1. Innovative compounds to battle multiresistence to antibiotics: use of PVA-Tannic acid nanoparticles to inibit staphylococcus pseudointermedius growth
- Author
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Martínez Muñoz, Guillermo, Pérez-Aranda Redondo, María, Merinero de los Santos, Manuel, Begines Ruiz, Belén, Ortiz Cerda, Tamara Andrea, Navarro de la Torre, Salvadora, Aguilera Velázquez, José Raúl, Martín Valero, María Jesús, Rodríguez Llorente, Ignacio David, Pajuelo Domínguez, Eloísa, Zaderenko Partida, Ana-Paula, Alcudia Cruz, Ana, Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica, Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica, Universidad de Sevilla. Departamento de Química Analítica, Universidad de Sevilla. Departamento de Microbiología y Parasitología, Universidad de Sevilla. FQM135: Carbohidratos y Polímeros, Universidad de Sevilla. CTS949: Biopatología y Estrés Oxidativo, Universidad de Sevilla. FQM291: Análisis Químico, and Universidad de Sevilla. BIO181: Fito Microbiomas como Herramientas Biotecnológicas
- Abstract
Antibiotic resistance is an increasing public health problem that affects numerous pathogens, including Staphylococcus pseudintermedius, which has a high prevalence of methicillin resistance and can be easily transmitted to humans. Nowadays, the scientific community is developing new compounds that not only improve classic therapies in fighting antibiotic resistances but also prevent its appearance, essential to maintain health protection. The main objective of the present study is to synthesize tannic acid and polyvinyl alcohol nanoparticles and to determine their potential as growth inhibitors for S. pseudintermedius, to be considered a potential alternative therapy. The study includes diameter and Z-potential measurements for nanoparticles characterization and antimicrobial effect assays with different nanoparticles concentrations. MIC90 is determined as 112 μg/mL. Nonetheless, further studies to identify the underlying action mechanisms of these nanoparticles are going on in our group.
- Published
- 2021