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1. Exogenous miRNAs from Moringa oleifera Lam. recover a dysregulated lipid metabolism

Author

Roglia, V, Potesta, M, Minchella, A, Bruno, Sp, Bernardini, R, Lettieri-Barbato, D, Iacovelli, F, Gismondi, A, Aquilano, K, Canini, A, Muleo, R, Colizzi, V, Mattei, M, Minutolo, A, and Montesano, C

Subjects
Inflammation, Settore BIO/01, lipid metabolism, plant miRNAs, cross-kingdom interactions, post transcriptional modification, Settore MED/04, Settore VET/03 - Patologia Generale e Anatomia Patologica Veterinaria, Biochemistry, Genetics and Molecular Biology (miscellaneous), Molecular Biology, Biochemistry
Abstract

A balanced diet is critical for human health, and edible plants play an important role in providing essential micronutrients as well as specific microRNAs (miRNAs) that can regulate human gene expression. Here we present the effects of Moringa oleifera (MO) miRNAs (mol-miRs) on lipid metabolism. Through in silico studies we identified the potential genes involved in lipid metabolism targeted by mol-miRs. To this end, we tested the efficacy of an aqueous extract of MO seeds (MOES), as suggested in traditional African ethnomedicine, or its purified miRNAs. The biological properties of MO preparations were investigated using a human derived hepatoma cell line (HepG2) as a model. MOES treatment decreased intracellular lipid accumulation and induced apoptosis in HepG2. In the same cell line, transfection with mol-miRs showed similar effects to MOES. Moreover, the effect of the mol-miR pool was investigated in a pre-obese mouse model, in which treatment with mol-miRs was able to prevent dysregulation of lipid metabolism.

Published
2022
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2. Awareness of kidney diseases in general population and in high school students. Italian report for World Kidney Days 2010-2011

Author

Apperti, V, Auricchio, Mr, Barbato, A, Bedani, Pl, Bellinghieri, G, Costantino, G, Boggi, R, Bonomini, M, Calabria, L, Calabria, M, Grimaldi, M, Capuano, M, Terribile, M, Caputo, C, Castellino, S, Centrone, E, Ciccarelli, M, Cicchetti, T, Costantino, E, D'Amaro, E, Dagostino, F, Napolitano, F, Bonifati, C, Dal Canton, A, Esposito, P, Delgado, G, D'Apice, L, Di Luca, M, Farfaglia, P, Cantù, P, Farina, M, Fasianos, E, Feriozzi, S, Galeotti, P, Fiorini, F, Frattolillo, P, Garibotto, Giacomo, Giannattasio, M, Detomaso, F, Latino, A, Li Vecchi, M, Maffucci, G, Anelli, Am, Mangano, S, Meneghel, G, Morrone, L, Mura, C, Novizio, D, Paglia, S, Cardone, F, Parsi, R, Pizzini, M, Polito, P, Prati, E, Brognoli, M, Rubino, F, Turchetta, L, Parravano, M, Sambati, M, Sicignano, M, Tarchini, R, Teatini, U, Gallieni, M, Colussi, G, Limido, A, Pozzi, C, Spotti, D, Brancaccio, D, Traversari, L, Venditti, G, Aucella, F, Garganico, R, Giovanni Rotondo, S, Cenerelli, S, Bozzi, M, Petrarulo, F, Casu, Md, Cavatorta, F, Montesano, C, Ferrara, Dd, Mazzola, Ma, De Simone, W, Del Rosso, G, Sozzo, Ee, Mangione, D, Emiliani, G, Fasianos, R, Ganadu, M, Garibotto, G, Lusenti, T, Manno, C, Orbello, G, Rondanini, V, Russo, D, Battaglia, Y, Sarli, P, Sozzo, E, Napoli, M, Valentini, Wd, Viganò, L., Y., Battaglia 1, L., Russo 1, R., Spadola 1, Russo, Domenico, Battaglia, Y, Russo, L., and Spadola, R.

