1. Prevalence of Mycoplasma genitalium Infection, Antimicrobial Resistance Mutations, and Symptom Resolution Following Treatment of Urethritis
- Author
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Bachmann, Laura H, Kirkcaldy, Robert D, Geisler, William M, Wiesenfeld, Harold C, Manhart, Lisa E, Taylor, Stephanie N, Seña, Arlene C, McNeil, Candice J, Newman, Lori, Myler, Noelle, Fuchs, Rachael, Bowden, Katherine E, and MAGNUM Laboratory Working Group
- Subjects
Male ,Urologic Diseases ,Clinical Trials and Supportive Activities ,Drug Resistance ,Mycoplasma genitalium ,Medical and Health Sciences ,Microbiology ,MAGNUM Laboratory Working Group ,resistance ,Clinical Research ,Prevalence ,Humans ,Mycoplasma Infections ,Urethritis ,Bacterial ,persistence ,urethritis ,Biological Sciences ,Anti-Bacterial Agents ,Infectious Diseases ,Good Health and Well Being ,Mutation ,Sexually Transmitted Infections ,Female ,Macrolides ,Antimicrobial Resistance ,Infection - Abstract
BackgroundAntimicrobial resistance in Mycoplasma genitalium (MG), a cause of urethritis, is a growing concern. Yet little is known about the geographic distribution of MG resistance in the United States or about its associated clinical outcomes. We evaluated the frequency of MG among men with urethritis, resistance mutations, and posttreatment symptom persistence.MethodsWe enrolled men presenting with urethritis symptoms to 6 US sexually transmitted disease (STD) clinics during June 2017-July 2018; men with urethritis were eligible for follow-up contact and, if they had persistent symptoms or MG, a chart review. Urethral specimens were tested for MG and other bacterial STDs. Mutations in 23S ribosomal ribonucleic acid (rRNA) loci (macrolide resistance-associated mutations [MRMs]) and in parC and gyrA (quinolone-associated mutations) were detected by targeted amplification/Sanger sequencing.ResultsAmong 914 evaluable participants, 28.7% (95% confidence interval [CI], 23.8-33.6) had MG. Men with MG were more often Black (79.8% vs 66%, respectively)
- Published
- 2020