1,114 results on '"Mohammad Abdollahi"'
Search Results
2. Modulating insulin secretion and inflammation against sodium arsenite toxicity by levosimendan as a novel pancreatic islets’ protector
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Marzieh Daniali, Mona Navaei-Nigjeh, Maryam Baeeri, Soheyl Mirzababaei, Mahdi Gholami, Mahban Rahimifard, and Mohammad Abdollahi
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Toxicology - Published
- 2023
3. MY LIFE AS A RESEARCHER, EDITOR AND MENTOR
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Mohammad Abdollahi
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General Earth and Planetary Sciences ,General Environmental Science - Abstract
MY LIFE AS A RESEARCHER, EDITOR AND MENTOR
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- 2022
4. The Hydro-alcoholic Extract of Achillea wilhelmsii C. Koch Ameliorates Acetic Acid-induced Ulcerative Colitis through TLR-4
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Saeideh Momtaz, Mohammad Amir Azimian, Pardis Gharazi, Mustafa Dehnamaki, Zahra Rezaei, Mahban Rahimifard, Maryam Baeeri, Ali Reza Abdollahi, Mohammad Abdollahi, Mohammad Hosein Farzaei, and Amir Hossein Abdolghaffari
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General Agricultural and Biological Sciences ,General Environmental Science - Published
- 2022
5. A novel in situ gelling probiotic microparticle formulation as a healing dressing for infectious burn wounds using QbD principles
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Fatemeh Moraffah, Nasrin Samadi, Mohammad Abdollahi, Roshanak Dolatabadi, Maryam Pirouzzadeh, and Alireza Vatanara
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Researchers have studied probiotic-containing dressings to tackle burn injury concerns like infection and microbial resistance. The current study looked into the effects of novel probiotic-loaded microparticles with in situ gelling properties on infectious burn wounds. Lactiplantibacillus plantarum was chosen as a strain with proven wound-healing properties. Then, a formulation was developed to stabilize and maintain probiotic growth potential. To avoid shedding from wounds, only polymers with rapid moisture absorption were employed. The spray-drying method stabilized the formulation by reducing its water content. The optimal formulation was determined by studying how spray-drying inlet temperature, polymer type, and concentration affected probiotic viability, process yield, swelling ratio, and rheological properties of the particles. The morphological analyses revealed particles with substantial exchangeable surface areas. The formulation's rheological characteristics indicated its thermal and mechanical resistance. Also, the FTIR and DCS spectra proved interlinking between polymers. A comparison of the growth curves of formulated and unformulated probiotics demonstrated an increase in lag time and a steady growth rate. Examination of the formula's efficacy against common wound pathogens confirmed its antibacterial properties. Animal experiments revealed that the optimal microparticles for all criteria outperformed the control groups and were more effective against Pseudomonas aeruginosa. Burn wound infection management would be enhanced by the proposed delivery system's simple administration and prohibition of normal flora transmission.
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- 2023
6. Health system performance in Iran: a systematic analysis for the Global Burden of Disease Study 2019
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Farshad Farzadfar, Mohsen Naghavi, Sadaf G Sepanlou, Sahar Saeedi Moghaddam, William James Dangel, Nicole Davis Weaver, Arya Aminorroaya, Sina Azadnajafabad, Sogol Koolaji, Esmaeil Mohammadi, Negar Rezaei, Jaffar Abbas, Behzad Abbasi, Mitra Abbasifard, Mohsen Abbasi-Kangevari, Zeinab Abbasi-Kangevari, Hedayat Abbastabar, Amir Abdoli, Mohammad Abdollahi, Sina Abdollahzade, Hassan Abolhassani, Zahra Abrehdari-Tafreshi, Soodabeh Aghababaei, Bahman Ahadinezhad, Ali Ahmadi, Sepideh Ahmadi, Hamid Ahmadieh, Mohammad Esmaeil Akbari, Yousef Alimohamadi, Vahid Alipour, Hesam Alizade, Saba Alvand, Saeed Amini, Sohrab Amiri, Ali Arash Anoushirvani, Fereshteh Ansari, Jalal Arabloo, Morteza Arab-Zozani, Zahra Aryan, Armin Aryannejad, Mehran Asadi-Aliabadi, Ali A Asadi-Pooya, Zatollah Asemi, Samaneh Asgari, Saeed Asgary, Babak Asghari, Mohammad Asghari Jafarabadi, Elham Ashrafi, Zahra Atafar, Seyyed Shamsadin Athari, Abolfazl Avan, Abbas Azadmehr, Hiva Azami, Mohammadreza Azangou-Khyavy, Samad Azari, Amirhossein Azari Jafari, Ghasem Azarian, Alireza Badirzadeh, Elham Bahrami, Mohammad Amin Bahrami, Nastaran Barati, Mohsen Bayati, Gholamreza Bazmandegan, Masoud Behzadifar, Ali Bijani, Somayeh Bohlouli, Shiva Borzouei, Parnaz Daneshpajouhnejad, Abdollah Dargahi, Ahmad Daryani, Jalal Davoodi Lahijan, Mojtaba Didehdar, Shirin Djalalinia, Saeid Doaei, Fariba Dorostkar, Leila Doshmangir, Mohammadreza Edraki, Amir Emami, Babak Eshrati, Sharareh Eskandarieh, Firooz Esmaeilzadeh, Shahriar Faghani, Mahdi Fakhar, Hamid Reza Farpour, Hossein Farrokhpour, Majid Fasihi Harandi, Mohammad Fereidouni, Masoud Foroutan, Mansour Ghafourifard, Azin Ghamari, Seyyed-Hadi Ghamari, Ahmad Ghashghaee, Fariba Ghassemi, Ali Gholami, Asadollah Gholamian, Abdolmajid Gholizadeh, Salime Goharinezhad, Pouya Goleij, Mostafa Hadei, Nima Hafezi-Nejad, Sanam Hariri, Edris Hasanpoor, Hossein Hassanian-Moghaddam, Soheil Hassanipour, Hadi Hassankhani, Mohammad Heidari, Reza Heidari-Soureshjani, Mohammad Hoseini, Mohammad-Salar Hosseini, Mostafa Hosseini, Seyed Kianoosh Hosseini, Ali Hosseinzadeh, Mehdi Hosseinzadeh, Soodabeh Hoveidamanesh, Pooya Iranpour, Seyed Sina Naghibi Irvani, Jalil Jaafari, Roxana Jabbarinejad, Morteza Jafarinia, Hamed Jafari-Vayghan, Mohammad Ali Jahani, Nader Jahanmehr, Mahsa Jalili, Roksana Janghorban, Fatemeh Javanmardi, Farahnaz Joukar, Ali Kabir, Leila R Kalankesh, Rohollah Kalhor, Zahra Kamiab, Naser Kamyari, Behzad Karami Matin, Amirali Karimi, Salah Eddin Karimi, Ali Kazemi Karyani, Leila Keikavoosi-Arani, Maryam Keramati, Pedram Keshavarz, Mohammad Keykhaei, Ali Khaleghi, Mohammad Khammarnia, Javad Khanali, Maryam Khayamzadeh, Sajad Khosravi, Mina Khosravifar, Omid Khosravizadeh, Neda Kianipour, Ali-Asghar Kolahi, Amirhosein Maali, Mokhtar Mahdavi Mahdavi, Afshin Maleki, Mohammad-Reza Malekpour, Kamyar Mansori, Borhan Mansouri, Mohammad Ali Mansournia, Mohammad Reza Maracy, Abdoljalal Marjani, Sahar Masoudi, Seyedeh Zahra Masoumi, Hossein Masoumi-Asl, Mahsa Mayeli, Entezar Mehrabi Nasab, Fereshteh Mehri, Mohammad Miri, Seyyedmohammadsadeq Mirmoeeni, Hamed Mirzaei, Maryam Mirzaei, Roya Mirzaei, Ashraf Mohamadkhani, Heidar Mohammadi, Seyyede Momeneh Mohammadi, Shadieh Mohammadi, Abdollah Mohammadian-Hafshejani, Noushin Mohammadifard, Reza Mohammadpourhodki, Mohammad Mohseni, Amin Mokari, Sara Momtazmanesh, Abdolvahab Moradi, Masoud Moradi, Yousef Moradi, Mohammad Moradi-Joo, Farhad Moradpour, Maliheh Moradzadeh, Rahmatollah Moradzadeh, Abbas Mosapour, Shandiz Moslehi, Simin Mouodi, Mehdi Naderi, Homa Naderifar, Zhila Najafpour, Javad Nazari, Seyed Aria Nejadghaderi, Leila Nemati-Anaraki, Amin Reza Nikpoor, Marzieh Nojomi, Maryam Noori, Hasti Nouraei, Ali Nowroozi, Morteza Oladnabi, Fatemeh Pashazadeh Kan, Majid Pirestani, Meghdad Pirsaheb, Mohammadreza Pourahmadi, Hadis Pourchamani, Hadi Pourjafar, Akram Pourshams, Mohammad Rabiee, Navid Rabiee, Alireza Rafiei, Sima Rafiei, Fakher Rahim, Amir Masoud Rahmani, Sina Rashedi, Vahid Rashedi, Amirfarzan Rashidi, Mahsa Rashidi, Mohammad-Mahdi Rashidi, Ramin Ravangard, Reza Rawassizadeh, Iman Razeghian-Jahromi, Mohammad Sadegh Razeghinia, Sofia B Redford, Maryam Rezaei, Nazila Rezaei, Nima Rezaei, Saeid Rezaei, Hossein Rezaei Aliabadi, Mohsen Rezaeian, Mohammad Sadegh Rezai, Aziz Rezapour, Hossein Rezazadeh, Sahba Rezazadeh-Khadem, Morteza Rostamian, Ehsan Sadeghi, Erfan Sadeghi, Masoumeh Sadeghi, Reihaneh Sadeghian, Saeid Sadeghian, Hamid Safarpour, Mahdi Safdarian, Sare Safi, Maryam Sahebazzamani, Amirhossein Sahebkar, Mohammad Ali Sahraian, Sarvenaz Salahi, Payman Salamati, Hossein Samadi Kafil, Yaser Sarikhani, Maryam Sarkhosh, Arash Sarveazad, Maryam Seyed-Nezhad, Omid Shafaat, Zahra Shaghaghi, Saeed Shahabi, Sarvenaz Shahin, Elaheh Shaker, Saeed Shakiba, MohammadBagher Shamsi, Erfan Shamsoddin, Kiomars Sharafi, Sakineh Sharifian, Maryam Shaygan, Abbas Sheikhtaheri, Amir Shiani, Kiarash Shirbandi, Reza Shirkoohi, Parnian Shobeiri, Azad Shokri, Soraya Siabani, Ali Reza Sima, Ahmad Sofi-Mahmudi, Amin Soheili, Shahin Soltani, Mohammad Sadegh Soltani-Zangbar, Moslem Soofi, Seidamir Pasha Tabaeian, Mohammadreza Tabary, Alireza Tahamtan, Majid Taheri, Amir Taherkhani, Masih Tajdini, Hamed Tavolinejad, Arash Tehrani-Banihashemi, Amir Tiyuri, Seyed Abolfazl Tohidast, Alireza Vakilian, Sahel Valadan Tahbaz, Bay Vo, Seyed Hossein Yahyazadeh Jabbari, Vahid Yazdi-Feyzabadi, Zabihollah Yousefi, Taraneh Yousefinezhadi, Mazyar Zahir, Telma Zahirian Moghadam, Maryam Zamanian, Hamed Zandian, Alireza Zangeneh, Hadi Zarafshan, Fariba Zare, Ali Zare Dehnavi, Kourosh Zarea, Ahmad Zarei, Zahra Zareshahrabadi, Arash Ziapour, Sina Zoghi, Nizal Sarrafzadegan, Vafa Rahimi-Movaghar, Hamid Reza Jamshidi, Ali H Mokdad, Simon I Hay, Christopher J L Murray, Ardeshir Khosravi, Maziar Moradi-Lakeh, Mohsen Asadi-Lari, Reza Malekzadeh, and Bagher Larijani
