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5,989 results on '"Moller, A."'

2. Moving psychiatric deinstitutionalisation forward: A scoping review of barriers and facilitators

Author

Cristian Montenegro Cortés, Josefa González Moller, Matías Irarrázaval Dominguez, Felicity Thomas, and Jorge Urrutia Ortiz

Subjects
General Earth and Planetary Sciences, General Environmental Science
Abstract

Psychiatric deinstitutionalisation (PDI) processes aim to transform long-term psychiatric care by closing or reducing psychiatric hospitals, reallocating beds, and establishing comprehensive community-based services for individuals with severe and persistent mental health difficulties. This scoping review explores the extensive literature on PDI, spanning decades, regions, socio-political contexts, and disciplines, to identify barriers and facilitators of PDI implementation, providing researchers and policymakers with a categorization of these factors.To identify barriers and facilitators, three electronic databases (Medline, CINAHL, and Sociological Abstracts) were searched, yielding 2250 references. After screening and reviewing, 52 studies were included in the final analysis. Thematic synthesis was utilized to categorize the identified factors, responding to the review question.The analysis revealed that barriers to PDI include inadequate planning, funding, and leadership, limited knowledge, competing interests, insufficient community-based alternatives, and resistance from the workforce, community, and family/caregivers. In contrast, facilitators encompass careful planning, financing and coordination, available research and evidence, strong and sustained advocacy, comprehensive community services, and a well-trained workforce engaged in the process. Exogenous factors, such as conflict and humanitarian disasters, can also play a role in PDI processes.Implementing PDI requires a multifaceted strategy, strong leadership, diverse stakeholder participation, and long-term political and financial support. Understanding local needs and forces is crucial, and studying PDI necessitates methodological flexibility and sensitivity to contextual variation. At the same time, based on the development of the review itself, we identify four limitations in the literature, concerning ‘time’, ‘location’, ‘focus’, and ‘voice’. We call for a renewed research and advocacy agenda around this neglected aspect of contemporary global mental health policy is needed.Impact StatementThe transition from a mental health system centred on long-term psychiatric hospital care to one centred on community-based services is complex, usually prolonged and requires adequate planning, sustained support and careful intersectoral coordination. The literature documenting and discussing psychiatric Deinstitutionalisation (PDI) processes is vast, running across different time periods, regions, socio-political circumstances, and disciplines, and involving diverse models of institutionalisation and community-based care. This scoping review maps this literature, identifying barriers and facilitators for PDI processes, developing a categorization that can help researchers and policymakers approach the various sources of complexity involved in this policy process.Based on the review, we propose five key areas of consideration for policymakers involved in PDI efforts: 1) Needs assessment, design and scaling up; 2) Financing the transition. 3) Workforce attitudes and development; 4) PDI Implementation and 5) Monitoring and quality assurance.We call for a multifaceted transition strategy that includes clear and strong leadership, participation from diverse stakeholders and long-term political and financial commitment. Countries going through the transition and those who are starting the process need a detailed understanding of their specific needs and contextual features at the legal, institutional, and political levels.

Published
2023
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3. Small vulnerable newborns—big potential for impact

Author

Per Ashorn, Ulla Ashorn, Yvonne Muthiani, Samira Aboubaker, Sufia Askari, Rajiv Bahl, Robert E Black, Nita Dalmiya, Christopher P Duggan, G Justus Hofmeyr, Stephen H Kennedy, Nigel Klein, Joy E Lawn, Jeremy Shiffman, Jonathon Simon, Marleen Temmerman, Yemisrach Okwaraji, Julia Krasevec, Ellen Bradley, Joel Conkle, Gretchen Stevens, Giovanna Gatica, Eric O. Ohuma, Chris Coffey, Diana Estevez Dominguez, Hannah Blencowe, Ben Kimathi, Ann Beth Moller, Alexandra Lewin, Laith Hussain-Alkhateeb, Joy E. Lawn, Elaine Borghi, and Chika Hayashi

Subjects
General Medicine
Published
2023
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5. The added effect of non-pharmaceutical interventions and lifestyle behaviors on vaccine effectiveness against severe COVID-19 in Chile: A matched case-double control study

Author

Cinthya Urquidi, Emilio Santelices, Anne J. Lagomarcino, María Teresa Valenzuela, Nicolás Larrañaga, Emilio Gonzalez, Axel Pavez, Amanda Wosiack, Marcela Maturana, Paulina Moller, Juan Pablo Torres, Sergio Muñoz, and Miguel O'Ryan G

Subjects
Infectious Diseases, General Veterinary, General Immunology and Microbiology, Public Health, Environmental and Occupational Health, Molecular Medicine
Published
2023
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7. Small babies, big risks: global estimates of prevalence and mortality for vulnerable newborns to accelerate change and improve counting

Author

Joy E Lawn, Eric O Ohuma, Ellen Bradley, Lorena Suárez Idueta, Elizabeth Hazel, Yemisrach B Okwaraji, Daniel J Erchick, Judith Yargawa, Joanne Katz, Anne C C Lee, Mike Diaz, Mihretab Salasibew, Jennifer Requejo, Chika Hayashi, Ann-Beth Moller, Elaine Borghi, Robert E Black, Hannah Blencowe, Per Ashorn, Ulla Ashorn, Nigel Klein, G Justus Hofmeyr, Marleen Temmerman, Sufia Askari, Samuel Chakwera, Laith Hussain-Alkhateeb, Alexandra Lewin, Wahyu Retno Mahanani, Emily White Johansson, Tina Lavin, Diana Estevez Fernandez, Giovanna Gatica Domínguez, Ayesha de Costa, Jenny A Cresswell, Julia Krasevec, Allisyn C Moran, Veronica Pingray, Gabriela Cormick, Luz Gibbons, José Belizan, Carlos Guevel, Kara Warrilow, Adrienne Gordon, Vicki Flenady, Jessica Sexton, Harriet Lawford, Enny S. Paixao, Ila Rocha Falcão, Mauricio Lima Barreto, Sarka Lisonkova, Qi Wen, Francisco Mardones, Raúl Caulier-Cisterna, José Acuña, Petr Velebil, Jitka Jirova, Erzsébet Horváth-Puhó, Henrik Toft Sørensen, Luule Sakkeus, Liili Abuladze, Mika Gissler, Maziar Moradi-Lakeh, Mohammad Heidarzadeh, Narjes Khalili, Khalid A. Yunis, Ayah Al Bizri, Pascale Nakad, Shamala Devi Karalasingam, J Ravichandran R Jeganathan, Nurakman binti Baharum, Lorena Suárez-Idueta, Arturo Barranco Flores, Jesus F Gonzalez Roldan, Sonia Lopez Alvarez, Aimée E. van Dijk, Lisa Broeders, Luis Huicho, Hugo G Quezada Pinedo, Kim N Cajachagua-Torres, Rodrigo M Carrillo-Larco, Carla Estefania Tarazona Meza, Wilmer Cristobal Guzman-Vilca, Tawa O. Olukade, Hamdy A. Ali, Fawziya Alyafei, Mai AlQubaisi, Mohamad R Alturk, Ho Yeon Kim, Geum Joon Cho, Neda Razaz, Jonas Söderling, Lucy K Smith, Jennifer J Kurinczuk, Ruth J Matthews, Bradley N Manktelow, Elizabeth S Draper, Alan C Fenton, Estelle Lowry, Neil Rowland, Rachael Wood, Kirsten Monteath, Isabel Pereyra, Gabriella Pravia, Celina Davis, Samantha Clarke, Lee S.F. Wu, Sachiyo Yoshida, Rajiv Bahl, Carlos Grandi, Alain B Labrique, Mabhubur Rashid, Salahuddin Ahmed, Arunangshu D. Roy, Rezwanul Haque, Saijuddin Shaikh, Abdullah H. Baqui, Samir K. Saha, Rasheda Khanam, Sayedur Rahman, Roger Shapiro, Rebecca Zash, Mariângela F. Silveira, Romina Buffarini, Patrick Kolsteren, Carl Lachat, Lieven Huybregts, Dominique Roberfroid, Lingxia Zeng, Zhonghai Zhu, Jianrong He, Xiu Qui, Seifu H. Gebreyesus, Kokeb Tesfamariam, Delayehu Bekele, Grace Chan, Estifanos Baye, Firehiwot Workneh, Kwaku P. Asante, Ellen Boanmah-Kaali, Seth Adu-Afarwuah, Kathryn G. Dewey, Stephaney Gyaase, Blair J. Wylie, Betty R. Kirkwood, Alexander Manu, Ravilla D Thulasiraj, James Tielsch, Ranadip Chowdhury, Sunita Taneja, Giridhara R Babu, Prafulla Shriyan, Kenneth Maleta, Charles Mangani, Sandra Acevedo-Gallegos, Maria J. Rodriguez-Sibaja, Subarna K. Khatry, Steven C. LeClerq, Luke C. Mullany, Fyezah Jehan, Muhammad Ilyas, Stephen J. Rogerson, Holger W. Unger, Rakesh Ghosh, Sabine Musange, Vundli Ramokolo, Wanga Zembe-Mkabile, Marzia Lazzerini, Rishard Mohamed, Dongqing Wang, Wafaie W. Fawzi, Daniel T.R. Minja, Christentze Schmiegelow, Honorati Masanja, Emily Smith, John P.A. Lusingu, Omari A. Msemo, Fathma M. Kabole, Salim N. Slim, Paniya Keentupthai, Aroonsri Mongkolchati, Richard Kajubi, Abel Kakuru, Peter Waiswa, Dilys Walker, Davidson H. Hamer, Katherine E.A. Semrau, Enesia B. Chaponda, R. Matthew Chico, Bowen Banda, Kebby Musokotwane, Albert Manasyan, Jake M. Pry, Bernard Chasekwa, Jean Humphrey, Abu Ahmed Shamim, Parul Christian, Hasmot Ali, Rolf D.W. Klemm, Alan B. Massie, Maithili Mitra, Sucheta Mehra, Kerry J. Schulze, Abu Amed Shamim, Alfred Sommer, Barkat Ullah, Keith P. West, Nazma Begum, Nabidul Haque Chowdhury, Shafiqul Islam, Dipak Kumar Mitra, Abdul Quaiyum, Modiegi Diseko, Joseph Makhema, Yue Cheng, Yixin Guo, Shanshan Yuan, Meselech Roro, Bilal Shikur, Frederick Goddard, Sebastien Haneuse, Bezawit Hunegnaw, Yemane Berhane, Alemayehu Worku, Seyram Kaali, Charles D. Arnold, Darby Jack, Seeba Amenga-Etego, Lisa Hurt, Caitlin Shannon, Seyi Soremekun, Nita Bhandari, Jose Martines, Sarmila Mazumder, Yamuna Ana, Deepa R, Lotta Hallamaa, Juha Pyykkö, Mario I. Lumbreras-Marquez, Claudia E. Mendoza-Carrera, Atiya Hussain, Muhammad Karim, Farzana Kausar, Usma Mehmood, Naila Nadeem, Muhammad Imran Nisar, Muhammad Sajid, Ivo Mueller, Maria Ome-Kaius, Elizabeth Butrick, Felix Sayinzoga, Ilaria Mariani, Willy Urassa, Thor Theander, Phillippe Deloron, Birgitte Bruun Nielsen, Alfa Muhihi, Ramadhani Abdallah Noor, Ib Bygbjerg, Sofie Lykke Moeller, Fahad Aftab, Said M. Ali, Pratibha Dhingra, Usha Dhingra, Arup Dutta, Sunil Sazawal, Atifa Suleiman, Mohammed Mohammed, Saikat Deb, Moses R. Kamya, Miriam Nakalembe, Jude Mulowooz, Nicole Santos, Godfrey Biemba, Julie M. Herlihy, Reuben K. Mbewe, Fern Mweena, Kojo Yeboah-Antwi, Jane Bruce, Daniel Chandramohan, and Andrew Prendergast

Subjects
General Medicine
Published
2023
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8. Perovskite-Sensitized Upconversion under Operando Conditions

Author

Alexander S. Bieber, Colette M. Sullivan, Katherine E. Shulenberger, Gregory Moller, Masoud Mardani, Sarah Wieghold, Theo Siegrist, and Lea Nienhaus

Subjects
General Energy, Physical and Theoretical Chemistry, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials
Published
2023
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9. The clinical effect of intravenous lipid emulsion on rabbits medicated with diazepam

Author

Stephanie Elise Muniz Tavares, Branco, Marcos Paulo Antunes, de Lima, Renata Andrade, Silva, Marina Moller, Nogueira, Raphael Rocha, Wenceslau, José Eduardo, Gonçalves, Suzane Lilian, Beier, Rubens Antônio, Carneiro, and Marília Martins, Melo

Subjects
General Veterinary
Abstract

Intravenous lipid emulsions (ILE) have been increasingly used to reverse a wide range of lipophilic drug intoxications. However, it is still unknown if these emulsions interfere with other lipophilic drugs routinely used while treating intoxicated patients, such as diazepam, one of the main antiepileptic drugs. Therefore, the objective of the present study was to evaluate whether the administration of a 20% ILE interferes with diazepam's clinical effect. We randomly allocated thirty rabbits to five groups. Three of those groups received diazepam (1.0 mg/kg, IV), one of which did not receive any additional treatment, while the two remaining groups were treated with ILE or lactated ringer solution (1.5 mL/kg followed by 0.25 mL/kg/min for 30 min). The fourth group only received lipid emulsion, and the fifth only lactated ringer. Successive neurological exams at 20 min intervals for a total of 100 min were performed to assess the rabbits' neurological state. We concluded that the ILE did not interfere with diazepam's clinical effect but, although unlikely, the possibility of recurrence of a sedative effect should be considered.

