1. Sequence of the 5'-flanking region of the gene encoding human muscle glycogen synthase
- Author
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Esumi Mariko, Nakabayashi Hiroki, and Nakayama Tomohiro
- Subjects
Placenta ,5' flanking region ,Molecular Sequence Data ,DNA, Satellite ,Polymerase Chain Reaction ,law.invention ,Start codon ,law ,Pregnancy ,Genetics ,Animals ,Humans ,Genomic library ,Cloning, Molecular ,Glycogen synthase ,Promoter Regions, Genetic ,Gene ,Polymerase chain reaction ,Sequence (medicine) ,DNA Primers ,Repetitive Sequences, Nucleic Acid ,Genomic Library ,Binding Sites ,Polymorphism, Genetic ,biology ,Base Sequence ,Muscles ,Hominidae ,General Medicine ,DNA ,Molecular biology ,TATA Box ,Rats ,Glycogen Synthase ,biology.protein ,Microsatellite ,Female ,Transcription Factors - Abstract
The 5'-flanking region of the gene encoding human muscle glycogen synthase was isolated from a human placental genomic library and sequenced. The sequence is TATA-less and G + C-rich, and putative transcription-controlling sequences were identified. Furthermore, a simple (dC-dA)n sequence repeat was identified about 4 kb upstream from the start codon. This sequence was highly polymorphic and five alleles were typed in the Japanese population using the polymerase chain reaction.
- Published
- 1994