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General Medicine - Published
- 2022
7. Factors related to hypermetabolism in individuals with type 2 diabetes mellitus and non-alcoholic fatty liver disease
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Asieh Mansour, Soudabe Motamed, Azita Hekmatdoost, Sara Karimi, Mohammad Reza Mohajeri-Tehrani, Mohammad Abdollahi, Reihane Jelodar, and Sayed Mahmoud Sajjadi-Jazi
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Multidisciplinary - Abstract
Considering the progressive prevalence and co-occurrence of type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD), as well as the current evidence suggesting the elevated levels of basal metabolic rate (BMR) among these individuals, the present study aimed to identify factors determining hypermetabolism in such subjects. This cross sectional study was conducted in 30 to 53-year-old individuals with concurrent T2DM and NAFLD (controlled attenuation parameter score ≥ 260 dB/m). Resting energy expenditure (REE) was determined by an indirect calorimetry device. Hypermetabolism was defined as an elevated measured REE > 110% of the predicted REE. The multivariate logistic regression test was used for detecting factors associated with hypermetabolism. Between September, 2017, and March, 2018, a total of 95 eligible participants (64.40% male) with both T2DM and NAFLD were included, while 32.63% of them were classified as hypermetabolic. Overall, the mean recruitment age ± standard deviation and median (interquartile range) body mass index were 44.69 ± 5.47 years and 30.20 (27.80–33.30) kg/m2, respectively. Demographic, anthropometric and biochemical variables did not vary significantly across two groups except for total body water, low-density lipoprotein cholesterol and dipeptidyl peptidase 4 (DPP-4) inhibitors (p
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- 2023
8. Combination therapy of cisplatin and resveratrol to induce cellular aging in gastric cancer cells: Focusing on oxidative stress, and cell cycle arrest
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Mahban Rahimifard, Maryam Baeeri, Taraneh Mousavi, Asaad Azarnezhad, Hamed Haghi-Aminjan, and Mohammad Abdollahi
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Pharmacology ,Pharmacology (medical) - Abstract
Background: As a medical dilemma, gastric cancer will have 7.3 million new cases in 2040. Despite the disease’s high economic and global burden, conventional chemotherapy regimens containing cisplatin have insufficient effectiveness and act non-specifically, leading to several adverse drug reactions To address these issues, the biological efficacy of the cisplatin-resveratrol combination was tested.Methods: To find IC50, gastric adenocarcinoma cells (AGS) were exposed to different concentrations of resveratrol and cisplatin. Anti-cancer and anti-metastatic effects of 100 M resveratrol with concentrations of cisplatin (25, 50, and 100 g/ml) were studied by assessing ß-galactosidase and telomerase activities, senescence and migration gene expression, reactive oxygen species (ROS) level, and cell cycle arrest.Results: Co-administration of cisplatin and resveratrol increased ß-galactosidase activity, ROS level as a key marker of oxidative stress, p53, p38, p16, p21, and MMP-2 gene expression, and induced G0/G1 cell cycle arrest. Additionally, telomerase activity, pro-inflammatory gene expression, and cell invasion were suppressed. The best results were achieved with 100 g/ml cisplatin co-administered with resveratrol.Conclusion: The current study proved the synergistic effect of the cisplatin-resveratrol combination on suppressing metastasis and inducing apoptosis and cell senescence through targeting P38/P53 and P16/P21 pathways. Such promising results warrant translation to animal models and the clinic. This may lead to cost-effective, available, and accessible treatment regimens with targeted action and the fewest ADRs.
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- 2023
9. Contributors
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Hasan Erbil Abaci, Mohammad Abdollahi, Nadia Aboutalebianaraki, Azadeh Izadyari Aghmiuni, Abdolreza Ahmadi, Navid Ahmadi Nasab, Abdullah Aldhaher, Nureddin Ashammakhi, Shokouh Attarilar, Alvarez Cespedes, Shu-Yung Chang, Terry Ching, Dong-Woo Cho, Won-Woo Cho, Muhammedin Deliorman, Mahmoud Ebrahimi, Yavuz Nuri Ertas, Maryam Ghaffari, Michinao Hashimoto, Fatemehsadat Hosseini, Motaharesadat Hosseini, Arman Jafari, Masoumeh Keshavarz, Saeed Heidari Keshel, Madisyn Messmore, Soheyl Mirzababaei, Kaylee Misiti, Mohammadmahdi Mobaraki, Maryam Mollazadeh-Bajestani, Ali Mousavi, Fathollah Moztarzadeh, Mona Navaei-Nigjeh, Xiaolei Nie, Alberto Pappalardo, Wonbin Park, Mohammad A. Qasaimeh, Mehdi Razavi, Kae Sato, Kiichi Sato, Houman Savoji, Fahimeh Shahabipour, Amir Shamloo, Angela Shar, Ghazal Shineh, Pavithra Sukumar, Safa Taherkhani, Yi-Chin Toh, Ha Linh Vu, Liqiang Wang, and Hee-Gyeong Yi
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- 2023
10. Hormesis
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Marzieh Noruzi, Mohammad Sharifzadeh, and Mohammad Abdollahi
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- 2023
11. Liver-on-a-chip
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Soheyl Mirzababaei, Mona Navaei-Nigjeh, Mohammad Abdollahi, and Amir Shamloo
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- 2023
12. Safety of Food and Beverages: Probiotics and Prebiotics
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Ida Adeli, Fatemeh Habibi, Negar Badami, and Mohammad Abdollahi
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- 2023
13. Pentobarbital sodium
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Masoumeh Nematbakhsh and Mohammad Abdollahi
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- 2023
14. Cell phones
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Mahshid Ataei and Mohammad Abdollahi
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- 2023
15. Pancreas-on-a-chip
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Soheyl Mirzababaei, Mona Navaei-Nigjeh, and Mohammad Abdollahi
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- 2023
16. Industrial hygiene
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D.L. Dahlstrom, M.D. Hoover, Marzieh Noruzi, and Mohammad Abdollahi
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- 2023
17. In Vitro-In Vivo Correlation for the Antibacterial Effect of Lactiplantibacillus plantarum as a Topical Healer for Infected Burn Wound
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Fatemeh Moraffah, Melika Kiani, Mohammad Abdollahi, Sepideh Yoosefi, Alireza Vatanara, and Nasrin Samadi
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Anti-Infective Agents ,Pseudomonas aeruginosa ,Wound Infection ,Humans ,Molecular Medicine ,Burns ,Molecular Biology ,Microbiology ,Anti-Bacterial Agents - Abstract
Difficulties in delivering antimicrobial agents to wound areas and emersion of multiple drug resistant organisms (MDROs) have converted managing burn infections into a complicated task in medicine. Probiotics emerged not only as a probable solution for burn infections but also as an accelerator in the healing process. The probability of in vitro-in vivo correlation (IVIVC) in probiotic activity leads to lower costs in finding new therapeutic options. Simulated wound fluid (SWF) was used to evaluate the antibacterial function of Lactiplantibacillus plantarum in wounds. The growth parameters in SWF were evaluated using a logistic model to predict growth behavior in the wound area. In addition, probiotic antimicrobial activity and secretion of antibacterial substances in SWF were also studied. Data were used to select the initial dose and apply frequency for in vivo study. The wound models were infected by two main pathogens (Pseudomonas aeruginosa or Staphylococcus aureus). In vitro results showed less lag time associated with considerable acid production in SWF. In the following, secretion of antimicrobial substances and co-aggregation with pathogens became more important. The susceptibility of pathogens to these factors was different, and culture medium affected the yield of each factor involved in eliminating pathogens. Histological analysis and macroscopic examination of wounds revealed probiotics as effective as positive control or more. There were some differences in the antibacterial functions of probiotics in simulated and real wound environments. The in vitro effect of probiotics on removal of pathogens was not the same as the trend seen in vivo.