Published
2023
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11. The Importance of Mental Health Measurement to Improve Global Adolescent Health

Author

Ann-Beth Moller, Liliana Carvajal, Million L. Mekuria, Jennifer Requejo, Regina Guthold, Peter Azzopardi, Joanna Inchley, Saeed Dastgiri, Chiara Servili, Tarun Dua, Emmanuel Adebayo, Lucy Fagan, Valentina Baltag, and B. Jane Ferguson

Subjects
medicine.medical_specialty, Adolescent, Mental Disorders, Adolescent Health, Public Health, Environmental and Occupational Health, Global Health, Mental health, Psychiatry and Mental health, Mental Health, Pediatrics, Perinatology and Child Health, medicine, Humans, Psychology, Psychiatry, Adolescent health
Abstract

No abstract available.

Published
2023
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12. mGlu3 metabotropic glutamate receptors as a target for the treatment of absence epilepsy: Preclinical and human genetics data

Author

Celli, R., Striano, P., Citraro, R., Di Menna, L., Cannella, M., Imbriglio, T., Koko, M., De Sarro, G., Monn, J. A., Battaglia, G., van Luijtelaar, G., Nicoletti, F., Russo, E., Leo, A., Palotie, A., Folkhalsan, A. -E. L., Ruppert, A. -K., Lal, D., Thiele, H., Altmuller, J., Jabbari, K., Nurnberg, P., Sander, T., Siren, A., Becker, F., Lerche, H., Weber, Y., Koeleman, B., Caglayan, H., Hjalgrim, H., Moller, R., Muhle, H., Helbig, I., Everett, K., May, P., Krause, R., Balling, R., Nabbout, R., Zara, F., Scala, M., Iacomino, M., Scudieri, P., Bocciardi, R., Balagura, G., Minetti, C., Riva, A., Vari, M. S., Amadori, E., Perinelli, M., Verrotti, A., Baulac, S., and Kunz, W.

Subjects
gaba, Pharmacology, cortico-thalamo-cortical network, Action, intention, and motor control, human genetics, glutamate, General Medicine, absence epilepsy, eeg, mglu3 receptors, Psychiatry and Mental health, Neurology, Pharmacology (medical), Neurology (clinical)
Abstract

Background: Previous studies suggest that different metabotropic glutamate (mGlu) receptor subtypes are potential drug targets for the treatment of absence epilepsy. However, no information is available on mGlu3 receptors. Objective: To examine whether (i) abnormalities changes of mGlu3 receptor expression/signaling are found in the somatosensory cortex and thalamus of WAG/Rij rats developing spontaneous absence seizures; (ii) selective activation of mGlu3 receptors with LY2794193 affects the number and duration of spike-wave discharges (SWDs) in WAG/Rij rats; and (iii) a genetic variant of GRM3 (encoding the mGlu3 receptor) is associated with absence epilepsy. Methods: Animals: immunoblot analysis of mGlu3 receptors, GAT-1, GLAST, and GLT-1; real-time PCR analysis of mGlu3 mRNA levels; assessment of mGlu3 receptor signaling; EEG analysis of SWDs; assessment of depressive-like behavior. Humans: search for GRM3 and GRM5 missense variants in 196 patients with absence epilepsy or other IGE/GGE Idiopathic Generalized Epilepsy (IGE)/ Genetic Generalized Epilepsy (GGE) and 125,748 controls. Results: mGlu3 protein levels and mGlu3-mediated inhibition of cAMP formation were reduced in the thalamus and somatosensory cortex of pre-symptomatic (25-27 days old) and symptomatic (6-7 months old) WAG/Rij rats compared to age-matched controls. Treatment with LY2794193 (1 or 10 mg/kg, i.p.) reduced absence seizures and depressive-like behavior in WAG/Rij rats. LY2794193 also enhanced GAT1, GLAST, and GLT-1 protein levels in the thalamus and somatosensory cortex. GRM3 and GRM5 gene variants did not differ between epileptic patients and controls. Conclusions: We suggest that mGlu3 receptors modulate the activity of the cortico-thalamo-cortical circuit underlying SWDs and that selective mGlu3 receptor agonists are promising candidate drugs for absence epilepsy treatment.

Published
2023

13. An international assessment of the adoption of enhanced recovery after surgery (ERAS®) principles across colorectal units in 2019–2020

