Licari, L., Campanella, S., Profita, G., Falco, N., Rotolo, G., Venturelli, P., De Marco, P., Marcianò, M., Picciariello, A., Chetta, N., Aquilino, F., Papagni, V., Coletta, D., Cerasari, S., Galiffa, G., Lapolla, P., Del Basso, C., Cirillo, B., De Toma, G., Fazzi, K., Bini, S., De Padua, C., Savino, G., Finotti, E., Ferrara, F., Stella, M., Gobatti, D., Tamini, N., Brenna, R., Giani, A., Tirotta, F., Famularo, S., Angrisani, M., Ceresoli, M., Talamo, G., Sucameli, F., Gennai, A., Moggia, E., Bianchi, C., Bonfante, P., Macina, S., Feleppa, C., Imperatore, M., Berti, S., Parini, D., Lanari, J., Giamundo, P., lo Conte, A., Pagano, G., Manigrasso, M., Danzi, M., Amato, R., Anastasio, L., Mastella, F., Basile, R., Peltrini, R., Marra, E., Luglio, G., Giglio, M., Anoldo, P., Vertaldi, S., Grimaldi, L., Tammaro, N., Ripetti, V., D'Alessio, R., Benvenuto, D., Pesce, A., Menduni, N., Giudicissi, R., Zalla, T., Baraghini, M., Romoli, L., Calussi, M., Vellei, S., Genzano, C., Feroci, F., Vita, M., Giani, I., Goldin, E., Ciccioli, E., Galgano, A., Zuin, M., Bettella, A., Barina, A., Vendramin, E., Palano, G., Schiavone, D., Rega, D., La Manna, V., Migliore, G., Aversano, A., Fares Bucci, A., Belli, A., Andriola, V., Lafranceschina, S., Gordini, L., Erdas, E., Podda, F., Cappellacci, F., Salaris, C., Sanna, S., Marcialis, J., Longheu, A., Foppa, C., Coratti, F., Montanelli, P., Grandi, S., Nelli, T., Ben Khaled, N., Cammelli, F., Ferrini, E., Billo, M. E., Piccolo, G., Romano, S., Gaetano, P., Pilotta, F., Baldassarre, L., Birindelli, A., D'Errico, U., Bianchini, S., Ferrari, C., Franceschi, A., Caristo, G., Ballarini, Z., Romelli, M., Ruggiero, S., Percassi, A., Milone, M., De Rosa, M., Pipitone Federico, N. S., Molteni, B., Magri Piccinini, A., Tilocca, P. L., Marrosu, A. G., Scognamillo, F., Pala, C., Attene, F., Carboni, L., Ruggiu, M. W., Gabbas, G., Sancini, G., Roggiani, A., Balsamo, F., Gori, A., Cuicchi, D., Vittori, L., Piozzi, G. N., Tringali, D., Bevilacqua, E., Panizzo, V., Lauretta, A., Poillucci, G., Mulas, S., Simcikas, D., Samalavicius, N. E., Nutautiene, V., Zeromskas, P., Jurgaitis, J., Aliosin, O., Slepavicius, A., Eismontas, V., Kybransiene, M., Portelli, L., Cachia, C., Cefai, C., Youssef, Y., Degaetano, D., Debono, S., Sammut, M., Cassar, J., Sammut, K., Andrejevic, P., van Wijnbergen, J. W. M., Dinger, T. L., ten Doesschate, S. F. H., van Dalen, A. S. H. M., Looijen, R. C., Becker, M. A. J., Comert, D., Stellingwerf, M. E., Abdulrahman, N., van den Bos, D. D., Grüter, A., Vroom, Y., Voeten, D. M., Feenstra, T., de Roy van Zuidewijn, D., Hansmann, M., Nasimi, B., Gerdsen, M., Stijns, R. C. H., Leow, T. Y. S., Penningnieuwland, G., Davids, J., Medina Feliz, J., Kuiper, S. Z., Sluijpers, N. R. F., van de Pas, K. G. H., Pruijssers, S. R., Molenaar, C. J. L., Thomas, G., Farik, S., Chen, S. Y., Kilpatrick, K., Kim, D. H., Ong, H. I., Elliott, B. M., Geneta, V. P., Alsadat, R., Cherry, R., Chapman, D. A., Singh, N., Clucas, A., Gatenby, G., Kelly, B., Ruppeldt, P., Mcintosh, N. D., Li, Y., Wilton, S., Mclaughlin, S. J. P., Kearney, J., Sprosen, H., Kerckhoffs, P., Kandelaki, H., Welman, D., Coulter, J., Morreau, M., Li, E., Rankin, A., Winders, J., Skipworth, C., Peng, S. L., Campbell, S., Lim, Y. K., Yassaie, S. S., Dixon, S., Yassaie, S., Murray, M., Haran, C., Koh, S., Wilms, H., Dalzell, F., Tewhaiti-Smith, J., Kader, T., Yam, S. T., Dahya, D., Hardie Boys, M., Fleischl, W., Desmond, B., Tan, J., Skavysh, A., Castro, J., Orelhas, L., Santos, J., Pacheco, A., Rocha, A. F., Jervis, M. J., Pedro, V., Paixão, V., Guerreiro, A., Melo, D., Laranjeira, A., Machado, A., Horta, V., Rocha-Melo, M., Patrício, J., Pereira, M., Lima, R., Cinza, A. M., Oliveira, J., Velez, C., Senhorinho, R., Catarino, S., Aveiro, D., Couto, M., Loureiro, A. R., Neves-Marques, C., Louro, T., Morgado, M., Ferreira, A. S., Alves, M., Oliveira, N., Lérias, R., Estalagem, I., Botelho, C., Alves-Vale, C., Correia, J. G., Jardim, J. A. M., Domingos, S. P., Baião, J. M., Rocha, B. S., Lopes, N. M. R. O., Jordão, D. M., Ângelo, M. D., Caroço, T., Vieira, B. N., Silva, A. G., Galvão, D., Mora, A., Bettencourt, R., Quintela, A. C., Alves, D., Dias, B., Costa, C., Gonçalves, J. P., Valente, P., Freire, L., Saraiva, R., Moreira, M., Peixoto, R., Serra, M. L., Santos, T. C., Lages, R. R., Pimentel, A., Martins, M., Maciel, J., Bártolo, J., Fidalgo Antunes, C., Cabral, F., Brito Silva, F., Dias Matos, A., Santos, M., Cunha, R., Duarte, M., Sousa, M., Cunha, M., Neves, J., Mónica, I., Oliveira, S., Ribeiro, H., Ferreira, M., Guimarães, N., Azevedo, J., Louro, H., Queiros, T., Castro, B., Fonseca, S., Carvalho, L., Torre, A. P., Amado, A., Leite, M., Romano, M., Gomes, J. R., Monteiro, R. G., Eiró, F., Borges, F., Simões, J., Botelho, P., Cismasiu, B., Romano, J., Monteiro, C., Silva, M., Claro, M., Almeida, P., Cruz, A., Vaz Pinto, G., Sousa, D., Costa Santos, D., Silva, A., Silva, F., Almeida, M. R., Parreira, R., Faustino, A., Medeiros, N., Castro, R., Soares, B., Resendes, M., Peyroteo, M., Canotilho, R., Correia, A. M., Martins, P. C., Machado, N. D., Sá, T. C., Bernardes, F. M., Saraiva, P., Almeida, J., Mendes, M., Fernandes, V., Ribeiro, A., Soares, D., Capote, H., Fialho, G., Reia, M., Pratas, N., Costa, J., Morais, S., Miranda, P., Cunha, C., Sousa, X., Amado, F., Batista, A., Seabra, J., Praxedes, V., Monteiro, N., Martins, I., Lamas, M., Devesa, H., Miranda, J., Martins, S. F., Cavadas, D., Silva, R., Pina, S., Paixão, I., Frade, S., Guerreiro, I., Tomé, M., Patrocinio, S., Costa, M., Rosete, M., Senaratne, R., Kakodkar, P., Balasubramanian, I., Hogan, A., Al-Salihi, A., Vyas, V., Vedadi, A., English, C., Mohammed, N., Dervan, L., Kang, S. J., Morrissey, E., Compton, M., Litvin, A., Romanova, E., Ponomarev, N., Savchenko, A., Mészárosová, K., Zubowicz, M., Suchán, P. K., Gerstmeier, J., Brazitikou, E., Fytrou, E., Celik, M., Dubovský, M., Schmalenbeck, J., Sautter, S. C., Ceyran, H., Panyko, A., Jaich, R., Fitchat, N., De Lima, H., Withey, K., Piperidis, A., Toyi, Y., Nicolaides, A., Brooks, S., Jaffer, T., Sparke, A., Van Staden, N., Mcduling, C. R., Claassen, L., Van Vuuren, S., Marx, M., Kruger, C., Weyers, J., Lecler, J., Nshalati Salvation, M., Mathebula, S., Chauke, J., Mculu, W., Ngwenya, Z., García Cardo, J., Mora-Guzmán, I., Sancho Muriel, J., de Andres Olabarria, U., Casaval Cornejo, L., Vicente Rodríguez, I., Jiménez Escovar, F., Calvo Fernández, M., Portugal Martínez, A., Badiola Bergara, I., Landaluce Olavarria, A., del Pozo Andrés, E., Muriel, P., Mestres, N., Cuello, E., Merichal, M., Sierra, J. E., Escoll, J., Rufas, M., Pinillos, A. I., Ortega, J., Cerdán, C., Jimenez Viñas, C., Alconchel, F., Martínez Díaz, J. M., Ruiz Manzanera, J. J., Navarro Barrios, Á., Rodríguez Pedreño, L., García Moreno, P., García Gómez, M., Rodrigues, K., Abrisqueta, J., Esteban Sinovas, O., Fairén Oro, C., López Otero, M., Samartín Toimil, C., Primo Álvarez, J. C., Rodriguez Fernandez, L., Paniagua Garcia Señorans, M., Figueroa Jiménez, S., Livianos Arias-Camisón, P., Nieto Arranz, J. M., Mateos Sexmero, M. 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D., Eizaguirre Ubegun, M., Novo Sukia, I., Uribe Isado, M., Ibañez Alda, M., Enriquez-Navascues, J. M., Uriol Peralta, P., Lima Pinto, F., Núñez O´Sullivan, S., Serrano Navidad, M., Vivas Angeles, P., Vives Figueras, R., Baena Sanfeliu, E., Campillo Alonso, B., Alberich Prats, M., Duran Arrocha, J., Cornellà Garceso, N., Uribe Galeano, C., Collado-Roura, F., Ripollés-Melchor, J., Garcea, A., Gómez Facundo, H., Troncoso Pereira, P., Garcia, J. M., Gil, A., Giordano, H. E., V Pérez Guarinos, C., Blaser, B., Imadalou, L., Piazza, G., Teixeira, H., Pittet, O., Gaspar, S., Gagliardi, B., Haller, M. L., Huot, A., Yurdaor, S. S., Alim, Y. E., Binbuga, M., Kürklü, Ö., Ceylan, C., Yilmaz, S., Çalar, S. N., Yildirim, N., Yavuz, G., Biyiklioglu, O., Kopac, O., Baykan, B., Abbasguliyev, H., Mutlu, V., Mahmoudi, Y., Dossa, S. A. A., Mizan, S. R., Demirtas, B., Cavus, T., Yuksek, A., Karabulut, K., Uyanik, A., Kargici, K., Banaz, T., Abdulrahman, S. M. F., Yesilsancak, M., Yanikoglu, E., Karabulut, A., Kuyumcu, O. F., Kutluk, F., Tunc, E., Ozmen, B. B., Kurtoglu, G. K., Sel, E. K., Isler, V. C., Yilmaz, B. S., Adiyaman, C., Kara, M., Demirkaya, H. C., Korkmaz, H. K., Pektas, A. M., Mutlu, D., Tiftik, E., Aksoy, A. B., Karagöz, E., Sabanci, R., Tümer, S. S., Sarigül, L., Aksoy, B., Emiroglu, B., Mollavelioglu, B., Gereklioglu, D., Guler, M., Toprak, S., Afsar, H. B., Guler, S. E., Alizade, E., Aydin, T., Yalcinkaya, A., Erdem, M., Kayacan, S., Sahin, C., Uysal, M., Karakus, K., Altiner, S., Demirci, Z. S., Eren, E., Yavas, M., Dogan, H., Ozoglu, F., Mazlum, S. S., Yelkenci, C., Baran, T., Satilmisoglu, M., Sahin, A. Z., Kilinç, A., Isik, K., Kocer, M. D., Güner, B., Islek, E. C., Tombul, H. B., Boztug, C. Y., Tinaz, A., Yilmaz, M., Karaman, Y., Akin, F. A., Dansuk, S., Basçavus, M., Kaya, M., Kutlu, B., Akyol, C., Bilicen, G., Yarenci, E., Demiroglu, Y., Sunal, A., Cinar, E. N., Tipi, O. U., Benli, G. 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W., Maese, S., Tandon, R., Gray, M., Kumar, A., Ciurleo, C., Nyamali, I., Hiremath, S., Sinha, S., Chowdhary, M., Kirupananthan, P., Boh, Z. Y., Dass, S., Soma, A., Newton, A., Hill, M., Shafiq, Y., Brkljac, M., Martin, H., Mcclarty, C., Sanyal, S., Alsaif, A., Bhopal, S., Muneeb, F., Page, O., Zeb, E., Al-Azzawi, A., Mcintosh, J., Vucicevic, A., Hughes, M., Brooks, L., Fanibi, B., Dixon, M., Njoku, P., Morris, D., Jobson, J., Trussell, S., Chowdhury, H., Alawode, D. O. T., Udayachandran, V., Alsoof, D., Ekert, J., Joseph, N., Zulkefley, N., Hunt, G., Christodoulou, T., Wright, O., Soman, S., Jamal, M., Beqiri, S., Borgas, P., Pereira, F., Browne, S., Yiu, J., Dworkin, A., Mak, J., Patrawala, S., Milinkovic, N., Schofield, R., Chauhan, M., Hartley, L., Hind, J., Heybourne, A., Morgan, H., Wickstone, C., Panagiotou, D., O'Connell, E., Dean, K., Iqbal, R., Walsh, L., Yu, N., Rana, N., Massie, E., Foong, J., Lee, Y. 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S., Chanut, F., Magnin, J., Schöning, L., CS Simon, S., Galata, C., Karampinis, I., Thäwel, T., Seckler, A. M., Kerem, C., Durdevic, S., Herrle, F., Artioli, E., Giaccari, S., Nevoso, V., Schimera, A., Marino, S., Resta, G., Ongaro, D., Baronio, G., Raimondo, S., Casiraghi, S., Salvadori, R., Armellini, A., Vulcano, I., Bertilone, E., Pintabona, G., Viscosi, F., Mazzeo, C., Olivieri, M., Belluco, C., Antona, A. D., Basso, S., Frattalone, M., Marino, F., Carbone, F., Incollingo, P., Romano, F. M., Anania, M., Pulighe, F., Cruccu, A., Murru, M. L., Massaiu, C., Balestra, F., Pazzona, M., De Nisco, C., Gusai, G. P., Giannella, A., Santangelo, M., Frangella, F., Magagnano, D., Liberatore, P., Rondelli, F., Castagnoli, G., Bartoli, A., Bellochi, R., Spaziani, A., Conti, D., Poponesi, V., Trippetti, M., Amicucci, S., Tazza, G., Procacci, P., Giovannini, F., Basile, E., Moschetta, G., Cosmi, F., Romeo, G., Gasparrini, M., Virgilio, E., Sparta, C., Mura, F. A., Barmina, M., Lorettu, A., Rettaroli, C., Mastino, G., Ruggiu, G. V., Mura, G. A., Perrone, B. A., De Angelis, M., Mereu, A., Adamo, V., Bianco, C., Ricciardiello, M., Campanaro, C., Panaccio, P., Esposito, L. M., Di Mola, F. F., D'Ascanio, F., Pietroletti, R., Di Marco, F., Amico, A., Schembari, E., Puglisi, S., Tuminello, F., Figà, F., Caiazzo, A., Selvaggi, L., Capozzolo, A., Braccio, B., Truškovs, A., Bartnick, A., Malcevs, E., Machatschek, M. J., Alm, J., Lapsa, S., Delorme, M., Zeynalov, F., Larnovskis, J., Sauka, J., Bodrov, D., Gailumsis, R., Wiemann, A. M., Müller, N. L., Jelovskis, I., Deksnis, D., Bauermeister Potts, O., Slimbajevs, T., Ancans, G., Dulskas, A., Kuliavas, J., Kavaliauskas, P., Kavaliauskaite, R., te Molder, L., Tromp, J., Matthee, E., Tissen, Y. M., Brinkhuis, E., de Vries, H. S., 't Hart, E., Beckers, K., Bekker, Y., Kakar, S., van Smaalen, T. C., Veen, O. C., Dingemans, S. A., van den Brink, L. C., Vijgen, G. H. E. J., van de Voort, E. M. F., van der Pool, A., van Rest, K. L. C., Haak, T., Gordinou de Gouberville, M. C., Saleh, S., Mens, M. A., Hoeks, E. M., Nieuwenhuizen, S., Brandsma, A. M., van Praag, E. M., Westerduin, E., Smit, M. P. C. M., van der Lely, S. J., de Ruiter, A., Ribbers, T., Aarts, C. A. M., Tulek, M. S., de Jonge, J., Kocak, S., Alqethami, H. J., Constansia, R., van Elst, P. C., Tissink, M. W., Azzahhafi, J., Bofarid, S., Kip, M., Saleh, W., Franssen, S., Boon, C. L., Franssen, R. J. M., Romaen, I., Jense, M. T. F., D'Souza, J., Pascoe, R., Scott, A., Stark, E., Mulholland, K., Lau, W. K., Smith, B., Adams, S. I. B., Shah, N., Ling, E., Young, J., Hawkins, R., Jacobson, A., Macfater, H., Stanfield, B., Henderson, N., Chuang, A., Maskill, L., Ker, H., Mouldey, K., Hu, R., Matthews, C., Aitken, E., Walker, M., Winstanley, J., Miguel, I., Martins, J., Cunha, M. F., Melo, J., Veiga, D. N., Rachadell, J., Amorim, E., Vareda, R., Roseira, J., Americano, M., Correia, D., Capella, V., Moinhos, T., Costa, F., Gil, I., Morgado, J., Varghese, S., Boyle, E., Aljohmani, L., Alexander, J., Graziadei, V., Mccaughey, C., Jain, A., O'Connor, D. B., Ramanayake, H., Sabnani, R., Colon, L. F., Bansal, N., Stephens, I., Tan, R., Hoo, M., Doherty, G., Fenn, S., Mulhare, E., Walsh, M., Leavey, C., Costigan, O., Griffin, S., Dockry, É., Khogali, E., Aly, A. K., Mcphedran, R., O'Gorman, D., Vermeulen, D., Gopaul, A., Pentony, A. R., Piong, C. L., Nossier, R., Hanna, J., Sabir, K., Eow, S. Y., Ladak, N., Boersma, D., Kamath, P. J., Soh, T. B. W., Dyer, A. H., Chee, S. Y., Tan, I. X. H., Kelliher, A., Scanlon, K., Adeusi, L., Howarth, N., Mccawley, N., O'Neill, A., Jones, M. R., Saleh, R., Singh, A., O'Dwyer, N., Mana, O. C., Gomez, H., Riba, L., Perez, J., Centeno, A., Ortega, C., Ossola, M. E., Camarero, E., Martínez Illán, M., Aranda García, L., Lázaro Cardona, M., Montalvo Olmedo, C., Izquierdo Moreno, A., Cuenca Ramírez, A., Margarida, A., Pando, B., Liquete Marín, L., Pérez Calle, M., Ramos Cordero, M. J., Sagredo Cuartango, A., Sánchez, E., Marcos Rodrigo, A., Fernandez, A., Curtis, C., Bosch, M., Triguero, D., Bosch Ramírez, M., De La Llave Serralvo, A., Sánchez, M. J., Martín-Borregón, P., Quevedo, A., Martínez, J., Marín, J. M., Rodríguez, P., Esteban Avendaño, I., Jiménez Relimpio, C., Lancho Lavilla, P., Blanco Bartolomé, I., Gómez Cano, I., Blasco Andrés, C., Abad-Motos, A., Marínez-Hurtado, E., Salvachua-Fernández, R., Muniesa, C., Avelino, L., Cholewa, H., Sancho-Muriel, J., Navasquillo, M., Navío, A., Abelló, D., De Jesus, M., Alvarez, E., Kefleyesus, A., Bugmann, A., Piotet, L. M., Meijers, L., Tonchev, P., Tamosiunas, A., Rottier, S. J., Negoi, I., Bernado, I. R., Eftychiou, S., RS: NUTRIM - R2 - Liver and digestive health, MUMC+: MA Mondzorg Kaak Aangezicht Chirurgie (9), Kindergeneeskunde, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, and Faculteit Medische Wetenschappen/UMCG
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renal failure ,cohort studies ,humans ,kidney ,postoperative complications ,prognosis ,prospective studies ,retrospective studies ,risk assessment ,risk factors ,acute kidney injury ,digestive system surgical procedures ,Prognosi ,Acute Kidney Injury/diagnosis ,Digestive System Surgical Procedures/adverse effects ,3121 Internal medicine ,Kidney ,Risk Assessment ,Cohort Studies ,Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] ,All institutes and research themes of the Radboud University Medical Center ,Postoperative Complications ,Retrospective Studie ,Risk Factors ,Gastrointestinal Surgery ,Humans ,preoperative care ,Prognostic Model ,Prospective Studies ,Digestive System Surgical Procedures ,Retrospective Studies ,Science & Technology ,Risk Factor ,MORTALITY ,General Medicine ,STARSurg Collaborative and EuroSurg Collaborative ,Acute Kidney Injury ,Prognosis ,surgical procedures ,Prospective Studie ,aki ,OAKS ,Postoperative Complications/etiology ,colorectal surgery ,Surgery ,Postoperative Complication ,Cohort Studie ,Life Sciences & Biomedicine ,Human - Abstract