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- 2022
18. Boosted 2D graphene nanosheets by organic-inorganic hybrid cross-linker for an efficient and stable supercapacitor
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Fatemeh Farbod, Mohammad Mazloum-Ardakani, Mohammad Abdollahi-Alibeik, Ali Mirvakili, and Zahra Ramazani
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Fuel Technology ,Renewable Energy, Sustainability and the Environment ,Energy Engineering and Power Technology ,Condensed Matter Physics - Published
- 2022
19. Bond behaviour of high-strength steel bars in concrete with steel fibres
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Mohammad Abdollahi, Ali Kheyroddin, and Hamed Arshadi
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Materials science ,Material consumption ,Bond ,High strength steel ,Building and Construction ,Composite material ,Civil and Structural Engineering ,Building construction - Abstract
Reductions in materials consumption through the use of high-strength materials is important in building construction. However, high-strength steel applications have possible challenges such as their effects on bond behaviour and structural ductility. The bond behaviour, total energy capacity and failure modes of headed and straight high-strength and normal-strength steel bars were investigated using pull-out tests. In the experimental programme, 48 concrete specimens with a compressive strength of 40 MPa, different ratios of steel fibres and embedded steel bars with different yield strengths were subject to pull-out tests. The results showed that the headed bars had far greater bond stress and total energy capacity than the straight bars. It was also found that the higher the yield strength of the bars, the higher the energy capacity and bond stress. Although increases in fibre ratios led to increases in energy capacity, they did not absolutely increase the bond stress. The specimens with both headed and straight bars failed by splitting.
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- 2022
20. Core–shell structured magnetic MCM-41-type mesoporous silica-supported Cu/Fe: A novel recyclable nanocatalyst for Ullmann-type homocoupling reactions
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Mohammad Abdollahi-Alibeik and Zahra Ramazani
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Materials Chemistry ,Metals and Alloys ,General Chemistry ,Condensed Matter Physics - Abstract
In this study, a novel magnetic MCM-41-type mesoporous silica-supported Fe/Cu (Fe3O4@Fe–Cu/MCM-41) was prepared, characterized, and used as a heterogeneous catalyst for the synthesis of symmetric biaryls by Ullmann cross-coupling reaction. This nanocomposite was characterized using Fourier transform infrared spectroscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, and nitrogen adsorption–desorption isotherm. The Fe3O4@Fe–Cu/MCM-41 was applied as an efficient catalyst in the synthesis of biaryls under optimum conditions. This nanocatalyst was recovered and reused several times without significant loss of activity.
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- 2022
21. Nanoparticles in Combating Neuronal Dysregulated Signaling Pathways: Recent Approaches to the Nanoformulations of Phytochemicals and Synthetic Drugs Against Neurodegenerative Diseases
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Sajad Fakhri, Sadaf Abdian, Seyede Nazanin Zarneshan, Seyed Zachariah Moradi, Mohammad Hosein Farzaei, and Mohammad Abdollahi
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Synthetic Drugs ,Phytochemicals ,Organic Chemistry ,apoptosis ,Biophysics ,therapeutic target ,Pharmaceutical Science ,Neurodegenerative Diseases ,Bioengineering ,Review ,General Medicine ,Biomaterials ,inflammation ,Neuroinflammatory Diseases ,Drug Discovery ,Humans ,Nanoparticles ,oxidative stress ,Tissue Distribution ,neuroprotection ,pharmacology ,Signal Transduction ,novel delivery system - Abstract
As the worldwide average life expectancy has grown, the prevalence of age-related neurodegenerative diseases (NDDs) has risen dramatically. A progressive loss of neuronal function characterizes NDDs, usually followed by neuronal death. Inflammation, apoptosis, oxidative stress, and protein misfolding are critical dysregulated signaling pathways that mainly orchestrate neuronal damage from a mechanistic point. Furthermore, in afflicted families with genetic anomalies, mutations and multiplications of α-synuclein and amyloid-related genes produce some kinds of NDDs. Overproduction of such proteins, and their excessive aggregation, have been proven in various models of neuronal malfunction and death. In this line, providing multi-target therapies carried by novel delivery systems would pave the road to control NDDs through simultaneous modulation of such dysregulated pathways. Phytochemicals are multi-target therapeutic agents, which employ several mechanisms towards neuroprotection. Besides, the blood–brain barrier (BBB) is a critical issue in managing NDDs since it inhibits the accessibility of drugs to the brain in sufficient concentration. Besides, discovering novel delivery systems is vital to improving the efficacy, bioavailability, and pharmacokinetic of therapeutic agents. Such novel formulations are also employed to improve the drug’s biodistribution, allow for the co-delivery of several medicines, and offer targeted intracellular delivery against NDDs. The present review proposes nanoformulations of phytochemicals and synthetic agents to combat NDDs by modulating neuroinflammation, neuroapoptosis, neuronal oxidative stress pathways and protein misfolding.
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- 2022
22. Evaluation of the effect of sofosbuvir and daclatasvir in hospitalized COVID-19 patients: a randomized double-blind clinical trial (DISCOVER)
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Atefeh Bonyadi, Fariborz Mansour-Ghanaei, Farhang Babamahmoodi, Esmat Radmanesh, Hadiseh Hosamirudsari, Javad Khodadadi, Sara Sayar, Zeinab Mehrabi, Amir Reza Bahadori, Shahin Merat, Minoo Moghimi, Gholamali Eslami, Hashem Mousavi, Lotfollah Davoodi, Mona Ebrahimzadeh, Farahnaz Joukar, Amir Anushiravani, Ali Ali Asgari, Ali Reza Davoudi Badabi, Elham Barahimi, Saeed Jelvay, Zahra Poormontaseri, Aida Zeinali, Nasim Khajavirad, Minoosh Shabani, Hamideh Abbaspour Kasgari, Zohreh Azarkar, Rohollah Moslemi, Ahmad Hormati, Azadeh Ebrahimzadeh, Hani Esmaeilian, Shokrollah Salmanzadeh, Elham Akbarpour, Lili Rezaie Keikhaie, Kaitlyn McCann, Amir Mohammad Shabani, Abdolali Tousi, Mohammad Abdollahi, Sara Mobarak, Mohammadreza Naghipour, Hadi Mirzaei, Mohammadreza Salehi, Shervin Shokouhi, Bryony Simmons, Morteza Mobarak, Helia Nateghi Baygi, Jacob Levi, Mehdi Hassaniazad, Andrew Hill, Zahra Arizavi, Nasrollah Hasooni Bahrini, Seyed Ali Dehghan Manshadi, Fatemeh Dehghani, Hannah Wentzel, Hossein Pourmasoomi, Masoome Noori Jangi, Shoeleh Yaghoubi, Alireza Nateghi Baygi, Mehdi Salasi, Farnaz Zolfaghari, Sara Yeganeh, Elmira Azimi, Jalal Karimi, Hafez Fakheri, Mahdi Afshari, Tofigh Yaghubi Kalurazi, Anahita Sadeghi, Farshid Abedi, Sajedeh Mousaviasl, Zahra Nekoukar, Dorsa Merat, and Masood Ziaee
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Adult ,Microbiology (medical) ,medicine.medical_specialty ,Pyrrolidines ,Randomization ,Daclatasvir ,Coronavirus disease 2019 (COVID-19) ,Sofosbuvir ,Placebo ,Antiviral Agents ,law.invention ,Randomized controlled trial ,law ,Internal medicine ,Clinical endpoint ,AcademicSubjects/MED00740 ,Humans ,Medicine ,Pharmacology (medical) ,Original Research ,Pharmacology ,SARS-CoV-2 ,business.industry ,Imidazoles ,COVID-19 ,Valine ,Institutional review board ,Clinical trial ,AcademicSubjects/MED00290 ,Treatment Outcome ,Infectious Diseases ,Relative risk ,Carbamates ,AcademicSubjects/MED00230 ,business ,medicine.drug - Abstract
Background: The combination of sofosbuvir (SOF) and daclatasvir (DCV) has shown preliminary efficacy for patients with COVID-19 in five open-label studies with small sample sizes. This larger trial aimed to assess if the addition of sofosbuvir and daclatasvir to standard care improved clinical endpoints in hospitalized patients with moderate or severe COVID-19. Methods: This was a placebo-controlled, randomized clinical trial in adults with moderate or severe COVID-19 admitted to 19 hospitals in Iran. Patients were randomized to SOF/DCV 400/60mg once-daily or placebo in addition to standard of care. Patients were included if they had positive PCR or diagnostic chest CT, O 2 saturation
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- 2021
23. The Effect of Levosimendan on Phosphine-Induced Nephrotoxicity: Biochemical and Histopathological Assessment
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Maryam Armandeh, Mohammad Abdollahi, Ramtin Farhadi, Mahban Rahimifard, Maryam Baeeri, Behnaz Bameri, Hamed Haghi-Aminjan, and Madiha Khalid
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Necrosis ,Phosphines ,Pharmacology ,Kidney ,medicine.disease_cause ,Nephrotoxicity ,Lipid peroxidation ,chemistry.chemical_compound ,Drug Discovery ,medicine ,Animals ,Blood urea nitrogen ,Simendan ,biology ,business.industry ,Heart ,General Medicine ,Rats ,Oxidative Stress ,medicine.anatomical_structure ,chemistry ,Myeloperoxidase ,Toxicity ,biology.protein ,medicine.symptom ,Reactive Oxygen Species ,business ,Oxidative stress - Abstract
Background Aluminum phosphide (AlP) toxicity is associated with a high risk of death due to heart, liver, and kidney failure as the target organs. Phosphine gas released due to the ingestion is the main factor involved in the multi-organ failure with various mechanisms. Levosimendan (LEV) is a calcium sensitizer with a pleiotropic effect on multiple organs. This study aimed to investigate whether LEV can alleviate AlP-induced nephrotoxicity in the rat model. Method Six groups included control group (almond oil only), sole LEV group (48 µg/kg), AlP group (LD50=10 µg/kg), and the poisoned groups treated with LEV at doses of 12, 24, and 48 µg/kg 30 min after AlP gavage. After 24 hours of treatment, serum and kidney samples were taken for biochemical and histopathological analyses. Result Biochemical analysis of the AlP group showed that the activity of complexes I, II, and IV was significantly reduced, while the levels of lipid peroxidation (LPO) and reactive oxygen species (ROS), lactate, and myeloperoxidase (MPO) activity significantly increased. Also, AlP reduced live renal cells and elevated necrosis. However, the levels of serum creatinine and blood urea nitrogen were not affected by the poisoning. LEV co-treatment could increase mitochondrial complex activity and reduce MPO activity, LPO, ROS, and lactate levels. Additionally, the histopathological analysis showed the detrimental effects of AlP on kidney tissue, which was mitigated by LEV administration. Conclusion Our findings showed that LEV can potentially improve oxidative stress, imbalance in the redox status, necrosis, and pathological injuries in kidney tissue following AlP-poisoning.