Author

Pinkney T., Taylor H., Tong C., Schmitz N. -D., Morton D. G., Pinkney T. D., Bhangu A., Blackwell S., Dardanov D., Dulskas A., Gallo G., Glasbey J., Keatley J., Knowles C., Li Y. E., McCourt V., Minaya-Bravo A., Neary P., Nepogodiev D., Pata F., Pellino G., Sivrikoz E., van Ramshorst G., Zmora O., Perry R., Magill E. L., Abdalkoddus M., Abelevich A., Abraham S., Abraham-Nordling M., Adamina M., Agalar C., Agresta F., Ahallat M., Ahmad N., Aiupov R., Akca O., Aleksic A., Aleotti F., Alias D., Alonso J., Alonso Goncalves S., Alonso Martin J., Alonso Poza A., Alonso-Hernandez N., Alos Company R., Al-Saeedi M., Alvarez-Laso C., Alvarez-Gallego M., Amanatidis T., Americano M., Amorim E., Anandan L., Anania G., Ancans G., Andreev P., Andrejevic P., Antonacci N., Anwer M., Aonzo P., Arencibia B., Argeny S., Arieli H., Arnold S., Ashraf M., Aslam M., Atanasov B., Atif M., Atladottir J., Avital S., Awny S., Aytac B., Azahr N., Aznar-Puig S., Bailey S., Balalis D., Baldi C., Baldonedo R., Balducci G., Balestra F., Balestri R., Balfour A., Baloyiannis I., Banky B., Baral J., Baranyai Z., Barbashinov N., Bargallo J., Barisic G., Barugola G., Batashki I., Battersby N., Belev N., Belli A., Beltran de Heredia J., Bemelman W., Benavides Buleje J., Benckert A., Bernal-Sprekelsen J., Bertocchi E., Beuran M., Bhan C., Bianco F., Bilali S., Bilali V., Bintintan V., Birindelli A., Birsan T., Blanco Antona F., Blas J., Blasco-Segura T., Blom R., Bocchetti T., Boerma E., Bogdan M., Boland M., Bomans B., Borda N., Bowen M., Bradulskis S., Branagan G., Brankovic B., Brenna M., Brewer H., Broadhurst J., Bronder C., Brouwer R., Buccianti P., Buchs N., Buchwald P., Bugatti A., Bui A., Burcos T., Buskens C., Bustamante C., Caceres N., Cagigas Fernandez C., Calero-Lillo A., Camps I., Canda A., Caravaca-Garcia I., Carballo F., Carcoforo P., Carlander J., Carlos S., Caro A., Carpelan A., Carrasco Prats M., Carrillo Lopez M., Carvello M., Casal E., Casoni Pattacini G., Castellvi Valls J., Castillo Diego J., Cavallesco G., Cavenaile V., Cayetano L., Ceccotti A., Cervera-Aldama J., Chabok A., Chafai N., Chandrasinghe P., Chandratreya N., Chaudhri S., Chaudhry Z., Cherdancev D., Chernov A., Chevallay M., Chirletti P., Chouillard E., Chouliaras C., Chowdri N., Cillo M., Cini C., Ciubotaru C., Ciuce C., Claeys D., Cocorullo G., Codina-Cazador A., Colak E., Coletta D., Colombo F., Copaescu C., Corte Real J., Corver M., Cosic J., Costa S., Costa Pereira J., Costa Pereira C., Costa-Navarro D., Cotte E., Cracco N., Cristian D., Cuadrado M., Cuk V., Cunha M., Cunha J., Curinga R., Curletti G., Curtis N., Dabic D., Dainius E., d'Alessandro A., Daniels I., Darvin V., Dauser B., David G., Davidova O., Davies E., de Andres Asenjo B., De franciscis S., de Graaf E., De la Portilla F., De Luca E., De Nisco C., De Toma G., Defoort B., Den Boer F., Di Candido F., Di Saverio S., Diaz Pavon J., Dieguez Fernandez B., Diez-Alonso M., Dimitrijevic I., Dindelegan G., Djuric M., Domingos H., Doornebosch P., Dos Santos M., Drami I., Dudarovaska H., Dusek T., Dzhumabaev H., Eden Y., Egenvall M., Eismiontas V., El Sorogy M., Elgeidie A., Elhemaly M., El-Hussuna A., Ellul S., Elmore U., ElNakeeb A., Elrefai M., Emile S., Enrriquez-Navascues J., Epstein J., Escartin J., Escola D., Escuder J., Espin E., Espina B., Estefania D., Etienne J., Fabbri S., Falato A., Fares R., Farina P., Farkasova M., Farres R., Fasolini F., Fatayer T., Febles G., Feliu F., Feo C., Feoktistov D., Fernandez F., Fernandez Isart M., Fernando J., Ferreira G., Ferrer R., Ferreras Garcia C., Ferri M., Figueiredo N., Finotti E., Fitzgerald J., Flateh Backe I., Flor-Lorente B., Forero-Torres A., Foschi D., Francart D., Francois Y., Frasson M., Freil-Lanter C., Frois Borges M., Fuzun M., Gala T., Galleano R., Galvez P., Galvez Saldana A., Gamundi Cuesta M., Garcia Cabrera A., Garcia Egea J., Garcia Olmo D., Garcia-Gonzalez J., Garcia-Granero A., Garcia-Granero E., Garcia-Septiem J., Gardea A., Garipov M., Gefen R., Geraghty A., Gerkis S., Germanos S., Ghaffari S., Ghilles E., Gianotti L., Gil Santos M., Gilsanz Martin C., Gingert C., Gklavas A., Glehen O., Golda T., Gomez N., Gomez R., Gomez Ruiz M., Gonzalez Santin V., Graham B., Grainger J., Grama F., Gregoir T., Gregori M., Grolich T., Grosek J., Guadalajara H., Guckenheimer S., Guevara J., Gulotta G., Gupta S., Gurevich N., Gurjar S., Haapaniemi S., Hahnloser D., Hamad Y., Hamid M., Hanly A., Harris G., Harsanyi L., Hartig N., Hawkin P., Henriques P., Herbst F., Hermann N., Hernandez Garcia M., Hoch J., Hrora A., Huhtinen H., Iarumov N., Ilkanich A., Insua C., Ioannidis P., Iqbal M., Iqbal A., Isik A., Ismaiel M., Ivlev D., Jadhav V., Jareno S., Jehaes C., Jimenez V., Jimenez-Toscano M., Jimenez-Miramon J., Jimenez-Rodriguez R., Jonsson T., Jotautas V., Julia D., Juloski J., Jung B., Kala Z., Kalayci M., Kara Y., Karachun A., Karagul S., Karvonen J., Katorkin S., Katsoulis I., Katsounis D., Kaubrys M., Kaul N., Kefalou E., Keijzers M., Kelly M., Kenic M., Kennelly R., Khan J., Khan M., Kho H., Kinas V., Knight J., Kocian P., Koeter T., Kokobelyan A., Konsten J., Koolen L., Kosir J., Kostic I., Krdzic I., Kreisler Moreno E., Krivokapic Z., Krstev P., Krsul D., Kumarasinghe N., La Torre F., Labarga F., Ladra M., Lage Laredo A., Lahodzich N., Lai C., Lakkis Z., Lal R., Lamas S., Lang T., Latkauskas T., Lawes D., Lazar G., Lebedev K., Lebedeva M., Lefevre J., Lekic Vitlov V., Lemma M., Leo C., Leon C., Leventoglu S., Levy B., Li L., Licari L., Lizdenis P., Loftas P., Longhi M., Longstaff L., Lopez Dominguez J., Lopez-Lara M., Lora P., Lorenzon L., Lorusso D., Lozev I., Lozoya Trujillo R., Lukic D., Lunins R., Luzan R., Luzzi A., Maderuelo V., Madsboll T., Mahotin D., Majbar M., Makhmudov A., Malik K., Maly O., Mamaloudis I., Mamedli Z., Manatakis D., Mandi D., Mangell P., Marharint T., Mariani N., Maric B., Marimuthu K., Marinello F., Marino F., Markiewicz S., Markovic V., Marom G., Maroni N., Maroulis I., Marsanic P., Marsman H., Martens M., Marti M., Martinek L., Martinez S., Martinez D., Martinez Manzano A., Martins R., Maslyankov S., McArdle K., McDermott F., Mege D., Mehraj A., Mehta A., Mendrila D., Menendez P., Mercantini P., Metwally I., Mikalauskas S., Millan M., Mingoli A., Mirshekar-Syahkal B., Moggia E., Mohan S., Moller P., Mompart Garcia S., Monami B., Moniz Pereira P., Montroni I., Morel P., Moshev B., Mostovoy E., Mothe S., Mukhtar H., Muller P., Munch S., Munoz Camarena J., Munoz-Collado S., Muratore A., Muscara F., Muysoms F., Myrelid P., N. Lah N., Nail S., Narayanan A., Nastos K., Negoi I., Nesbakken A., Nestler G., Nestorovic M., Nesytykh A., Newton K., Ng Y., Ngu J., Nguyen B., Nijs Y., Nikberg M., Nimmersgern T., Nogues E., Norcic G., Nutautiene V., Nygren J., O'Brien J., Ochogavia Segui A., O'Kelly J., Oliveira-Cunha M., Omar W., Omar G., Onishchenko S., Onody P., Opocher E., Orhalmi J., Oshowo A., Otero J., Ozgen U., Pace K., Padin H., Papaconstantinou I., Papadopoulos A., Papadopoulos G., Papandrea M., Paral J., Parc Y., Paredes J., Parmar M., Parra Banos P., Parray F., Pascual Damieta M., Pascual Miguelanez I., Passot G., Pastor C., Paszt A., Patel P., Paterson H., Patron Uriburu J., Paulos A., Pavlov V., Pcolkins A., Pecic V., Pena Ros E., Penkov R., Pera Roman M., Perunicic V., Pery R., Petrovic D., Pezzolla F., Photi E., Pikarsky A., Piramanayagam B., Pisani Ceretti A., Planellas P., Platt E., Pletinckx P., Podda M., Poskus T., Poskus E., Pozdnyakov A., Pravosudov I., Previsic A., Prieto D., Prochazka V., Prodan A., Proud D., Psaila J., Psaras G., Pulighe F., Pullig F., Qureshi M., Rachadell J., Radovanovic Z., Radovanovic D., Raguan B., Rahman M., Raiss M., Ramirez Faraco M., Ramos J., Ramos-Prada J., Rantala A., Rao M., Rasulov A., Ratnatunga K., Raymond T., Refky B., Reggiani L., Regusci L., Reyes Diaz M., Richardson J., Richiteanu G., Rios A., Ris F., Rodriguez Garcia P., Roffi N., Romairone E., Romano G., Romero I., Romero de Diego A., Romero-Simo M., Roque C., Rosati R., Rossi B., Rossi E., Rossini R., Ruano A., Rubbini M., Rubio-Perez I., Ruffo G., Ruiz H., Ruiz Carmona M., Ryska O., Sabia D., Sacchi M., Sacco R., Sakr A., Saladzinskas Z., Salamone G., Salomon M., Salvans Ruiz S., Sammarco G., Sampietro G., Samsonov D., Samsonyuk V., Sanchez J., Sanchez Romero A., Sanchez-Guillen L., Santak G., Santamaria-Olabarrieta M., Santos J., Saraceno F., Saralegui Y., Sarici I., Savino G., Scabini S., Schafli J., Schiltz B., Schofield A., Schon M., Scurtu R., Segalini E., Segelman J., 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Cervera-Aldama J., Chabok A., Chafai N., Chandrasinghe P., Chandratreya N., Chaudhri S., Chaudhry Z., Cherdancev D., Chernov A., Chevallay M., Chirletti P., Chouillard E., Chouliaras C., Chowdri N., Cillo M., Cini C., Ciubotaru C., Ciuce C., Claeys D., Cocorullo G., Codina-Cazador A., Colak E., Coletta D., Colombo F., Copaescu C., Corte Real J., Corver M., Cosic J., Costa S., Costa Pereira J., Costa Pereira C., Costa-Navarro D., Cotte E., Cracco N., Cristian D., Cuadrado M., Cuk V., Cunha M., Cunha J., Curinga R., Curletti G., Curtis N., Dabic D., Dainius E., d'Alessandro A., Daniels I., Darvin V., Dauser B., David G., Davidova O., Davies E., de Andres Asenjo B., De franciscis S., de Graaf E., De la Portilla F., De Luca E., De Nisco C., De Toma G., Defoort B., Den Boer F., Di Candido F., Di Saverio S., Diaz Pavon J., Dieguez Fernandez B., Diez-Alonso M., Dimitrijevic I., Dindelegan G., Djuric M., Domingos H., Doornebosch P., Dos Santos M., Drami I., Dudarovaska H., Dusek T., Dzhumabaev H., Eden Y., Egenvall M., Eismiontas V., El Sorogy M., Elgeidie A., Elhemaly M., El-Hussuna A., Ellul S., Elmore U., ElNakeeb A., Elrefai M., Emile S., Enrriquez-Navascues J., Epstein J., Escartin J., Escola D., Escuder J., Espin E., Espina B., Estefania D., Etienne J., Fabbri S., Falato A., Fares R., Farina P., Farkasova M., Farres R., Fasolini F., Fatayer T., Febles G., Feliu F., Feo C., Feoktistov D., Fernandez F., Fernandez Isart M., Fernando J., Ferreira G., Ferrer R., Ferreras Garcia C., Ferri M., Figueiredo N., Finotti E., Fitzgerald J., Flateh Backe I., Flor-Lorente B., Forero-Torres A., Foschi D., Francart D., Francois Y., Frasson M., Freil-Lanter C., Frois Borges M., Fuzun M., Gala T., Galleano R., Galvez P., Galvez Saldana A., Gamundi Cuesta M., Garcia Cabrera A., Garcia Egea J., Garcia Olmo D., Garcia-Gonzalez J., Garcia-Granero A., Garcia-Granero E., Garcia-Septiem J., Gardea A., Garipov M., Gefen R., Geraghty A., Gerkis S., Germanos S., Ghaffari S., Ghilles E., Gianotti L., Gil Santos M., Gilsanz Martin C., Gingert C., Gklavas A., Glehen O., Golda T., Gomez N., Gomez R., Gomez Ruiz M., Gonzalez Santin V., Graham B., Grainger J., Grama F., Gregoir T., Gregori M., Grolich T., Grosek J., Guadalajara H., Guckenheimer S., Guevara J., Gulotta G., Gupta S., Gurevich N., Gurjar S., Haapaniemi S., Hahnloser D., Hamad Y., Hamid M., Hanly A., Harris G., Harsanyi L., Hartig N., Hawkin P., Henriques P., Herbst F., Hermann N., Hernandez Garcia M., Hoch J., Hrora A., Huhtinen H., Iarumov N., Ilkanich A., Insua C., Ioannidis P., Iqbal M., Iqbal A., Isik A., Ismaiel M., Ivlev D., Jadhav V., Jareno S., Jehaes C., Jimenez V., Jimenez-Toscano M., Jimenez-Miramon J., Jimenez-Rodriguez R., Jonsson T., Jotautas V., Julia D., Juloski J., Jung B., Kala Z., Kalayci M., Kara Y., Karachun A., Karagul S., Karvonen J., Katorkin S., Katsoulis I., Katsounis D., Kaubrys M., Kaul N., Kefalou E., Keijzers M., Kelly M., Kenic M., Kennelly R., Khan J., Khan M., Kho H., Kinas V., Knight J., Kocian P., Koeter T., Kokobelyan A., Konsten J., Koolen L., Kosir J., Kostic I., Krdzic I., Kreisler Moreno E., Krivokapic Z., Krstev P., Krsul D., Kumarasinghe N., La Torre F., Labarga F., Ladra M., Lage Laredo A., Lahodzich N., Lai C., Lakkis Z., Lal R., Lamas S., Lang T., Latkauskas T., Lawes D., Lazar G., Lebedev K., Lebedeva M., Lefevre J., Lekic Vitlov V., Lemma M., Leo C., Leon C., Leventoglu S., Levy B., Li L., Licari L., Lizdenis P., Loftas P., Longhi M., Longstaff L., Lopez Dominguez J., Lopez-Lara M., Lora P., Lorenzon L., Lorusso D., Lozev I., Lozoya Trujillo R., Lukic D., Lunins R., Luzan R., Luzzi A., Maderuelo V., Madsboll T., Mahotin D., Majbar M., Makhmudov A., Malik K., Maly O., Mamaloudis I., Mamedli Z., Manatakis D., Mandi D., Mangell P., Marharint T., Mariani N., Maric B., Marimuthu K., Marinello F., Marino F., Markiewicz S., Markovic V., Marom G., Maroni N., Maroulis I., Marsanic P., Marsman H., Martens M., Marti M., Martinek L., Martinez S., Martinez D., Martinez Manzano A., Martins R., Maslyankov S., McArdle K., McDermott F., Mege D., Mehraj A., Mehta A., Mendrila D., Menendez P., Mercantini P., Metwally I., Mikalauskas S., Millan M., Mingoli A., Mirshekar-Syahkal B., Moggia E., Mohan S., Moller P., Mompart Garcia S., Monami B., Moniz Pereira P., Montroni I., Morel P., Moshev B., Mostovoy E., Mothe S., Mukhtar H., Muller P., Munch S., Munoz Camarena J., Munoz-Collado S., Muratore A., Muscara F., Muysoms F., Myrelid P., N.Lah N., Nail S., Narayanan A., Nastos K., Negoi I., Nesbakken A., Nestler G., Nestorovic M., Nesytykh A., Newton K., Ng Y., Ngu J., Nguyen B., Nijs Y., Nikberg M., Nimmersgern T., Nogues E., Norcic G., Nutautiene V., Nygren J., O'Brien J., Ochogavia Segui A., O'Kelly J., Oliveira-Cunha M., Omar W., Omar G., Onishchenko S., Onody P., Opocher E., Orhalmi J., Oshowo A., Otero J., Ozgen U., Pace K., Padin H., Papaconstantinou I., Papadopoulos A., Papadopoulos G., Papandrea M., Paral J., Parc Y., Paredes J., Parmar M., Parra Banos P., Parray F., Pascual Damieta M., Pascual Miguelanez I., Passot G., Pastor C., Paszt A., Patel P., Paterson H., Patron Uriburu J., Paulos A., Pavlov V., Pcolkins A., Pecic V., Pena Ros E., Penkov R., Pera Roman M., Perunicic V., Pery R., Petrovic D., Pezzolla F., Photi E., Pikarsky A., Piramanayagam B., Pisani Ceretti A., Planellas P., Platt E., Pletinckx P., Podda M., Poskus T., Poskus E., Pozdnyakov A., Pravosudov I., Previsic A., Prieto D., Prochazka V., Prodan A., Proud D., Psaila J., Psaras G., Pulighe F., Pullig F., Qureshi