Background Postoperative acute kidney injury (AKI) is a common complication of major gastrointestinal surgery with an impact on short- and long-term survival. No validated system for risk stratification exists for this patient group. This study aimed to validate externally a prognostic model for AKI after major gastrointestinal surgery in two multicentre cohort studies. Methods The Outcomes After Kidney injury in Surgery (OAKS) prognostic model was developed to predict risk of AKI in the 7 days after surgery using six routine datapoints (age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker). Validation was performed within two independent cohorts: a prospective multicentre, international study (‘IMAGINE’) of patients undergoing elective colorectal surgery (2018); and a retrospective regional cohort study (‘Tayside’) in major abdominal surgery (2011–2015). Multivariable logistic regression was used to predict risk of AKI, with multiple imputation used to account for data missing at random. Prognostic accuracy was assessed for patients at high risk (greater than 20 per cent) of postoperative AKI. Results In the validation cohorts, 12.9 per cent of patients (661 of 5106) in IMAGINE and 14.7 per cent (106 of 719 patients) in Tayside developed 7-day postoperative AKI. Using the OAKS model, 558 patients (9.6 per cent) were classified as high risk. Less than 10 per cent of patients classified as low-risk developed AKI in either cohort (negative predictive value greater than 0.9). Upon external validation, the OAKS model retained an area under the receiver operating characteristic (AUC) curve of range 0.655–0.681 (Tayside 95 per cent c.i. 0.596 to 0.714; IMAGINE 95 per cent c.i. 0.659 to 0.703), sensitivity values range 0.323–0.352 (IMAGINE 95 per cent c.i. 0.281 to 0.368; Tayside 95 per cent c.i. 0.253 to 0.461), and specificity range 0.881–0.890 (Tayside 95 per cent c.i. 0.853 to 0.905; IMAGINE 95 per cent c.i. 0.881 to 0.899). Conclusion The OAKS prognostic model can identify patients who are not at high risk of postoperative AKI after gastrointestinal surgery with high specificity. Presented to Association of Surgeons in Training (ASiT) International Conference 2018 (Edinburgh, UK), European Society of Coloproctology (ESCP) International Conference 2018 (Nice, France), SARS (Society of Academic and Research Surgery) 2020 (Virtual, UK).
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- 2022
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16. Results of a Multi-Disciplinary Approach Involving Geriatricians of a Clinic for Older People Living with HIV
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Aylin Cansu Ates, Andrei Bachnak, Yana Murateva, Yarden Toiber Kent, Sophie Blackburn, Marta Boffito, Ana Milinkovic, Tim Tong, and Maithili Varadarajan
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Infectious Diseases ,Public Health, Environmental and Occupational Health - Published
- 2023
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17. THE PROBLEM OF (MIS)UNDERSTANDING THE EQUALS SIGN IN JUNIOR GRADES OF PRIMARY SCHOOL
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Sanja Maričić and Nenad Milinkovic
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Correct understanding of the equals sign is the key to understanding arithme- tic, and a fundamental concept important for learning other areas of mathematics. Research around the world repeatedly mentions problems with correctly understanding the equals sign, emphasising the limited view of the equals sign as a command ”to calculate“ among students. The goal of the research was to identify the development of the concept of equality in line with the operationalised levels (operational, relational, and relational in the context of real-life prob- lem solving) and determine differences in understanding between students of the second (N = 190) and the fourth (N = 210) grade of primary school. The research was carried out using the testing technique. The research results show that students do not possess sufficiently developed relational understanding of the equals sign and that operational understanding prevails. Students of the fourth grade demonstrated better understanding of the equals sign at all levels of under- standing than the second graders.
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- 2022
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18. sj-pdf-1-jso-10.1177_23971983231163413 – Supplemental material for Consensus on the assessment of systemic sclerosis–associated primary heart involvement: World Scleroderma Foundation/Heart Failure Association guidance on screening, diagnosis, and follow-up assessment
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Bruni, Cosimo, Buch, Maya H, Djokovic, Aleksandra, De Luca, Giacomo, Dumitru, Raluca B, Giollo, Alessandro, Galetti, Ilaria, Steelandt, Alexia, Bratis, Konstantinos, Suliman, Yossra Atef, Milinkovic, Ivan, Baritussio, Anna, Hasan, Ghadeer, Xintarakou, Anastasia, Isomura, Yohei, Markousis-Mavrogenis, George, Mavrogeni, Sophie, Gargani, Luna, Caforio, Alida LP, Tschöpe, Carsten, Ristic, Arsen, Plein, Sven, Behr, Elijah, Allanore, Yannick, Kuwana, Masataka, Denton, Christopher P, Furst, Daniel E, Khanna, Dinesh, Krieg, Thomas, Marcolongo, Renzo, Pepe, Alessia, Distler, Oliver, Sfikakis, Petros, Seferovic, Petar, and Matucci-Cerinic, Marco
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110322 Rheumatology and Arthritis ,FOS: Clinical medicine - Abstract
Supplemental material, sj-pdf-1-jso-10.1177_23971983231163413 for Consensus on the assessment of systemic sclerosis–associated primary heart involvement: World Scleroderma Foundation/Heart Failure Association guidance on screening, diagnosis, and follow-up assessment by Cosimo Bruni, Maya H Buch, Aleksandra Djokovic, Giacomo De Luca, Raluca B Dumitru, Alessandro Giollo, Ilaria Galetti, Alexia Steelandt, Konstantinos Bratis, Yossra Atef Suliman, Ivan Milinkovic, Anna Baritussio, Ghadeer Hasan, Anastasia Xintarakou, Yohei Isomura, George Markousis-Mavrogenis, Sophie Mavrogeni, Luna Gargani, Alida LP Caforio, Carsten Tschöpe, Arsen Ristic, Sven Plein, Elijah Behr, Yannick Allanore, Masataka Kuwana, Christopher P Denton, Daniel E Furst, Dinesh Khanna, Thomas Krieg, Renzo Marcolongo, Alessia Pepe, Oliver Distler, Petros Sfikakis, Petar Seferovic and Marco Matucci-Cerinic in Journal of Scleroderma and Related Disorders
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- 2023
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19. Learning from the past: case studies of past 'local’ curriculum reforms
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O'Meara, Niamh and Milinkovic, Jasmina
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Education - Abstract
This chapter presents some results of a survey designed by some of the theme A participants to gain an insight into curriculum reform efforts in different countries internationally. The survey sought to gather information in relation to: • how and why the reform movement came about; • the ideologies underpinning the reform movement; • the aim of the reform movement; • the agents or stakeholders involved in the reform movement; • the impact of the reform on mathematical content, mathematical teaching and mathematical assessment; • the lessons learnt from the reform movement. In total, six research colleagues from different countries (Brazil, Japan, Ireland, Italy, Serbia and South Africa) responded to the survey, ensuring a geographical spread across four continents. Three survey responses were analysed in detail for the purpose of this chapter. The countries selected were Ireland, Serbia and South Africa. These were selected for consideration due to the commonalities in some aspects of the curriculum reform efforts as well as quite unique differences. Many of the responses from these countries also refected, in part, the reactions from the other respondents, and so the authors believed a comprehensive overview could be achieved with this limited sample
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- 2023
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20. Lessons from the Past: The Right to Abortion in Three Pictures
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Jelena Milinkovic
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Cultural Studies ,Linguistics and Language ,History ,Literature and Literary Theory ,Language and Linguistics - Abstract
Lessons from the Past: The Right to Abortion in Three PicturesThe starting point in this paper is the current situation in several countries regarding the prohibition or permission of abortion. In parallel with the pandemic, i.e., the COVID-19 crisis in European countries, there is also a crisis of women’s rights and freedoms. Within the already won rights and freedoms, and as a consequence of the traditionalization of state policies, the right to abortion is most endangered during crises. To show what the struggle for women’s rights might look like, an example from the past is taken: the struggle of Yugoslav women for the right to abortion during the 1920s and 1930s. Three aspects are analyzed: 1) the legal regulation of the right to abortion, 2) the discussion regarding this issue in the Ženski pokret [Women’s Movement] (1920–1938) journal, and 3) the topic of abortion in literature.Lekcja z przeszłości. Prawo do aborcji w trzech obrazachPunktem wyjścia w artykule jest aktualna sytuacja w kilku krajach dotycząca zakazu lub zezwolenia na aborcję. Równolegle z pandemią, czyli kryzysem COVID-19 w krajach europejskich, następuje również kryzys praw i wolności kobiet. W ramach wywalczonych już praw i wolności oraz w wyniku tradycjonalizacji polityki państwa prawo do aborcji jest najbardziej zagrożone w czasie kryzysów. Aby pokazać, jak mogłaby wyglądać walka o prawa kobiet, posłużono się przykładem z przeszłości dotyczącym walki kobiet jugosłowiańskich o prawo do aborcji w latach 20. i 30. XX wieku. Analizie poddane zostały trzy kwestie: 1) prawne uregulowanie prawa do aborcji, 2) dyskusja na ten temat w czasopiśmie „Ženski pokret” [„Ruch kobiet”] (1920–1938), 3) temat aborcji w literaturze.
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21. Assessing the average global EMF exposure using mobile network data and measurements
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Milica Popovic Sakovic, Mladen Koprivica, Jelena Milinkovic, and Aleksandar Neskovic
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- 2022
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22. Notch down‐regulation and inflammatory cytokines and RANKL overexpression involvement in peri‐implant mucositis and peri‐implantitis: A cross‐sectional study
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Ana Djinic Krasavcevic, Jelena Carkic, Jelena Milasin, Sasha Jankovic, Zoran Aleksic, Iva Milinkovic, Marija Jezdic, and Nadja Nikolic
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Mucositis ,medicine.medical_specialty ,Peri-implant mucositis ,Osteolysis ,Notch signaling pathway ,Down-Regulation ,03 medical and health sciences ,0302 clinical medicine ,Osteoclast ,Internal medicine ,medicine ,Humans ,Notch 2 ,Notch 1 ,030304 developmental biology ,Dental Implants ,0303 health sciences ,biology ,business.industry ,030206 dentistry ,medicine.disease ,Peri-Implantitis ,3. Good health ,Cross-Sectional Studies ,Endocrinology ,medicine.anatomical_structure ,RANKL ,biology.protein ,Cytokines ,Oral Surgery ,business - Abstract
OBJECTIVES Notch signaling pathway, known to influence bone resorption in several oral diseases, has not been analyzed in peri-implantitis yet. Therefore, the aims of the present study were to determine the levels of Notch cascade, bone remodeling mediators, and pro-inflammatory cytokines, in conjunction with clinical parameters, in subjects with peri-implant mucositis and peri-implantitis. MATERIAL AND METHODS Clinical parameters: peri-implant probing depth, bleeding on probing, suppuration on probing, and plaque index (PI) were recorded. Samples were collected from 130 participants, divided into peri-implantitis (PI), peri-implant mucositis (PM), and healthy implants (HI) group. Relative expression levels (REL) of Notch 1, Notch 2, Jagged 1, Hes 1, Hey 1, TNF-α, IL-17, IL-1β, IL-6, RANKL, and OPG mRNA were determined by reverse transcriptase-real-time polymerase chain reaction. Quantitation of Notch 1, Il-17, and IL-6 proteins was performed using ELISA assays. RESULTS All clinical parameters were significantly higher in PI compared to HI. Significant decrease of Notch 1, and higher REL of Hey 1, IL-1β, IL-6, and RANKL were found in PI compared to HI. PM showed significant increase of IL-1β REL in comparison with HI. In PI versus PM, significantly higher REL was found for Hey 1, TNF-α, IL-17, IL-1β, IL-6, and RANKL. Additionally, higher protein concentrations of IL-6 and IL-17 were detected in PI versus PM and versus HI group. CONCLUSION The combined effect of Notch 1 down-regulation and elevated expression of some key inflammation modulators might result in osteoclast activity increase and subsequent osteolysis in peri-implantitis.
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- 2021
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23. Adjunctive Application of Systemic Antibiotics in Non-surgical Aggressive Periodontitis Treatment: Clinical and Microbiological Findings
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Biljana Milicic, Bojan Janjic, Aleksa Markovic, Nadja Nikolic, Iva Mijailovic, Jelena Milasin, Zoran Aleksic, Iva Milinkovic, and Dina Vasovic
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0303 health sciences ,medicine.medical_specialty ,business.industry ,medicine.drug_class ,medicine.medical_treatment ,Bleeding on probing ,Antibiotics ,030206 dentistry ,General Medicine ,Amoxicillin ,Antimicrobial ,medicine.disease ,3. Good health ,03 medical and health sciences ,Metronidazole ,0302 clinical medicine ,Debridement (dental) ,Internal medicine ,Adjunctive treatment ,medicine ,Aggressive periodontitis ,medicine.symptom ,business ,030304 developmental biology ,medicine.drug - Abstract
BACKGROUND: Aggressive periodontitis (AgP) is associated with an extensive and rapid destruction of periodontal tissues. Unpredictable treatment outcomes of the disease are consequences of various cross-linked factors. Antimicrobial adjunctive treatment is routinely used as a part of non-surgical periodontal treatment (NSPT) of AgP. AIM: Therefore, the aim of this study was to compare the effects of active periodontal treatment (APT) combined with systemic antibiotics with mechanical debridement alone, in patients with generalized AgP (GAgP). METHODS: Two groups, consisting of 10 participants each, were randomly formed. Both groups were clinically and microbiologically tested and monitored for 3 months. Test group received APT with antimicrobial supplementation (amoxicillin and metronidazole [AMX-MET]). Patients from the control group were treated by APT only. Clinical and microbiological parameters were recorded at baseline and 3 months following the NSPT. Clinical measurements involved probing depth, clinical attachment level, bleeding on probing, and plaque index. Samples of subgingival crevicular fluid were analyzed by qualitative polymerase chain reaction. RESULTS: Significant improvement of all clinical parameters was observed 3 months following the NSPT (p < 0.05), but significant difference between groups was not found (p > 0.05). Periodontal pathogens’ detection between baseline and 3 months follow-up was also not statistically significant in both examined groups (p > 0.05). CONCLUSION: Similarity of results obtained in both treatment groups underlined the key role of APT in the treatment of AgP. The AMX-MET supplementation did not improve clinical and microbiological outcomes, when compared to APT alone. Longer follow-up period, with larger sample, could provide a more comprehensive insight into this issue.
