1. Thrombin generation predicts early recurrence in breast cancer patients
- Author
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Marina Marchetti, Cinzia Giaccherini, Giovanna Masci, Cristina Verzeroli, Laura Russo, Luigi Celio, Roberta Sarmiento, Sara Gamba, Carmen J. Tartari, Erika Diani, Alfonso Vignoli, Paolo Malighetti, Daniele Spinelli, Nicole M. Kuderer, Federico Nichetti, Mauro Minelli, Carlo Tondini, Sandro Barni, Francesco Giuliani, Fausto Petrelli, Andrea D’Alessio, Giampietro Gasparini, Roberto Labianca, Armando Santoro, Filippo De Braud, Anna Falanga, Francesca Schieppati, Antonia Martinetti, Elisabetta Gennaro, Mara Ghilardi, Marchetti, M, Giaccherini, C, Masci, G, Verzeroli, C, Russo, L, Celio, L, Sarmiento, R, Gamba, S, Tartari, C, Diani, E, Vignoli, A, Malighetti, P, Spinelli, D, Kuderer, N, Nichetti, F, Tondini, C, Barni, S, Giuliani, F, Petrelli, F, D'Alessio, A, Gasparini, G, Labianca, R, Santoro, A, De Braud, F, Falanga, A, and Hypercan, I
- Subjects
Oncology ,medicine.medical_specialty ,Multivariate analysis ,medicine.medical_treatment ,Breast Neoplasms ,030204 cardiovascular system & hematology ,disease recurrence ,03 medical and health sciences ,Breast cancer ,0302 clinical medicine ,risk model ,Internal medicine ,medicine ,Humans ,Derivation ,Prospective Studies ,Mastectomy ,Proportional hazards model ,business.industry ,breast cancer ,hypercoagulability ,thrombin generation ,Thrombin ,Cancer ,Hematology ,Settore ING-IND/35 - Ingegneria Economico-Gestionale ,medicine.disease ,Prognosis ,Cohort ,Neoplasm Recurrence, Local ,business ,Risk assessment - Abstract
Background: Cancer patients present with a hypercoagulable state often associated with poor disease prognosis. Objectives: This study aims to evaluate whether thrombin generation (TG), a global coagulation test, may be a useful tool to improve the identification of patients at high risk of early disease recurrence (i.e. E-DR within 2 years) after breast cancer surgery. Patients/methods: A cohort of 522 newly diagnosed patients with surgically resected high-risk breast cancer were enrolled in the ongoing prospective HYPERCAN study. TG potential was measured in plasma samples collected before starting systemic chemotherapy. Significant predictive hemostatic and clinic-pathological parameters were identified in the derivation cohort by Cox-regression analysis. A risk prognostic score for E-DR was generated in the derivation and tested in the validation cohort. Results: After a median observation period of 3.4 years, DR occurred in 51 patients, 28 of whom were E-DR. E-DR subjects presented with the highest TG values as compared to both late-DR (from 2 to 5 years) and no relapse subjects (p
- Published
- 2019