M., Rachadell J., Radovanovic Z., Radovanovic D., Raguan B., Rahman M., Raiss M., Ramirez Faraco M., Ramos J., Ramos-Prada J., Rantala A., Rao M., Rasulov A., Ratnatunga K., Raymond T., Refky B., Reggiani L., Regusci L., Reyes Diaz M., Richardson J., Richiteanu G., Rios A., Ris F., Rodriguez Garcia P., Roffi N., Romairone E., Romano G., Romero I., Romero de Diego A., Romero-Simo M., Roque C., Rosati R., Rossi B., Rossi E., Rossini R., Ruano A., Rubbini M., Rubio-Perez I., Ruffo G., Ruiz H., Ruiz Carmona M., Ryska O., Sabia D., Sacchi M., Sacco R., Sakr A., Saladzinskas Z., Salamone G., Salomon M., Salvans Ruiz S., Sammarco G., Sampietro G., Samsonov D., Samsonyuk V., Sanchez J., Sanchez Romero A., Sanchez-Guillen L., Santak G., Santamaria-Olabarrieta M., Santos J., Saraceno F., Saralegui Y., Sarici I., Savino G., Scabini S., Schafli J., Schiltz B., Schofield A., Schon M., Scurtu R., Segalini E., Segelman J., Segura-Sampedro J., Seicean R., Sekulic A., Selniahina L., Seretis F., Serrano Paz P., Shaikh I., Shalaby M., Shams N., Sharma A., Sharma G., Shukla A., Shussman N., Shweejawee Z., Sielezneff I., Sigurdsson H., Sileri P., Silva M., Simcikas D., Simoes J., Simonka Z., Singh B., Sivins A., Skroubis G., Skull A., Slavchev M., Slavin M., Smart N., Smart C., Smart P., Smedh K., Smolarek S., Sokmen S., Sokolov M., Solana Bueno A., Solar L., Sorrentino L., Sotona O., Spacca D., Spinelli A., Stanojevic G., Stearns A., Stefan S., Stift A., Stijns J., Stoyanov V., Straarup D., Strupas K., Stubbs B., Subocius A., Sudlow A., Suero C., Sungurtekin U., Svagzdys S., Syk I., Tamelis A., Tamhane R., Tamini N., Tamosiunas A., Tanis P., Tarasov N., Tate S., Tennakoon A., Teo N., Terzi C., Tezas S., Thabet W., Tham J., Thavanesan N., Theodosopoulos T., Thomas W., Tiret E., Tiselius C., Todorov G., Tomazic A., Tomulescu V., Torkington J., Totis M., Trostchansky I., Truan N., Tulchinsky H., Tutino R., Tzivanakis A., Tzovaras G., Ugolini G., Unger L., Upanishad I., Urbani L., Uth Ovesen A., Vaizey C., Vallribera F., Valsdottir E., Valverde I., Valverde-Sintas J., Van Belle K., Van Cleven S., van Hagen P., van Loon Y., van Ruler O., Van Wijck K., Varabei A., Varcada M., Varpe P., Vartic M., Velchuru V., Vencius J., Venskutonis D., Vercher D., Vermaas M., Vertruyen M., Verza L., Vescio G., Vezakis A., Vieira P., Vignali A., Vigorita V., Vila Tura M., Vinson-Bonnet B., Viso Pons L., Voloshin S., Voronin Y., Vukusic L., Wang X., Wang J., Wani R., Warusavitarne J., Wasserberg N., Weerts J., Weiss D., Weizman A., Westerduin E., Wheat J., White I., Wik T., Wilson J., Winter D., Wolthuis A., Wong M., Yahia S., Yamamoto T., Yanishev A., Yao C., Yildiz A., Yuksel O., Zain Z., Zakaria A., Zakaria Z., Zampitis N., Zarand A., Zarco-Pleguezuelos A., Zattoni D., Zelic M., Zeromskas P., Zhuravlev A., Zimmerman D., Zuhdy M., Zukanovic G., Pinkney, T. D., Taylor, H., Tong, C., Schmitz, N. -D., Morton, D. G., Bhangu, A., Blackwell, S., Dardanov, D., Dulskas, A., Gallo, G., Glasbey, J., Keatley, J., Knowles, C., Li, Y. E., Mccourt, V., Minaya-Bravo, A., Neary, P., Nepogodiev, D., Pata, F., Pellino, G., Sivrikoz, E., van Ramshorst, G., Zmora, O., Perry, R., Magill, E. L., Abdalkoddus, M., Abelevich, A., Abraham, S., Abraham-Nordling, M., Adamina, M., Agalar, C., Agresta, F., Ahallat, M., Ahmad, N., Aiupov, R., Akca, O., Aleksic, A., Aleotti, F., Alias, D., Alonso, J., Alonso Goncalves, S., Alonso Martin, J., Alonso Poza, A., Alonso-Hernandez, N., Alos Company, R., Al-Saeedi, M., Alvarez-Laso, C., Alvarez-Gallego, M., Amanatidis, T., Americano, M., Amorim, E., Anandan, L., Anania, G., Ancans, G., Andreev, P., Andrejevic, P., Antonacci, N., Anwer, M., Aonzo, P., Arencibia, B., Argeny, S., Arieli, H., Arnold, S., Ashraf, M., Aslam, M., Atanasov, B., Atif, M., Atladottir, J., Avital, S., Awny, S., Aytac, B., Azahr, N., Aznar-Puig, S., Bailey, S., Balalis, D., Baldi, C., Baldonedo, R., Balducci, G., Balestra, F., Balestri, R., Balfour, A., Baloyiannis, I., Banky, B., Baral, J., Baranyai, Z., Barbashinov, N., Bargallo, J., Barisic, G., Barugola, G., Batashki, I., Battersby, N., Belev, N., Belli, A., Beltran de Heredia, J., Bemelman, W., Benavides Buleje, J., Benckert, A., Bernal-Sprekelsen, J., Bertocchi, E., Beuran, M., Bhan, C., Bianco, F., Bilali, S., Bilali, V., Bintintan, V., Birindelli, A., Birsan, T., Blanco Antona, F., Blas, J., Blasco-Segura, T., Blom, R., Bocchetti, T., Boerma, E., Bogdan, M., Boland, M., Bomans, B., Borda, N., Bowen, M., Bradulskis, S., Branagan, G., Brankovic, B., Brenna, M., Brewer, H., Broadhurst, J., Bronder, C., Brouwer, R., Buccianti, P., Buchs, N., Buchwald, P., Bugatti, A., Bui, A., Burcos, T., Buskens, C., Bustamante, C., Caceres, N., Cagigas Fernandez, C., Calero-Lillo, A., Camps, I., Canda, A., Caravaca-Garcia, I., Carballo, F., Carcoforo, P., Carlander, J., Carlos, S., Caro, A., Carpelan, A., Carrasco Prats, M., Carrillo Lopez, M., Carvello, M., Casal, E., Casoni Pattacini, G., Castellvi Valls, J., Castillo Diego, J., Cavallesco, G., Cavenaile, V., Cayetano, L., Ceccotti, A., Cervera-Aldama, J., Chabok, A., Chafai, N., Chandrasinghe, P., Chandratreya, N., Chaudhri, S., Chaudhry, Z., Cherdancev, D., Chernov, A., Chevallay, M., Chirletti, P., Chouillard, E., Chouliaras, C., Chowdri, N., Cillo, M., Cini, C., Ciubotaru, C., Ciuce, C., Claeys, D., Cocorullo, G., Codina-Cazador, A., Colak, E., Coletta, D., Colombo, F., Copaescu, C., Corte Real, J., Corver, M., Cosic, J., Costa, S., Costa Pereira, J., Costa Pereira, C., Costa-Navarro, D., Cotte, E., Cracco, N., Cristian, D., Cuadrado, M., Cuk, V., Cunha, M., Cunha, J., Curinga, R., Curletti, G., Curtis, N., Dabic, D., Dainius, E., D'Alessandro, A., Daniels, I., Darvin, V., Dauser, B., David, G., Davidova, O., Davies, E., de Andres Asenjo, B., De franciscis, S., de Graaf, E., De la Portilla, F., De Luca, E., De Nisco, C., De Toma, G., Defoort, B., Den Boer, F., Di Candido, F., Di Saverio, S., Diaz Pavon, J., Dieguez Fernandez, B., Diez-Alonso, M., Dimitrijevic, I., Dindelegan, G., Djuric, M., Domingos, H., Doornebosch, P., Dos Santos, M., Drami, I., Dudarovaska, H., Dusek, T., Dzhumabaev, H., Eden, Y., Egenvall, M., Eismiontas, V., El Sorogy, M., Elgeidie, A., Elhemaly, M., El-Hussuna, A., Ellul, S., Elmore, U., Elnakeeb, A., Elrefai, M., Emile, S., Enrriquez-Navascues, J., Epstein, J., Escartin, J., Escola, D., Escuder, J., Espin, E., Espina, B., Estefania, D., Etienne, J., Fabbri, S., Falato, A., Fares, R., Farina, P., Farkasova, M., Farres, R., Fasolini, F., Fatayer, T., Febles, G., Feliu, F., Feo, C., Feoktistov, D., Fernandez, F., Fernandez Isart, M., Fernando, J., Ferreira, G., Ferrer, R., Ferreras Garcia, C., Ferri, M., Figueiredo, N., Finotti, E., Fitzgerald, J., Flateh Backe, I., Flor-Lorente, B., Forero-Torres, A., Foschi, D., Francart, D., Francois, Y., Frasson, M., Freil-Lanter, C., Frois Borges, M., Fuzun, M., Gala, T., Galleano, R., Galvez, P., Galvez Saldana, A., Gamundi Cuesta, M., Garcia Cabrera, A., Garcia Egea, J., Garcia Olmo, D., Garcia-Gonzalez, J., Garcia-Granero, A., Garcia-Granero, E., Garcia-Septiem, J., Gardea, A., Garipov, M., Gefen, R., Geraghty, A., Gerkis, S., Germanos, S., Ghaffari, S., Ghilles, E., Gianotti, L., Gil Santos, M., Gilsanz Martin, C., Gingert, C., Gklavas, A., Glehen, O., Golda, T., Gomez, N., Gomez, R., Gomez Ruiz, M., Gonzalez Santin, V., Graham, B., Grainger, J., Grama, F., Gregoir, T., Gregori, M., Grolich, T., Grosek, J., Guadalajara, H., Guckenheimer, S., Guevara, J., Gulotta, G., Gupta, S., Gurevich, N., Gurjar, S., Haapaniemi, S., Hahnloser, D., Hamad, Y., Hamid, M., Hanly, A., Harris, G., Harsanyi, L., Hartig, N., Hawkin, P., Henriques, P., Herbst, F., Hermann, N., Hernandez Garcia, M., Hoch, J., Hrora, A., Huhtinen, H., Iarumov, N., Ilkanich, A., Insua, C., Ioannidis, P., Iqbal, M., Iqbal, A., Isik, A., Ismaiel, M., Ivlev, D., Jadhav, V., Jareno, S., Jehaes, C., Jimenez, V., Jimenez-Toscano, M., Jimenez-Miramon, J., Jimenez-Rodriguez, R., Jonsson, T., Jotautas, V., Julia, D., Juloski, J., Jung, B., Kala, Z., Kalayci, M., Kara, Y., Karachun, A., Karagul, S., Karvonen, J., Katorkin, S., Katsoulis, I., Katsounis, D., Kaubrys, M., Kaul, N., Kefalou, E., Keijzers, M., Kelly, M., Kenic, M., Kennelly, R., Khan, J., Khan, M., Kho, H., Kinas, V., Knight, J., Kocian, P., Koeter, T., Kokobelyan, A., Konsten, J., Koolen, L., Kosir, J., Kostic, I., Krdzic, I., Kreisler Moreno, E., Krivokapic, Z., Krstev, P., Krsul, D., Kumarasinghe, N., La Torre, F., Labarga, F., Ladra, M., Lage Laredo, A., Lahodzich, N., Lai, C., Lakkis, Z., Lal, R., Lamas, S., Lang, T., Latkauskas, T., Lawes, D., Lazar, G., Lebedev, K., Lebedeva, M., Lefevre, J., Lekic Vitlov, V., Lemma, M., Leo, C., Leon, C., Leventoglu, S., Levy, B., Li, L., Licari, L., Lizdenis, P., Loftas, P., Longhi, M., Longstaff, L., Lopez Dominguez, J., Lopez-Lara, M., Lora, P., Lorenzon, L., Lorusso, D., Lozev, I., Lozoya Trujillo, R., Lukic, D., Lunins, R., Luzan, R., Luzzi, A., Maderuelo, V., Madsboll, T., Mahotin, D., Majbar, M., Makhmudov, A., Malik, K., Maly, O., Mamaloudis, I., Mamedli, Z., Manatakis, D., Mandi, D., Mangell, P., Marharint, T., Mariani, N., Maric, B., Marimuthu, K., Marinello, F., Marino, F., Markiewicz, S., Markovic, V., Marom, G., Maroni, N., Maroulis, I., Marsanic, P., Marsman, H., Martens, M., Marti, M., Martinek, L., Martinez, S., Martinez, D., Martinez Manzano, A., Martins, R., Maslyankov, S., Mcardle, K., Mcdermott, F., Mege, D., Mehraj, A., Mehta, A., Mendrila, D., Menendez, P., Mercantini, P., Metwally, I., Mikalauskas, S., Millan, M., Mingoli, A., Mirshekar-Syahkal, B., Moggia, E., Mohan, S., Moller, P., Mompart Garcia, S., Monami, B., Moniz Pereira, P., Montroni, I., Morel, P., Moshev, B., Mostovoy, E., Mothe, S., Mukhtar, H., Muller, P., Munch, S., Munoz Camarena, J., Munoz-Collado, S., Muratore, A., Muscara, F., Muysoms, F., Myrelid, P., N. Lah, N., Nail, S., Narayanan, A., Nastos, K., Negoi, I., Nesbakken, A., Nestler, G., Nestorovic, M., Nesytykh, A., Newton, K., Ng, Y., Ngu, J., Nguyen, B., Nijs, Y., Nikberg, M., Nimmersgern, T., Nogues, E., Norcic, G., Nutautiene, V., Nygren, J., O'Brien, J., Ochogavia Segui, A., O'Kelly, J., Oliveira-Cunha, M., Omar, W., Omar, G., Onishchenko, S., Onody, P., Opocher, E., Orhalmi, J., Oshowo, A., Otero, J., Ozgen, U., Pace, K., Padin, H., Papaconstantinou, I., Papadopoulos, A., Papadopoulos, G., Papandrea, M., Paral, J., Parc, Y., Paredes, J., Parmar, M., Parra Banos, P., Parray, F., Pascual Damieta, M., Pascual Miguelanez, I., Passot, G., Pastor, C., Paszt, A., Patel, P., Paterson, H., Patron Uriburu, J., Paulos, A., Pavlov, V., Pcolkins, A., Pecic, V., Pena Ros, E., Penkov, R., Pera Roman, M., Perunicic, V., Pery, R., Petrovic, D., Pezzolla, F., Photi, E., Pikarsky, A., Piramanayagam, B., Pisani Ceretti, A., Planellas, P., Platt, E., Pletinckx, P., Podda, M., Poskus, T., Poskus, E., Pozdnyakov, A., Pravosudov, I., Previsic, A., Prieto, D., Prochazka, V., Prodan, A., Proud, D., Psaila, J., Psaras, G., Pulighe, F., Pullig, F., Qureshi, M., Rachadell, J., Radovanovic, Z., Radovanovic, D., Raguan, B., Rahman, M., Raiss, M., Ramirez Faraco, M., Ramos, J., Ramos-Prada, J., Rantala, A., Rao, M., Rasulov, A., Ratnatunga, K., Raymond, T., Refky, B., Reggiani, L., Regusci, L., Reyes Diaz, M., Richardson, J., Richiteanu, G., Rios, A., Ris, F., Rodriguez Garcia, P., Roffi, N., Romairone, E., Romano, G., Romero, I., Romero de Diego, A., Romero-Simo, M., Roque, C., Rosati, R., Rossi, B., Rossi, E., Rossini, R., Ruano, A., Rubbini, M., Rubio-Perez, I., Ruffo, G., Ruiz, H., Ruiz Carmona, M., Ryska, O., Sabia, D., Sacchi, M., Sacco, R., Sakr, A., Saladzinskas, Z., Salamone, G., Salomon, M., Salvans Ruiz, S., Sammarco, G., Sampietro, G., Samsonov, D., Samsonyuk, V., Sanchez, J., Sanchez Romero, A., Sanchez-Guillen, L., Santak, G., Santamaria-Olabarrieta, M., Santos, J., Saraceno, F., Saralegui, Y., Sarici, I., Savino, G., Scabini, S., Schafli, J., Schiltz, B., Schofield, A., Schon, M., Scurtu, R., Segalini, E., Segelman, J., Segura-Sampedro, J., Seicean, R., Sekulic, A., Selniahina, L., Seretis, F., Serrano Paz, P., Shaikh, I., Shalaby, M., Shams, N., Sharma, A., Sharma, G., Shukla, A., Shussman, N., Shweejawee, Z., Sielezneff, I., Sigurdsson, H., Sileri, P., Silva, M., Simcikas, D., Simoes, J., Simonka, Z., Singh, B., Sivins, A., Skroubis, G., Skull, A., Slavchev, M., Slavin, M., Smart, N., Smart, C., Smart, P., Smedh, K., Smolarek, S., Sokmen, S., Sokolov, M., Solana Bueno, A., Solar, L., Sorrentino, L., Sotona, O., Spacca, D., Spinelli, A., Stanojevic, G., Stearns, A., Stefan, S., Stift, A., Stijns, J., Stoyanov, V., Straarup, D., Strupas, K., Stubbs, B., Subocius, A., Sudlow, A., Suero, C., Sungurtekin, U., Svagzdys, S., Syk, I., Tamelis, A., Tamhane, R., Tamini, N., Tamosiunas, A., Tanis, P., Tarasov, N., Tate, S., Tennakoon, A., Teo, N., Terzi, C., Tezas, S., Thabet, W., Tham, J., Thavanesan, N., Theodosopoulos, T., Thomas, W., Tiret, E., Tiselius, C., Todorov, G., Tomazic, A., Tomulescu, V., Torkington, J., Totis, M., Trostchansky, I., Truan, N., Tulchinsky, H., Tutino, R., Tzivanakis, A., Tzovaras, G., Ugolini, G., Unger, L., Upanishad, I., Urbani, L., Uth Ovesen, A., Vaizey, C., Vallribera, F., Valsdottir, E., Valverde, I., Valverde-Sintas, J., Van Belle, K., Van Cleven, S., van Hagen, P., van Loon, Y., van Ruler, O., Van Wijck, K., Varabei, A., Varcada, M., Varpe, P., Vartic, M., Velchuru, V., Vencius, J., Venskutonis, D., Vercher, D., Vermaas, M., Vertruyen, M., Verza, L., Vescio, G., Vezakis, A., Vieira, P., Vignali, A., Vigorita, V., Vila Tura, M., Vinson-Bonnet, B., Viso Pons, L., Voloshin, S., Voronin, Y., Vukusic, L., Wang, X., Wang, J., Wani, R., Warusavitarne, J., Wasserberg, N., Weerts, J., Weiss, D., Weizman, A., Westerduin, E., Wheat, J., White, I., Wik, T., Wilson, J., Winter, D., Wolthuis, A., Wong, M., Yahia, S., Yamamoto, T., Yanishev, A., Yao, C., Yildiz, A., Yuksel, O., Zain, Z., Zakaria, A., Zakaria, Z., Zampitis, N., Zarand, A., Zarco-Pleguezuelos, A., Zattoni, D., Zelic, M., Zeromskas, P., Zhuravlev, A., Zimmerman, D., Zuhdy, M., and Zukanovic, G.