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- 2021
24. A systematic review on the role of melatonin and its mechanisms on diabetes-related reproductive impairment in non-clinical studies
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Maryam Armandeh, Behnaz Bameri, Hamed Haghi-Aminjan, Roham Foroumadi, Mahshid Ataei, Shokoufeh Hassani, Mahedeh Samadi, Mohammad Reza Hooshangi Shayesteh, and Mohammad Abdollahi
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Endocrinology, Diabetes and Metabolism - Abstract
BackgroundDiabetes-induced reproductive complications can lead to subfertility and infertility, raising the need to protect reproductive organs. There are limited medications used to improve reproductive health in diabetic patients. Melatonin, mainly produced by the pineal gland, may improve diabetes-associated reproductive complications through various mechanisms and may be a preferred candidate to protect the reproductive system. The present review aims to elucidate the underlying mechanisms of melatonin’s effect on the reproductive system adversely affected by diabetes mellitus (DM).MethodsA comprehensive systematic literature electronic search was done using the PRISMA guidelines. Web of Science, PubMed, Embase, and Scopus were searched for publications up to June 2022. Search terms were selected based on the study purpose and were explored in titles and abstracts. After screening, out of a total of 169 articles, 14 pertinent articles were included based on our inclusion and exclusion criteria.ResultsThe results of studies using rats and mice suggest that DM adversely affects reproductive tissues, including testes and epididymis, prostate, corpus cavernosum, and ovary leading to alterations in histological and biochemical parameters compared to the normal groups. Treatment with melatonin improves oxidative stress, blocks apoptosis induced by endoplasmic reticulum stress and caspase activation, reduces pro-inflammation cytokines, and enhances steroidogenesis.ConclusionMelatonin exerted a protective action on the impaired reproductive system in in-vivo and in-vitro models of DM. The topic has to be followed up in human pregnancy cases that will need more time to be collected and approved.
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- 2022
25. The electrocardiographic, hemodynamic, echocardiographic, and biochemical evaluation of treatment with edaravone on acute cardiac toxicity of aluminum phosphide
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Nader, Rahimi Kakavandi, Tayebeh, Asadi, Mohammad Reza, Hooshangi Shayesteh, Maryam, Baeeri, Mahban, Rahimifard, Amir, Baghaei, Marzieh, Noruzi, Mohammad, Sharifzadeh, and Mohammad, Abdollahi
- Subjects
Pharmacology ,Pharmacology (medical) - Abstract
Aluminum phosphide (AlP) poisoning can be highly fatal due to its severe toxicity to the heart. Based on the evidence, edaravone (EDA) has protective effects on various pathological conditions of the heart. This research aimed to examine the potential protective effects of EDA on AlP-induced cardiotoxicity in rats. The rats were divided into six groups, including almond oil (control), normal saline, AlP (LD50), and AlP + EDA (20, 30, and 45 mg/kg). Thirty minutes following AlP poisoning, the electrocardiographic (ECG), blood pressure (BP), and heart rate (HR) parameters were examined for 180 min. The EDA was injected 60 min following the AlP poisoning intraperitoneally. Also, 24 h after poisoning, echocardiography was carried out to evaluate the ejection fraction (EF), stroke volume (SV), and cardiac output (CO). The biochemical and molecular parameters, such as the activities of the mitochondrial complexes, reactive oxygen species (ROS), apoptosis and necrosis, and troponin I and lactate levels, were also examined after 12 and 24 h in the heart tissue. According to the results, AlP-induced ECG abnormalities, decrease in blood pressure, heart rate, SV, EF%, and CO were significantly improved with EDA at doses of 30 and 45 mg/kg. Likewise, EDA significantly improved complex I and IV activity, apoptosis and necrosis, ROS, troponin I, and lactate levels following AlP-poisoning (p < 0.05). Also, the mean survival time was increased following EDA treatment, which can be attributed to the EDA’s protective effects against diverse underlying mechanisms of phosphine-induced cardiac toxicity. These findings suggest that EDA, by ameliorating heart function and modulating mitochondrial activity, might relieve AlP-induced cardiotoxicity. Nonetheless, additional investigations are required to examine any potential clinical advantages of EDA in this toxicity.
- Published
- 2022
26. The pharmacotherapeutic management of duodenal and gastric ulcers
- Author
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Taraneh Mousavi, Shekoufeh Nikfar, and Mohammad Abdollahi
- Subjects
medicine.medical_specialty ,Cochrane Library ,Helicobacter Infections ,chemistry.chemical_compound ,Pharmacotherapy ,Antibiotic resistance ,Health care ,medicine ,Humans ,Pharmacology (medical) ,Stomach Ulcer ,Intensive care medicine ,Adverse effect ,Pharmacology ,Helicobacter pylori ,biology ,business.industry ,Ilaprazole ,Proton Pump Inhibitors ,General Medicine ,biology.organism_classification ,Anti-Bacterial Agents ,Clinical trial ,chemistry ,business - Abstract
INTRODUCTION Although the incidence and prevalence of duodenal and gastric ulcers have been declining, it remains challenging for health care systems. Based on the underlying cause, history, and characteristics of ulcers, management is generally provided by administering proton pump inhibitors (PPIs) or antibiotics. AREAS COVERED This article is based on global guidelines and English language literature from the past decade obtained through searches using PubMed, Clinicaltrials.gov, the US FDA, and the Cochrane library. Using a stepwise approach, dose and duration of treatment, drug interactions, warnings and contraindications, adverse effects, and administration points were specified. New drug candidates that may get American and European approvals were also introduced. EXPERT OPINION Despite the wide use of PPIs, their development lags behind the clinical need. There is an absolute requirement to develop third-generation PPIs with higher potency and improved pharmacokinetic and safety profiles. Regarding the antibiotic resistance crisis, including those used against H. pylori, conducting more clinical trials and investigating regional antibiotic resistance are warranted. Potassium competitive acid blockers, ilaprazole, and an H. pylori vaccine all show promise for the future.
- Published
- 2021
27. A Novel Clustering Protocol Based on Willow Butterfly Algorithm for Diffusing Data in Wireless Sensor Networks
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Mohammad Abdollahi Azgomi, Shayesteh Tabatabaei, Mohammad Reza Ebrahimi Dishabi, and Alireza Allahverdi Mamaghani
- Subjects
Routing protocol ,Computer science ,business.industry ,ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS ,Encryption ,Computer Science Applications ,Base station ,Node (computer science) ,Wireless ,Electrical and Electronic Engineering ,Routing (electronic design automation) ,business ,Cluster analysis ,Algorithm ,Wireless sensor network - Abstract
Mobile sensor networks consist of a set of mobile sensor nodes, which establish wireless communications within a specific area. In WSNs, mobile sensor nodes can sense the physical status of a given environment, process information and report them to the sink node or the base station. Due to nodes’ movements, these networks do not have a fixed infrastructure. There is no centralized controlling infrastructure for wireless sensor networks and different nodes are at relative liberty for joining and leaving network. Furthermore, due to the specific applications of these networks, it is highly probable that malicious nodes may exist in the network. The available malicious nodes in these networks do not follow the general principles, which dominate the execution of the routing protocols. They make hostile changes and abuse the rules, so as to disrupt the normal functioning of the routing protocols. In this way, malicious nodes aim to demolish the network or they refuse to cooperate fully with other available nodes in the network so that they can preserve their own limited energy. Consequently, they would like to destroy the possibility for providing services for some users. In order to ensure routing security in sensor networks and consider their fundamental challenge, i.e. nodes’ optimal power consumption, we proposed clustering-based secure routing protocol by capitalizing on willow butterfly algorithm. It has three phases, i.e. clustering, encryption and routing. The results of simulating the proposed method using OPNET showed its better performance in terms of power consumption, data transmission delay and access delay to media, data-packet loss rate by destructive nodes and productivity rate.