Subjects
Male, Nephrology, Health Knowledge, Attitudes, Practice, Pediatrics, Kidney Disease, Global Health, Surveys and Questionnaires, Prevalence, Global health, Surveys and Questionnaire, Young adult, Reagent Strips, Practice, Kidney, education.field_of_study, Health Knowledge, Urinalysi, Awareness, Middle Aged, Proteinuria, Treatment Outcome, medicine.anatomical_structure, Italy, Hypertension, Kidney Diseases, Female, Reagent Strip, Student, Comprehension, Human, Adult, medicine.medical_specialty, Adolescent, Population, Health knowledge, Health literacy, Health Promotion, Urinalysis, Young Adult, Terminology as Topic, Internal medicine, medicine, Humans, Students, education, Aged, business.industry, Blood Pressure Determination, Health Literacy, Adolescent Behavior, Awarene, Health promotion, Attitudes, Family medicine, business
Published
2012
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3. Selection of microbial epitopes for immune recognition. North-South transfer in Biotechnology of Tuberculosis and AIDS. University of Rome 'Tor Vergata'. UNESCO Interdisciplinary Chair in Biotechnology. Vittorio Colizzi, Luc Mantagnier, 2004

Author

AMICOSANTE M, MONTESANO C, GOLETTI G, GIOIA C, VINCENTI D, CARRARA S, PUCILLO LP, DIELI, Francesco, CACCAMO, Nadia Rosalia, SALERNO, Alfredo, COLIZZI V., MONTAGNIER L., AMICOSANTE M, DIELI F, MONTESANO C, GOLETTI G, GIOIA C, VINCENTI D, CARRARA S, CACCAMO N, SALERNO A, and PUCILLO LP

Published
2004

4. Development of a post-exposure paediatric anti HIV-AIDS vaccine based on the combined synthetic/recombinant HIV peptides and BCG for boosting innate and acquired immunity. North-South transfer in Biotechnology of Tuberculosis and AIDS. University of Rome 'Tor Vergata'. UNESCO Interdisciplinary Chair in Biotechnology. Vittorio Colizzi, Luc Montagnier, 2004

Author

AMICOSANTE M, ANDREONI M, ANSELMI A, CASTELLI G, CIARAMELLA A, COLIZZI V, D'ARRIGO R, ERCOLI L, FRAZIANO M, GARG SK, MARCHIONE P, MATTEI M, PALMIERI G, PERNO F, SALTINI C, SANTUCCI M, SUMERSKA T, ROSSI P, VENDETTI S, CAPPELLI G, CAVONE A, GRASSI M, MARIANI F, MIGNONE M, PERRETTA G, CASETTI R, HOREJSH D, MARTINI F, MONTESANO C, GIOIA C, POCCIA F, PUCILLO L, SACCHI A, DI SANO C, CAIRO C, GALLO R, REDFIELD R, PAUZA D, CHENAL H, MONTAGNIER L, OLIVIER R, TONI T, MAULE L, SIMPORE J., DI GIORGIO, Giuseppa, MARTINO, Andrea, BONANNO, Cesira, DIELI, Francesco, SALERNO, Alfredo, COLIZZI V., MONTAGNIER L., AMICOSANTE M, ANDREONI M, ANSELMI A, CASTELLI G, CIARAMELLA A, COLIZZI V, D'ARRIGO R, DI GIORGIO G, ERCOLI L, FRAZIANO M, GARG SK, MARCHIONE P, MATTEI M, PALMIERI G, PERNO F, SALTINI C, SANTUCCI M, SUMERSKA T, ROSSI P, VENDETTI S, CAPPELLI G, CAVONE A, GRASSI M, MARIANI F, MIGNONE M, PERRETTA G, CASETTI R, HOREJSH D, MARTINO A, MARTINI F, MONTESANO C, GIOIA C, POCCIA F, PUCILLO L, SACCHI A, BONANNO CT, DIELI F, DI SANO C, SALERNO A, CAIRO C, GALLO R, REDFIELD R, PAUZA D, CHENAL H, MONTAGNIER L, OLIVIER R, TONI T, MAULE L, and SIMPORE J

