1. Fatigue in multiple sclerosis: The contribution of resting-state functional connectivity reorganization
- Author
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Renato Docimo, Alessandro d’Ambrosio, Antonio Gallo, Giuseppina Caiazzo, Leonardo Sinisi, Mario Cirillo, Simona Bonavita, Alvino Bisecco, Gioacchino Tedeschi, Federica Di Nardo, Rocco Capuano, Fabrizio Esposito, Bisecco, Alvino, Nardo, Federica Di, Docimo, Renato, Caiazzo, Giuseppina, D'Ambrosio, Alessandro, Bonavita, Simona, Capuano, Rocco, Sinisi, Leonardo, Cirillo, Mario, Esposito, Fabrizio, Tedeschi, Gioacchino, and Gallo, Antonio
- Subjects
Adult ,Male ,0301 basic medicine ,Multiple Sclerosis ,Rest ,sensorimotor network ,Gyrus Cinguli ,default mode network ,03 medical and health sciences ,0302 clinical medicine ,Neural Pathways ,Image Processing, Computer-Assisted ,medicine ,Humans ,Multiple sclerosi ,resting state ,Fatigue ,Default mode network ,Brain Mapping ,fatigue ,functional magnetic resonance imaging ,Multiple sclerosis ,Neurology ,Neurology (clinical) ,Resting state fMRI ,medicine.diagnostic_test ,business.industry ,Functional connectivity ,medicine.disease ,Magnetic Resonance Imaging ,030104 developmental biology ,Relapsing remitting ,Sensorimotor network ,Female ,Nerve Net ,Functional magnetic resonance imaging ,business ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Objectives: To investigate resting-state functional connectivity (RS-FC) of the default-mode network (DMN) and of sensorimotor network (SMN) network in relapsing remitting (RR) multiple sclerosis (MS) patients with fatigue (F) and without fatigue(NF). Methods: In all, 59 RRMS patients and 29 healthy controls (HC) underwent magnetic resonance imaging (MRI) protocol including resting-state fMRI (RS-fMRI). Functional connectivity of the DMN and SMN was evaluated by independent component analysis (ICA). A linear regression analysis was performed to explore whether fatigue was mainly driven by changes observed in the DMN or in the SMN. Regional gray matter atrophy was assessed by voxel-based morphometry (VBM). Results: Compared to HC, F-MS patients showed a stronger RS-FC in the posterior cingulate cortex (PCC) and a reduced RS-FC in the anterior cingulated cortex (ACC) of the DMN. F-MS patients, compared to NF-MS patients, revealed (1) an increased RS-FC in the PCC and a reduced RS-FC in the ACC of the DMN and (2) an increased RS-FC in the primary motor cortex and in the supplementary motor cortex of the SMN. The regression analysis suggested that fatigue is mainly driven by RS-FC changes of the DMN. Conclusions: Fatigue in RRMS is mainly associated to a functional rearrangement of non-motor RS networks.
- Published
- 2017
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