- Published
- 2021
28. Senolytic Effect of Cerium Oxide Nanoparticles (CeO2 NPs) by Attenuating p38/NF-кB, and p53/p21 Signaling Pathways
- Author
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Hamed Haghi-Aminjan, Mohammad Reza Hooshangi Shayesteh, Mahban Rahimifard, Madiha Khalid, Maryam Baeeri, Mohammad Abdollahi, and Elaheh Mahdizadeh
- Subjects
Senescence ,chemistry.chemical_classification ,Reactive oxygen species ,Cell cycle checkpoint ,Cell ,General Chemistry ,Condensed Matter Physics ,medicine.disease_cause ,Biochemistry ,Cell cycle phase ,Cell biology ,Lipid peroxidation ,chemistry.chemical_compound ,medicine.anatomical_structure ,chemistry ,medicine ,General Materials Science ,Signal transduction ,Oxidative stress - Abstract
Oxidative stress induces cell senescence and aging. Cell senescence is an irreversible cell cycle arrest mechanism responsible for various pathological diseases and aging. Cerium oxide nanoparticles (CeO2 NPs) have been found to have anti-oxidant effects with a capacity to scavenge free radicals. With this background, we aimed to investigate the senolytic property of CeO2 NPs on mouse embryonic fibroblasts (NIH3T3). NIH3T3 cells were exposed to CeO2 NPs with or without hydrogen peroxide (H2O2). The senolytic effect of CeO2 NPs was evaluated by measuring reactive oxygen species (ROS) production, lipid peroxidation (LPO), β-galactosidase, cell cycle phase analysis, and expression of p21, p38, p53, and NF-кB genes. EC50 of CeO2 NPs significantly reduced the β-galactosidase activity in NIH3T3 cells without apparent cytotoxicity and generation of ROS. Also, it decreased LPO, and expression of IL-6. The number of cells increased significantly, indicating that CeO2 NPs can reverse cell senescence and cell cycle arrest in the S phase. Also, p21, p38, p53, and NF-кB gene expressions were significantly down-regulated. CeO2 NPs as a senolytic or inhibitor of senescence can attenuate the senescence-inducing signal transduction pathways, i.e., p38/ NF-кB and p53/p21. It reduced the production of ROS and LPO and the expression of IL-6.
- Published
- 2021
29. Targeting miRNA by Natural Products: A Novel Therapeutic Approach for Nonalcoholic Fatty Liver
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Mohammad Hosein Farzaei, Fatemeh Parvizi, Mohammad Bagher Majnooni, Mohammad Abdollahi, Mehdi Zobeiri, and Mohammad Reza Kalhori
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Fatty liver ,Lipid metabolism ,Context (language use) ,Review Article ,Biology ,Chronic liver disease ,medicine.disease ,Bioinformatics ,digestive system diseases ,Other systems of medicine ,Insulin resistance ,Complementary and alternative medicine ,microRNA ,Nonalcoholic fatty liver disease ,Gene expression ,medicine ,RZ201-999 - Abstract
The increasing prevalence of nonalcoholic fatty liver disease (NAFLD) as multifactorial chronic liver disease and the lack of a specific treatment have begun a new era in its treatment using gene expression changes and microRNAs. This study aimed to investigate the potential therapeutic effects of natural compounds in NAFLD by regulating miRNA expression. MicroRNAs play essential roles in regulating the cell’s biological processes, such as apoptosis, migration, lipid metabolism, insulin resistance, and adipocyte differentiation, by controlling the posttranscriptional gene expression level. The impact of current NAFLD pharmacological management, including drug and biological therapies, is uncertain. In this context, various dietary fruits or medicinal herbal sources have received worldwide attention versus NAFLD development. Natural ingredients such as berberine, lychee pulp, grape seed, and rosemary possess protective and therapeutic effects against NAFLD by modifying the gene’s expression and noncoding RNAs, especially miRNAs.
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- 2021
30. Association of maternal intake of nitrate and risk of birth defects and preterm birth: a systematic review and dose-response meta-analysis
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Morteza Abyadeh, Nader Rahimi Kakavandi, Tayebeh Asadi, Ahmad Habibian Sezavar, Mohammad Abdollahi, Habib Yarizadeh, and Motahareh Hashemi Moosavi
- Subjects
medicine.medical_specialty ,Nitrates ,business.industry ,Obstetrics ,Cleft Lip ,Health, Toxicology and Mutagenesis ,Infant, Newborn ,Public Health, Environmental and Occupational Health ,Infant ,Heart defect ,Toxicology ,chemistry.chemical_compound ,Nitrate ,chemistry ,Meta-analysis ,Humans ,Premature Birth ,Medicine ,Female ,business ,Analysis method ,General Environmental Science - Abstract
In this study, the high versus low analysis method was applied to evaluate the association of maternal nitrate intake and risk of heart defect, limb deficiency, cleft lip, and preterm birth. Also, linear and non-linear dose-response associations between maternal intake of nitrate and risk of heart defects were investigated. In high versus low intake, the risk of heart defects in infants is directly associated with the level of nitrate exposure, but no significant relationship was found between the cleft lip, limb deficiency, and preterm birth. The linear dose-response meta-analysis was associated with risk of heart defects (RR: 1.03; 95% CI: 1.00 to 1.05, P = 0.400, I2= 0%, P heterogeneity= 0.602, n = 3) and nonlinear dose-response meta-analysis showed that maternal intake of nitrate higher than ∼4 mg/day is positively associated with heart defects risk (P non-linearity= 0.012).
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- 2021
31. Effect of Antihypertensive Drugs on Cognition and Behavioral Symptoms of Patients with Alzheimer’s Disease: A Meta-analysis
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Shekoufeh Nikfar, Mohammad Hosein Farzaei, Reza Heidary Moghaddam, Roja Rahimi, Mohammad Abdollahi, and Masoud Sadeghi
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medicine.medical_specialty ,business.industry ,MEDLINE ,Pharmaceutical Science ,Disease ,Cochrane Library ,Placebo ,Jadad scale ,law.invention ,Randomized controlled trial ,law ,Meta-analysis ,Internal medicine ,Clinical Global Impression ,Medicine ,business ,Biotechnology - Abstract
Background: It has been found that there is a link between hypertension and elevated risk of Alzheimer’s Disease (AD). Herein, a meta-analysis based on Randomized Clinical Trials (RCTs) was used to assess the effect of antihypertensive drugs on cognition and behavioral symptoms of AD patients. Methods: The three databases, PubMed/Medline, Scopus, and Cochrane Library, were searched up to March 2020. The quality of the studies included in the meta-analysis was evaluated by the Jadad score. Clinical Global Impression of Change (CGIC) included in two studies, Mini-Mental State Examination (MMSE) included in three studies, and Neuropsychiatric Inventory (NPI) in three studies were the main outcomes in this systematic review. Results: Out of 1506 studies retrieved in the databases, 5 RCTs were included and analyzed in the meta-analysis. The pooled mean differences of CGIC, MMSE, and NPI in patients with AD receiving antihypertensive drugs compared to placebo were -1.76 with (95% CI = -2.66 to -0.86; P=0.0001), 0.74 (95% CI = 0.20 to 1.28; P= 0.007), and -9.49 (95% CI = -19.76 to 0.79; P = 0.07), respectively. Conclusion: The findings of the present meta-analysis show that antihypertensive drugs may improve cognition and behavioral symptoms of patients with AD. However, more well-designed RCTs with similar drugs are needed to achieve more conclusive results.
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- 2021
32. The role of levosimendan in phosphine-induced cardiotoxicity: evaluation of electrocardiographic, echocardiographic, and biochemical parameters
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Mahban Rahimifard, Maryam Baeeri, Behnaz Bameri, Rohollah Hosseini, Mahedeh Samadi, Mohammad Abdollahi, Majid Masoudi Fard, Madiha Khalid, Hamed Haghi-Aminjan, Mohammad Reza Hooshangi Shayesteh, Shokoufeh Hassani, and Maryam Armandeh
- Subjects
Cardiotoxicity ,medicine.medical_specialty ,Phosphines ,business.industry ,musculoskeletal, neural, and ocular physiology ,Health, Toxicology and Mutagenesis ,food and beverages ,Levosimendan ,Toxicology ,Rats ,Electrocardiography ,chemistry.chemical_compound ,chemistry ,Echocardiography ,Internal medicine ,Aluminum phosphide ,cardiovascular system ,Cardiology ,Animals ,Medicine ,Rats, Wistar ,business ,Simendan ,Phosphine ,medicine.drug - Abstract
Aluminum phosphide (AlP) causes serious poisoning in which severe cardiac suppression is the significant lethal consequence. According to evidence, levosimendan can exert outstanding cardiac support and protection in different pathological conditions. This study aimed to investigate the mechanisms by which levosimendan may alleviate cardiovascular toxicity due to AlP intoxication in the rat model. The groups included control group (normal saline only), sole levosimendan groups (12, 24, 48 μg/kg), AlP group (10 mg/kg), and AlP + levosimendan groups receiving 12, 24, 48 μg/kg levosimendan intraperitoneally 30 min after AlP administration. Electrocardiographic (ECG) parameters (QRS and PR duration and ST height), heart rate, and blood pressure were monitored for 180 minutes. Also, after 24 h of poisoning, echocardiography was applied to assess left ventricle function. Evaluation of the biochemical parameters in heart tissue, including mitochondrial complexes I, II, IV activity, ADP/ATP ratio, the rate of apoptosis, malondialdehyde (MDA), lactate, and troponin I levels, were done after 12 and 24 h. AlP-induced ECG abnormalities (PR duration and ST height), reduction in heart rate, blood pressure, cardiac output, ejection fraction, and stroke volume were improved by levosimendan administration. Besides, levosimendan significantly improved complex IV activity, the ADP/ATP ratio, apoptosis, MDA, lactate, and troponin I level following AlP-poisoning. Our results suggest that levosimendan might alleviate AlP-induced cardiotoxicity by modulating mitochondrial activity and improving cardiac function. However, the potential clinical use of levosimendan in this toxicity needs more investigations.