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- 2021
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24. Notch signalling cascade and proinflammatory mediators in peri-implant lesions with different RANKL/OPG ratios-An observational study
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Ana Djinic Krasavcevic, Nadja Nikolic, Iva Milinkovic, Jelena Carkic, Marija Jezdic, Sasha Jankovic, Zoran Aleksic, and Jelena Milasin
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Periodontics - Abstract
Notch signaling pathway has been linked to bone loss in periodontitis and peri-implantitis. This research aimed to determine the Notch signaling molecules expression levels (Notch1, Notch2, Jagged1, Hes1, and Hey1), along with bone remodeling mediators (RANKL and OPG) and proinflammatory cytokines (TNF-α, IL-17, IL-1β, and IL-6) in patients with peri-implant diseases. The aforementioned markers' expression was evaluated in patients with different RANKL/OPG ratios.Fifty patients with peri-implantitis (PI group) and 45 patients with peri-implant mucositis (PM group) were enrolled. Relative gene expression levels of investigated molecules were determined by reverse transcriptase-real-time polymerase chain reaction. On the basis of RANKL/OPG ratio, all peri-implant lesions were divided into subgroups: RANKL-predominant (RANKL OPG) and OPG-predominant (RANKL OPG). Clinical periodontal parameters (probing depth-PD, bleeding on probing-BOP, clinical attachment level-CAL and plaque index-PLI), were recorded for each patient around every tooth, and around placed implants (PDi, BOPi, CALi, PLIi).RANKL-predominant PM patients exhibited higher expression levels of Notch2 (p = .044) and Hey1 (p = .005) compared to OPG-predominant lesions. In all RANKL-predominant cases, Hey1 (p = .001), IL-1β (p = .005), IL-6 (p = .002) were overexpressed in PI comparing to PM, accompanied with significantly higher PDi, CALi and PLIi in PI than PM (p = .001, p = .001 and p = .009).Notch2 upregulation in RANKL-predominant PM lesions could be an important contributor to alveolar bone resorption and represent a predictor of PM to PI transition. Similarly, the overexpression of IL-1β and IL-6 might provide an osteoclastogenic environment in PI RANKL-predominant lesions.
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- 2022
25. The Quality of Life of Patients with Colorectal Carcinoma and Stoma
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Vladimir Markovic, Helena Marić, Radmil Marić, Nenad Lalovic, Ružica Lukic, Bojan Kujundzic, Alma Alihodzic Pasalic, Dragan Spaic, Srđan Masic, Biljana Milinkovic, and Veljko Maric
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General Medicine - Abstract
Surgical treatment and formation of a stoma can be lifesaving for colorectal cancer patients. However, the quality of life is often impaired in patients with stoma. The goal of this study is to determine the quality of life of patients with stoma and cancer, and the relationship between the quality of life and characteristics of these patients. The study was conducted from 2018 to 2020 and included a total of 64 patients of both sexes with colorectal cancer and temporary or permanent stoma. The European Organization for Research and Treatment of Cancer with Quality of Life Questionnaire (EORTC QLQC29-30) and the anonymous WHO Quality of Life Questionnaire SF-36 were used for self-assessment of quality of life. Our study included 39 (61.0%) men and 25 (39.0%) women. 24 patients (37.5%) had colostomy, 14 patients (21.9%) had ileostomy, and 26 patients (40.6%) underwent surgery for resection of colorectal cancer without stoma. A significant number of women were in the group of patients with a permanent stoma (p = 0.01). There was no statistically significant difference in the assessment of general health (p = 0.680) and quality of life (p = 0.721) during the past month in relation to gender. Patients without a stoma rated their general health better compared to those with stoma and the difference reached statistical significance (p = 0.035). There was no statistically significant difference in the assessment of quality of life between the group of patients with stoma and without stoma, as well as between the patients of different age groups. Patients with stoma rated their general health as worse, but not their quality of life.
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- 2022
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26. Substrate stiffness reduces particle uptake by epithelial cells and macrophages in a size-dependent manner through mechanoregulation
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Aaron Lee, Mauro Sousa de Almeida, Daela Milinkovic, Dedy Septiadi, Patricia Taladriz-Blanco, Céline Loussert-Fonta, Sandor Balog, Amelie Bazzoni, Barbara Rothen-Rutishauser, and Alke Petri-Fink
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stiffness ,topography ,Macrophages ,Cell Adhesion ,endocytosis ,Polystyrenes ,General Materials Science ,YAP-Signaling Proteins ,Epithelial Cells ,Dimethylpolysiloxanes ,mechanobiology ,particle uptake ,Mechanotransduction, Cellular - Abstract
Cells continuously exert forces on their environment and respond to changes in mechanical forces by altering their behaviour. Many pathologies such as cancer and fibrosis are hallmarked by dysregulation in the extracellular matrix, driving aberrant behaviour through mechanotransduction pathways. We demonstrate that substrate stiffness can be used to regulate cellular endocytosis of particles in a size-dependent fashion. Culture of A549 epithelial cells and J774A.1 macrophages on polystyrene/glass (stiff) and polydimethylsiloxane (soft) substrates indicated that particle uptake is increased up to six times for A549 and two times for macrophages when cells are grown in softer environments. Furthermore, we altered surface characteristics through the attachment of submicron-sized particles as a method to locally engineer substrate stiffness and topography to investigate the biomechanical changes which occurred within adherent epithelial cells,i.e.characterization of A549 cell spreading and focal adhesion maturation. Consequently, decreasing substrate rigidity and particle-based topography led to a reduction of focal adhesion size. Moreover, expression levels of Yes-associated protein were found to correlate with the degree of particle endocytosis. A thorough appreciation of the mechanical cues may lead to improved solutions to optimize nanomedicine approaches for treatment of cancer and other diseases with abnormal mechanosignalling.
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- 2022
27. The Effects of Disease-Modifying Therapies on Oxidative Stress in Patients With Relapsing-Remitting Multiple Sclerosis
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Aleksandra Topic, Marija Vasic, Bojan Markovic, Neda Milinkovic, and Evica Dincic
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Pharmacology ,Male ,Oxidative Stress ,Multiple Sclerosis, Relapsing-Remitting ,Multiple Sclerosis ,8-Hydroxy-2'-Deoxyguanosine ,Creatinine ,Humans ,Pharmacology (medical) ,Female ,Neurology (clinical) ,Antioxidants - Abstract
Oxidative stress (OS) has a role in the pathogenesis and progression of multiple sclerosis. The effects of disease-modifying therapies (DMTs) on OS are unclear. We aimed to explore the association between DMTs and OS in patients with relapsing-remitting multiple sclerosis (RRMS).The study conducted in 167 patients (102 received and 65 not received the DMTs). The DMTs included interferon beta-1a (n = 15), interferon beta-1b (n = 20), glatiramer acetate (n = 10), and sphingosine-1-phosphate receptor modulators (n = 57). Oxidative stress assessed by total antioxidant status (TAS) and total oxidant status (TOS) (determined by spectrophotometric method), oxidative index (OSI was calculated), and urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG/creatinine was determined by high-performance liquid chromatography and tandem mass spectrometry). Patients were classified by Multiple Sclerosis Severity Score (MSSS) to mild/moderate (MSSS,6.7) and severe (MSSS,6.7).Disease-modifying therapies are associated with increased TAS, decreased TOS, OSI, and 8-oxodG/creatinine. Regardless of therapy, women had a less favorable redox status (lower TAS, higher TOS and OSI). Patients with MSSS6.7 and without DMTs had higher OSI than patients who received DMTs. Women with MSSS6.7 without DMTs had lower TAS than women with DMTs, whereas in the same stage of MS, men without DMTs had higher TOS than patients with DMTs. Women with MSSS6.7 and with DMTs had lower 8-oxodG/creatinine compared with those without DMT therapy.The antioxidant effects of DMTs were evidenced in this study. The gender-related effects of DMTs on the OS imply the personalized antioxidant pharmacotherapy, especially for the women. The OS biomarkers have a potential as the prognostic for the assessment of DMTs outcomes in patients with RRMS.
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- 2022
28. Immunohistochemical Analysis of Soft Tissue Response to Polyetheretherketone (Peek) and Titanium Healing Abutments on Dental Implants: a Randomized Pilot Clinical Study
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Iva Milinkovic, Ana Djinic Krasavcevic, Sasha Jankovic, Jelena Sopta, and Zoran Aleksic
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Dental Implants ,Titanium ,Inflammation ,Humans ,Pilot Projects ,Dental Abutments ,Ketones ,General Dentistry ,Polyethylene Glycols - Abstract
BackgroundThe data on polyetheretherketone (PEEK) influence on the peri-implant soft tissues in clinical settings are deficient. The aims of this pilot study were to analyze and compare soft tissues’ response to PEEK and titanium (Ti) healing abutments (HA) by means of histological and immunohistochemical analyses.MethodsA total of 22 implants with PEEK or Ti HA were placed in 11 patients, applying the “split-mouth” study design. Three months later, soft tissue specimens were harvested from 20 implants for histology in order to qualitatively detect the inflammatory cells’ presence, to semi-qualitatively analyze the inflammation intensity and to assess the inflammatory responses type by immunohistochemical analysis using LCA, CD3, CD20 and CD68 antibodies.ResultsEpithelial infiltrate followed by an intensive inflammation in sub-epithelium was observed in 100% around PEEK HA. A number of LCA+ and CD 68+ cells was significantly higher in PEEK comparing to Ti group (p = 0.001 andp = 0.020, respectively), while CD 20+ and CD3+ counted cells were found in a significantly higher amount in Ti than in PEEK group (p = 0.006 andp = 0.010, respectively).ConclusionPEEK HA seems to evoke the more intense tissue inflammatory response demonstrated predominantly by histocytes’ and plasmacytes’ activation, while Ti HA triggers the inflammatory reaction of lower intensity, dominantly mediated by B-cells.Trial registrationThe study registered atClinicalTrials.gov(NCT04436939).
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- 2022
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29. Molybdenum(VI) Bis(imido) Complexes: From Frustrated Lewis Pairs to Weakly Coordinating Cations
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Angela Milinkovic, Antoine Dupé, Ferdinand Belaj, and Nadia C. Mösch‐Zanetti
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Organic Chemistry ,General Chemistry ,Catalysis - Abstract
Molybdenum(VI) bis(imido) complexes [Mo(NtBu)
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- 2022
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30. Association between common cardiovascular risk factors and clinical phenotype in patients with hypertrophic cardiomyopathy from the European Society of Cardiology (ESC) EurObservational Research Programme (EORP) Cardiomyopathy/Myocarditis registry
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Lopes, Luis R, Losi, Maria-Angela, Sheikh, Nabeel, Laroche, Cécile, Charron, Philippe, Gimeno, Juan, Kaski, Juan P, Maggioni, Aldo P, Tavazzi, Luigi, Arbustini, Eloisa, Brito, Dulce, Celutkiene, Jelena, Hagege, Albert, Linhart, Ales, Mogensen, Jens, Garcia-Pinilla, José Manuel, Ripoll-Vera, Tomas, Seggewiss, Hubert, Villacorta, Eduardo, Caforio, Alida, Elliott, Perry M, Komissarova, S, Chakova, N, Niyazova, S, Linhart, A, Kuchynka, P, Palecek, T, Podzimkova, J, Fikrle, M, Nemecek, E, Bundgaard, H, Tfelt-Hansen, J, Theilade, J, Thune, J J, Axelsson, A, Mogensen, J, Henriksen, F, Hey, T, Nielsen, S K, Videbaek, L, Andreasen, S, Arnsted, H, Saad, A, Ali, M, Lommi, J, Helio, T, Nieminen, M S, Dubourg, O, Mansencal, N, Arslan, M, Tsieu, V Siam, Damy, T, Guellich, A, Guendouz, S, Tissot, C M, Lamine, A, Rappeneau, S, Hagege, A, Desnos, M, Bachet, A, Hamzaoui, M, Charron, P, Isnard, R, Legrand, L, Maupain, C, Gandjbakhch, E, Kerneis, M, Pruny, J-F, Bauer, A, Pfeiffer, B, Felix, S B, Dorr, M, Kaczmarek, S, Lehnert, K, Pedersen, A-L, Beug, D, Bruder, M, Böhm, M, Kindermann, I, Linicus, Y, Werner, C, Neurath, B, Schild-Ungerbuehler, M, Seggewiss, H, Neugebauer, A, Mckeown, P, Muir, A, Mcosker, J, Jardine, T, Divine, G, Elliott, P, Lorenzini, M, Watkinson, O, Wicks, E, Iqbal, H, Mohiddin, S, O'Mahony, C, Sekri, N, Carr-White, G, Bueser, T, Rajani, R, Clack, L, Damm, J, Jones, S, Sanchez-Vidal, R, Smith, M, Walters, T, Wilson, K, Rosmini, S, Anastasakis, A, Ritsatos, K, Vlagkouli, V, Forster, T, Sepp, R, Borbas, J, Nagy, V, Tringer, A, Kakonyi, K, Szabo, L A, Maleki, M, Bezanjani, F Noohi, Amin, A, Naderi, N, Parsaee, M, Taghavi, S, Ghadrdoost, B, Jafari, S, Khoshavi, M, Rapezzi, C, Biagini, E, Corsini, A, Gagliardi, C, Graziosi, M, Longhi, S, Milandri, A, Ragni, L, Palmieri, S, Olivotto, I, Arretini, A, Castelli, G, Cecchi, F, Fornaro, A, Tomberli, B, Spirito, P, Devoto, E, Bella, P Della, Maccabelli, G, Sala, S, Guarracini, F, Peretto, G, Russo, M G, Calabro, R, Pacileo, G, Limongelli, G, Masarone, D, Pazzanese, V, Rea, A, Rubino, M, Tramonte, S, Valente, F, Caiazza, M, Cirillo, A, Del Giorno, G, Esposito, A, Gravino, R, Marrazzo, T, Trimarco, B, Losi, M-A, Nardo, C Di, Giamundo, A, Musella, F, Pacelli, F, Scatteia, A, Canciello, G, Caforio, A, Iliceto, S, Calore, C, Leoni, L, Marra, M Perazzolo, Rigato, I, Tarantini, G, Schiavo, A, Testolina, M, Arbustini, E, Toro, A Di, Giuliani, L P, Serio, A, Fedele, F, Frustaci, A, Alfarano, M, Chimenti, C, Drago, F, Baban, A, Calò, L, Lanzillo, C, Martino, A, Uguccioni, M, Zachara, E, Halasz, G, Re, F, Sinagra, G, Carriere, C, Merlo, M, Ramani, F, Kavoliuniene, A, Krivickiene, A, Tamuleviciute-Prasciene, E, Viezelis, M, Celutkiene, J, Balkeviciene, L, Laukyte, M, Paleviciute, E, Pinto, Y, Wilde, A, Asselbergs, F W, Sammani, A, Van Der Heijden, J, Van Laake, L, De Jonge, N, Hassink, R, Kirkels, J H, Ajuluchukwu, J, Olusegun-Joseph, A, Ekure, E, Mizia-Stec, K, Tendera, M, Czekaj, A, Sikora-Puz, A, Skoczynska, A, Wybraniec, M, Rubis, P, Dziewiecka, E, Wisniowska-Smialek, S, Bilinska, Z, Chmielewski, P, Nieradko, B Foss, Michalak, E, Stepien-Wojno, M, Mazek, B, Lopes, L Rocha, Almeida, A R, Cruz, I, Gomes, A C, Pereira, A R, Brito, D, Madeira, H, Francisco, A R, Menezes, M, Moldovan, O, Guimaraes, T Oliveira, Silva, D, Ginghina, C, Jurcut, R, Mursa, A, Popescu, B A, Apetrei, E, Militaru, S, Coman, I Mircea, Frigy, A, Fogarasi, Z, Kocsis, I, Szabo, I A, Fehervari, L, Nikitin, I, Resnik, E, Komissarova, M, Lazarev, V, Shebzukhova, M, Ustyuzhanin, D, Blagova, O, Alieva, I, Kulikova, V, Lutokhina, Y, Pavlenko, E, Varionchik, N, Ristic, A D, Seferovic, P M, Veljic, I, Zivkovic, I, Milinkovic, I, Pavlovic, A, Radovanovic, G, Simeunovic, D, Zdravkovic, M, Aleksic, M, Djokic, J, Hinic, S, Klasnja, S, Mircetic, K, Monserrat, L, Fernandez, X, Garcia-Giustiniani, D, Larrañaga, J