Subjects
medicine.medical_specialty, Prehabilitation, medicine.medical_treatment, MEDLINE, Colorectal Neoplasm, Perioperative Care, NO, medicine, Humans, 03.02. Klinikai orvostan, Perioperative Optimisation, Enhanced recovery after surgery, Digestive System Surgical Procedures, LS7_4, Enhanced Recovery After Surgery (ERAS), business.industry, Gastroenterology, Digestive System Surgical Procedure, Guideline, Colorectal surgery, Surgery, Family medicine, Perioperative care, Nasogastric intubation, Preoperative fasting, Colorectal Neoplasms, Enhanced Recovery After Surgery, business, Colorectal Surgery, Human
Abstract

Aim The Enhanced Recovery After Surgery (ERAS® ) Society guidelines aim to standardise perioperative care in colorectal surgery via 25 principles. We aimed to assess the variation in uptake of these principles across an international network of colorectal units. Method An online survey was circulated amongst European Society of Coloproctology members in 2019/20. For each ERAS® principle, respondents were asked to score how frequently the principle was implemented in their hospital, from 1 ('rarely') to 4 ('always'). Respondents were also asked to recall whether practice had changed since 2017. Subgroup analyses based on hospital characteristics were conducted. Results Of hospitals approached, 58% responded to the survey (195/335), with 296 individual responses (multiple responses were received from some hospitals). The majority were European (163/195 [83.6%]). Overall, respondents indicated they 'most often' or 'always' adhered to most individual ERAS® principles (18/25 [72%]). Variability in uptake of principles was reported, with universal uptake of some principles (e.g., prophylactic antibiotics; early mobilisation) and inconsistency from 'rarely' to 'always' in others (e.g., no nasogastric intubation; no preoperative fasting and carbohydrate drinks). In alignment with 2018 ERAS® guideline updates, adherence to principles for prehabilitation, managing anaemia, and postoperative nutrition appears to have increased since 2017. Conclusions Uptake of ERAS® principles varied across hospitals, and not all 25 principles were equally adhered to. Whilst some principles exhibited a high level of acceptance, others had a wide variability in uptake indicative of controversy or barriers to uptake. Further research into specific principles is required to improve ERAS® implementation.

Published
2021
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15. Reductions in leaf area index, pod production, seed size, and harvest index drive yield loss to high temperatures in soybean

Author

Charles H Burroughs, Christopher M Montes, Christopher A Moller, Noah G Mitchell, Anne Marie Michael, Bin Peng, Hyungsuk Kimm, Taylor L Pederson, Alexander E Lipka, Carl J Bernacchi, Kaiyu Guan, and Elizabeth A Ainsworth

Subjects
Physiology, Plant Science
Abstract

Improvements in genetics, technology, and agricultural intensification have increased soybean yields; however, adverse climate conditions may prevent these gains from being fully realized in the future. Higher growing season temperatures reduce soybean yields in key production regions including the US Midwest, and better understanding of the developmental and physiological mechanisms that constrain soybean yield under high temperature conditions is needed. This study tested the response of two soybean cultivars to four elevated temperature treatments (+1.7, +2.6, +3.6, and +4.8 °C) in the field over three growing seasons and identified threshold temperatures for response and linear versus non-linear trait responses to temperature. Yield declined non-linearly to temperature, with decreases apparent when canopy temperature exceeded 20.9 °C for the locally adapted cultivar and 22.7°C for a cultivar adapted to more southern locations. While stem node number increased with increasing temperature, leaf area index decreased substantially. Pod production, seed size, and harvest index significantly decreased with increasing temperature. The seasonal average temperature of even the mildest treatment exceeded the threshold temperatures for yield loss, emphasizing the importance of improving temperature tolerance in soybean germplasm with intensifying climate change.

Published
2022
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18. Resultados a corto plazo del tratamiento de fracturas de cadera en población infantil

Author

Felipe Hodgson Ovalle, Francesca Moller, Manuela Angulo, Maria-Jesus Figueroa, Alejandro Gündel, and Ismael Cañete

Subjects
Orthopedics and Sports Medicine, Surgery
Abstract

Resumen Introducción Las fracturas del fémur proximal pediátricas son infrecuentes, se asocian a traumas de alta energía, y presentan complicaciones devastadoras. La mayoría de los casos se tratan en forma quirúrgica utilizando diversos tipos de fijación. El objetivo de este estudio es reportar los resultados de una serie de casos de pacientes quirúrgicos en dos hospitales de referencia en Chile. Materiales y métodos Serie de casos tratados entre el 2004y el 2018, en la que se incluyeron pacientes pediátricos con diagnóstico de fractura de fémur proximal que fueron operados. Se realizó estadística descriptiva de las variables demográficas, la energía del accidente, la clasificación según Delbet, el tipo de tratamiento, la técnica de osteosíntesis, la aparición de complicaciones, y la evaluación clínico-radiológica. Resultados Se evaluaron 17 casos, de los cuales un 76,5% fueron secundarios a accidentes de alta energía. La mediana de edad de la muestra fue de 7 años, y había un 58,8% de niñas. Hubo 3 casos de tipo II en la clasificación de Delbet, 9 de tipo III, y 5 de tipo IV. Como método de fijación, se utilizaron tornillos canulados (9 casos), placa de compresión de bloqueo (locking compression plate, LCP, en inglés; 5 casos), tornillo dinámico de cadera (dynamic hip screw, DHS, en inglés; 2 casos), y placa de compresión dinámica (dynamic compression plate, DCP, en inglés; 1 caso). La mediana de seguimiento fue de 2,3 años (rango: 0,5 a 12,8 años). Se presentaron complicaciones: coxa vara en un caso, y discrepancia de longitud de extremidades inferiores en otro caso, y no hubo osteonecrosis. Se realizó retiro de osteosíntesis en siete pacientes. Se obtuvieron buenos resultados en todos los pacientes según los criterios de Ratliff. Conclusiones La mayoría de las fracturas se asociaron a traumas de alta energía, siendo el tipo más frecuente el III de Delbet. Todos los pacientes fueron tratados en forma quirúrgica, con buenos resultados, sin observar osteonecrosis.Nivel de evidencia: 4.