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- 2021
33. Vinpocetine Effect on the Juncture of Diabetes and Aging: An in-vitro study
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Mohammad Abdollahi, Maryam Baeeri, Mahban Rahimifard, Hamed Haghi-Aminjan, Shermineh Moini-Nodeh, and Mahshid Hodjat
- Subjects
0301 basic medicine ,Metabolite ,Population ,Vincamine ,Inflammation ,Pharmacology ,medicine.disease_cause ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Vinpocetine ,Diabetes mellitus ,Drug Discovery ,Diabetes Mellitus ,medicine ,Animals ,Humans ,education ,Vinca Alkaloids ,Aged ,education.field_of_study ,geography ,geography.geographical_feature_category ,business.industry ,NF-kappa B ,General Medicine ,medicine.disease ,Islet ,Rats ,Oxidative Stress ,030104 developmental biology ,chemistry ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Oxidative stress ,medicine.drug - Abstract
The rapid-growing population of diabetic patients and the elderly are among the direst challenges that the science of medicine is facing today. Targeting these two challenges can shed light on new means to control and ideally reverse this trend. In this experiment, Vinpocetine's effect on aged pancreatic beta-cell functions in correlation with oxidative stress was studied.Islet cells were isolated from the pancreas of aged rats and exposed to Vinpocetine, dissolved in acetone and RPMI, for 48 h. Then, senescence-associated molecular parameters, includingExperimental results showed that Vinpocetine could significantly increase aged islets insulin secretion and also make a meaningful reduction in oxidative stress markers. This drug can also decrease expression levels ofThe current study showed that Vinpocetine, a derivative of the secondary plant metabolite called Vincamine, could break this vicious cycle of oxidative stress and aging by reducing oxidative stress and inflammation, thus inhibiting cellular aging.The rapid-growing population of diabetic patients and the elderly are among the direst challenges that the science of medicine is facing today. Targeting these two challenges can shed light on new means to control and ideally reverse this trend. In this experiment, Vinpocetine’s effect on aged pancreatic beta-cell functions in correlation with oxidative stress was studied.Islet cells were isolated from the pancreas of aged rats and exposed to Vinpocetine, dissolved in acetone and RPMI, for 48 h. Then, senescence-associated molecular parameters, includingExperimental results showed that Vinpocetine could significantly increase aged islets insulin secretion and also make a meaningful reduction in oxidative stress markers. This drug can also decrease expression levels ofThe current study showed that Vinpocetine, a derivative of the secondary plant metabolite called Vincamine, could break this vicious cycle of oxidative stress and aging by reducing oxidative stress and inflammation, thus inhibiting cellular aging.
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- 2021
34. Comprehensive study on the administrative, economic, regional, and regulatory prospects of complementary and alternative medicine (CAM) in inflammatory bowel disease (IBD)
- Author
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Taraneh Mousavi, Mohammad Abdollahi, and Shekoufeh Nikfar
- Subjects
Complementary Therapies ,medicine.medical_specialty ,business.industry ,Cost-Benefit Analysis ,Age Factors ,Alternative medicine ,General Medicine ,Cost-effectiveness analysis ,Inflammatory Bowel Diseases ,medicine.disease ,Inflammatory bowel disease ,digestive system diseases ,Sex Factors ,Epidemiology ,medicine ,Humans ,Pharmacology (medical) ,General Pharmacology, Toxicology and Pharmaceutics ,Intensive care medicine ,business ,Adverse effect ,health care economics and organizations - Abstract
Due to the high cost, low effectiveness, and adverse effects plus the life-long nature of inflammatory bowel disease (IBD), and misconception on safety, efficacy, and cost-effectiveness of compleme...
- Published
- 2021
35. Serpin A12 (Vaspin) as a Serine Protease Inhibitor
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Armin Salek Maghsoudi, Shokoufeh Hassani, Kayvan Mirnia, and Mohammad Abdollahi
- Published
- 2022
36. Synthesis, characterization and application of magnetic mesoporous Fe3O4@Fe-Cu/MCM‐41 as efficient and recyclable nanocatalyst for the Buchwald-Hartwig C-N cross-coupling reaction
- Author
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Mohammad Abdollahi-Alibeik and Zahra Ramazani
- Subjects
General Chemistry - Published
- 2022
37. Comparison of the safety and efficacy of fingolimod and tofacitinib in the zebrafish model of colitis
- Author
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Taraneh Mousavi, Shokoufeh Hassani, Maryam Baeeri, Mahban Rahimifard, Faezeh Vakhshiteh, Mahdi Gholami, Elmira Ghafour-Broujerdi, and Mohammad Abdollahi
- Subjects
Trinitrobenzenesulfonic Acid ,Fingolimod Hydrochloride ,Myeloid Differentiation Factor 88 ,Animals ,General Medicine ,Toxicology ,Colitis ,Inflammatory Bowel Diseases ,Zebrafish ,Food Science - Abstract
Oral targeted small molecules, including sphingosine 1 phosphate receptor (S1PR) modulators and tyrosine kinase inhibitors (TKIs), seem to revolutionize the management of inflammatory bowel disease (IBD). To select the most effective treatment, there is an unmet need to comparatively study their mechanism of action, efficacy, and toxicity in the preclinical stage and further translate it into clinical practice.Using 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced adult zebrafish colitis model, LC50 of fingolimod and tofacitinib were determined based on the acute toxicity test to compare aquatic toxicity potential. Subsequently, the efficacy of different concentrations of tofacitinib and fingolimod was compared using flow cytometry, qPCR, and histopathology analyses.TNBS significantly reduced the length of villi, and the number of goblet cells increased the level of TNF-α, MyD88, and NF-κB2, the thickness of villi and necrosis, and induced histopathological changes. All of these parameters were reversed almost dose-dependently with both medications, with the highest concentration of fingolimod being superior to other groups. Additionally, results from qPCR analysis suggested that these medications might suppress canonical and non-canonical NF-κB pathways by targeting toll-like receptors and MyD88. LC50 of tofacitinib and fingolimod was 0.9014 and 0.36 mg/L, respectively. Hence, both are in the cory 1 of the Global Harmonization System (GHS) aquatic toxicity and are toxic to adult zebrafish life.Given the better efficacy of fingolimod, it is worth translating the effectiveness and safety of S1PR modulators into IBD patients and comparing them with TKIs in head-to-head studies; albeit, their toxicity should not be overlooked.
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- 2022
38. A numerical evaluation of a latent heat thermal energy storage system in the presence of various types of nanoparticles
- Author
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Mohammad Abdollahi-Moghaddam and Masoud Rahimi
- Subjects
Energy Engineering and Power Technology ,Industrial and Manufacturing Engineering - Published
- 2023
39. Study on the Interaction of 1,5-diaryl Pyrrole Derivatives with α-glucosidase; Synthesis, Molecular Docking, and Kinetic Study
- Author
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Ebrahim Saeedian Moghadam, Tadesse Bekele Tafesse, Mohammad Ali Faramarzi, Mohammed Bule, Mohsen Amini, and Mohammad Abdollahi
- Subjects
biology ,Stereochemistry ,Binding energy ,In vitro ,Enzyme assay ,chemistry.chemical_compound ,Postprandial ,chemistry ,Docking (molecular) ,Drug Discovery ,Mole ,biology.protein ,medicine ,Pyrrole ,Acarbose ,medicine.drug - Abstract
Background: The delaying of absorption of glucose is one of the principal therapeutic approaches of type 2 diabetes. α-glucosidase inhibitors compete with the α-glucosidase enzyme activity, which helps to reduce the conversion of carbohydrates into glucose and thereby control the postprandial hyperglycemia incidence. Objective: The aim of this study was to synthesize a series of novel 1,5-diphenyl pyrrole derivatives and evaluate their in vitro α-glucosidase inhibitory activities. Methods: Compounds were synthesized through a multistep reaction and were evaluated for α- glucosidase inhibitory activities. Molecular docking and kinetic studies were carried out to predict the mode of binding and mechanism of inhibition for the most active compounds, 5g and 5b, against α-glucosidase. Results: Synthesized compounds showed good in vitro α-glucosidase inhibitory activity with IC50 values in the range of (117.5 ± 3.8 to 426.0 ± 10.2 μM) as compared to acarbose, the standard drug, (750 ± 8.7 μM). Compound 5g (117.5 ± 3.8 μM) ascertained as the most potent inhibitor of α-glucosidase in a competitive mode. The binding energies of compounds 5g and 5b (119.0 ± 7.5 μM), as observed from the best docking conformations, indicate that they have a lower free binding energy (-3.26 kcal/mol and -3.0 kcal/mol, respectively) than acarbose (2.47 kcal/mol). Conclusion: The results of our study revealed that the synthesized compounds are a potential candidate for α-glucosidase inhibitors for the management of postprandial hyperglycemia for further investigation.
- Published
- 2021
40. Combined effect of β-aminobutyric acid and silver nanoparticles on eggplants, Solanum melongena, infected with Meloidogyne javanica
- Author
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Samaneh S. Shekoohi, Habiballah Charehgani, Mohammad Abdollahi, and Hamid Reza Rajabi
- Subjects
Nematology ,Horticulture ,Melongena ,biology ,Solanum ,biology.organism_classification ,Agronomy and Crop Science ,Aminobutyric acid ,Ecology, Evolution, Behavior and Systematics ,Silver nanoparticle ,Meloidogyne javanica - Abstract
Summary The acquired resistance of plants to root-knot nematodes (Meloidogyne spp.) can be achieved by applying chemical inducers, such as β-aminobutyric acid (BABA). Recently, the use of metal nanoparticles with multifunctional use against plant-parasitic nematodes has been presented. In this study, silver nanoparticles (AgNPs) were synthesised using the aqueous leaf extract of Malva sylvestris. The effect of different AgNPs concentrations on hatching and mortality of the second-stage juveniles (J2) of Meloidogyne javanica was investigated in vitro. The effects of AgNPs on eggplants infected with 0, 1, 2, 4 and 8 eggs (cm3 soil)−1 were investigated under glasshouse conditions. The combined effects of AgNPs and BABA on eggplants infected with 4 and 8 eggs (cm3 soil)−1 were investigated in another study. The results showed that increasing the concentration of AgNPs the hatching of M. javanica decreased and the mortality of J2 increased. The number of eggs, galls, egg masses and reproduction factor in plants treated with AgNPs infected with 4 eggs (cm3 soil)−1 decreased by 43.4, 24.7, 23.5 and 43.2%, and in plants infected with 8 eggs (cm3 soil)−1, decreased by 64.5, 25.5, 63.1 and 64.5%, respectively, compared to control plants. The reproduction factor in infected plants with 4 and 8 eggs (cm3 soil)−1 that were treated with BABA (1 mM) and AgNPs decreased by 51.6 and 55.9%, respectively, compared to control plants. The results of this study demonstrated the effects of BABA, AgNPs and the combination of these two substances in reducing the damage of different inoculum densities of M. javanica in eggplant.
