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1. Supplementary Methods and Materials from PD-1–Expressing Tumor-Infiltrating T Cells Are a Favorable Prognostic Biomarker in HPV-Associated Head and Neck Cancer

Author

Eric Tartour, Daniel Brasnu, Daniel Olive, Ludger Johannes, Stephane Oudard, Francois M. Lemoine, Wolf H. Fridman, Patrick Bruneval, Françoise Quintin-Colonna, Federico Sandoval, Beatrix Barry, Sebastien Albert, Cécile Alanio, Estelle Dransart, Anne Chauvat, Coralie L. Guerin, Thi Tran, Hélène Pere, Rinat Rotem-Yehudar, Alain Gey, Nicolas Besnier, Ali Si-Mohamed, Mevyn Nizard, Emeline Levionnois, Nadine Benhamouda, Patrice Ravel, Cordélia Van Ryswick, Nathalie Merillon, Stéphane Hans, and Cécile Badoual

Abstract

PDF file - 81K

Published
2023
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2. Supplementary Table 1 from PD-1–Expressing Tumor-Infiltrating T Cells Are a Favorable Prognostic Biomarker in HPV-Associated Head and Neck Cancer

Author

Eric Tartour, Daniel Brasnu, Daniel Olive, Ludger Johannes, Stephane Oudard, Francois M. Lemoine, Wolf H. Fridman, Patrick Bruneval, Françoise Quintin-Colonna, Federico Sandoval, Beatrix Barry, Sebastien Albert, Cécile Alanio, Estelle Dransart, Anne Chauvat, Coralie L. Guerin, Thi Tran, Hélène Pere, Rinat Rotem-Yehudar, Alain Gey, Nicolas Besnier, Ali Si-Mohamed, Mevyn Nizard, Emeline Levionnois, Nadine Benhamouda, Patrice Ravel, Cordélia Van Ryswick, Nathalie Merillon, Stéphane Hans, and Cécile Badoual

Abstract

PDF file - 54K, Patient characteristics

Published
2023
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3. Supplementary Figure 1 from PD-1–Expressing Tumor-Infiltrating T Cells Are a Favorable Prognostic Biomarker in HPV-Associated Head and Neck Cancer

Author

Eric Tartour, Daniel Brasnu, Daniel Olive, Ludger Johannes, Stephane Oudard, Francois M. Lemoine, Wolf H. Fridman, Patrick Bruneval, Françoise Quintin-Colonna, Federico Sandoval, Beatrix Barry, Sebastien Albert, Cécile Alanio, Estelle Dransart, Anne Chauvat, Coralie L. Guerin, Thi Tran, Hélène Pere, Rinat Rotem-Yehudar, Alain Gey, Nicolas Besnier, Ali Si-Mohamed, Mevyn Nizard, Emeline Levionnois, Nadine Benhamouda, Patrice Ravel, Cordélia Van Ryswick, Nathalie Merillon, Stéphane Hans, and Cécile Badoual

Abstract

PDF file - 2.6MB, Characterization of PD1+CD45+ cells

Published
2023
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4. Supplementary Figure 3 from PD-1–Expressing Tumor-Infiltrating T Cells Are a Favorable Prognostic Biomarker in HPV-Associated Head and Neck Cancer

Author

Eric Tartour, Daniel Brasnu, Daniel Olive, Ludger Johannes, Stephane Oudard, Francois M. Lemoine, Wolf H. Fridman, Patrick Bruneval, Françoise Quintin-Colonna, Federico Sandoval, Beatrix Barry, Sebastien Albert, Cécile Alanio, Estelle Dransart, Anne Chauvat, Coralie L. Guerin, Thi Tran, Hélène Pere, Rinat Rotem-Yehudar, Alain Gey, Nicolas Besnier, Ali Si-Mohamed, Mevyn Nizard, Emeline Levionnois, Nadine Benhamouda, Patrice Ravel, Cordélia Van Ryswick, Nathalie Merillon, Stéphane Hans, and Cécile Badoual

Abstract

PDF file - 2.6MB, Relationship between tumor infiltration with Foxp3 regulatory T cells and survival

Published
2023
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5. Supplementary Figure 2 from PD-1–Expressing Tumor-Infiltrating T Cells Are a Favorable Prognostic Biomarker in HPV-Associated Head and Neck Cancer

Author

Eric Tartour, Daniel Brasnu, Daniel Olive, Ludger Johannes, Stephane Oudard, Francois M. Lemoine, Wolf H. Fridman, Patrick Bruneval, Françoise Quintin-Colonna, Federico Sandoval, Beatrix Barry, Sebastien Albert, Cécile Alanio, Estelle Dransart, Anne Chauvat, Coralie L. Guerin, Thi Tran, Hélène Pere, Rinat Rotem-Yehudar, Alain Gey, Nicolas Besnier, Ali Si-Mohamed, Mevyn Nizard, Emeline Levionnois, Nadine Benhamouda, Patrice Ravel, Cordélia Van Ryswick, Nathalie Merillon, Stéphane Hans, and Cécile Badoual