Published
2004

5. Risk factors for kidney diseases and awareness of blood pressure and proteinuria in general population and in high school students: Italian report for World Kidney Days 2012-2013

Author

Agate, *Square Project: V. M., Anelli, A. M., Apicella, L., Avino, D., Battaglia, Y., Bedani, P. L., Bellinghieri, Guido, Bernardi, A. M., Bonifati, C., Borzumati, M., Botti, P. L., Brigante, M., Brighina, F., Calzavara, P., Caputo, C., Cardone, F., Cavatorta, F., Confessore, N., Cossu, M., Costantino, E., Costantino, Giuseppe, D’Apice, L., D’Arcangelo, R., Dagostino, F., Dal Canton, A., Delgado, G., Di Pietro, R., Esposito, C., Esposito, P., Fasianos, E., Fiorini, F., Galeotti, P., Garibotto, G., Gemelli, A., Gregorini, M. C., Iuliano, P., La Peccerella, L., Liuzzi, M., Merola, M., Montesano, C., Morrone, L. F., Napoli, M., Napolitano, F., Paglia, S., Parravano, M., Pasquali, S., Rosa, A., Sambati, M. L., Schiavone, P., Sozzo, E., Storari, A., Tarchini, R., Tirino, G., Bellinghieri, L. T. u. r. c. h. e. t. t. a. School Project: G., Beltrame, G., Bozzi, M., Casolino, E., Centrone, E., Ciccarelli, M., Cicchetti, T., Colturi, C., Costantino, G., Garibotto, Indraccolo, F., Lombardi, M., Minoretti, C., Parsi, R., Petrarulo, F., Prati, E., Quarello, F., Rondanini, V., Russo, D., Tira, P., Turina, S., and Valentini, W. D.

Subjects
Adult, Male, Pathology, medicine.medical_specialty, Health Knowledge, Attitudes, Practice, Adolescent, Population, Health Promotion, Risk Factors, Medicine, Humans, Renal Insufficiency, Chronic, Renal Insufficiency, Chronic, education, Students, education.field_of_study, Practice, business.industry, Health Knowledge, Middle Aged, Proteinuria, Italy, Nephrology, Cardiovascular Diseases, Attitudes, Female, Kidney Diseases, business, Humanities
Abstract