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- 2021
41. Antidiabetic and neuroprotective effects of a novel repaglinide analog
- Author
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Roham Foroumadi, Maryam Baeeri, Sara Asgarian, Zahra Emamgholipour, Fereshteh Goli, Loghman Firoozpour, Mohammad Keykhaei, Mahdi Gholami, Ahmad R. Dehpour, Mohammad Abdollahi, and Alireza Foroumadi
- Subjects
Blood Glucose ,Health, Toxicology and Mutagenesis ,Glucose Transport Proteins, Facilitative ,Toxicology ,Biochemistry ,Antioxidants ,Diabetes Mellitus, Experimental ,Adenosine Triphosphate ,Glutamate Dehydrogenase ,KATP Channels ,Piperidines ,Glucokinase ,Animals ,Hypoglycemic Agents ,Insulin ,RNA, Messenger ,Hematoxylin ,Molecular Biology ,Secretagogues ,General Medicine ,Benzoic Acid ,Rats ,Molecular Docking Simulation ,Oxidative Stress ,Neuroprotective Agents ,Potassium ,Eosine Yellowish-(YS) ,Molecular Medicine ,Carbamates ,Reactive Oxygen Species ,Biomarkers - Abstract
Repaglinide (RPG) is an oral insulin secretagogue used in the treatment of diabetes. In this study, a new RPG analog was synthesized. Its antidiabetic and neuroprotective effects on dorsal root ganglions (DRG) in streptozotocin (STZ)-induced diabetic rats were examined compared to RPG. To assess the effects of 2-methoxy-4-(2-((3-methyl-1-(2-(piperidin-1-yl)phenyl)butyl)amino)-2-oxoethoxy)benzoic acid (OXR), the impact of OXR on oxidative stress biomarkers, motor function, and the expression of the glutamate dehydrogenase 1 (GLUD1), SLC2A2/glucose transporter 2 (GLUT2), and glucokinase (GCK) genes in STZ-induced diabetic rats were assessed. DRGs were examined histologically using hemotoxylin and eosin staining. Molecular docking was used to investigate the interactions between OXR and the binding site of RPG, the ATP-sensitive potassium (KATP) channel. Following 5 weeks of treatment, OXR significantly increased the level of total antioxidant power, decreased reactive oxygen species, and lipid peroxidation in the DRGs of diabetic rats. OXR restored STZ-induced pathophysiological damages in DRG tissues. Administration of OXR improved motor function of rats with diabetic neuropathy. Administration of 0.5 mg/kg OXR reduced blood glucose while promoting insulin, mainly through upregulation of messenger RNA expression of GLUD1, GLUT2, and GCK in the pancreas. Molecular docking revealed a favorable binding mode of OXR to the KATP channel. In conclusion, OXR has neuroprotective effects in diabetic rats by lowering oxidative stress, lowering blood glucose, and stimulating insulin secretion. We report that 0.5 mg/kg OXR administration was the most effective concentration of the compound in this study. OXR may be a promising target for further research on neuroprotective antidiabetic molecules.
- Published
- 2022
42. A Model for Power-Performance Optimization in Fog-Cloud Environment by Task Off-Loading of IoT Applications
- Author
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Rojin Naseri, Ali Naghash Asadi, and Mohammad Abdollahi Azgomi
- Published
- 2022
43. Microfluidically fabricated fibers containing pancreatic islets and mesenchymal stromal cells improve longevity and sustained normoglycemia in diabetic rats
- Author
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Mona Navaei-Nigjeh, Soheyl Mirzababaei, Mohammad Adel Ghiass, Kaveh Roshanbinfar, Mahdi Gholami, and Mohammad Abdollahi
- Subjects
Longevity ,Biomedical Engineering ,Islets of Langerhans Transplantation ,Bioengineering ,Mesenchymal Stem Cells ,General Medicine ,Biochemistry ,Rats ,Diabetes Mellitus, Experimental ,Biomaterials ,Islets of Langerhans ,Diabetes Mellitus, Type 1 ,Animals ,Insulin ,Rats, Wistar ,Biotechnology - Abstract
Type 1 diabetes mellitus is an autoimmune disease characterized by the loss of pancreatic islet β cells. Insulin injections and pancreas transplants are currently available therapies. The former requires daily insulin injections, while the latter is constrained by donor organ availability. Islet transplantation is a promising alternative treatment for type 1 diabetes mellitus that may overcome the limitations of previous techniques. Two challenges, however, must be addressed: limited cell retention as a result of the immune response and limited function of the transplanted cells that survive. To address these problems, we developed a microfluidic technology for a one-step generation of islet-laden fibers to protect them from the immune response. This approach enables continuous generation of microfibers with a diameter suitable for islet encapsulation (275 µm). We, then, transplanted islet-laden fibers into diabetic Wistar rats. While islet-laden fibers alone were unable to restore normoglycemia in diabetic rats, adding mesenchymal stromal cells (MSCs) restored normoglycemia for an extended time. It increased the animals’ lifespan by up to 75 d. Additionally, it improved the glucose-stimulated response of islets to the point where there was no significant difference between the treatment group and the healthy animals. Additionally, the presence of MSCs suppressed the immune response, as seen by decreased levels of pro-inflammatory cytokines such as tumor necrosis factor-α. Taken together, these fibers including islet and MSCs provide a versatile platform for concurrently improving cell preservation and functioning following in vivo transplantation.
- Published
- 2022
44. Comparison of the Safety and Efficacy of Tofacitinib and Fingolimod in TNBS‐Induced Colitis Model in Adult Zebrafish: The Role of Myd88/NF‐κB/TNF‐α Signaling Pathway
- Author
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Taraneh Mousavi, Shokoufeh Hassani, Mahdi Gholami, Faezeh Vakhshiteh, Maryam Baeeri, Mahban Rahimifard, Elmira Ghafour‐Broujerdi, and Mohammad Abdollahi
- Subjects
Genetics ,Molecular Biology ,Biochemistry ,Biotechnology - Published
- 2022
45. Biological Control Agents in the Management of Different Initial Population Densities of Meloidogyne javanica in Tomato
- Author
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Habiballah Charehgani, Rasool Rezaei, Mohammad Abdollahi, and L. Mosahaneh
- Subjects
Horticulture ,biology ,Insect Science ,Biological pest control ,Plant Science ,biology.organism_classification ,Population density ,Meloidogyne javanica - Abstract
The efficacy of single and combined application of Trichoderma harzianum and Pseudomonas fluorescens (CHA0) in the controlling of Meloidogyne javanica on tomato plants was evaluated under green house conditions. Seeds of the susceptible tomato cv. Early-Urbana were sown in clean plastic pots containing 1.5 kg steam sterilized soil. Four weeks after planting, the soil of each pot was infested with a suspension of 20 ml/kg soil of T. harzianum (106 spores/ ml) and a suspension of 15 ml/kg soil of P. fluorescens (CHA0) (108 CFU/ ml). Soil of other pots were infested with the two tested bio-agents together as a combined application. Seven days later, plants in all pots, except the controls, were inoculated with M. javanica at initial population densities of 1, 2 or 4 eggs/ cm3 soil. Sixty days after nematode inoculation, the parameters of plant growth and nematode reproduction were determined. Results showed that the nematode reproduction factor (Rf) on the plants infected with 1, 2 and 4 eggs/ cm3 decreased by 58, 63 and 31% after the single application of T. harzianum, 11, 33 and 12% after the single application of P. fluorescens (CHA0) and 43, 55 and 49% after the combined application of the bio-agents, respectively. Combined application of the two bio-agents was found to be the most effective in controlling the higher initial population density of the nematode (4 eggs/ cm3).