M, Ortiz-Genga, M, Barriales-Villa, R, Martinez-Veira, C, Veira, E, Cequier, A, Salazar-Mendiguchia, J, Manito, N, Gonzalez, J, Fernández-Avilés, F, Medrano, C, Yotti, R, Cuenca, S, Espinosa, M A, Mendez, I, Zatarain, E, Alvarez, R, Pavia, P Garcia, Briceno, A, Cobo-Marcos, M, Dominguez, F, Galvan, E De Teresa, Pinilla, J M García, Abdeselam-Mohamed, N, Lopez-Garrido, M A, Hidalgo, L Morcillo, Ortega-Jimenez, M V, Mezcua, A Robles, Guijarro-Contreras, A, Gomez-Garcia, D, Robles-Mezcua, M, Blanes, J R Gimeno, Castro, F J, Esparza, C Munoz, Molina, M Sabater, García, M Sorli, Cuenca, D Lopez, Ripoll-Vera, T, Alvarez, J, Nunez, J, Gomez, Y, Fernandez, P L Sanchez, Villacorta, E, Avila, C, Bravo, L, Diaz-Pelaez, E, Gallego-Delgado, M, Garcia-Cuenllas, L, Plata, B, Lopez-Haldon, J E, Pena Pena, M L, Perez, E M Cantero, Zorio, E, Arnau, M A, Sanz, J, Marques-Sule, E, Gale, Christopher Peter, Beleslin, Branko, Budaj, Andrzej, Chioncel, Ovidiu, Dagres, Nikolaos, Danchin, Nicolas, Erlinge, David, Emberson, Jonathan, Glikson, Michael, Gray, Alastair, Kayikcioglu, Meral, Maggioni, Aldo, Nagy, Klaudia Vivien, Nedoshivin, Aleksandr, Petronio, Anna-Sonia, Hesselink, Jolien Roo, Wallentin, Lars, Zeymer, Uwe, Caforio, Alida, Blanes, Juan Ramon Gimeno, Charron, Philippe, Elliott, Perry, Kaski, Juan Pablo, Maggioni, Aldo P, Tavazzi, Luigi, Tendera, Michal, Komissarova, S., Chakova, N., Niyazova, S., Linhart, A., Kuchynka, P., Palecek, T., Podzimkova, J., Fikrle, M., Nemecek, E., Bundgaard, H., Tfelt-Hansen, J., Theilade, J., Thune, J J, Axelsson, A., Mogensen, J., Henriksen, F., Hey, T., Nielsen, S K, Videbaek, L., Andreasen, S., Arnsted, H., Saad, A., Ali, M., Lommi, J., Helio, T., Nieminen, M S, Dubourg, O., Mansencal, N., Arslan, M., Tsieu, V Siam, Damy, T., Guellich, A., Guendouz, S., Tissot, C M, Lamine, A., Rappeneau, S., Hagege, A., Desnos, M., Bachet, A., Hamzaoui, M., Charron, P., Isnard, R., Legrand, L., Maupain, C., Gandjbakhch, E., Kerneis, M., Pruny, J-F, Bauer, A., Pfeiffer, B., Felix, S B, Dorr, M., Kaczmarek, S., Lehnert, K., Pedersen, A-L, Beug, D., Bruder, M., Böhm, M., Kindermann, I., Linicus, Y., Werner, C., Neurath, B., Schild-Ungerbuehler, M., Seggewiss, H., Neugebauer, A., McKeown, P., Muir, A., McOsker, J., Jardine, T., Divine, G., Elliott, P., Lorenzini, M., Watkinson, O., Wicks, E., Iqbal, H., Mohiddin, S., O'Mahony, C., Sekri, N., Carr-White, G., Bueser, T., Rajani, R., Clack, L., Damm, J., Jones, S., Sanchez-Vidal, R., Smith, M., Walters, T., Wilson, K., Rosmini, S., Anastasakis, A., Ritsatos, K., Vlagkouli, V., Forster, T., Sepp, R., Borbas, J., Nagy, V., Tringer, A., Kakonyi, K., Szabo, L A, Maleki, M., Bezanjani, F Noohi, Amin, A., Naderi, N., Parsaee, M., Taghavi, S., Ghadrdoost, B., Jafari, S., Khoshavi, M., Rapezzi, C., Biagini, E., Corsini, A., Gagliardi, C., Graziosi, M., Longhi, S., Milandri, A., Ragni, L., Palmieri, S., Olivotto, I., Arretini, A., Castelli, G., Cecchi, F., Fornaro, A., Tomberli, B., Spirito, P., Devoto, E., Bella, P Della, Maccabelli, G., Sala, S., Guarracini, F., Peretto, G., Russo, M G, Calabro, R., Pacileo, G., Limongelli, G., Masarone, D., Pazzanese, V., Rea, A., Rubino, M., Tramonte, S., Valente, F., Caiazza, M., Cirillo, A., Del Giorno, G., Esposito, A., Gravino, R., Marrazzo, T., Trimarco, B., Losi, M-A, Di Nardo, C., Giamundo, A., Musella, F., Pacelli, F., Scatteia, A., Canciello, G., Caforio, A., Iliceto, S., Calore, C., Leoni, L., Marra, M Perazzolo, Rigato, I., Tarantini, G., Schiavo, A., Testolina, M., Arbustini, E., Di Toro, A., Giuliani, L P, Serio, A., Fedele, F., Frustaci, A., Alfarano, M., Chimenti, C., Drago, F., Baban, A., Calò, L., Lanzillo, C., Martino, A., Uguccioni, M., Zachara, E., Halasz, G., Re, F., Sinagra, G., Carriere, C., Merlo, M., Ramani, F., Kavoliūnienė, Aušra, Krivickienė, Aušra, Tamulevičiūtė-Prascienė, Eglė, Vieželis, Mindaugas, Balkevičienė, Laura, Laukytė, M., Palevičiūtė, Eglė, Pinto, Y., Wilde, A., Asselbergs, F W, Sammani, A., Van Der Heijden, J., Van Laake, L., De Jonge, N., Hassink, R., Kirkels, J H, Ajuluchukwu, J., Olusegun-Joseph, A., Ekure, E., Mizia-Stec, K., Tendera, M., Czekaj, A., Sikora-Puz, A., Skoczynska, A., Wybraniec, M., Rubis, P., Dziewiecka, E., Wisniowska-Smialek, S., Bilinska, Z., Chmielewski, P., Foss-Nieradko, B., Michalak, E., Stepien-Wojno, M., Mazek, B., Lopes, L Rocha, Almeida, A R, Cruz, I., Gomes, A C, Pereira, A R, Brito, D., Madeira, H., Francisco, A R, Menezes, M., Moldovan, O., Guimaraes, T Oliveira, Silva, D., Ginghina, C., Jurcut, R., Mursa, A., Popescu, B A, Apetrei, E., Militaru, S., Coman, I Mircea, Frigy, A., Fogarasi, Z., Kocsis, I., Szabo, I A, Fehervari, L., Nikitin, I., Resnik, E., Komissarova, M., Lazarev, V., Shebzukhova, M., Ustyuzhanin, D., Blagova, O., Alieva, I., Kulikova, V., Lutokhina, Y., Pavlenko, E., Varionchik, N., Ristic, A D, Seferovic, P M, Veljic, I., Zivkovic, I., Milinkovic, I., Pavlovic, A., Radovanovic, G., Simeunovic, D., Zdravkovic, M., Aleksic, M., Djokic, J., Hinic, S., Klasnja, S., Mircetic, K., Monserrat, L., Fernandez, X., Garcia-Giustiniani, D., Larrañaga, J M, Ortiz-Genga, M., Barriales-Villa, R., Martinez-Veira, C., Veira, E., Cequier, A., Salazar-Mendiguchia, J., Manito, N., Gonzalez, J., Fernández-Avilés, F., Medrano, C., Yotti, R., Cuenca, S., Espinosa, M A, Mendez, I., Zatarain, E., Alvarez, R., Pavia, P Garcia, Briceno, A., Cobo-Marcos, M., Dominguez, F., Galvan, E De Teresa, Pinilla, J M García, Abdeselam-Mohamed, N., Lopez-Garrido, M A, Hidalgo, L Morcillo, Ortega-Jimenez, M V, Mezcua, A Robles, Guijarro-Contreras, A., Gomez-Garcia, D., Robles-Mezcua, M., Blanes, J R Gimeno, Castro, F J, Esparza, C Munoz, Molina, M Sabater, García, M Sorli, Cuenca, D Lopez, de Mallorca, Palma, Ripoll-Vera, T., Alvarez, J., Nunez, J., Gomez, Y., Fernandez, P L Sanchez, Villacorta, E., Avila, C., Bravo, L., Diaz-Pelaez, E., Gallego-Delgado, M., Garcia-Cuenllas, L., Plata, B., Lopez-Haldon, J E, Pena Pena, M L, Perez, E M Cantero, Zorio, E., Arnau, M A, Sanz, J., Marques-Sule, E., Repositório da Universidade de Lisboa, Lopes, Lr, Losi, Ma, Sheikh, N, Laroche, C, Charron, P, Gimeno, J, Kaski, Jp, Maggioni, Ap, Tavazzi, L, Arbustini, E, Brito, D, Celutkiene, J, Hagege, A, Linhart, A, Mogensen, J, Garcia-Pinilla, Jm, Ripoll-Vera, T, Seggewiss, H, Villacorta, E, Caforio, A, and Elliott, Pm
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Genotype ,Health Policy ,Diabetes ,Cardiovascular risk factors ,Hypertension ,Hypertrophic cardiomyopathy ,Obesity ,Cardiomyopathy, Hypertrophic ,Ventricular Dysfunction, Left ,diabete ,Cardiovascular Diseases ,Risk Factors ,Heart Disease Risk Factors ,cardiovascular risk factor ,Humans ,Female ,03.02. Klinikai orvostan ,Cardiology and Cardiovascular Medicine ,Cardiomyopathies ,obesity - Abstract
© The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited., Aims: The interaction between common cardiovascular risk factors (CVRF) and hypertrophic cardiomyopathy (HCM) is poorly studied. We sought to explore the relation between CVRF and the clinical characteristics of patients with HCM enrolled in the EURObservational Research Programme (EORP) Cardiomyopathy registry. Methods and results: 1739 patients with HCM were studied. The relation between hypertension (HT), diabetes (DM), body mass index (BMI) and clinical traits was analyzed. Analyses were stratified according to the presence or absence of a pathogenic variant in a sarcomere gene.The prevalence of HT, DM and obesity (Ob) was 37%, 10%, and 21%, respectively. HT, DM and Ob were associated with older age (p
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- 2022
31. Prevalence and Outcomes for Heavily Treatment-Experienced Individuals Living With Human Immunodeficiency Virus in a European Cohort
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Pelchen-Matthews, A., Borges, A. H., Reekie, J., Rasmussen, L. D., Wiese, L., Weber, J., Pradier, C., Degen, O., Paredes, R., Tau, L., Flamholc, L., Gottfredsson, M., Kowalska, J. D., Jablonowska, E., Mozer-Lisewska, I., Radoi, R., Vasylyev, M., Kuznetsova, A., Begovac, J., Svedhem, V., Clark, A., Cozzi-Lepri, A., Harxhi, A., Losso, M., Kundro, M., Schmied, B., Zangerle, R., Karpov, I., Vassilenko, A., Mitsura, V. M., Paduto, D., Clumeck, N., De Wit, S., Delforge, M., Florence, E., Vandekerckhove, L., Hadziosmanovic, V., Machala, L., Jilich, D., Sedlacek, D., Kronborg, G., Benfield, T., Gerstoft, J., Katzenstein, T., Pedersen, C., Johansen, I. S., Ostergaard, L., Moller, N. F., Nielsen, L. N., Zilmer, K., Smidt, J., Aho, I., Viard, J. -P., Girard, P. -M., Fontas, E., Duvivier, C., Rockstroh, J., Behrens, G., Stellbrink, H. J., Stephan, C., Goethe, J. W., Bogner, J., Fatkenheuer, G., Chkhartishvili, N., Sambatakou, H., Adamis, G., Paissios, N., Szlavik, J., Kelly, C., Turner, D., Burke, M., Shahar, E., Hassoun, G., Elinav, H., Haouzi, M., Elbirt, D., D'Arminio Monforte, A., Esposito, R., Mazeu, I., Mussini, C., Mazzotta, F., Gabbuti, A., Lazzarin, A., Castagna, A., Gianotti, N., Galli, M., Ridolfo, A., Uzdaviniene, V., Matulionyte, R., Staub, T., Hemmer, R., Dragas, S., Stevanovic, M., Reiss, P., Trajanovska, J., Reikvam, D. H., Maeland, A., Bruun, J., Knysz, B., Gasiorowski, J., Inglot, M., Bakowska, E., Flisiak, R., Grzeszczuk, A., Parczewski, M., Maciejewska, K., Aksak-Was, B., Beniowski, M., Mularska, E., Kamerys, J., Wojcik, K., Rozplochowski, B., Zagalo, A., Mansinho, K., Maltez, F., Oprea, C., Yakovlev, A., Trofimora, T., Khromova, I., Kuzovatova, E., Borodulina, E., Vdoushkina, E., Ranin, J., Tomazic, J., Miro, J. M., Laguno, M., Martinez, E., Garcia, F., Blanco, J. L., Martinez-Rebollar, M., Mallolas, J., Callau, P., Rojas, J., Inciarta, A., Moreno, S., del Campo, S., Clotet, B., Jou, A., Puig, J., Llibre, J. M., Santos, J. R., Domingo, P., Gutierrez, M., Mateo, G., Sambeat, M. A., Laporte, J. M., Falconer, K., Thalme, A., Sonnerborg, A., Treutiger, C. J., Scherrer, A., Weber, R., Cavassini, M., Calmy, A., Furrer, H., Battegay, M., Schmid, P., Mikhalik, J., Sluzhynska, M., Milinkovic, A., Johnson, A. M., Simons, E., Edwards, S., Phillips, A., Johnson, M. A., Mocroft, A., Orkin, C., Winston, A., Leen, C., Wandeler, G., Lundgren, J., Guaraldi, G., Kirk, O., Peters, L., Bojesen, A., Raben, D., Hansen, E. V., Kristensen, D., Larsen, J. F., Fischer, A. H., Amele, S., and Roen, A.
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Adult ,Male ,antiretroviral treatment ,medicine.medical_specialty ,Anti-HIV Agents ,Human immunodeficiency virus (HIV) ,non-AIDS-defining clinical conditions ,Comorbidity ,Rate ratio ,medicine.disease_cause ,symbols.namesake ,heavily treatment experienced ,Acquired immunodeficiency syndrome (AIDS) ,Antiretroviral Therapy, Highly Active ,Internal medicine ,medicine ,Humans ,Pharmacology (medical) ,Prospective Studies ,Poisson regression ,Prospective cohort study ,Acquired Immunodeficiency Syndrome ,business.industry ,Confounding ,HIV resistance ,acquired immunodeficiency syndrome ,Middle Aged ,Viral Load ,prevalence ,outcomes ,heavily ,treatment-experienced ,individuals ,HIV ,medicine.disease ,Europe ,AIDS ,Treatment Outcome ,Infectious Diseases ,Cohort ,symbols ,Female ,business ,Viral load - Abstract
Background: Although antiretroviral treatments have improved survival of persons living with HIV, their long-term use may limit available drug options. We estimated the prevalence of heavily treatment-experienced (HTE) status and the potential clinical consequences of becoming HTE. Setting: EuroSIDA, a European multicenter prospective cohort study. Methods: A composite definition for HTE was developed, based on estimates of antiretroviral resistance and prior exposure to specific antiretroviral regimens. Risks of progressing to clinical outcomes were assessed by Poisson regression, comparing every HTE individual with 3 randomly selected controls who never became HTE. Results: Of 15,570 individuals under follow-up in 2010-2016, 1617 (10.4%, 95% CI: 9.9% to 10.9%) were classified as HTE. 1093 individuals became HTE during prospective follow-up (HTE incidence rate 1.76, CI: 1.66 to 1.87 per 100 person-years of follow-up). The number of HTE individuals was highest in West/Central Europe (636/4019 persons, 15.7%) and lowest in East Europe (26/2279 persons, 1.1%). Although most HTE individuals maintained controlled viral loads (
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- 2021
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32. Anatomic and Biomechanical Properties of Flat Medial Patellofemoral Ligament Reconstruction Using an Adductor Magnus Tendon Graft: A Human Cadaveric Study
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Christoph Kittl, Elmar Herbst, Danko Dan Milinkovic, Mirco Herbort, Petri Silanpää, Christian Fink, and Michael J. Raschke
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Knee Joint ,Physical Therapy, Sports Therapy and Rehabilitation ,Medial patellofemoral ligament ,Tendons ,Patellofemoral Joint ,03 medical and health sciences ,0302 clinical medicine ,Cadaver ,medicine ,Humans ,Orthopedics and Sports Medicine ,Femur ,030222 orthopedics ,business.industry ,Biomechanics ,Patella ,030229 sport sciences ,Anatomy ,Knee ligament ,medicine.anatomical_structure ,Ligaments, Articular ,Adductor magnus tendon ,Cadaveric spasm ,business ,Adductor tendon - Abstract
Background:In contrast to the majority of existing techniques for reconstruction of the medial patellofemoral ligament (MPFL), the technique described in this article uses the adductor magnus muscle tendon to gain a flat, broad graft, leaving its distal femoral insertion intact, and does not require drilling within or near the femoral physis. It also allows for soft tissue patellar fixation and could facilitate anatomic MPFL reconstruction in skeletally immature patients.Purpose:To evaluate the anatomic and structural properties of the native MPFL and the adductor tendon (AT), followed by biomechanical evaluation of the proposed reconstruction.Study Design:Descriptive laboratory study.Methods:The morphological and topographical features of the AT and MPFL were evaluated in 12 fresh-frozen cadaveric knees. The distance between the distal insertion of the AT on the adductor tubercle and the adductor hiatus, as well as the desired length of the graft, was measured to evaluate this graft’s application potential. Load-to-failure tests were performed to determine the biomechanical properties of the proposed reconstruction construct. The construct was placed in a uniaxial testing machine and cyclically loaded 500 times between 5 and 50 N, followed by load to failure, to measure the maximum elongation, stiffness, and maximum load.Results:The mean ± SD length of the AT was 12.6 ± 1.5 cm, and the mean distance between the insertion on the adductor tubercle and adductor hiatus was 10.8 ± 1.3 cm, exceeding the mean desired length of the graft (7.5 ± 0.5 cm) by 3.3 ± 0.7 cm. The distal insertion of the AT was slightly proximal and posterior to the insertion of the MPFL. The maximum elongation after cyclical loading was 1.9 ± 0.4 mm. Ultimately, the mean stiffness and load to failure were 26.2 ± 7.6 N/mm and 169.7 ± 19.2 N, respectively. The AT graft failed at patellar fixation in 2 of the initially tested specimens and at the femoral insertion in the remaining 10.Conclusion:The described reconstruction using the AT has potential for MPFL reconstruction. The AT graft presents a graft of significant volume, beneficial anatomic topography, and adequate tensile properties in comparison with the native MPFL following the data from previously published studies.Clinical Relevance:Given its advantageous anatomic relationship as an application that avoids femoral drilling and osseous patellar fixation, the AT may be considered a graft for MPFL reconstruction in skeletally immature patients.