*Square Project: V.M. Agate (Palmanova, UD), A.M. Anelli (Pistoia), L. Apicella (Salerno), D. Avino (Vairano Scalo, CE), Y. Battaglia (Ferrara), P.L. Bedani (Ferrara), G. Bellinghieri (Messina), A.M. Bernardi (Rovigo), C. Bonifati (Corato, BA), M. Borzumati (Verbania), P.L. Botti (Mantova), M. Brigante (Campobasso), F. Brighina (San Nicola La Strada, CE), P. Calzavara (Conegliano, TV), C. Caputo (Albenga, SV), F. Cardone (Lavello, PZ), F. Cavatorta (Imperia), N. Confessore (Scafati, SA), M. Cossu (Sassari), E. Costantino (Gavardo, BS), G. Costantino (Messina), L. D’Apice (Caserta), R. D’Arcangelo (Arzano, NA), F. Dagostino (Corato, BA), A. Dal Canton (Pavia), G. Delgado (Teano, CE), R. Di Pietro (Napoli), C. Esposito (Pavia), P. Esposito (Pavia), E. Fasianos (Altamura, BA), F. Fiorini (Rovigo), P. Galeotti (Viterbo), G. Garibotto (Genova), A. Gemelli (Rovigo), M.C. Gregorini (Reggio Emilia), P. Iuliano (Benevento), L. La Peccerella (Benevento), M. Liuzzi (Benevento), M. Merola (Sorrento, NA), C. Montesano (Imperia), L.F. Morrone (Benevento), M. Napoli (Galatina, LE), F. Napolitano (Corato, BA), S. Paglia (Lavello, PZ), M. Parravano (Sora, FR), S. Pasquali (Reggio Emilia), A. Rosa (Benevento), M.L. Sambati (Taranto), P. Schiavone (Brindisi), E. Sozzo (Galatina, LE), A. Storari (Ferrara), R. Tarchini (Mantova), G. Tirino (Montesarchio, BN), L. Turchetta (Sora, FR). School Project: G. Bellinghieri (Messina), G. Beltrame (Torino), M. Bozzi (Bari), E. Casolino (Rionero in Vulture, PZ), E. Centrone (Ruvo di Puglia, BA), M. Ciccarelli (Reggio Calabria), T. Cicchetti (Rossano, CS), C. Colturi (Sondrio), E. Costantino (Gavardo, BS), G. Costantino (Messina), F. Dagostino (Corato, BA), E. Fasianos (Altamura, BA), P. Galeotti (Viterbo), Garibotto (Genova), F. Indraccolo (S. Fermo della Battaglia, CO), M. Lombardi (Borgo S. Lorenzo, FI), C. Minoretti (S. Fermo della Battaglia, CO), F. Napolitano (Corato, BA), R. Parsi (Alcamo, TP), F. Petrarulo (Bari), E. Prati (Desenzano del Garda, BS), F. Quarello (Torino), V. Rondanini (Palmi, RC), D. Russo (Barletta), P. Tira (Manerbio, BS), S. Turina (Manerbio, BS), W.D. Valentini (Rieti) WORLD KIDNEY DAY

Published
2013

8. HIV replication leads to skewed maturation of CD8-positive T-cell responses in infected children

Author

Montesano, C., Anselmi, A., Palma, P., Bernardi, S., Cicconi, R., Mattei, M., Guido Castelli-Gattinara, Ciccozzi, M., Colizzi, V., and Amicosante, M.

Subjects
CD4-Positive T-Lymphocytes, Settore MED/04 - Patologia Generale, Adolescent, HIV Infections, T-Cell Antigen Receptor Specificity, Cell Differentiation, CD8-Positive T-Lymphocytes, Viral Load, Virus Replication, Treatment Outcome, Anti-Retroviral Agents, Disease Progression, HIV-1, Humans, Viremia, Lymphocyte Count, Child, Immunologic Memory

10. Knowledge and Attitudes of Population Living in Rural and Semi-Rural Areas towards Covid-19 :Case of the Menoua Division, Cameroon

Author

Zogning Makemjio, E., Tiotsia Tsapi, A., Défo Tamgno, E., GHYSLAINE BRUNA DJEUNANG DONGHO, Nguefack-Tsague, G., Montesano, C., Colizzi, V., Gianluca Russo, and Sanou Sobze, M.

Subjects
Adult, Male, Rural Population, Health Knowledge, Attitudes, Practice, SARS-CoV-2, Pneumonia, Viral, COVID-19, covid, rural area, Betacoronavirus, Young Adult, Cross-Sectional Studies, Surveys and Questionnaires, Humans, Female, Cameroon, Coronavirus Infections, camerun, Pandemics
Abstract