Published
2022
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19. High abundance of high-risk Human Papillomavirus genotypes in wastewater in Uruguay

Author

Matías Victoria, Ana Moller, Matías Salvo, Natalia Baccardatz, and Rodney Colina

Subjects
Microbiology (medical), Infectious Diseases, Public Health, Environmental and Occupational Health, Waste Management and Disposal, Water Science and Technology
Abstract

The aim of this study was to determine the frequency of Human Papillomavirus (HPV) genotypes in wastewater of Salto city, Uruguay, in order to obtain a general overview of the circulating genotypes in their population. HPV was detected in 34% (32/93) of the wastewater samples collected and analyzed during 2020/21 in Salto city, Uruguay. Thirty-three genotypes were observed, of which 16 presented read abundance higher than 1%, including both high-risk (HR) and low-risk (LR) genotypes. HR genotypes 31, 16, 58, 52, 33 and 59 were detected representing 40% (163,220 reads) of the total read abundance, with genotypes 31 (64,365), 16 (39,337) and 58 (36,332) being the most abundant. LR genotypes 72, 6, 11 and 40 were also detected in a high frequency, accounting for 37% (148,359) of the HPV reads. This study highlights the high frequency of HR genotypes of HPV, circulating in the population of Salto city which is a burden in public health mainly due to the devastating impact of cervical cancer in women.

Published
2022
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20. Exploring NSF-Funded Evaluators’ and Principal Investigators’ Definitions and Measurement of Diversity, Equity, and Inclusion

Author

Ayesha S. Boyce, Tiffany L.S. Tovey, Onyinyechukwu Onwuka, J.R. Moller, Tyler Clark, and Aundrea Smith

Subjects
Health (social science), Sociology and Political Science, Social Psychology, Strategy and Management, Business and International Management, Education
Abstract

More evaluators have anchored their work in equity-focused, culturally responsive, and social justice ideals. Although we have a sense of approaches that guide evaluators as to how they should attend to culture, diversity, equity, and inclusion (DEI), we have not yet established an empirical understanding of how evaluators measure DEI. In this article, we report an examination of how evaluators and principal investigators (PIs) funded by the National Science Foundation's Advanced Technological Education (ATE) program define and measure DEI within their projects. Evaluators gathered the most evidence related to diversity and less evidence related to equity and inclusion. On average, PIs’ projects engaged in activities designed to increase DEI, with the highest focus on diversity. We believe there continues to be room for improvement and implore the movement of engagement with these important topics from the margins to the center of our field's education, theory, and practice.

Published
2022
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21. A safe and just operating space for human identity: a systems perspective

Author

Tom H Oliver, Bob Doherty, Andre Dornelles, Nigel Gilbert, Matthew P Greenwell, Laura J Harrison, Ian M Jones, Alastair C Lewis, Sarah J Moller, Vanessa J Pilley, Philip Tovey, and Netta Weinstein

Subjects
Health (social science), Earth, Planet, Health Policy, Public Health, Environmental and Occupational Health, Humans, Medicine (miscellaneous)
Abstract

A safe and just operating space for socioecological systems is a powerful bridging concept in sustainability science. It integrates biophysical earth-system tipping points (ie, thresholds at which small changes can lead to amplifying effects) with social science considerations of distributional equity and justice. Often neglected, however, are the multiple feedback loops between self-identity and planetary boundaries. Environmental degradation can reduce self-identification with nature, leading to decreased pro-environmental behaviours and decreased cooperation with out-groups, further increasing the likelihood of transgressing planetary boundaries. This vicious cycle competes with a virtuous one, where improving environmental quality enhances the integration of nature into self-identity and improves health, thereby facilitating prosocial and pro-environmental behaviour. These behavioural changes can also cascade up to influence social and economic institutions. Given a possible minimum degree of individual self-care to maintain health and prosperity, there would seem to exist an analogous safe and just operating space for self-identity, for which system stewardship for planetary health is crucial.

Published
2022
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22. Contraceptive use and the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation

Author

Yue Yin Xia, Jacek Gronwald, Beth Karlan, Jan Lubinski, Jeanna M. McCuaig, Jennifer Brooks, Pal Moller, Andrea Eisen, Sophie Sun, Leigha Senter, Louise Bordeleau, Susan L. Neuhausen, Christian F. Singer, Nadine Tung, William D. Foulkes, Ping Sun, Steven A. Narod, Joanne Kotsopoulos, Rinat Yerushalmi, Robert Fruscio, Antonella Rastelli, Stefania Zovato, Zerin Hyder, Tomasz Huzarski, Cezary Cybulski, Kevin Sweet, Marie Wood, Wendy McKinnon, Christine Elser, Tuya Pal, Georgia Wiesner, Eitan Friedman, Wendy Meschino, Carrie Snyder, Kelly Metcalfe, Aletta Poll, Nicole Gojska, Ellen Warner, Raymond H. Kim, Barry Rosen, Rochelle Demsky, Peter Ainsworth, Karen Panabaker, Linda Steele, Howard Saal, Kim Serfas, Seema Panchal, Carey A. Cullinane, Robert E. Reilly, Joanne L. Blum, Ava Kwong, Daniel Rayson, Claudine Isaacs, Teresa Ramón y Cajal, Jeffrey Dungan, Stephanie Cohen, Xia, Y, Gronwald, J, Karlan, B, Lubinski, J, Mccuaig, J, Brooks, J, Moller, P, Eisen, A, Sun, S, Senter, L, Bordeleau, L, Neuhausen, S, Singer, C, Tung, N, Foulkes, W, Sun, P, Narod, S, Kotsopoulos, J, Yerushalmi, R, Fruscio, R, Rastelli, A, Zovato, S, Hyder, Z, Huzarski, T, Cybulski, C, Sweet, K, Wood, M, Mckinnon, W, Elser, C, Pal, T, Wiesner, G, Friedman, E, Meschino, W, Snyder, C, Metcalfe, K, Poll, A, Gojska, N, Warner, E, Kim, R, Rosen, B, Demsky, R, Ainsworth, P, Panabaker, K, Steele, L, Saal, H, Serfas, K, Panchal, S, Cullinane, A, Reilly, R, Blum, J, Kwong, A, Rayson, D, Isaacs, C, Ramón y Cajal, T, Dungan, J, and Cohen, S

Subjects
BRCA2 Protein, Ovarian Neoplasms, Heterozygote, BRCA1 Protein, BRCA, Obstetrics and Gynecology, Breast Neoplasms, Carcinoma, Ovarian Epithelial, Case-control, Contraception, Oncology, Risk Factors, Ovarian cancer, Case-Control Studies, Mutation, Humans, Intrauterine device, Female, Contraceptives, Oral
Abstract

Background BRCA1 and BRCA2 (BRCA) mutation carriers face a high lifetime risk of developing ovarian cancer. Oral contraceptives are protective in this population; however, the impact of other types of contraception (e.g. intrauterine devices, implants, injections) is unknown. We undertook a matched case-control study to evaluate the relationship between type of contraception and risk of ovarian cancer among women with BRCA mutations. Methods A total of 1733 matched pairs were included in this analysis. Women were matched according to year of birth, date of study entry, country of residence, BRCA mutation type and history of breast cancer. Detailed information on hormonal, reproductive and lifestyle exposures were collected from a routinely administered questionnaire. Conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) associated with each contraceptive exposure. Results Ever use of any contraceptive was significantly associated with reduced risk of ovarian cancer (OR = 0.62; 95% CI 0.52–0.75; P < 0.0001), which was driven by significant inverse associations with oral contraceptives (OR = 0.66; 95% CI 0.54–0.79; P < 0.0001) and contraceptive implants (OR = 0.30; 95% CI 0.12–0.73; P = 0.008). We observed a similar effect with use of injections (OR = 0.37; 95% CI 0.10–1.38; P = 0.14), but this did not achieve significance. No significant associations were observed between patterns of intrauterine device use and risk of ovarian cancer. Conclusions These findings support a protective effect of oral contraceptives and implants on risk of ovarian cancer among women with BRCA mutations. The possible protective effect of injections requires further evaluation.

Published
2022
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23. The Acute Cytokine Response to 30-Minute Exercise Bouts Before and After 8-Week Endurance Training in Individuals With Obesity

Author

Thomas Goj, Miriam Hoene, Louise Fritsche, Patrick Schneeweiss, Jürgen Machann, Agnese Petrera, Stefanie M Hauck, Andreas Fritsche, Andreas L Birkenfeld, Andreas Peter, Martin Heni, Andreas M Niess, Anja Moller, and Cora Weigert

Subjects
Endocrinology, Endocrinology, Diabetes and Metabolism, Biochemistry (medical), Clinical Biochemistry, Biochemistry
Abstract

Context One acute bout of exercise leads to a rapid increase in the systemic cytokine concentration. Regular exercise might alter the cytokine response, in particular in beforehand untrained and obese individuals. Objective Using a proximity extension assay, we studied the effects of acute exercise as well as endurance training on a panel of 92 cytokines related to inflammation. Methods A total of 22 individuals (30 ± 9 years; peak oxygen uptake [VO2peak] 25.2 ± 4.2 mL/[kg × min]; body mass index [BMI] 31.7 ± 4.4) participated in an 8-week endurance exercise intervention. Blood samples were collected before and immediately after 30 minutes’ ergometer exercise at 80% VO2peak. Results Before and after the training intervention, 40 and 37 cytokines, respectively, were acutely increased more than 1.2-fold (Benjamini-Hochberg [BH]-adjusted P < .05). The exercise intervention did not change the acute increase in cytokines nor the resting cytokine levels, whereas fitness was improved and adiposity reduced. The increase in fitness led to a slight increase in power output when exercising at the same heart rate, which might explain the comparable increase in cytokines before and after the intervention. The largest acute increase was found for OSM, TGFA, CXCL1 and 5, and TNFSF14 (≥ 1.9-fold, BH-adjusted P < .001). The transcript levels of these proteins in whole blood were also elevated, particularly in the trained state. Only the acute increase in IL6 (1.3-fold) was related to the increase in lactate, confirming the lactate-driven secretion of IL6. Conclusion Our comprehensive proteomics approach detected several underexplored serum exerkines with up to now less understood function in the adaptation to exercise.

Published
2022
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28. Evolution of Structural and Optical Properties of Cuprous Oxide Particles for Visible Light Absorption

Author

A. R. Carrasco-Hernández, R. I. Ruvalcaba-Ontiveros, E. Martínez-Guerra, J. A. Duarte-Moller, and H. E. Esparza-Ponce

Subjects
Article Subject, General Materials Science
Abstract

Absorbent materials are being developed to replace semiconductor materials such as p-type silicon, GaAs, CdTe, and quaternary compounds such as CIGS (copper indium gallium selenide). Cu2O is a potential candidate because it is non-toxic, inexpensive, an abundant compound in the Earth’s crust, and has good optical properties, such as a high absorption coefficient. In this work, Cu2O was obtained simply by reducing Benedict’s solution with glucose in an alkaline medium (pH 10.2 ± 0.2) at 65°C. The samples were synthesized by varying glucose content from 1 g to 7 g. The results showed a phase proportion variation between 95.56% and 99.50% of the Cu2O phase. It was found that the changes in crystallite size, microstrains, particle size, and morphology are due to reaction times, which were influenced by the use of different glucose amounts. The use of a higher glucose amount in the synthesis favors a faster reaction, forming smaller crystallites with more microstrains. Lower glucose amount leads to a slower reaction giving the crystallites more time to grow, which relaxes the microstrains. When increasing glucose content, the obtained morphologies changed from cubes, irregular cubes, prismatic spheres, cauliflower-like, to spherical shapes. The XPS spectra confirmed only the presence of chemical species such as Cu(I) and Cu(II), and chemical defects, such as oxygen vacancies (Vo), were detected in the samples. All samples presented a broad absorption range from 200 nm to 570 nm indistinctly of the morphology. The band gap showed an insignificant change from 2.04 eV to 2.09 eV when glucose was increased from 1 g to 7 g. The in-situ phase transformation study was analyzed from 25°C to 700°C. The results indicated a phase transition from Cu2O to Cu and CuO when the temperature was above 280°C.