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- 2021
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33. The association between hepatitis B virus infection and nonliver malignancies in persons living with HIV: results from the EuroSIDA study
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Mocroft, Amanda, Miro, Jose M., Wandeler, Gilles, Llibre, Josep M., Boyd, Anders, van Bremen, Kathrin, Beniowski, Marek, Mikhalik, Julia, Cavassini, Matthias, Maltez, Fernando, Duvivier, Claudine, Uberti Foppa, Caterina, Knysz, Brygida, Bakowska, Elzbieta, Kuzovatova, Elena, Domingo, Pere, Zagalo, Alexandra, Viard, Jean Paul, Degen, Olaf, Milinkovic, Ana, Benfield, Thomas, Peters, Lars, Harxhi, A., Losso, M., Kundro, M., Schmied, B., Zangerle, R., Karpov, I., Vassilenko, A., Mitsura, V. M., Paduto, D., Clumeck, N., De Wit, S., Delforge, M., Florence, E., Vandekerckhove, L., Hadziosmanovic, V., Begovac, J., Machala, L., Sedlacek, D., Kronborg, G., Gerstoft, J., Katzenstein, T., Pedersen, C., Johansen, I. S., Ostergaard, L., Wiese, L., Moller, N. F., Nielsen, L. N., Zilmer, K., Smidt, J., Aho, I., Lacombe, K., Pradier, C., Fontas, E., Rockstroh, J., Behrens, G., Hoffmann, C., Stellbrink, H. J., Stefan, C., Bogner, J., Fätkenheuer, G., Chkhartishvili, N., Sambatakou, H., Adamis, G., Paissios, N., Szlávik, J., Gottfredsson, M., Devitt, E., Tau, L., Turner, D., Burke, M., Shahar, E., Wattad, L. M., Elinav, H., Haouzi, M., Elbirt, D., D’Arminio Monforte, A., Esposito, R., Mazeu, I., Mussini, C., Mazzotta, F., Gabbuti, A., Lazzarin, A., Castagna, A., Gianotti, N., Galli, M., Ridolfo, A., Uzdaviniene, V., Matulionyte, R., Staub, T., Hemmer, R., Dragas, S., Stevanovic, M., vd Valk, M., Trajanovska, J., Reikvam, D. H., Maeland, A., Bruun, J., Szetela, B., Inglot, M., Flisiak, R., Grzeszczuk, A., Parczewski, M., Maciejewska, K., Aksak-Was, B., Mularska, E., Jablonowska, E., Kamerys, J., Wojcik, K., Mozer-Lisewska, I., Rozplochowski, B., Mansinho, K., Radoi, R., Oprea, C., Gusev, D., Trofimova, T., Khromova, I., Borodulina, E., Ranin, J., Tomazic, J., Miró, J. M., Laguno, M., Martinez, E., Garcia, F., Blanco, J. L., Martinez-Rebollar, M., Mallolas, J., Callau, P., Rojas, J., Inciarta, A., Moreno, S., del Campo, S., Clotet, B., Jou, A., Paredes, R., Puig, J., Santos, J. R., Gutierrez, M., Mateo, G., Sambeat, M. A., Laporte, J. M., Svedhem, V., Thalme, A., Sönnerborg, A., Brännström, J., Flamholc, L., Kusejko, K., Braun, D., Calmy, A., Furrer, H., Battegay, M., Schmid, P., Kuznetsova, A., Sluzhynska, M., Johnson, M. A., Simons, E., Edwards, S., Phillips, A., Orkin, C., Winston, A., Clarke, A., Leen, C., Lundgren, J., Rasmussen, L. D., Kowalska, J. D., Guaraldi, G., Larsen, J. F., Bojesen, A., Neesgaard, B., Jaschinski, N., Fursa, O., Sather, M., Raben, D., Hansen, E. V., Kristensen, D., Fischer, A. H., Jensen, S. K., Elsing, T. W., Reekie, J., Cozzi-Lepri, A., Amele, S., Pelchen-Matthews, A., Roen, A., Tusch, E. S., Bannister, W., Mocroft, A., Miro, J. M., Wandeler, G., Llibre, J. M., Boyd, A., van Bremen, K., Beniowski, M., Mikhalik, J., Cavassini, M., Maltez, F., Duvivier, C., Uberti Foppa, C., Knysz, B., Bakowska, E., Kuzovatova, E., Domingo, P., Zagalo, A., Viard, J. -P., Degen, O., Milinkovic, A., Benfield, T., Peters, L., Harxhi, A., Losso, M., Kundro, M., Schmied, B., Zangerle, R., Karpov, I., Vassilenko, A., Mitsura, V. M., Paduto, D., Clumeck, N., De Wit, S., Delforge, M., Florence, E., Vandekerckhove, L., Hadziosmanovic, V., Begovac, J., Machala, L., Sedlacek, D., Kronborg, G., Gerstoft, J., Katzenstein, T., Pedersen, C., Johansen, I. S., Ostergaard, L., Wiese, L., Moller, N. F., Nielsen, L. N., Zilmer, K., Smidt, J., Aho, I., Lacombe, K., Pradier, C., Fontas, E., Rockstroh, J., Behrens, G., Hoffmann, C., Stellbrink, H. J., Stefan, C., Bogner, J., Fatkenheuer, G., Chkhartishvili, N., Sambatakou, H., Adamis, G., Paissios, N., Szlavik, J., Gottfredsson, M., Devitt, E., Tau, L., Turner, D., Burke, M., Shahar, E., Wattad, L. M., Elinav, H., Haouzi, M., Elbirt, D., D'Arminio Monforte, A., Esposito, R., Mazeu, I., Mussini, C., Mazzotta, F., Gabbuti, A., Lazzarin, A., Castagna, A., Gianotti, N., Galli, M., Ridolfo, A., Uzdaviniene, V., Matulionyte, R., Staub, T., Hemmer, R., Dragas, S., Stevanovic, M., vd Valk, M., Trajanovska, J., Reikvam, D. H., Maeland, A., Bruun, J., Szetela, B., Inglot, M., Flisiak, R., Grzeszczuk, A., Parczewski, M., Maciejewska, K., Aksak-Was, B., Mularska, E., Jablonowska, E., Kamerys, J., Wojcik, K., Mozer-Lisewska, I., Rozplochowski, B., Mansinho, K., Radoi, R., Oprea, C., Gusev, D., Trofimova, T., Khromova, I., Borodulina, E., Ranin, J., Tomazic, J., Laguno, M., Martinez, E., Garcia, F., Blanco, J. L., Martinez-Rebollar, M., Mallolas, J., Callau, P., Rojas, J., Inciarta, A., Moreno, S., del Campo, S., Clotet, B., Jou, A., Paredes, R., Puig, J., Santos, J. R., Gutierrez, M., Mateo, G., Sambeat, M. A., Laporte, J. M., Svedhem, V., Thalme, A., Sonnerborg, A., Brannstrom, J., Flamholc, L., Kusejko, K., Braun, D., Calmy, A., Furrer, H., Battegay, M., Schmid, P., Kuznetsova, A., Sluzhynska, M., Johnson, A. M., Simons, E., Edwards, S., Phillips, A., Johnson, M. A., Orkin, C., Winston, A., Clarke, A., Leen, C., Lundgren, J., Rasmussen, L. D., Kowalska, J. D., Guaraldi, G., Larsen, J. F., Bojesen, A., Neesgaard, B., Jaschinski, N., Fursa, O., Sather, M., Raben, D., Hansen, E. V., Kristensen, D., Fischer, A. H., Jensen, S. K., Elsing, T. W., Reekie, J., Cozzi-Lepri, A., Amele, S., Pelchen-Matthews, A., Roen, A., Tusch, E. S., Bannister, W., and Infectious diseases
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Hepatitis B virus ,Hepatitis B Surface Antigens ,Health Policy ,virus diseases ,HIV Infections ,Hepatitis B ,digestive system diseases ,HBV DNA ,hepatitis B ,nonliver cancer ,Infectious Diseases ,Hepatitis B, Chronic ,Neoplasms ,DNA, Viral ,Humans ,Pharmacology (medical) ,610 Medicine & health - Abstract
Objectives: The aim of this study was to assess the impact of hepatitis B virus (HBV) infection on non-liver malignancies in people living with HIV (PLWH). Methods: All persons aged ≥18 years with known hepatitis B virus (HBV) surface antigen (HBsAg) status after the latest of 1January 2001 and enrolment in the EuroSIDA cohort (baseline) were included in the study; persons were categorized as HBV positive or negative using the latest HBsAg test and followed to their first diagnosis of nonliver malignancy or their last visit. Results: Of 17485 PLWH included in the study, 1269 (7.2%) were HBV positive at baseline. During 151766 person-years of follow-up (PYFU), there were 1298 nonliver malignancies, 1199 in those currently HBV negative [incidence rate (IR)8.42/1000 PYFU; 95% confidence interval (CI) 7.94–8.90/1000 PYFU] and 99 in those HBV positive (IR10.54/1000 PYFU; 95% CI8.47–12.62/1000 PYFU). After adjustment for baseline confounders, there was a significantly increased incidence of nonliver malignancies in HBV-positive versus HBV-negative individuals [adjusted incidence rate ratio (aIRR)1.23; 95% CI 1.00–1.51]. Compared to HBV-negative individuals, HBsAg-positive/HBV-DNA-positive individuals had significantly increased incidences of nonliver malignancies (aIRR 1.37; 95% CI 1.00–1.89) and NHL (aIRR 2.57; 95% CI 1.16–5.68). There was no significant association between HBV and lung or anal cancer. Conclusions: We found increased rates of nonliver malignancies in HBsAg-positive participants, the increases being most pronounced in those who were HBV DNA positive and for NHL. If confirmed, these results may have implications for increased cancer screening in HIV-positive subjects with chronic HBV infection.
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- 2021
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34. Soft-tissue fixation is not inferior to suture-anchor fixation in reconstruction of the medial patellofemoral ligament using a nonresorbable suture tape
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Felix Zimmermann, Mareike Schonhoff, Sebastian Jäger, Danko Dan Milinkovic, Jochen Franke, Paul Alfred Grützner, Peter Balcarek, and Sven Vetter
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Orthopedics and Sports Medicine ,Surgery - Abstract
Reconstruction of the medial patellofemoral ligament (MPFL-R) with nonresorbable suture tape (FiberTapeIn ten human, fresh-frozen knee joint specimens (m/f 6/4; age 74 ± 9 a), the MPFL was identified and dissected near the femoral insertion site. In five knee joints, the MPFL-R using FT was performed with soft-tissue fixation at the patella (study group; SG), and in five knee joints, the FT was fixed via suture anchors (control group, CG). All reconstructions were evaluated until load to failure of the patella-side fixation with a displacement rate of 200 mm/min.The mean maximum load to failure in the SG was 395.3 ± 57.9 N. All reconstructions failed by complete tearing off the medial patellar retinaculum from its medial patellar margin, but fixation of the FT remained stable. In the CG, the mean maximum load to failure was 239.4 ± 54.5 N and was significantly different compared to the SG (p = 0.04). All reconstructions failed via pullout of the suture anchors. Stiffness and elongation did not differ between the groups, and no failure of the FT was observed in any of the specimens.Primary stability of soft-tissue MPFL-R using FT was superior to suture-anchor fixation. Both fixation techniques provided sufficient primary stability, superior to previously reported native MPFL tensile strengths. MPFL-R with FT could be a possible alternative procedure for MPFL-R, eliminating potential complications due to autologous tendon graft harvesting.
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- 2022
35. Sex‐ and age‐related differences in the management and outcomes of chronic heart failure: an analysis of patients from the ESC HFA EORP Heart Failure Long‐Term Registry
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Lainscak, M., Milinkovic, I., Polovina, M., Crespo-Leiro, M. G., Lund, L. H., Anker, S. D., Laroche, C., Ferrari, R., Coats, A. J. S., Mcdonagh, T., Filippatos, G., Maggioni, A. P., Piepoli, M. F., Rosano, G. M. C., Ruschitzka, F., Simic, D., Asanin, M., Eicher, J. -C., Yilmaz, M. B., Seferovic, P. M., Gale, C. P., Chair, G. B., Branko Beleslin, R. S., Andrzej Budaj, P. L., Ovidiu Chioncel, R. O., Nikolaos Dagres, D. E., Nicolas Danchin, F. R., David Erlinge, S. E., Jonathan Emberson, G. B., Michael Glikson, I. L., Alastair Gray, G. B., Meral Kayikcioglu, T. R., Aldo Maggioni, I. T., Klaudia Vivien Nagy, H. U., Aleksandr Nedoshivin, R. U., Anna-Sonia Petronio, I. T., Jolien Roos-Hesselink, N. L., Lars Wallentin, S. E., Uwe Zeymer, D. E., Crespo-Leiro, M., Anker, S., Mebazaa, A., Coats, A., A. Goda A. L., M. Diez A. R., A. Fernandez A. R., F. Fruhwald A. T., Fazlibegovic, E., P. Gatzov B. G., A. Kurlianskaya B. Y., R. Hullin C. H., T. Christodoulides C. Y., J. Hradec C. Z., O. Wendelboe Nielsen D. K., R. Nedjar D. Z., T. Uuetoa E. E., M. Hassanein E. G., J. F. Delgado Jimenez E. S., P. Harjola F. I., V, D. Logeart F. R., V. Chumburidze G. E., D. Tousoulis G. R., D. Milicic H. R., B. Merkely H. U., O'Donoghue IE, E., O. Amir I. L., A. Shotan I. L., D. Shafie I. R., M. Metra I. T., A. Matsumori J. P., E. Mirrakhimov K. G., A. Kavoliuniene L. T., A. Erglis L. V., Vataman, E., M. Otljanska M. K., E. Srbinovska Kostovska M. K., D. Cassar DeMarco M. T., J. Drozdz P. L., Fonseca, C., O. Chioncel R. O., M. Dekleva R. S., E. Shkolnik R. U., U. Dahlstrom S. E., M. Lainscak S. I., E. Goncalvesova S. K., A. Temizhan T. R., V. Estrago U. Y., G. Bajraktari X. K., Auer, J., Ablasser, K., Fruhwald, F., Dolze, T., Brandner, K., Gstrein, S., Poelzl, G., Moertl, D., Reiter, S., Podczeck-Schweighofer, A., Muslibegovic, A., Vasilj, M., Cesko, M., Zelenika, D., Palic, B., Pravdic, D., Cuk, D., Vitlianova, K., Katova, T., Velikov, T., Kurteva, T., Gatzov, P., Kamenova, D., Antova, M., Sirakova, V., Krejci, J., Mikolaskova, M., Spinar, J., Krupicka, J., Malek, F., Hegarova, M., Lazarova, M., Monhart, Z., Hassanein, M., Sobhy, M., El Messiry, F., El Shazly, A. H., Elrakshy, Y., Youssef, A., Moneim, A. A., Noamany, M., Reda, A., Dayem, T. K. A., Farag, N., Halawa, S. I., Hamid, M. A., Said, K., Saleh, A., Ebeid, H., Hanna, R., Aziz, R., Louis, O., Enen, M. A., Ibrahim, B. S., Nasr, G., Elbahry, A., Sobhy, H., Ashmawy, M., Gouda, M., Aboleineen, W., Bernard, Y., Luporsi, P., Meneveau, N., Pillot, M., Morel, M., Seronde, M. -F., Schiele, F., Briand, F., Delahaye, F., Damy, T., de Groote, P., Fertin, M., Lamblin, N., Isnard, R., Lefol, C., Thevenin, S., Hagege, A., Jondeau, G., Logeart, D., Le Marcis, V., J. -F., Ly, Coisne, D., Lequeux, B., Le Moal, V., Mascle, S., Lotton, P., Behar, N., Donal, E., Thebault, C., Ridard, C., Reynaud, A., Basquin, A., Bauer, F., Codjia, R., Galinier, M., Tourikis, P., Stavroula, M., Tousoulis, D., Stefanadis, C., Chrysohoou, C., Kotrogiannis, I., Matzaraki, V., Dimitroula, T., Karavidas, A., Tsitsinakis, G., Kapelios, C., Nanas, J., Kampouri, H., Nana, E., Kaldara, E., Eugenidou, A., Vardas, P., Saloustros, I., Patrianakos, A., Tsaknakis, T., Evangelou, S., Nikoloulis, N., Tziourganou, H., Tsaroucha, A., Papadopoulou, A., Douras, A., Polgar, L., Merkely, B., Kosztin, A., Nyolczas, N., Nagy, A. C., Halmosi, R., Elber, J., Alony, I., Shotan, A., Fuhrmann, A. V., Amir, O., Romano, S., Marcon, S., Penco, M., Di Mauro, M., Lemme, E., Carubelli, V., Rovetta, R., Metra, M., Bulgari, M., Quinzani, F., Lombardi, C., Bosi, S., Schiavina, G., Squeri, A., Barbieri, A., Di Tano, G., Pirelli, S., Fucili, A., Passero, T., Musio, S., Di Biase, M., Correale, M., Salvemini, G., Brognoli, S., Zanelli, E., Giordano, A., Agostoni, P., Italiano, G., Salvioni, E., Copelli, S., Modena, M. G., Reggianini, L., Valenti, C., Olaru, A., Bandino, S., Deidda, M., Mercuro, G., Dessalvi, C. C., Marino, P. N., Di