The pandemic situation the world is facing caused by the new SARS-Cov-2 continues to evolve and still represent a real problem. With more than eight thousand reported cases infection, Cameroon stands as the seventh most affected country in Africa. Prevention remains the best way to fight against this zoonosis. However, the limited information available about this infection is a great barrier to stopping the propagation of the virus within the population, especially in rural and semi-rural areas, where the lack of financial and material resources is a reality. This study aimed to assessing Awareness and attitudes of the population of the Menoua Division on COVID-19 infection.A cross-sectional study was conducted from March 9 to April 15 2020 amongst the populations of rural and semi-rural areas of the Menoua Division. Data were collected using a questionnaire administered face to face to each participant. The analysis was carried out using the Statistical Analysis System software (SAS version 9.4). The significance threshold was set at a P value of less than 0.05.A total of 434 participants of which male majority (sex ratio 1.07) were included in this study. The most represented age group was [21 - 40] years old representing 40.29% of the participants. Approximately all participants (98.57%) were aware of the world emergency state due to Coronavirus. 75.56%, 91% and 90.93% of the participants knew respectively that having close contacts, kissing and touching the face with the hands could favor the transmission of the virus. However, nearly 91.14% were not aware of the clinical symptoms of the disease. Moreover, 85.02% responded that they would not be able to comply with the confinement measures if they were applied at national level. The level of awareness varied significantly according to the occupation (p=0.038) and the educational level (plt;0.001)of the participants.The average level of awareness of the population of the Menoua Division on COVID-19 infection was relatively low. Overcoming this pandemic disease means ensuring the flow of the correct information towards the population. Community outreach activities focus on clinical manifestations and what to do in case of COVID-19 infection as well as material and financial support should be help the population to protect themselves effectively against pandemic, particularly in rural areas and surrounding.

14. Lymphocyte distribution and intrahepatic compartmentalization during HCV infection: a main role for MHC-unrestricted T cells

Author

Chiara Agrati, Nisii, C., Oliva, A., D Offizi, G., Montesano, C., Pucillo, L. P., and Poccia, F.

Subjects
Settore MED/04 - Patologia Generale, gamma-delta, T-Cell, Hepatitis C, Lymphocyte Subsets, Liver, T-Lymphocyte Subsets, Antigen, Receptors, Natural, Cytokines, Animals, Killer Cells, Humans, Inflammation Mediators, Receptors, Antigen, T-Cell, gamma-delta, Killer Cells, Natural

15. Personalized Metabolic Profile by Synergic Use of NMR and HRMS

Author

Greta Petrella, Vincenzo Summa, Sara Lentini, Domitilla Vanni, Daniel O. Cicero, Roberto Speziale, Edith Monteagudo, Camilla Montesano, Giorgia Ciufolini, Francesco Montorsi, Laura Orsatti, Andrea Salonia, Riccardo Vago, Petrella, G., Montesano, C., Lentini, S., Ciufolini, G., Vanni, D., Speziale, R., Salonia, A., Montorsi, F., Summa, V., Vago, R., Orsatti, L., Monteagudo, E., and Cicero, D. O.

Subjects
Male, 0301 basic medicine, Magnetic Resonance Spectroscopy, Metabolite, Cystiti, Pharmaceutical Science, Urine, Nuclear magnetic resonance, Analytical Chemistry, chemistry.chemical_compound, QD241-441, 0302 clinical medicine, Tandem Mass Spectrometry, Cystitis, Drug Discovery, 80 and over, Medicine, Precision Medicine, Mass spectrometry, Normal ranges, Personalized metabolic profile, Urine metabolome, Adult, Aged, Aged, 80 and over, Chromatography, High Pressure Liquid, Female, Humans, Magnetic Resonance Imaging, Metabolome, Metabolomics, Middle Aged, Urinary Bladder Neoplasms, mass spectrometry, Chromatography, Healthy subjects, Clinical Practice, Chemistry (miscellaneous), High Pressure Liquid, 030220 oncology & carcinogenesis, Urinary Bladder Neoplasm, Molecular Medicine, Metabolic profile, Human, Metabolomic, Computational biology, Article, 03 medical and health sciences, Normal range, Settore BIO/10, Physical and Theoretical Chemistry, business.industry, nuclear magnetic resonance, urine metabolome, normal ranges, personalized metabolic profile, Organic Chemistry, Disease progression, Missing data, 030104 developmental biology, chemistry, business
Abstract