Published
2022
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30. Deep Learning Electrocardiographic Analysis for Detection of Left-Sided Valvular Heart Disease

Author

Pierre Elias, Timothy J. Poterucha, Vijay Rajaram, Luca Matos Moller, Victor Rodriguez, Shreyas Bhave, Rebecca T. Hahn, Geoffrey Tison, Sean A. Abreau, Joshua Barrios, Jessica Nicole Torres, J. Weston Hughes, Marco V. Perez, Joshua Finer, Susheel Kodali, Omar Khalique, Nadira Hamid, Allan Schwartz, Shunichi Homma, Deepa Kumaraiah, David J. Cohen, Mathew S. Maurer, Andrew J. Einstein, Tamim Nazif, Martin B. Leon, and Adler J. Perotte

Subjects
Electrocardiography, Deep Learning, Aortic Valve Insufficiency, Heart Valve Diseases, Humans, Mitral Valve Insufficiency, Aortic Valve Stenosis, Cardiology and Cardiovascular Medicine
Abstract

Valvular heart disease is an important contributor to cardiovascular morbidity and mortality and remains underdiagnosed. Deep learning analysis of electrocardiography (ECG) may be useful in detecting aortic stenosis (AS), aortic regurgitation (AR), and mitral regurgitation (MR).This study aimed to develop ECG deep learning algorithms to identify moderate or severe AS, AR, and MR alone and in combination.A total of 77,163 patients undergoing ECG within 1 year before echocardiography from 2005-2021 were identified and split into train (n = 43,165), validation (n = 12,950), and test sets (n = 21,048; 7.8% with any of AS, AR, or MR). Model performance was assessed using area under the receiver-operating characteristic (AU-ROC) and precision-recall curves. Outside validation was conducted on an independent data set. Test accuracy was modeled using different disease prevalence levels to simulate screening efficacy using the deep learning model.The deep learning algorithm model accuracy was as follows: AS (AU-ROC: 0.88), AR (AU-ROC: 0.77), MR (AU-ROC: 0.83), and any of AS, AR, or MR (AU-ROC: 0.84; sensitivity 78%, specificity 73%) with similar accuracy in external validation. In screening program modeling, test characteristics were dependent on underlying prevalence and selected sensitivity levels. At a prevalence of 7.8%, the positive and negative predictive values were 20% and 97.6%, respectively.Deep learning analysis of the ECG can accurately detect AS, AR, and MR in this multicenter cohort and may serve as the basis for the development of a valvular heart disease screening program.

Published
2022
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31. A computational study of the thermodynamic and magnetic properties of Co-alloyed MnPt

Author

R. G. Diale, P. E. Ngoepe, J. S. Moema, M. J. Phasha, H. Moller, and H. R. Chauke

Subjects
Mechanics of Materials, Mechanical Engineering, General Materials Science, Condensed Matter Physics
Abstract

Magnetic functional materials remain an area of research interest for applications in electronic devices. Among these materials, Mn50Pt50 alloy has received a great deal of attention in practical potential applications such as spintronics due to its high-thermal and magnetic stability. It was reported previously that L10 Mn50Pt50 alloy shows ferromagnetic ordering at room temperature. In this study, the effect of the partial substitution of Pt with Co was investigated using density functional theory (DFT) approach. The thermodynamic, magnetic and mechanical properties were determined to check the stability of Mn50Pt50-xCox alloys. The results showed that the L10 phase has the lowest heat of formation when the c/a ratio is 1.10 for 6.25 at.% Co. Overall magnetic moments improve with an increase in Co compositions when the c/a ratio is 1.10. The obtained results reveal that Mn50Pt50-xCox alloys exhibit attractive magnetic and mechanical properties for future magnets in spintronics applications. Graphical Abstract

Published
2023
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34. SMYD5 is a novel epigenetic gatekeeper of the mild hypothermia response

Author

Salvor Rafnsdottir, Kijin Jang, Sara Tholl Halldorsdottir, Arnhildur Tomasdottir, Meghna Vinod, Katrin Moller, Tinna Reynisdottir, Laufey Halla Atladottir, Kristin Elisabet Allison, Jin He, Li Zhang, Frances J. Northington, Raul Chavez-Valdez, Kimberley Jade Anderson, and Hans Bjornsson

Abstract

Organisms have homeostatic mechanisms to respond to cold to ensure survival including the activation of the neuroprotective mild hypothermia response (MHR) in mammals at 32C. We show activation of the MHR by one FDA-approved medication, Entacapone, a proof-of-principle that the MHR can be medically manipulated. Utilizing a forward CRISPR-Cas9 mutagenesis screen, we identify the histone lysine methyltransferase SMYD5 as an epigenetic gatekeeper of the MHR. SMYD5 represses the key MHR gene SP1 at euthermia but not at 32C. This repression is mirrored by temperature-dependent levels of H3K36me3 at the SP1-locus and globally indicating the mammalian MHR is regulated at the level of histone modifications. We identified 45 additional SMYD5-temperature dependent genes suggesting a broader MHR-related role for SMYD5. Our study provides an example of how the epigenetic machinery integrates environmental cues into the genetic circuitry of mammalian cells and suggests novel therapeutic avenues for neuroprotection after catastrophic events.

Published
2023
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35. MscS inactivation and recovery are slow voltage-dependent processes sensitive to interactions with lipids

Author

Madolyn Britt, Elissa Moller, Joseph Maramba, Andriy Anishkin, and Sergei Sukharev

Subjects
Article
Abstract

Mechanosensitive channel MscS, the major bacterial osmolyte release valve, shows a characteristic adaptive behavior. With a sharp onset of activating tension, the channel population readily opens, but under prolonged action of moderate near-threshold tension, it inactivates. The inactivated state is non-conductive and tension-insensitive, which suggests that the gate gets uncoupled from the lipid-facing domains. The kinetic rates for tension-driven opening-closing transitions are 4-6 orders of magnitude higher than the rates for inactivation and recovery. Here we show that inactivation is augmented and recovery is slowed down by depolarization. Hyperpolarization, conversely, impedes inactivation and speeds up recovery. We then address the question of whether protein-lipid interactions may set the rates and influence voltage dependence of inactivation and recovery. Mutations of conserved arginines 46 and 74 anchoring the lipid-facing helices to the inner membrane leaflet to tryptophans do not change the closing transitions, but instead change the kinetics of both inactivation and recovery and essentially eliminate their voltage-dependence. Uncharged polar substitutions (S or Q) for these anchors produce functional channels but increase the inactivation and reduce the recovery rates. The data suggest that it is not the activation and closing transitions, but rather the inactivation and recovery pathways that involve substantial rearrangements of the protein-lipid boundary associated with the separation of the lipid-facing helices from the gate. The discovery that hyperpolarization robustly assists MscS recovery indicates that membrane potential can regulate osmolyte release valves by putting them either on the ‘ready’ or ‘standby’ mode depending on the cell’s metabolic state.

Published
2023
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36. MscS is a critical component for osmotic survival ofVibrio cholerae

Author

Madolyn Britt, Joseph Maramba, Andriy Anishkin, Claudia C. Häse, Kristen M. Ramsey, Elissa Moller, Blake Ushijima, and Sergei Sukharev

Subjects
Component (thermodynamics), Vibrio cholerae, Mesenchymal stem cell, Biophysics, medicine, Biology, medicine.disease_cause, Article, Microbiology
Abstract

Intestinal bacteria, including the facultative pathogenVibrio cholerae, can adapt to a wide range of osmotic environments. In high-osmolarity media, bacteria accumulate small compatible metabolites to maintain turgor pressure, but under drastic osmotic down-shifts bacteria are able to avoid mechanical rupture by rapidly releasing these metabolites through mechanosensitive (MS) channels. Previous experiments onV. choleraehave identified two major types of MS channels - MscS and MscL. We functionally examine these channels’ specific roles inVibrio’sosmotic rescuing via genetic modification, bacterial patch-clamp electrophysiology, and stopped-flow light scattering. The light scattering kinetics revealed that WTVibriocells were capable of releasing up to 10% of their total non-aqueous content within ∼30 ms. To investigate each channel’s individual contribution toV. cholerae’sosmotic permeability response, we generated and characterized the first individualΔmscS, ΔmscL, and doubleΔmscL ΔmscSmutants inV. choleraeO395. Both mutants lacking MscS exhibited delayed osmolyte release kinetics and decreased osmotic survival rates compared to WT. Surprisingly, theΔmscLmutant had comparable kinetics to WT, but a much higher osmotic survival, whereas ΔmscShad low survival, comparable to the doubleΔmscLΔmscSmutant. The data indicate that MscS is much more efficient in osmotic adjustment and is up-regulated in the absence of MscL, whereas in the absence of the low-threshold MscS, MscL even becomes toxic. Kinetic modeling of the cell swelling process and channel activation reveals the advantage of low-threshold MscS in curbing tension surges inVibrioand its role in proper termination of the osmotic permeability response.

Published
2023
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38. Centralisation of post-resuscitation care after out-of-hospital cardiac arrest at heart centres - a nationwide follow-up study

Author

S Rasalingam Mork, E Gregers, K Kragholm, J Kjaergaard, F Folke, C Torp-Pedersen, L Kober, A M Boas Soja, C Juhl Terkelsen, F Michalik, J Eifer Moller, F Lund Henriksen, K Bundgaard Ringgren, C Hassager, and H Soholm

Subjects
General Medicine, Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine
Abstract

Funding Acknowledgements Type of funding sources: None. Background Recent guidelines recommend centralisation of post-resuscitation care in out-of-hospital cardiac arrest (OHCA) patients in dedicated Cardiac Arrest Centres (CACs) aiming to improve outcome. Purpose To describe the process of implementation of the centralisation policy and impact on 30-day mortality rate. Methods This nationwide study included all adult OHCA patients (>18 years) based on the Danish Cardiac Arrest Registry. Centralisation was introduced in 2009, 2010, and 2012 in four regions (A, B, C, D), and one region has not yet implemented the policy (control). Parallel trends assumption was made and a difference-in-difference model with repeated cross-sections was used to estimate the average treatment effect on the treated patients. The 30-day mortality was compared between patients living in regions that introduced centralisation versus control region without centralisation. Results A total of 20,566 patients with OHCA were identified between 2007 and 2020. The majority were between 50 to 75 years (53.7%) and 67.8% male. Bystander cardiopulmonary resuscitation was performed in 55.3%. Shockable rhythm was present in 34.6% of the patients. The policy of centralisation of OHCA in CACs has been gradually and not yet completely implemented (Figure 1A). Patients with shockable rhythms (72%), and younger patients < 50 years (64%) were more frequently transported to CACs. The 30-day mortality was lower among patients transported to CACs (Figure 1B). Centralisation significantly improved survival by 6% (95% CI: 2%-10%) percentage points compared to the control region after controlling for all known covariates (sex, age, Charlson Comobidity Index, shockable rhythm, and bystander cardiopulmonary resuscitation). Conclusions In this nationwide study, centralisation of post-resuscitation care of OHCA in dedicated CACs has been gradually implemented over time. Although, OHCA patients with favorable prognostic factors were more frequently transported to CACs, centralisation increased survival by 6 absolute percentage points.