Ruocco, M. V., Sartori, C., Piccinino, C., Parrinello, G., Licata, G., Torres, D., Giambanco, S., Busalacchi, S., Arrotti, S., Novo, S., Inciardi, R. M., Pieri, P., Chirco, P. R., Galifi, M. A., Teresi, G., Buccheri, D., Minacapelli, A., Veniani, M., Frisinghelli, A., Priori, S. G., Cattaneo, S., Opasich, C., Gualco, A., Pagliaro, M., Mancone, M., Fedele, F., Cinque, A., Vellini, M., Scarfo, I., Romeo, F., Ferraiuolo, F., Sergi, D., Anselmi, M., Melandri, F., Leci, E., Iori, E., Bovolo, V., Pidello, S., Frea, S., Bergerone, S., Botta, M., Canavosio, F. G., Gaita, F., Merlo, M., Cinquetti, M., Sinagra, G., Ramani, F., Fabris, E., Stolfo, D., Artico, J., Miani, D., Fresco, C., Daneluzzi, C., Proclemer, A., Cicoira, M., Zanolla, L., Marchese, G., Torelli, F., Vassanelli, C., Voronina, N., Erglis, A., Tamakauskas, V., Smalinskas, V., Karaliute, R., Petraskiene, I., Kazakauskaite, E., Rumbinaite, E., Kavoliuniene, A., Vysniauskas, V., Brazyte-Ramanauskiene, R., Petraskiene, D., Stankala, S., Switala, P., Juszczyk, Z., Sinkiewicz, W., Gilewski, W., Pietrzak, J., Orzel, T., Kasztelowicz, P., Kardaszewicz, P., Lazorko-Piega, M., Gabryel, J., Mosakowska, K., Bellwon, J., Rynkiewicz, A., Raczak, G., Lewicka, E., Dabrowska-Kugacka, A., Bartkowiak, R., Sosnowska-Pasiarska, B., Wozakowska-Kaplon, B., Krzeminski, A., Zabojszcz, M., Mirek-Bryniarska, E., Grzegorzko, A., Bury, K., Nessler, J., Zalewski, J., Furman, A., Broncel, M., Poliwczak, A., Bala, A., Zycinski, P., Rudzinska, M., Jankowski, L., Kasprzak, J. D., Michalak, L., Soska, K. W., Drozdz, J., Huziuk, I., Retwinski, A., Flis, P., Weglarz, J., Bodys, A., Grajek, S., Kaluzna-Oleksy, M., Straburzynska-Migaj, E., Dankowski, R., Szymanowska, K., Grabia, J., Szyszka, A., Nowicka, A., Samcik, M., Wolniewicz, L., Baczynska, K., Komorowska, K., Poprawa, I., Komorowska, E., Sajnaga, D., Zolbach, A., Dudzik-Plocica, A., Abdulkarim, A. -F., Lauko-Rachocka, A., Kaminski, L., Kostka, A., Cichy, A., Ruszkowski, P., Splawski, M., Fitas, G., Szymczyk, A., Serwicka, A., Fiega, A., Zysko, D., Krysiak, W., Szabowski, S., Skorek, E., Pruszczyk, P., Bienias, P., Ciurzynski, M., Welnicki, M., Mamcarz, A., Folga, A., Zielinski, T., Rywik, T., Leszek, P., Sobieszczanska-Malek, M., Piotrowska, M., Kozar-Kaminska, K., Komuda, K., Wisniewska, J., Tarnowska, A., Balsam, P., Marchel, M., Opolski, G., Kaplon-Cieslicka, A., Gil, R. J., Mozenska, O., Byczkowska, K., Gil, K., Pawlak, A., Michalek, A., Krzesinski, P., Piotrowicz, K., Uzieblo-Zyczkowska, B., Stanczyk, A., Skrobowski, A., Ponikowski, P., Jankowska, E., Rozentryt, P., Polonski, L., Gadula-Gacek, E., Nowalany-Kozielska, E., Kuczaj, A., Kalarus, Z., Szulik, M., Przybylska, K., Klys, J., Prokop-Lewicka, G., Kleinrok, A., Aguiar, C. T., Ventosa, A., Pereira, S., Faria, R., Chin, J., De Jesus, I., Santos, R., Silva, P., Moreno, N., Queiros, C., Lourenco, C., Pereira, A., Castro, A., Andrade, A., Guimaraes, T. O., Martins, S., Placido, R., Lima, G., Brito, D., Francisco, A. R., Cardiga, R., Proenca, M., Araujo, I., Marques, F., Moura, B., Leite, S., Campelo, M., Silva-Cardoso, J., Rodrigues, J., Rangel, I., Martins, E., Correia, A. S., Peres, M., Marta, L., da Silva, G. F., Severino, D., Durao, D., Leao, S., Magalhaes, P., Moreira, I., Cordeiro, A. F., Ferreira, C., Araujo, C., Ferreira, A., Baptista, A., Radoi, M., Bicescu, G., Vinereanu, D., Sinescu, C. -J., Macarie, C., Popescu, R., Daha, I., Dan, G. -A., Stanescu, C., Dan, A., Craiu, E., Nechita, E., Aursulesei, V., Christodorescu, R., Otasevic, P., Simeunovic, D., Ristic, A. D., Celic, V., Pavlovic-Kleut, M., Lazic, J. S., Stojcevski, B., Pencic, B., Stevanovic, A., Andric, A., Iric-Cupic, V., Jovic, M., Davidovic, G., Milanov, S., Mitic, V., Atanaskovic, V., Antic, S., Pavlovic, M., Stanojevic, D., Stoickov, V., Ilic, S., Ilic, M. D., Petrovic, D., Stojsic, S., Kecojevic, S., Dodic, S., Adic, N. C., Cankovic, M., Stojiljkovic, J., Mihajlovic, B., Radin, A., Radovanovic, S., Krotin, M., Klabnik, A., Goncalvesova, E., Pernicky, M., Murin, J., Kovar, F., Kmec, J., Semjanova, H., Strasek, M., Iskra, M. S., Ravnikar, T., Suligoj, N. C., Komel, J., Fras, Z., Jug, B., Glavic, T., Losic, R., Bombek, M., Krajnc, I., Krunic, B., Horvat, S., Kovac, D., Rajtman, D., Cencic, V., Letonja, M., Winkler, R., Valentincic, M., Melihen-Bartolic, C., Bartolic, A., Vrckovnik, M. P., Kladnik, M., Pusnik, C. S., Marolt, A., Klen, J., Drnovsek, B., Leskovar, B., Anguita, M. J. F., Page, J. C. G., Martinez, F. M. S., Andres, J., Genis, A. B., Mirabet, S., Mendez, A., Garcia-Cosio, L., Roig, E., Leon, V., Gonzalez-Costello, J., Muntane, G., Garay, A., Alcade-Martinez, V., Fernandez, S. L., Rivera-Lopez, R., Puga-Martinez, M., Fernandez-Alvarez, M., Serrano-Martinez, J. L., Grille-Cancela, Z., Marzoa-Rivas, R., Blanco-Canosa, P., Paniagua-Martin, M. J., Barge-Caballero, E., Cerdena, I. L., Baldomero, I. F. H., Padron, A. L., Rosillo, S. O., Gonzalez-Gallarza, R. D., Montanes, O. S., Manjavacas, A. M. I., Conde, A. C., Araujo, A., Soria, T., Garcia-Pavia, P., Gomez-Bueno, M., Cobo-Marcos, M., Alonso-Pulpon, L., Cubero, J. S., Sayago, I., Gonzalez-Segovia, A., Briceno, A., Subias, P. E., Hernandez, M. V., Cano, M. J. R., Sanchez, M. A. G., Jimenez, J. F. D., Garrido-Lestache, E. B., Pinilla, J. M. G., de la Villa, B. G., Sahuquillo, A., Marques, R. B., Calvo, F. T., Perez-Martinez, M. T., Gracia-Rodenas, M. R., Garrido-Bravo, I. P., Pastor-Perez, F., Pascual-Figal, D. A., Molina, B. D., Orus, J., Gonzalo, F. E., Bertomeu, V., Valero, R., Martinez-Abellan, R., Quiles, J., Rodrigez-Ortega, J. A., Mateo, I., Elamrani, A., Fernandez-Vivancos, C., Valero, D. B., Almenar-Bonet, L., Sanchez-Lazaro, I. J., Marques-Sule, E., Facila-Rubio, L., Perez-Silvestre, J., Garcia-Gonzalez, P., Ridocci-Soriano, F., Garcia-Escriva, D., Pellicer-Cabo, A., de la Fuente Galan, L., Diaz, J. L., Platero, A. R., Arias, J. C., Blasco-Peiro, T., Julve, M. S., Sanchez-Insa, E., Aured-Guallar, C., Portoles-Ocampo, A., Melin, M., Hagglund, E., Stenberg, A., Lindahl, I. -M., Asserlund, B., Olsson, L., Dahlstrom, U., Afzelius, M., Karlstrom, P., Tengvall, L., Wiklund, P. -A., Olsson, B., Kalayci, S., Temizhan, A., Cavusoglu, Y., Gencer, E., Gunes, H., Lainscak, M., Milinkovic, I., Polovina, M., Crespo-Leiro, M. G., Lund, L. H., Anker, S. D., Laroche, C., Ferrari, R., Coats, A. J. S., Mcdonagh, T., Filippatos, G., Maggioni, A. P., Piepoli, M. F., Rosano, G. M. C., Ruschitzka, F., Simic, D., Asanin, M., Eicher, J. -C., Yilmaz, M. B., Seferovic, P. M., Gale, C. P., Chair, G. B., Branko Beleslin, R. S., Andrzej Budaj, P. L., Ovidiu Chioncel, R. O., Nikolaos Dagres, D. E., Nicolas Danchin, F. R., David Erlinge, S. E., Jonathan Emberson, G. B., Michael Glikson, I. L., Alastair Gray, G. B., Meral Kayikcioglu, T. R., Aldo Maggioni, I. T., Klaudia Vivien Nagy, H. U., Aleksandr Nedoshivin, R. U., Anna-Sonia Petronio, I. T., Jolien Roos-Hesselink, N. L., Lars Wallentin, S. E., Uwe Zeymer, D. E., Crespo-Leiro, M., Anker, S., Mebazaa, A., Coats, A., A. Goda A., L., M. Diez A., R., A. Fernandez A., R., F. Fruhwald A., T., Fazlibegovic, E., P. Gatzov B., G., A. Kurlianskaya B., Y., R. Hullin C., H., T. Christodoulides C., Y., J. Hradec C., Z., O. Wendelboe Nielsen D., K., R. Nedjar D., Z., T. Uuetoa E., E., M. Hassanein E., G., J. F. Delgado Jimenez E., S., V-, P. Harjola F. I., D. Logeart F., R., V. Chumburidze G., E., D. Tousoulis G., R., D. Milicic H., R., B. Merkely H., U., O'Donoghue IE, E., O. Amir I., L., A. Shotan I., L., D. Shafie I., R., M. Metra I., T., A. Matsumori J., P., E. Mirrakhimov K., G., A. Kavoliuniene L., T., A. Erglis L., V., Vataman, E., M. Otljanska M., K., E. Srbinovska Kostovska M., K., D. Cassar DeMarco M., T., J. Drozdz P., L., Fonseca, C., O. Chioncel R., O., M. Dekleva R., S., E. Shkolnik R., U., U. Dahlstrom S., E., M. Lainscak S., I., E. Goncalvesova S., K., A. Temizhan T., R., V. Estrago U., Y., G. Bajraktari X., K., Auer, J., Ablasser, K., Fruhwald, F., Dolze, T., Brandner, K., Gstrein, S., Poelzl, G., Moertl, D., Reiter, S., Podczeck-Schweighofer, A., Muslibegovic, A., Vasilj, M., Cesko, M., Zelenika, D., Palic, B., Pravdic, D., Cuk, D., Vitlianova, K., Katova, T., Velikov, T., Kurteva, T., Gatzov, P., Kamenova, D., Antova, M., Sirakova, V., Krejci, J., Mikolaskova, M., Spinar, J., Krupicka, J., Malek, F., Hegarova, M., Lazarova, M., Monhart, Z., Hassanein, M., Sobhy, M., El Messiry, F., El Shazly, A. H., Elrakshy, Y., Youssef, A., Moneim, A. A., Noamany, M., Reda, A., Dayem, T. K. A., Farag, N., Halawa, S. I., Hamid, M. A., Said, K., Saleh, A., Ebeid, H., Hanna, R., Aziz, R., Louis, O., Enen, M. A., Ibrahim, B. S., Nasr, G., Elbahry, A., Sobhy, H., Ashmawy, M., Gouda, M., Aboleineen, W., Bernard, Y., Luporsi, P., Meneveau, N., Pillot, M., Morel, M., Seronde, M. -F., Schiele, F., Briand, F., Delahaye, F., Damy, T., de Groote, P., Fertin, M., Lamblin, N., Isnard, R., Lefol, C., Thevenin, S., Hagege, A., Jondeau, G., Logeart, D., Le Marcis, V., Ly, J. -F., Coisne, D., Lequeux, B., Le Moal, V., Mascle, S., Lotton, P., Behar, N., Donal, E., Thebault, C., Ridard, C., Reynaud, A., Basquin, A., Bauer, F., Codjia, R., Galinier, M., Tourikis, P., Stavroula, M., Tousoulis, D., Stefanadis, C., Chrysohoou, C., Kotrogiannis, I., Matzaraki, V., Dimitroula, T., Karavidas, A., Tsitsinakis, G., Kapelios, C., Nanas, J., Kampouri, H., Nana, E., Kaldara, E., Eugenidou, A., Vardas, P., Saloustros, I., Patrianakos, A., Tsaknakis, T., Evangelou, S., Nikoloulis, N., Tziourganou, H., Tsaroucha, A., Papadopoulou, A., Douras, A., Polgar, L., Merkely, B., Kosztin, A., Nyolczas, N., Nagy, A. C., Halmosi, R., Elber, J., Alony, I., Shotan, A., Fuhrmann, A. V., Amir, O., Romano, S., Marcon, S., Penco, M., Di Mauro, M., Lemme, E., Carubelli, V., Rovetta, R., Metra, M., Bulgari, M., Quinzani, F., Lombardi, C., Bosi, S., Schiavina, G., Squeri, A., Barbieri, A., Di Tano, G., Pirelli, S., Fucili, A., Passero, T., Musio, S., Di Biase, M., Correale, M., Salvemini, G., Brognoli, S., Zanelli, E., Giordano, A., Agostoni, P., Italiano, G., Salvioni, E., Copelli, S., Modena, M. G., Reggianini, L., Valenti, C., Olaru, A., Bandino, S., Deidda, M., Mercuro, G., Dessalvi, C. C., Marino, P. N., Di Ruocco, M. V., Sartori, C., Piccinino, C., Parrinello, G., Licata, G., Torres, D., Giambanco, S., Busalacchi, S., Arrotti, S., Novo, S., Inciardi, R. M., Pieri, P., Chirco, P. R., Galifi, M. A., Teresi, G., Buccheri, D., Minacapelli, A., Veniani, M., Frisinghelli, A., Priori, S. G., Cattaneo, S., Opasich, C., Gualco, A., Pagliaro, M., Mancone, M., Fedele, F., Cinque, A., Vellini, M., Scarfo, I., Romeo, F., Ferraiuolo, F., Sergi, D., Anselmi, M., Melandri, F., Leci, E., Iori, E., Bovolo, V., Pidello, S., Frea, S., Bergerone, S., Botta, M., Canavosio, F. G., Gaita, F., Merlo, M., Cinquetti, M., Sinagra, G., Ramani, F., Fabris, E., Stolfo, D., Artico, J., Miani, D., Fresco, C., Daneluzzi, C., Proclemer, A., Cicoira, M., Zanolla, L., Marchese, G., Torelli, F., Vassanelli, C., Voronina, N., Erglis, A., Tamakauskas, V., Smalinskas, V., Karaliute, R., Petraskiene, I., Kazakauskaite, E., Rumbinaite, E., Kavoliuniene, A., Vysniauskas, V., Brazyte-Ramanauskiene, R., Petraskiene, D., Stankala, S., Switala, P., Juszczyk, Z., Sinkiewicz, W., Gilewski, W., Pietrzak, J., Orzel, T., Kasztelowicz, P., Kardaszewicz, P., Lazorko-Piega, M., Gabryel, J., Mosakowska, K., Bellwon, J., Rynkiewicz, A., Raczak, G., Lewicka, E., Dabrowska-Kugacka, A., Bartkowiak, R., Sosnowska-Pasiarska, B., Wozakowska-Kaplon, B., Krzeminski, A., Zabojszcz, M., Mirek-Bryniarska, E., Grzegorzko, A., Bury, K., Nessler, J., Zalewski, J., Furman, A., Broncel, M., Poliwczak, A., Bala, A., Zycinski, P., Rudzinska, M., Jankowski, L., Kasprzak, J. D., Michalak, L., Soska, K. W., Drozdz, J., Huziuk, I., Retwinski, A., Flis, P., Weglarz, J., Bodys, A., Grajek, S., Kaluzna-Oleksy, M., Straburzynska-Migaj, E., Dankowski, R., Szymanowska, K., Grabia, J., Szyszka, A., Nowicka, A., Samcik, M., Wolniewicz, L., Baczynska, K., Komorowska, K., Poprawa, I., Komorowska, E., Sajnaga, D., Zolbach, A., Dudzik-Plocica, A., Abdulkarim, A. -F., Lauko-Rachocka, A., Kaminski, L., Kostka, A., Cichy, A., Ruszkowski, P., Splawski, M., Fitas, G., Szymczyk, A., Serwicka, A., Fiega, A., Zysko, D., Krysiak, W., Szabowski, S., Skorek, E., Pruszczyk, P., Bienias, P., Ciurzynski, M., Welnicki, M., Mamcarz, A., Folga, A., Zielinski, T., Rywik, T., Leszek, P., Sobieszczanska-Malek, M., Piotrowska, M., Kozar-Kaminska, K., Komuda, K., Wisniewska, J., Tarnowska, A., Balsam, P., Marchel, M., Opolski, G., Kaplon-Cieslicka, A., Gil, R. J., Mozenska, O., Byczkowska, K., Gil, K., Pawlak, A., Michalek, A., Krzesinski, P., Piotrowicz, K., Uzieblo-Zyczkowska, B., Stanczyk, A., Skrobowski, A., Ponikowski, P., Jankowska, E., Rozentryt, P., Polonski, L., Gadula-Gacek, E., Nowalany-Kozielska, E., Kuczaj, A., Kalarus, Z., Szulik, M., Przybylska, K., Klys, J., Prokop-Lewicka, G., Kleinrok, A., Aguiar, C. T., Ventosa, A., Pereira, S., Faria, R., Chin, J., De Jesus, I., Santos, R., Silva, P., Moreno, N., Queiros, C., Lourenco, C., Pereira, A., Castro, A., Andrade, A., Guimaraes, T. O., Martins, S., Placido, R., Lima, G., Brito, D., Francisco, A. R., Cardiga, R., Proenca, M., Araujo, I., Marques, F., Moura, B., Leite, S., Campelo, M., Silva-Cardoso, J., Rodrigues, J., Rangel, I., Martins, E., Correia, A. S., Peres, M., Marta, L., da Silva, G. F., Severino, D., Durao, D., Leao, S., Magalhaes, P., Moreira, I., Cordeiro, A. F., Ferreira, C., Araujo, C., Ferreira, A., Baptista, A., Radoi, M., Bicescu, G., Vinereanu, D., Sinescu, C. -J., Macarie, C., Popescu, R., Daha, I., Dan, G. -A., Stanescu, C., Dan, A., Craiu, E., Nechita, E., Aursulesei, V., Christodorescu, R., Otasevic, P., Simeunovic, D., Ristic, A. D., Celic, V., Pavlovic-Kleut, M., Lazic, J. S., Stojcevski, B., Pencic, B., Stevanovic, A., Andric, A., Iric-Cupic, V., Jovic, M., Davidovic, G., Milanov, S., Mitic, V., Atanaskovic, V., Antic, S., Pavlovic, M., Stanojevic, D., Stoickov, V., Ilic, S., Ilic, M. D., Petrovic, D., Stojsic, S., Kecojevic, S., Dodic, S., Adic, N. C., Cankovic, M., Stojiljkovic, J., Mihajlovic, B., Radin, A., Radovanovic, S., Krotin, M., Klabnik, A., Goncalvesova, E., Pernicky, M., Murin, J., Kovar, F., Kmec, J., Semjanova, H., Strasek, M., Iskra, M. S., Ravnikar, T., Suligoj, N. C., Komel, J., Fras, Z., Jug, B., Glavic, T., Losic, R., Bombek, M., Krajnc, I., Krunic, B., Horvat, S., Kovac, D., Rajtman, D., Cencic, V., Letonja, M., Winkler, R., Valentincic, M., Melihen-Bartolic, C., Bartolic, A., Vrckovnik, M. P., Kladnik, M., Pusnik, C. S., Marolt, A., Klen, J., Drnovsek, B., Leskovar, B., Anguita, M. J. F., Page, J. C. G., Martinez, F. M. S., Andres, J., Genis, A. B., Mirabet, S., Mendez, A., Garcia-Cosio, L., Roig, E., Leon, V., Gonzalez-Costello, J., Muntane, G., Garay, A., Alcade-Martinez, V., Fernandez, S. L., Rivera-Lopez, R., Puga-Martinez, M., Fernandez-Alvarez, M., Serrano-Martinez, J. L., Grille-Cancela, Z., Marzoa-Rivas, R., Blanco-Canosa, P., Paniagua-Martin, M. J., Barge-Caballero, E., Cerdena, I. L., Baldomero, I. F. H., Padron, A. L., Rosillo, S. O., Gonzalez-Gallarza, R. D., Montanes, O. S., Manjavacas, A. M. I., Conde, A. C., Araujo, A., Soria, T., Garcia-Pavia, P., Gomez-Bueno, M., Cobo-Marcos, M., Alonso-Pulpon, L., Cubero, J. S., Sayago, I., Gonzalez-Segovia, A., Briceno, A., Subias, P. E., Hernandez, M. V., Cano, M. J. R., Sanchez, M. A. G., Jimenez, J. F. D., Garrido-Lestache, E. B., Pinilla, J. M. G., de la Villa, B. G., Sahuquillo, A., Marques, R. B., Calvo, F. T., Perez-Martinez, M. T., Gracia-Rodenas, M. R., Garrido-Bravo, I. P., Pastor-Perez, F., Pascual-Figal, D. A., Molina, B. D., Orus, J., Gonzalo, F. E., Bertomeu, V., Valero, R., Martinez-Abellan, R., Quiles, J., Rodrigez-Ortega, J. A., Mateo, I., Elamrani, A., Fernandez-Vivancos, C., Valero, D. B., Almenar-Bonet, L., Sanchez-Lazaro, I. J., Marques-Sule, E., Facila-Rubio, L., Perez-Silvestre, J., Garcia-Gonzalez, P., Ridocci-Soriano, F., Garcia-Escriva, D., Pellicer-Cabo, A., de la Fuente Galan, L., Diaz, J. L., Platero, A. R., Arias, J. C., Blasco-Peiro, T., Julve, M. S., Sanchez-Insa, E., Aured-Guallar, C., Portoles-Ocampo, A., Melin, M., Hagglund, E., Stenberg, A., Lindahl, I. -M., Asserlund, B., Olsson, L., Dahlstrom, U., Afzelius, M., Karlstrom, P., Tengvall, L., Wiklund, P. -A., Olsson, B., Kalayci, S., Temizhan, A., Cavusoglu, Y., Gencer, E., Gunes, H., University of Zurich, and Seferović, Petar M