A new strategy that takes advantage of the synergism between NMR and LC-HRMS (SYNHMET), and that allows to obtain a unique list of the absolute concentrations of 164 metabolites in urine, is presented. Metabolite identification and quantification by this method in one of the most difficult biofluids to characterize, due to complexity and variability, is more accurate than what can be obtained using the two techniques separately. This result is achieved without the need for chemical reactions to cross-check the data between the two types of spectra, nor the use of analytical standards and calibration curves. The fact that the absolute rather than relative concentration is obtained allows the final dataset to be used to determine a patient's personalized profile. The number of quantifiable metabolites by the application of this method can be expanded in the future with further analysis. We will illustrate the use of SYNHMET in the study of urine samples from healthy subjects, patients with chronic cystitis and bladder cancer.

Published
2021
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16. In HIV-positive patients, myeloid-derived suppressor cells induce T-cell anergy by suppressing CD3ζ expression through ELF-1 inhibition

Author

Chiara Agrati, Federica Turchi, Silvia Meschi, Alessandra Sacchi, Nicola Tumino, Vittorio Colizzi, Eleonora Cimini, Federico Martini, Veronica Bordoni, Carla Montesano, Eleonora Lalle, Rita Casetti, Tumino, N., Turchi, F., Meschi, S., Lalle, E., Bordoni, V., Casetti, R., Agrati, C., Cimini, E., Montesano, C., Colizzic, V., Martini, F., and Sacchi, A.

Subjects
Male, CD3 Complex, T-Lymphocytes, MDSC, Adolescent, Adult, Aged, Aged, 80 and over, Antigens, CD3, Blotting, Western, Female, Flow Cytometry, Gene Expression Profiling, HIV Infections, Humans, Immunophenotyping, Middle Aged, Nuclear Proteins, RNA, Messenger, Real-Time Polymerase Chain Reaction, Transcription Factors, Young Adult, Clonal Anergy, Down-Regulation, Messenger, Cell, 80 and over, Immunology and Allergy, biology, medicine.diagnostic_test, Clonal anergy, Blotting, Infectious Diseases, medicine.anatomical_structure, Western, CD3, Immunology, γδ T cells, Peripheral blood mononuclear cell, Flow cytometry, Immune system, medicine, Antigens, αβ T cell, Settore MED/04 - Patologia Generale, HIV, Molecular biology, HIV-specific T-cell response immune suppression, biology.protein, Myeloid-derived Suppressor Cell, RNA
Abstract

Objective During HIV infection, a down-modulation of CD3ζ was found on T cells, contributing to T-cell anergy. In this work, we studied the correlation between myeloid-derived suppressor cells (MDSC) frequency and T-cell CD3ζ expression. Moreover, we investigated the mechanisms of CD3ζ decrease exploited by MDSC. Design and method CD3ζ expression and MDSC frequency were evaluated by flow cytometry on peripheral blood mononuclear cells from 105 HIV-positive (HIV+) patients. The role of MDSC in the modulation of the HIV-specific T-cell response was evaluated. The level of CD3ζ mRNA and ELF-1 protein were analysed by real-time-PCR and western blot, respectively. Results We found that granulocytic-MDSC (Gr-MDSC) were expanded in HIV+ patients compared with healthy donors; in particular, in cART-treated individuals a higher Gr-MDSC frequency was observed in patients with a CD4 T-cell count below 400 cells/μl. We found an inverse correlation between the percentage of Gr-MDSC and CD3ζ level. Moreover, in-vitro MDSC depletion induced the up-regulation of CD3ζ in T cells, restoring the functionality of αβ, but not γδ T cells. The in-vitro effect of isolated MDSC on CD3ζ expression was found cell contact-dependent, and was not mediated by previously described molecules. CD3ζ down-modulation corresponds to the decrease of its mRNA induced by silencing the transcription factor ELF-1. Conclusion Our data provide new knowledge on mechanisms used by Gr-MDSC in immune-modulation and on their role in the immune reconstitution during antiviral treatments.

Published
2015
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