Published
2023
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39. Serious complications of pancreatoduodenectomy correlate with lower rates of adjuvant chemotherapy: Results from the recurrence after Whipple's (RAW) study

Author

Thomas B. Russell, Peter L. Labib, Fabio Ausania, Elizabeth Pando, Keith J. Roberts, Ambareen Kausar, Vasileios K. Mavroeidis, Gabriele Marangoni, Sarah C. Thomasset, Adam E. Frampton, Pavlos Lykoudis, Manuel Maglione, Nassir Alhaboob, Hassaan Bari, Andrew M. Smith, Duncan Spalding, Parthi Srinivasan, Brian R. Davidson, Ricky H. Bhogal, Daniel Croagh, Ismael Dominguez, Rohan Thakkar, Dhanny Gomez, Michael A. Silva, Pierfrancesco Lapolla, Andrea Mingoli, Alberto Porcu, Nehal S. Shah, Zaed Z.R. Hamady, Bilal Al-Sarrieh, Alejandro Serrablo, Somaiah Aroori, Adam Streeter, Jemimah Denson, Mark Puckett, Shang-Ming Zhou, Matthew Browning, Keith Roberts, Sarah Thomasset, Adam Frampton, Andrew Smith, Brian Davidson, Ricky Bhogal, Michael Silva, Nehal Sureshkumar Shah, Zaed Hamady, Carolina Gonzalez-Abos, Nair Fernandes, Elsa Garcia Moller, Cristina Dopazo Taboada, Rupaly Pande, Jameel Alfarah, Samik Bandyopadhyay, Ahmed Abdelrahim, Ayesha Khan, Caitlin Jordan, Jonathan R.E. Rees, Harry Blege, William Cambridge, Olga White, Sarah Blacker, Jessie Blackburn, Casie Sweeney, Daniel Field, Mohammed Gouda, Ruben Bellotti, Hytham K.S. Hamid, Hassan Ahmed, Catherine Moriarty, Louise White, Mark Priestley, Kerry Bode, Judith Sharp, Rosie Wragg, Beverley Jackson, Samuel Craven, Matyas Fehervari, Madhava Pai, Laith Alghazawi, Anjola Onifade, Julliette Ribaud, Ashitha Nair, Michael Mariathasan, Niamh Grayson, Stephanos Pericleous, Krishna Patel, Conrad Shaw, Nolitha Morare, Mohamad Khish Zaban, Joseph Doyle, Alan Guerrero, Andre Moguel, Carlos Chan, Michael Jones, Edward Buckley, Nasreen Akter, Kyle Treherne, Gregory Gordon, Daniel Hughes, Tomas Urbonas, Gioia Brachini, Roberto Caronna, Piero Chirletti, Teresa Perra, Nurul Nadhirah Abd Kahar, Thomas Hall, Nabeegh Nadeem, Shoura Karar, Ali Arshad, Adam Yarwood, Mohammed Hammoda, Maria Artigas, and Sandra Paterna-López

Subjects
Oncology, Surgery, General Medicine
Published
2023
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40. Blood-pressure targets in comatose survivors of cardiac arrest with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention - a BOX sub-study

Author

A Klein, H E L L E Soeholm, J E Moller, H Schmidt, C Hassager, and J Kjaergaard

Subjects
General Medicine, Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine
Abstract

Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): Novo Nordisk Foundation. Background After successful resuscitation from out-of-hospital cardiac arrest (OHCA), patients who remain comatose often need hemodynamic support with vasoactive drugs in order to secure an adequate perfusion pressure to vital organs. However, evidence regarding specific blood-pressure targets is sparse, and patients with concomitant heart disease such as acute ST-elevation myocardial infarction (STEMI) might benefit from a lower afterload and lower doses of vasoactive drugs. Purpose To assess the impact of blood-pressure on biochemical infarct size in comatose survivors of OHCA with STEMI and, further, to investigate whether a high or low mean arterial blood-pressure target is superior in preventing death or severe brain injury. Methods The BOX study (n=789) is a randomized trial with a 2-by-2 factorial design which evaluated a double-blind intervention of a high (77 mmHg) versus a low (63 mmHg) mean arterial blood-pressure target in comatose survivors of OHCA of presumed cardiac cause. In this pre-specified sub-study we included patients who had an initial electrocardiogram with STEMI recorded after return of spontaneous circulation (ROSC). The primary outcome was creatine kinase (CK), creatine kinase MB (CKMB), and troponin T (TnT) levels measured at 48 hours as surrogate markers of infarct size. A secondary outcome was a composite of all-cause death within one year from admission or discharge from the hospital with a Cerebral Performance Category (CPC) of 3 to 4, indicating severe neurological disability or a comatose or vegetative state. Results A total of 350 patients were included. Mean time to ROSC was 21±13 minutes. The mean age was 63±12 years and approximately 4 out of 5 were male. The prevalence of relevant prior medical history was as follows; hypertension 42%, diabetes 12%, chronic ischemic heart disease 20%, percutaneous coronary intervention 11%, coronary artery bypass grafting 4%, and congestive heart failure 10%. Mean CK, CKMB and TnT measured at 48 hours did not differ between the two blood-pressure target groups (p=0.42, p=0.14 and p=0.65, respectively). Within one year, 138 patients (39%) had died or been discharged with a CPC of 3 to 4 with no difference found between high or low blood pressure targets (hazard ratio, 1.02; 95% CI, 0.73-1.43; p=0.9). Conclusion Targeting a high versus a low mean arterial blood-pressure in comatose survivors of OHCA with STEMI did not affect infarct size estimated by coronary biomarkers at 48 hours nor did it result in a significant difference in death or severe neurologic disability. Although not evaluating side effects, this study thus suggests that the use of pharmacologic circulatory support in post-resuscitation care can be limited.

Published
2023
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42. An analysis framework to evaluate irrigation decisions using short-term ensemble weather forecasts

Author

Danlu Guo, Quan J. Wang, Dongryeol Ryu, Qichun Yang, Peter Moller, and Andrew W. Western

Subjects
Soil Science, Agronomy and Crop Science, Water Science and Technology
Abstract

Irrigation water is an expensive and limited resource and optimal scheduling can boost water efficiency. Scheduling decisions often need to be made several days prior to an irrigation event, so a key aspect of irrigation scheduling is the accurate prediction of crop water use and soil water status ahead of time. This prediction relies on several key inputs including initial soil water status, crop conditions and weather. Since each input is subject to uncertainty, it is important to understand how these uncertainties impact soil water prediction and subsequent irrigation scheduling decisions. This study aims to develop an uncertainty-based analysis framework for evaluating irrigation scheduling decisions under uncertainty, with a focus on the uncertainty arising from short-term rainfall forecasts. To achieve this, a biophysical process-based crop model, APSIM (The Agricultural Production Systems sIMulator), was used to simulate root-zone soil water content for a study field in south-eastern Australia. Through the simulation, we evaluated different irrigation scheduling decisions using ensemble short-term rainfall forecasts. This modelling produced an ensemble of simulations of soil water content, as well as ensemble simulations of irrigation runoff and drainage. This enabled quantification of risks of over- and under-irrigation. These ensemble estimates were interpreted to inform the timing of the next irrigation event to minimize both the risks of stressing the crop and/or wasting water under uncertain future weather. With extension to include other sources of uncertainty (e.g., evapotranspiration forecasts, crop coefficient), we plan to build a comprehensive uncertainty framework to support on-farm irrigation decision-making.

Published
2022
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43. The Clinical Variant Analysis Tool: Analyzing the evidence supporting reported genomic variation in clinical practice

Author

Hui-Lin Chin, Nour Gazzaz, Stephanie Huynh, Iulia Handra, Lynn Warnock, Ashley Moller-Hansen, Pierre Boerkoel, Julius O.B. Jacobsen, Christèle du Souich, Nan Zhang, Kent Shefchek, Leah M. Prentice, Nicole Washington, Melissa Haendel, Linlea Armstrong, Lorne Clarke, Wenhui Laura Li, Damian Smedley, Peter N. Robinson, and Cornelius F. Boerkoel

Subjects
Exome Sequencing, Genetic Variation, Humans, Exome, Genetic Testing, Genomics, Article, Genetics (clinical)
Abstract

PURPOSE: Genomic test results, regardless of laboratory variant classification, require clinical practitioners to judge the applicability of a variant for medical decisions. Teaching and standardizing clinical interpretation of genomic variation calls for a methodology or tool. METHODS: To generate such a tool, we distilled the Clinical Genome Resource framework of causality and the American College of Medical Genetics/Association of Molecular Pathology and Quest Diagnostic Laboratory scoring of variant deleteriousness into the Clinical Variant Analysis Tool (CVAT). Applying this to 289 clinical exome reports, we compared the performance of junior practitioners with that of experienced medical geneticists and assessed the utility of reported variants. RESULTS: CVAT enabled performance comparable to that of experienced medical geneticists. In total, 124 of 289 (42.9%) exome reports and 146 of 382 (38.2%) reported variants supported a diagnosis. Overall, 10.5% (1 pathogenic [P] or likely pathogenic [LP] variant and 39 variants of uncertain significance [VUS]) of variants were reported in genes without established disease association; 20.2% (23 P/LP and 54 VUS) were in genes without sufficient phenotypic concordance; 7.3% (15 P/LP and 13 VUS) conflicted with the known molecular disease mechanism; and 24% (91 VUS) had insufficient evidence for deleteriousness. CONCLUSION: Implementation of CVAT standardized clinical interpretation of genomic variation and emphasized the need for collaborative and transparent reporting of genomic variation.

Published
2022
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44. Pressing need for national governmental recognition of forensic anthropology in South Africa as illustrated in a medico-legal case

Author

Victoria Elaine Gibbon, Chandra Finaughty, Izelle Moller, and Devin Alexander Finaughty

Subjects
South Africa, Forensic Anthropology, Humans, Pathology and Forensic Medicine
Abstract

Forensic anthropology in South Africa is well developed in the higher education sector, with advanced training and research programmes. Despitethis and decades of academic involvement in casework, forensic anthropology still lacks a defined framework and mandate ata governmentallevel. Therefore, the involvement of forensic anthropologists' expertise varies markedly between cases, provinces, and among various stakeholderswithinthe country, to the detriment of dispensation of social and criminal justice. The lack ofclearly defined guidelines for the renderingof the service was exemplified and demonstrated through a recent forensic case. Here,contextual information was absent, and the remains posed a challenge to analyse, ostensibly due tomissing information. Numerous questions were raised during the analysis of the remains, and broader concerns about the investigative involvement of a forensic anthropologist within South African casework were brought to the fore. Through the analysis of this case, we describe the deductive processes that led to the formation of an opinion that the skeletal linear defects were the result of taphonomic changes. In addition, we highlighthow these efforts where constrained and each step in theprocess unnecessarily hindered. Finally, we demonstrate the capacity andwillingness offorensic anthropology practitioners to be involved, and how, withoutgovernmentalsupport, it is a great potential lamentably untapped.

Published
2022
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46. Chemometric Tools in the Analysis of Pharmaceutics Samples: a Comparison Among Several Multivariate Calibration Methods

Author

Nancy E. Ornelas-Soto, José Alberto Duarte-Moller, Judith Amador-Hernández, Alma Rocío Rivera-Gomez, Rafael Pacheco , Contreras, Rolando Flores Ochoa, Ignacio Yocupicio , Villegas, and Pedro L. López-De-Alba

Subjects
Biomedical Engineering, Bioengineering, General Medicine, General Biochemistry, Genetics and Molecular Biology
Abstract

Bivariate calibration algorithm is compared with the results obtained by the usage of high-dimensional calibration methods such as partial least squares (PLS) and multi-way partial least-squares (N-PLS) by using UV-Vis spectrophotometric data of first and second-order. The algorithms were applied to the determination of a mixture of an analgesic and a stimulant compound and their actual concentrations of them were calculated by using spectroscopic data. The direct reading of absorbance values at 227 nm and 271 nm were employed for quantification of the compounds in the case of the bivariate method. The approaches of first-order and multi-way methods were applied with a previous optimization of the calibration matrix by constructing sets of calibration and validation with 20 and 10 samples (mixtures) respectively according to a central composite design and their UV absorption spectra were recorded at 200-350 nm. All algorithms were satisfactorily applied to the simultaneous determination of these compounds in pharmaceutical formulations with mean percentage recovery of 100.5 ± 3.67, 98.7 ± 3.42, and 100.5 ± 3.74 for bivariate, PLS-1, and N-PLS, respectively. The statistical evaluation of the bivariate method showed that this procedure is comparable with those algorithms that employ high-dimensional structured information. The aim of the work is to compare the methods under study and it can be seen that there are no significant differences, so a simple spectrophotometer can be used up to a very specialized one. However, the advantage of bivariate calibration is its simplicity, due to the minimal experimental manipulation.

Published
2022
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47. Stressing Halide Perovskites with Light and Electric Fields

Author

Sarah Wieghold, Emily M. Cope, Gregory Moller, Nozomi Shirato, Burak Guzelturk, Volker Rose, and Lea Nienhaus

Subjects
Fuel Technology, Renewable Energy, Sustainability and the Environment, Chemistry (miscellaneous), Materials Chemistry, Energy Engineering and Power Technology
Published
2022
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