- Subjects
Male ,Registry ,medicine.medical_specialty ,Adverse outcomes ,610 Medicine & health ,Angiotensin-Converting Enzyme Inhibitors ,030204 cardiovascular system & hematology ,Independent predictor ,2705 Cardiology and Cardiovascular Medicine ,Ventricular Function, Left ,03 medical and health sciences ,Age ,0302 clinical medicine ,Internal medicine ,Age related ,Hospitalization ,Mortality ,Sex ,medicine ,Humans ,Registries ,Medical prescription ,Aged ,Heart Failure ,Ejection fraction ,business.industry ,Stroke Volume ,medicine.disease ,Ageing ,Heart failure ,10209 Clinic for Cardiology ,Female ,Angiotensin Receptor Blockers ,Cardiology and Cardiovascular Medicine ,business - Abstract
[Abstract] Aims. This study aimed to assess age‐ and sex‐related differences in management and 1‐year risk for all‐cause mortality and hospitalization in chronic heart failure (HF) patients. Methods and results. Of 16 354 patients included in the European Society of Cardiology Heart Failure Long‐Term Registry, 9428 chronic HF patients were analysed [median age: 66 years; 28.5% women; mean left ventricular ejection fraction (LVEF) 37%]. Rates of use of guideline‐directed medical therapy (GDMT) were high (angiotensin‐converting enzyme inhibitors/angiotensin receptor blockers, beta‐blockers and mineralocorticoid receptor antagonists: 85.7%, 88.7% and 58.8%, respectively). Crude GDMT utilization rates were lower in women than in men (all differences: P ≤ 0.001), and GDMT use became lower with ageing in both sexes, at baseline and at 1‐year follow‐up. Sex was not an independent predictor of GDMT prescription; however, age >75 years was a significant predictor of GDMT underutilization. Rates of all‐cause mortality were lower in women than in men (7.1% vs. 8.7%; P = 0.015), as were rates of all‐cause hospitalization (21.9% vs. 27.3%; P < 0.001) and there were no differences in causes of death. All‐cause mortality and all‐cause hospitalization increased with greater age in both sexes. Sex was not an independent predictor of 1‐year all‐cause mortality (restricted to patients with LVEF ≤45%). Mortality risk was significantly lower in patients of younger age, compared to patients aged >75 years. Conclusions. There was a decline in GDMT use with advanced age in both sexes. Sex was not an independent predictor of GDMT or adverse outcomes. However, age >75 years independently predicted lower GDMT use and higher all‐cause mortality in patients with LVEF ≤45%.
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- 2019
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36. The Moral and Legal Status of Artificial Intelligence (Present Dilemmas and Future Challenges)
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Igor Milinkovic
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Legal status ,Engineering ethics ,Sociology - Abstract
The rapid development of artificial intelligence (AI) systems raises dilemmas regarding their moral and legal status. Can artificial intelligence possess moral status (significance)? And under what conditions? Can one speak of the dignity of artificial intelligence as the basis of its moral status? According to some authors, if there are entities who have the capacities on which the dignity of human beings is based, they would also possess intrinsic dignity. If dignity is not an exclusive feature of human beings, such status also could be recognised by artificial intelligence entities. The first part of the paper deals with the problem of moral status of artificial intelligence and the conditions that must be fulfilled for such a status to be recognised. A precondition for the existence of moral status of artificial intelligence is its ability to make autonomous decisions. This part of the paper considers whether developing autonomous AI is justified, or, as some authors suggest, the creation of AI agents capable of autonomous action should be avoided. The recognition of the moral status of artificial intelligence would reflect on its legal status. The second part of the paper deals with the question of justifiability of ascribing legal personhood to the AI agents. Under what conditions would recognition of legal personhood by the artificial intelligence be justified and should its legal subjectivity be recognised in full scope or only partially (by ascribing to the AI agents a “halfway-status,” as some authors suggest)? The current state of the legal regulation of artificial intelligence will be observed as well.
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- 2021
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37. Comparison of Average Total EMF Exposure for Microcell/Macrocell Topologies Using Novel Methodology Based on Operational Network Measurements
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Aleksandar M. Neskovic, Jelena Milinkovic, Milica V. Popovic Sakovic, and Mladen Koprivica
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General Computer Science ,business.industry ,GSM/UMTS network topology ,uplink/downlink exposure ,020209 energy ,EMF exposure ,Real-time computing ,General Engineering ,02 engineering and technology ,TK1-9971 ,Base station ,User equipment ,GSM ,0202 electrical engineering, electronic engineering, information engineering ,Cellular network ,Microcell ,micro/macro base stations ,020201 artificial intelligence & image processing ,General Materials Science ,Actual SAR ,Electrical engineering. Electronics. Nuclear engineering ,Macrocell ,Mobile telephony ,business ,UMTS frequency bands - Abstract
Two outdoor base station macrocell/microcell topologies in operational Global System for Mobile communications (GSM) and Universal Mobile Telecommunications Service (UMTS) networks are compared with respect to average Electromagnetic Field (EMF) exposure over population in an area. A novel joint metric is used, accounting for exposure from both base stations and user equipment. The demonstrated method tends to use as much data as possible that can be extracted from various network systems, for the exact time of measurements or on long-term basis, with the aim of identifying the potential for EMF-awareness of future networks. The reduction of total exposure with the introduction of the microcell layer is shown using the proposed method with experimental measurements and compared by mobile network technologies. The introduction of the micro layer brought reduction to total population exposure of 84.6%, in the micro base station coverage area, mostly due to user device exposure reduction in GSM. UMTS user device exposure reduction was even more pronounced, 97.8%, but having less impact on overall exposure, contributing only 1%. Even with the increase in exposure originating from base stations, the reduction of total exposure was visible over the macro area as well, measuring 2.22%. The uncertainties of the evaluation method are identified and usage of advanced tools and methods is proposed to mitigate them.
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- 2021
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38. Graph coloring-based approach for railway station design analysis and capacity determination
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Predrag Jovanović, Norbert Pavlovic, Ivan Belošević, and Sanjin Milinkovic
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Vertex (graph theory) ,050210 logistics & transportation ,Mathematical optimization ,Sequence ,021103 operations research ,Information Systems and Management ,Design analysis ,General Computer Science ,Selection (relational algebra) ,Computer science ,05 social sciences ,0211 other engineering and technologies ,02 engineering and technology ,Management Science and Operations Research ,Travelling salesman problem ,Industrial and Manufacturing Engineering ,Vertex (geometry) ,Modeling and Simulation ,0502 economics and business ,Graph coloring - Abstract
This study develops an optimization model for strategic decision-making in railway station design, enabling the comparison and selection of a station layout that maximizes the theoretical infrastructure capacity, completely independent of timetables. The model, using well-known combinatorial problems, such as the weighted vertex coloring problem and traveling salesman problem, identifies a route sequence that occupies a minimum amount of infrastructure and calculates the theoretical capacity. The model is tested on six different layouts for a station in the design phase, as well as on one fully operating station. The test results demonstrate the simplicity of implementing the model.
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- 2020
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39. Patient-Reported Outcomes After Revision Surgery for Failed Medial Patellofemoral Ligament Reconstruction: A Matched-Pair Analysis Including Correction of Predisposing Factors
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Felix Zimmermann, Juliane Börtlein, Peter Balcarek, and Danko Dan Milinkovic
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Adult ,Joint Instability ,Male ,Reoperation ,medicine.medical_specialty ,Matched Pair Analysis ,Adolescent ,Matched-Pair Analysis ,Patellar Dislocation ,Physical Therapy, Sports Therapy and Rehabilitation ,Economic shortage ,Medial patellofemoral ligament ,Cohort Studies ,Patellofemoral Joint ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Orthopedics and Sports Medicine ,Patient Reported Outcome Measures ,030222 orthopedics ,business.industry ,030229 sport sciences ,Plastic Surgery Procedures ,Surgery ,medicine.anatomical_structure ,Ligaments, Articular ,Quality of Life ,Female ,business - Abstract
Background: Complications and the need for revision surgery after medial patellofemoral ligament reconstruction (MPFLR) are evident in the current literature. However, there is a shortage of clinical data evaluating the results of revision surgery in individual patients after failed MPFLR. Purpose: To investigate the results of tailored revision surgery for failed MPFLR, including the correction of predisposing factors. Study Design: Cohort study; Level of evidence, 3. Methods: Between August 2015 and March 2019, 25 patients (male:female, n = 9:16; mean ± SD age, 25.9 ± 6.5 years) underwent revision surgery for failed MPFLR (study group). The Banff Patella Instability Instrument 2.0 (BPII 2.0) and a numerical analog scale (0-10) for patellofemoral pain and subjective knee joint function were used to assess patient-reported quality of life before and after revision surgery. The control group of 50 patients (male:female, n = 18:32; age, 22.8 ± 4.3 years) who underwent identical patellar-stabilizing procedures was matched 1:2 by the surgical procedure, predisposing factors, sex, age, and follow-up time. Results: Evaluation was performed postoperatively at a mean 27.8 ± 14.0 months (range, 12-54 months) in the study group and 26.1 ± 11.2 months (range, 12-56 months) in the control group ( P = .55). The BPII 2.0 score increased from 28.6 ± 17.9 points to 68.7 ± 22.3 points ( P < .0001) in the study group and from 43.8 ± 22.5 points to 75.5 ± 21.4 points ( P < .0001) in the control group from preoperatively to postoperatively, respectively. Before revision surgery, the BPII 2.0 scores in the study group were significantly inferior to those in the control group ( P = .0026). At the final follow-up, the BPII 2.0 score in the study group was not significantly lower ( P = .174), and a similar number of patients in the study group and the control group achieved the minimally clinically important difference ( P = .49). Patellofemoral pain and subjective knee joint function improved significantly in both groups ( P < .0001, P < .0001), without any significant difference between them at the final follow-up ( P = .85, P = .86). Conclusion: Revision surgery for MPFLR failure, including the correction of major anatomic risk factors, yielded a significant improvement in patient-reported quality-of-life outcome measures. Patients with failed MPFLR, however, were significantly more restricted before revision surgery than patients without previous interventions when evaluated with the BPII 2.0.
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- 2020
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40. Unrecognized assets created by public-sector investments in health and social services
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Christopher J. Longo, Jeremiah Hurley, Deborah Milinkovic, Susan McCracken, David Feeny, Arthur Sweetman, and Jean-Eric Tarride
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Finance ,Government ,Public Administration ,business.industry ,Strategy and Management ,media_common.quotation_subject ,05 social sciences ,Public sector ,Social Welfare ,050201 accounting ,Human capital ,Intangible asset ,Argument ,Service (economics) ,0502 economics and business ,Business ,Asset (economics) ,050203 business & management ,media_common - Abstract
PurposeThis paper analyzes two types of potential intangible public-sector assets for consideration by public-sector accounting boards. Government investments in health and social programs can create two potential intangible assets: the intangible infrastructure used to deliver the health or social program and the enhanced human capital embodied in the recipients of program services. Because neither of these assets is currently recognized in a government's year-end financial statements or broader general-purpose financial reports (GPFR), these reports may underrepresent the government's true fiscal and service capacity.Design/methodology/approachThe paper uses an international accounting standards framework to analyze: whether investments in health and social programs create intangible assets that meet the definition of an asset as set out by International Public Sector Accounting Standards (IPSAS), whether they are assets of the government and whether they are recognizable for the purpose of financial reporting.FindingsThe intangible infrastructure asset created to facilitate the delivery of health and social programs would often qualify as a recognizable asset of the government. However, the enhanced recipient human capital asset created through the delivery of health and social programs would, in most instances, not qualify as a recognizable asset of the government, though there likely would be benefits from reporting on it through GPFRs or other mechanisms.Originality/valueThis paper makes two contributions. First, it identifies a previously overlooked intangible asset – the infrastructure created to facilitate the delivery of health and social programs. Second, it presents an argument regarding why, even when it fails to generate a recognizable intangible asset to government, it would be valuable for government to report such investments in supplementary statements.