- Published
- 2021
46. Cinnamaldehyde targets TLR-4 and inflammatory mediators in acetic-acid induced ulcerative colitis model
- Author
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Mahban Rahimifard, Mohammad Abdollahi, Amir Hossein Abdolghaffari, Mustafa Dehnamaki, Negin Bakouee, Maryam Navabakhsh, Maryam Baeeri, Mohamad Hosein Farzaei, Saeideh Momtaz, and Alireza Abdollahi
- Subjects
0106 biological sciences ,0301 basic medicine ,Inflammation ,Plant Science ,Pharmacology ,01 natural sciences ,Biochemistry ,Inflammatory bowel disease ,03 medical and health sciences ,Genetics ,medicine ,Colitis ,Molecular Biology ,Ecology, Evolution, Behavior and Systematics ,Dexamethasone ,biology ,business.industry ,Interleukin ,Cell Biology ,medicine.disease ,Ulcerative colitis ,030104 developmental biology ,Myeloperoxidase ,biology.protein ,Animal Science and Zoology ,Tumor necrosis factor alpha ,medicine.symptom ,business ,010606 plant biology & botany ,medicine.drug - Abstract
Cinnamon and its bioactive ingredients such as cinnamaldehyde (CA), with broad pharmacological profiles, are important parts of daily diet in many cultures. Moreover, there are plenty motivating patents on efficacy of nutritional phytochemicals as novel anti-inflammatory drugs in patients with inflammatory bowel disease (IBD). This study intended to evaluate the effects of CA on inflammatory biomarkers in acetic acid-induced colitis rats. Colitis was induced in all animals, except in sham group, using acetic acid (4%). Following colitis induction, in 3 groups, CA was administrated orally at 2, 4 and 8 mg/kg/day for 2 days (once a day). Other groups were defined as the control (only treated with acetic acid), sham group (normal saline), and a standard group (Dexamethasone). To evaluate the inflammation sites, macroscopic and microscopic markers were assessed. Tissue concentrations of interleukin (IL)-6 and tumor necrosis factor-alpha (TNF)-α, were assessed by ELISA assay kits, while myeloperoxidase (MPO) was measured spectrophotometrically. The mRNA expression of toll like receptor (TLR)-4 in colon tissue was assessed by Real time-PCR. CA at 4 mg/kg/day and 8 mg/kg/day significantly improved microscopic and macroscopic manifestations of colitis tissues. TNF-α, MPO, and IL-6 levels were significantly lower in CA treated groups at all the concentrations tested (P
- Published
- 2021
47. Mesenchymal stem cells’ seeded amniotic membrane as a tissue-engineered dressing for wound healing
- Author
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Fereshteh Mohamadi-Jahani, Mahdi Gholami, Babak Arjmand, Parisa Goodarzi, Akram Tayanloo-Beik, Moloud Payab, Bagher Larijani, Mohammad Abdollahi, Hamid Reza Aghayan, Sepideh Alavi-Moghadam, and Motahareh Sheikh Hosseini
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Angiogenesis ,Pharmaceutical Science ,Adipose tissue ,02 engineering and technology ,030226 pharmacology & pharmacy ,Regenerative medicine ,03 medical and health sciences ,0302 clinical medicine ,Tissue engineering ,Animals ,Medicine ,Amnion ,Rats, Wistar ,Wound Healing ,integumentary system ,business.industry ,Regeneration (biology) ,Mesenchymal stem cell ,Mesenchymal Stem Cells ,021001 nanoscience & nanotechnology ,Bandages ,Rats ,Stem cell ,0210 nano-technology ,business ,Wound healing - Abstract
Different biomaterials have been used as biological dressing for wound regeneration. For many decades, human amniotic membrane graft (AM) has been widely applied for treating acute and chronic wounds. It has minimal toxicity and immunogenicity, supports mesenchymal cell in-growth, improves epidermal cell adherence and proliferation, and finally is inexpensive and readily available. Enrichment of tissue grafts with the stem cells is a new approach to improve their regenerative effects. This animal study aimed at investigating feasibility, safety, and efficacy of tissue-engineered dressings composed of AM and two different types of mesenchymal stem cells (MSCs) in the excisional wound model in rats. Human adipose-derived MSCs (ADMSCs) and placenta-derived MSCs (PLMSCs) were manufactured from the donated adipose and placenta tissues respectively. After cell characterization, MSCs were seeded on acellular AM (AAM) and cultivated for 5 days. Excisional wound model was developed in 24 male Wistar rats that were randomly classified into four groups including control, AAM, ADMSCs + AAM, and PLMSCs + AAM (n = 6 in each group). Tissue-engineered constructs were applied, and photographs were taken on days 0, 7, and 14 for observing the wound healing rates. In days 7 and 14 post-treatment, three rats from each group were euthanized, and wound biopsies were harvested, and histopathologic studies were conducted. The results of wound closure rate, re-epithelialization, angiogenesis, and collagen remodeling demonstrated that in comparison with the control groups, the MSC-seeded AAMs had superior regenerative effects in excisional wound animal model. Between MSCs group, the PLMSCs showed better healing effect. Our data suggested that seeding of MSCs on AAM can boosts its regenerative effects in wound treatment. We also found that PLMSCs had superior regenerative effects to ADMSc in the rat model of excisional wound.
- Published
- 2021
48. A narrative review of herbal preparations against RNA viruses
- Author
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Amir Hossein Abdolghaffari, Mohammad Abdollahi, S. Momtazyen, E. Jasemiyen, and R. Ghaffarzadegan
- Subjects
2019-20 coronavirus outbreak ,biology ,Coronavirus disease 2019 (COVID-19) ,Traditional medicine ,Mechanism (biology) ,In vivo ,Herbal preparations ,RNA ,Lamiaceae ,Narrative review ,biology.organism_classification - Abstract
Background: Throughout history, the plant kingdom has been a source of medicine in almost all cultures. Nowadays, ensuring the safety, quality, and effectiveness of medicinal herbs and their products has become an essential issue in industrialized and developing countries. Phytochemicals are usually involved in pharmacological actions and are used worldwide for various purposes, including the treatment of infectious diseases. Objectives: Although several therapeutics were designed to control infectious diseases, viral infections are still fatal. Currently, evidence extracted from in vivo, in vitro, and silico studies support the antiviral activity of many herbs scientifically; however, the therapeutic potential of many other herbs is still unknown. Plants and their products may potentially control the propagation of viruses in a variety of conditions. Methods: Data were extracted from PubMed, Scopus, Google Scholar, and Science Direct from 1983-2020. We gathered a list of plant extracts, phytochemicals, and herbal formulations that can inhibit RNA viral infections, mainly those are originated from the coronaviruses family. We also provided an overview of their inhibitory mechanism of actions. Results: Plant families, including Lamiaceae, Asteraceae, and Myrtaceae, contain the highest number of species with anti-coronaviruses activities, respectively. Conclusion: It can be suggested that the combination of these antiviral ingredients with each other, any synthetic compound, or already approved drugs or inhibitors can be a novel approach for antiviral therapies.
- Published
- 2021
49. An Evidence-based Review of Medicinal Plants used in Traditional Persian Medicine for Treatment of Osteoarthritis
- Author
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Mohammad Abdollahi, Soodeh Karami, Roja Rahimi, and Shiva Shamshiri
- Subjects
Evidence-Based Medicine ,Plants, Medicinal ,Traditional medicine ,business.industry ,Phytochemicals ,Drug Evaluation, Preclinical ,Osteoarthritis ,Disease ,medicine.disease ,Obesity ,Clinical trial ,Medicine, Persian ,Drug Discovery ,medicine ,Humans ,Zingiber officinale ,business ,Medicinal plants ,Body mass index ,Dyslipidemia ,Phytotherapy - Abstract
Osteoarthritis (OA) is known to be the leading cause of pain and disability in the elderly. The prevalence of this disease in adults over 60 years was 9.6% in men and 18% in women. The therapeutic goals of this disease generally include pain relief with the least side effects, improvement of articular function and improvement of life, in which pharmacological and nonpharmacological treatments are performed in different protocols. Due to the common side effects of pain relievers and complaints after invasive joint surgeries, there is a growing interest in the use of Traditional and Complementary protocols in OA treatment. In this paper, different sources of Traditional Persian Medicine (TPM) were searched to obtain any evidence evaluating any medicinal plants in the management of OA. Over 250 effective medicinal plants for the treatment of OA have been introduced in these sources, and by searching electronic databases including PubMed and Scopus, we have found that of these plants, 39 have direct or indirect evidence in the treatment of this complication by different mechanism of actions such as effect on Body mass index (BMI), obesity and dyslipidemia, anti-inflammatory, anti-nociceptive and antioxidant activity. The most important medicinal plants with direct evidence in the management of OA are Allium sativum, Commiphora mukul, Linum usitatissimum, Matricaria chamomilla, Nigella sativa, Zingiber officinale, and Piper nigrum. Medicinal plants seem to be a valuable source for discovering and identifying new drugs for treatment of OA; however, since most of the studies are preclinical, further clinical trials are required to achieve more conclusive results.
- Published
- 2021
50. Recent Advances in Nanotechnology-Based Biosensors Development for Detection of Arsenic, Lead, Mercury, and Cadmium
- Author
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Armin Salek Maghsoudi, Kayvan Mirnia, Shokoufeh Hassani, and Mohammad Abdollahi
- Subjects
Aptamer ,Biophysics ,Pharmaceutical Science ,chemistry.chemical_element ,Bioengineering ,Nanotechnology ,Environmental pollution ,Review ,Biosensing Techniques ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Biomaterials ,Lead (geology) ,Metals, Heavy ,Drug Discovery ,Humans ,heavy metals ,nanomaterials ,Arsenic ,Cadmium ,Organic Chemistry ,technology, industry, and agriculture ,toxicity ,Heavy metals ,General Medicine ,biosensors ,021001 nanoscience & nanotechnology ,Nanostructures ,0104 chemical sciences ,Mercury (element) ,chemistry ,Environmental science ,Environmental Pollution ,0210 nano-technology ,Biosensor - Abstract
Heavy metals cause considerable environmental pollution due to their extent and non-degradability in the environment. Analysis and trace levels of arsenic, lead, mercury, and cadmium as the most toxic heavy metals show that they can cause various hazards in humans’ health. To achieve rapid, high-sensitivity methods for analyzing ultra-trace amounts of heavy metals in different environmental and biological samples, novel biosensors have been designed with the participation of strategies applied in nanotechnology. This review attempted to investigate the novel, sensitive, efficient, cost-benefit, point of care, and user-friendly biosensors designed to detect these heavy metals based on functional mechanisms. The study’s search strategies included examining the primary databases from 2015 onwards and various keywords focusing on heavy metal biosensors’ performance and toxicity mechanisms. The use of aptamers and whole cells as two important bio-functional nanomaterials is remarkable in heavy metal diagnostic biosensors’ bioreceptor design. The application of hybridized nanomaterials containing a specific physicochemical function in the presence of a suitable transducer can improve the sensing performance to achieve an integrated detection system. Our study showed that in addition to both labeled and label-free detection strategies, a wide range of nanoparticles and nanocomposites were used to modify the biosensor surface platform in the detection of heavy metals. The detection limit and linear dynamic range as an essential characteristic of superior biosensors for the primary toxic metals are studied. Furthermore, the perspectives and challenges facing the design of heavy metal biosensors are outlined. The development of novel biosensors and the application of nanotechnology, especially in real samples, face challenges such as the capability to simultaneously detect multiple heavy metals, the interference process in complex matrices, the efficiency and stability of nanomaterials implemented in various laboratory conditions.
- Published
- 2021
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