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- 2020
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41. PREDICTING LEADERSHIP STYLES BASED ON ACHIEVEMENT MOTIVATION
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Ivana Kovačević and Ivana Milinkovic
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General Arts and Humanities ,media_common.quotation_subject ,05 social sciences ,Need for achievement ,General Social Sciences ,0506 political science ,Transactional leadership ,Transformational leadership ,Originality ,0502 economics and business ,050602 political science & public administration ,Trait ,Personality ,Leadership style ,Psychological testing ,Psychology ,Social psychology ,050203 business & management ,media_common - Abstract
Purpose: The fields of motivation and leadership are very wide, and there is a large number of factors that mediate their relationships. The research aimed to examine is there a correlation between leaders’ achievement motivation and their leadership styles (transformational, transactional, and passive), and whether the achievement motive can be a predictor of leadership style. Methodology: Quantitative research was conducted in 4 companies from the territory of Serbia. Leaders and their subordinates completed two questionnaires, MLQ (Multifactor Leadership Questionnaire) and AMI (Achievement Motivation Inventory). The MLQ was used to measure transformational, transactional, and passive leadership style. AMI is a psychological test that was used to evaluate the expression of achievement motivation. Main Findings: The results showed that there is a correlation between achievement motivation and passive (r = -. 544; p
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- 2020
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42. The use of collagen porcine dermal matrix and connective tissue graft with modified coronally advanced tunnel technique in the treatment of multiple adjacent type I gingival recessions: A randomized, controlled clinical trial
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Ivan A. Soldatovic, Sasa Jankovic, Iva Milinkovic, Dragana Rakasevic, Zoran Aleksic, and Natasa Nikolic-Jakoba
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Swine ,Test group ,0206 medical engineering ,Gingiva ,Connective tissue ,Dentistry ,02 engineering and technology ,Matrix (biology) ,Surgical Flaps ,03 medical and health sciences ,0302 clinical medicine ,Animals ,Humans ,Medicine ,Gingival Recession ,Clinical significance ,Tooth Root ,General Dentistry ,Test site ,business.industry ,Surgical wound ,030206 dentistry ,020601 biomedical engineering ,3. Good health ,Clinical trial ,Treatment Outcome ,medicine.anatomical_structure ,Connective Tissue ,Collagen ,business ,Dermal matrix - Abstract
Objective To assess the clinical efficacy and esthetic outcome of porcine-derived dermal collagen matrix in comparison with connective tissue graft in the treatment of multiple adjacent gingival recessions (MAGR), 6 and 12 months after the surgery. Materials and methods Twenty patients with bilateral type I MAGR were treated randomly with porcine-derived dermal collagen matrix (test site) or connective tissue graft (control site) in combination with a modified coronally advanced tunnel technique. The primary objectives were to evaluate the mean and complete root coverage. The secondary objectives were to assess keratinized tissue width, gingival thickness gain, and root coverage esthetic score. Results Six and 12 months postoperatively, both groups achieved significant improvements in all clinical parameters compared to baseline, with no statistically significant differences between the groups. Mean root coverage change (Δ12m - 6 m) was statistically significant between the groups in favor of connective tissue graft, and twice as many patients exhibited a complete coverage of all recessions in the control group than the test group. Conclusion The porcine-derived dermal collagen matrix combined with a modified coronally advanced tunnel technique resulted in satisfactory clinical and esthetic outcomes, which were similar to connective tissue graft. Clinical significance Porcine-derived dermal collagen matrix (XDM) may be proposed as a substitute for connective tissue graft in multiple adjacent recession treatment due to successful root coverage, a significant increase of gingival thickness, and high esthetic outcomes. The clinical benefits for the use of XDM could be: (a) second surgical wound avoidance, (b) patient discomfort decrease, and (c) lower complications' rate.
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- 2020
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43. Correlation between different equations to calculate free testosterone for improved detection of hypogonadism in people living with HIV
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Shuang WU, Orla HILTON, Branca PEREIRA, Nicolo GIROMETTI, Ana MILINKOVIC, Giangiacomo OLLANDINI, and Marta BOFFITO
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Infectious Diseases ,Hypogonadism ,Public Health, Environmental and Occupational Health ,Humans ,Pharmacology (medical) ,HIV Infections ,Testosterone ,Dermatology - Abstract
The diagnosis of hypogonadism in people living with HIV (PLWH) remains challenging by the lack of a standardised diagnostic algorithm. Since sexual hormone-binding globulin levels are commonly increased in PLWH, guidelines recommend assessing free testosterone (FT) along with total testosterone levels. We compared different online equations available to estimate FT levels and found a good correlation amongst all algorithms. Estimating FT levels increased diagnostic accuracy of hypogonadism and therefore should be encouraged in clinical practice in PLWH with clinical symptoms of hypogonadism, even when total testosterone levels are normal.
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- 2022
44. Mental and physical health-related quality of life in patients with recurrent patellar dislocations-a generic and disease-specific quality of life questionnaire assessment
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Peter Balcarek, Danko Dan Milinkovic, Alexander Zimmerer, and Felix Zimmermann
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Orthopedics and Sports Medicine - Abstract
Purpose There is a paucity of quality of life (QoL) assessments in studies evaluating patients treated for recurrent lateral patellar dislocation (LPD). The primary aim of this study was to investigate whether mental well-being is impaired in patients with chronic (recurrent) LPD and, if so, to assess whether the mental health-related QoL dimension improves equivalently to the physical-related QoL dimension after successful surgical treatment. Methods Thirty-eight patients with recurrent LPD over a mean course of the disease of 4.7 ± 3.9 years (1—18 years) prior to surgery were included. Generic health-related QoL (HRQoL) (Short Form 36; SF-36) and disease-specific QoL (Banff Patella Instability Instrument 2.0; BPII 2.0) were assessed preoperatively and after a mean follow-up of 3.5 ± 0.8 years (2 – 5 years) postoperatively. Results Untreated LPD significantly impacted the physical dimension of patients’ generic HRQoL and their disease-specific QoL. When compared to age-equivalent normative data sets, the mental HRQoL dimension was not reduced prior to operative treatment but increased during the follow-up period. Surgical treatment normalized the physical dimension of patients’ generic HRQoL and significantly improved their disease-specific QoL. However, BPII 2.0 values remained reduced, albeit patellae were successfully stabilized. Conclusion The results of this study indicate that patients with recurrent LPD are generally in good mental health, although physical impairment is striking. Notwithstanding that surgery prevented further dislocations and normalized the generic HRQoL, the disease-specific QoL remained reduced as far as this can be interpreted without population-based data. Level of evidence Level IV; Retrospective case series.
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- 2022
45. Return to Sports and Patients' Rehabilitation Continuum After Deepening Trochleoplasty and Concomitant Patellar-Stabilizing Procedures: A Case Series of 111 Patients at 2 to 4 Years of Follow-up
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Natalie Mengis, Felix Zimmermann, Larissa Schemel, Jules N. Rippke, Danko D. Milinkovic, and Peter Balcarek
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Adult ,Joint Instability ,Male ,Adolescent ,Patellar Dislocation ,Physical Therapy, Sports Therapy and Rehabilitation ,Return to Sport ,Patellofemoral Joint ,Young Adult ,Ligaments, Articular ,Quality of Life ,Humans ,Orthopedics and Sports Medicine ,Female ,Follow-Up Studies - Abstract
Background: There are few reports on the return to sports after complex patellar-stabilizing surgery. Purposes: To evaluate patients’ ability to return to sports and to investigate the extent to which the preoperative level of sports participation influences sports activity after deepening trochleoplasty (TP) and concomitant patellar-stabilizing procedures. Study Design: Case series; Level of evidence, 4. Methods: Between April 2015 and April 2019, 144 patellar-stabilizing procedures, including deepening TP and medial patellofemoral ligament reconstruction or medial reefing with and without concomitant realignment procedures, were carried out in 142 patients. The Banff Patellofemoral Instability Instrument 2.0 (BPII 2.0) and the Tegner activity score were used to assess patients’ quality of life and sports activity level. In addition, a numerical analog scale was used to evaluate patellofemoral pain intensity during rest and activity and subjective knee joint function. Results: Outcomes were available for 111 patients (112 knees) (male/female, 77/34; mean age, 23.4 ± 7.8 years), yielding a 77.7% follow-up rate at a mean of 39.2 ± 9.9 months (range, 24-48 months). Two-thirds of the patients returned to their preoperative level of activity or higher, but their Tegner scores did not change significantly (4.5 ± 2.4 vs 4.7 ± 1.6; P = .365). Low-level athletes (preoperative Tegner score 0-4) participated at a higher level of sports activity (2.7 ± 1.4 to 4.1 ± 1.2; P < .0001), whereas higher-level athletes (preoperative Tegner score 5-10) participated at a lower level (6.8 ± 1.3 to 5.5 ± 1.7; P < .0001). The likelihood of returning to the preoperative activity level (Tegner score) was significantly higher in the low-level activity group than in the high-level activity group ( P = .0001; 95% CI, 4.055-27.05; odds ratio, 10.47). All of the patient-reported outcome measures improved postoperatively, independent of the patients’ age, sex, and body mass index. Conclusion: Patients undergoing deepening TP and medial soft tissue stabilization with or without concomitant realignment surgery for complex patellar instability can expect good clinical results and a high rate of return to sports participation, with two-thirds of patients returning to their preoperative Tegner-level of activity or higher. However, higher-level athletes should be informed that their likelihood of returning to sports at the preoperative level or full participation at a competitive level is reduced.
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- 2022
46. Medial patellofemoral ligament reconstruction using nonresorbable sutures yields comparable outcomes to reconstruction with a pedicled quadriceps tendon autograft when performed in addition to bony risk factor correction
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Danko Dan Milinkovic, Felix Zimmermann, and Peter Balcarek
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Orthopedics and Sports Medicine ,Surgery - Abstract
Purpose To evaluate the results for reconstruction of the medial patellofemoral ligament using synthetic nonresorbable sutures (S-MPFL-R) in comparison to MPFL-R using quadriceps tendon autograft (QT-MPFL-R) in patients undergoing simultaneous correction of anatomic risk factors for lateral patellar instability (LPI) at a minimum of 2 years of follow-up. Methods Between November 2018 and June 2019, 19 patients (male/female 8/11; mean age 26 ± 7 years) underwent S-MPFL-R (FiberTape®) in combination with the correction of predisposing risk factors for LPI. The control group of 38 patients (male/female 16/22, mean age 26 ± 6 years) who underwent QT-MPFL-R was matched 1:2 by sex, age, anatomic risk factors, and concomitant surgical correction of bony risk factors. The Banff Patella Instability Instrument 2.0 (BPII 2.0) and a numerical analog scale (NAS 0–10) for patellofemoral pain and subjective knee joint function were used to assess patients’ reported quality of life before and after surgery. Results The BPII 2.0 score increased from 35.0 ± 21.7 points to 79.7 ± 13.3 points (p p p p Conclusions This study demonstrates that nonresorbable sutures can serve as a viable option for MPFL-R, yielding comparable outcomes compared to quadriceps tendon autograft reconstruction when performed concomitantly with the correction of anatomic risk factors for LPI. This option reduces the need for autologous tendon harvesting or the use of allografts for MPFL-R. Level of evidence Level III.
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- 2022
47. Consensus on the assessment of systemic sclerosis–associated primary heart involvement: World Scleroderma Foundation/Heart Failure Association guidance on screening, diagnosis, and follow-up assessment
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Cosimo Bruni, Maya H Buch, Aleksandra Djokovic, Giacomo De Luca, Raluca B Dumitru, Alessandro Giollo, Ilaria Galetti, Alexia Steelandt, Konstantinos Bratis, Yossra Atef Suliman, Ivan Milinkovic, Anna Baritussio, Ghadeer Hasan, Anastasia Xintarakou, Yohei Isomura, George Markousis-Mavrogenis, Sophie Mavrogeni, Luna Gargani, Alida LP Caforio, Carsten Tschöpe, Arsen Ristic, Sven Plein, Elijah Behr, Yannick Allanore, Masataka Kuwana, Christopher P Denton, Daniel E Furst, Dinesh Khanna, Thomas Krieg, Renzo Marcolongo, Alessia Pepe, Oliver Distler, Petros Sfikakis, Petar Seferovic, and Marco Matucci-Cerinic
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Rheumatology ,Immunology ,Immunology and Allergy - Abstract
Introduction: Heart involvement is a common problem in systemic sclerosis. Recently, a definition of systemic sclerosis primary heart involvement had been proposed. Our aim was to establish consensus guidance on the screening, diagnosis and follow-up of systemic sclerosis primary heart involvement patients. Methods: A systematic literature review was performed to investigate the tests used to evaluate heart involvement in systemic sclerosis. The extracted data were categorized into relevant domains (conventional radiology, electrocardiography, echocardiography, cardiac magnetic resonance imaging, laboratory, and others) and presented to experts and one patient research partner, who discussed the data and added their opinion. This led to the formulation of overarching principles and guidance statements, then reviewed and voted on for agreement. Consensus was attained when the mean agreement was ⩾7/10 and of ⩾70% of voters. Results: Among 2650 publications, 168 met eligibility criteria; the data extracted were discussed over three meetings. Seven overarching principles and 10 guidance points were created, revised and voted on. The consensus highlighted the importance of patient counseling, differential diagnosis and multidisciplinary team management, as well as defining screening and diagnostic approaches. The initial core evaluation should integrate history, physical examination, rest electrocardiography, trans-thoracic echocardiography and standard serum cardiac biomarkers. Further investigations should be individually tailored and decided through a multidisciplinary management. The overall mean agreement was 9.1/10, with mean 93% of experts voting above 7/10. Conclusion: This consensus-based guidance on screening, diagnosis and follow-up of systemic sclerosis primary heart involvement provides a foundation for standard of care and future feasibility studies that are ongoing to support its application in clinical practice.
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- 2023
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48. COVAC1 phase 2a expanded safety and immunogenicity study of a self-amplifying RNA vaccine against SARS-CoV-2
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Szubert, AJ, Pollock, KM, Cheeseman, HM, Alagaratnam, J, Bern, H, Bird, O, Boffito, M, Byrne, R, Cole, T, Cosgrove, CA, Faust, SN, Fidler, S, Galiza, E, Hassanin, H, Kalyan, M, Libri, V, McFarlane, LR, Milinkovic, A, O'Hara, J, Owen, DR, Owens, D, Pacurar, M, Rampling, T, Skene, S, Winston, A, Woolley, J, Yim, YTN, Dunn, DT, McCormack, S, Shattock, RJ, and COVAC 1 Study Team
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General Medicine - Abstract
Background: lipid nanoparticle (LNP) encapsulated self-amplifying RNA (saRNA) is well tolerated and immunogenic in SARS-CoV-2 seronegative and seropositive individuals aged 18–75. Methods: a phase 2a expanded safety and immunogenicity study of a saRNA SARS-CoV-2 vaccine candidate LNP-nCoVsaRNA, was conducted at participating centres in the UK between 10th August 2020 and 30th July 2021. Participants received 1 μg then 10 μg of LNP-nCoVsaRNA, ∼14 weeks apart. Solicited adverse events (AEs) were collected for one week post-each vaccine, and unsolicited AEs throughout. Binding and neutralisating antiSARS-CoV-2 antibody raised in participant sera was measured by means of an anti-Spike (S) IgG ELISA, and SARS-CoV-2 pseudoneutralisation assay. (The trial is registered: ISRCTN17072692, EudraCT 2020-001646-20). Findings: 216 healthy individuals (median age 51 years) received 1.0 μg followed by 10.0 μg of the vaccine. 28/216 participants were either known to have previous SARS-CoV2 infection and/or were positive for anti-Spike (S) IgG at baseline. Reactogenicity was as expected based on the reactions following licensed COVID-19 vaccines, and there were no serious AEs related to vaccination. 80% of baseline SARS-CoV-2 naïve individuals (147/183) seroconverted two weeks post second immunization, irrespective of age (18–75); 56% (102/183) had detectable neutralising antibodies. Almost all (28/31) SARS-CoV-2 positive individuals had increased S IgG binding antibodies following their first 1.0 μg dose with a ≥0.5log10 increase in 71% (22/31). Interpretation: encapsulated saRNA was well tolerated and immunogenic in adults aged 18–75 years. Seroconversion rates in antigen naïve were higher than those reported in our dose-ranging study. Further work is required to determine if this difference is related to a longer dosing interval (14 vs. 4 weeks) or dosing with 1.0 μg followed by 10.0 μg. Boosting of S IgG antibodies was observed with a single 1.0 μg injection in those with pre-existing immune responses.Funding: grants and gifts from the Medical Research Council UKRI (MC_PC_19076), the National Institute for Health Research/Vaccine Task Force, Partners of Citadel and Citadel Securities, Sir Joseph Hotung Charitable Settlement, Jon Moulton Charity Trust, Pierre Andurand, and Restore the Earth.
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- 2023
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49. Nepoznata i promenljiva – problem učenja rane algebre
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Nenad Milinkovic
- Abstract
The paper draws attention to the difficulties associated with the introduction of symbols and symbolic notation in junior grades of primary school. In this context, the paper draws special attention to the proper understanding of the concepts of unknown and variable at this age and also point to a wide range of problems related to understanding letters as symbols used to denote an unknown or variable in early algebra. The shaping of a real-world context problem at different levels of abstraction is exemplified with the formation of the concepts of unknown andvariable. In this process, real-world situations represent a source of developing mathematical concepts, tools and procedures in which students can apply their mathematical knowledge at a later stage because it gradually becomes more general and formalized and therefore less contextrelated.
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- 2022
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50. Effects of short-term magnesium supplementation on ionized, total magnesium and other relevant electrolytes levels
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Nevena Dj Ivanovic, Branimir Radosavljevic, Milica Zekovic, Davor Korcok, Svetlana Ignjatovic, Brizita Djordjevic, and Neda Milinkovic
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Magnesium carbonate ,0303 health sciences ,Pharmaceutical dosage ,030309 nutrition & dietetics ,Metals and Alloys ,Biological Availability ,030209 endocrinology & metabolism ,Magnesium citrate ,General Biochemistry, Genetics and Molecular Biology ,Biomaterials ,Electrolytes ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Dietary Supplements ,Humans ,Calcium ,Female ,Magnesium ,Mineral status ,Supplements ,General Agricultural and Biological Sciences ,Ionized magnesium ,Magnesium oxide - Abstract
This study aimed to investigate the short-term effects of three magnesium (Mg) dietary supplements containing mineral immediately available for absorption on Mg biochemical status indices (ionized and total Mg), as well as their effects on electrolytes levels in healthy female young adults (n = 61). After a 10-days intervention period supplementation with powder/granulate containing Mg oxide led to an increase in both ionized Mg concentration and % in total Mg in comparison with the baseline. Supplementation with Mg citrate was associated with the significant increase in % of ionized fraction and decrease in serum total Mg concentration. By contrast, among participants consuming Mg carbonate in the form of effervescent tablets ionized Mg concentration and % in total Mg decreased, without detectable changes in serum total Mg. In conclusion, after the short-term supplementation period, Mg oxide demonstrated superior bioavailability compared to the other examined Mg supplements without affecting other minerals' levels.
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- 2022
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