Abstract

PDF file - 3.4MB, Relationship between PDL-1 expression and survival

Published
2023
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6. Supplementary Table 2 from PD-1–Expressing Tumor-Infiltrating T Cells Are a Favorable Prognostic Biomarker in HPV-Associated Head and Neck Cancer

Author

Eric Tartour, Daniel Brasnu, Daniel Olive, Ludger Johannes, Stephane Oudard, Francois M. Lemoine, Wolf H. Fridman, Patrick Bruneval, Françoise Quintin-Colonna, Federico Sandoval, Beatrix Barry, Sebastien Albert, Cécile Alanio, Estelle Dransart, Anne Chauvat, Coralie L. Guerin, Thi Tran, Hélène Pere, Rinat Rotem-Yehudar, Alain Gey, Nicolas Besnier, Ali Si-Mohamed, Mevyn Nizard, Emeline Levionnois, Nadine Benhamouda, Patrice Ravel, Cordélia Van Ryswick, Nathalie Merillon, Stéphane Hans, and Cécile Badoual

Abstract

PDF file - 64K, List of antibodies used for immunofluorescence staining

Published
2023
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7. Supplementary Figure 4 from PD-1–Expressing Tumor-Infiltrating T Cells Are a Favorable Prognostic Biomarker in HPV-Associated Head and Neck Cancer

Author

Eric Tartour, Daniel Brasnu, Daniel Olive, Ludger Johannes, Stephane Oudard, Francois M. Lemoine, Wolf H. Fridman, Patrick Bruneval, Françoise Quintin-Colonna, Federico Sandoval, Beatrix Barry, Sebastien Albert, Cécile Alanio, Estelle Dransart, Anne Chauvat, Coralie L. Guerin, Thi Tran, Hélène Pere, Rinat Rotem-Yehudar, Alain Gey, Nicolas Besnier, Ali Si-Mohamed, Mevyn Nizard, Emeline Levionnois, Nadine Benhamouda, Patrice Ravel, Cordélia Van Ryswick, Nathalie Merillon, Stéphane Hans, and Cécile Badoual

Abstract

PDF file - 2.7MB, Correlation between PDL-1 expression and PD-1 positive infiltrating T cells

Published
2023
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8. Supplementary Figure 5 from PD-1–Expressing Tumor-Infiltrating T Cells Are a Favorable Prognostic Biomarker in HPV-Associated Head and Neck Cancer

Author

Eric Tartour, Daniel Brasnu, Daniel Olive, Ludger Johannes, Stephane Oudard, Francois M. Lemoine, Wolf H. Fridman, Patrick Bruneval, Françoise Quintin-Colonna, Federico Sandoval, Beatrix Barry, Sebastien Albert, Cécile Alanio, Estelle Dransart, Anne Chauvat, Coralie L. Guerin, Thi Tran, Hélène Pere, Rinat Rotem-Yehudar, Alain Gey, Nicolas Besnier, Ali Si-Mohamed, Mevyn Nizard, Emeline Levionnois, Nadine Benhamouda, Patrice Ravel, Cordélia Van Ryswick, Nathalie Merillon, Stéphane Hans, and Cécile Badoual

Abstract

PDF file - 4.8MB, Colocalization between PD1 positive cells and Foxp3- or Tim3- positive cells

Published
2023
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9. Supplementary Figure 6 from PD-1–Expressing Tumor-Infiltrating T Cells Are a Favorable Prognostic Biomarker in HPV-Associated Head and Neck Cancer

Author

Eric Tartour, Daniel Brasnu, Daniel Olive, Ludger Johannes, Stephane Oudard, Francois M. Lemoine, Wolf H. Fridman, Patrick Bruneval, Françoise Quintin-Colonna, Federico Sandoval, Beatrix Barry, Sebastien Albert, Cécile Alanio, Estelle Dransart, Anne Chauvat, Coralie L. Guerin, Thi Tran, Hélène Pere, Rinat Rotem-Yehudar, Alain Gey, Nicolas Besnier, Ali Si-Mohamed, Mevyn Nizard, Emeline Levionnois, Nadine Benhamouda, Patrice Ravel, Cordélia Van Ryswick, Nathalie Merillon, Stéphane Hans, and Cécile Badoual

Abstract

PDF file - 4.8MB, Synergy between anti-HPV vaccine and anti-PDL-1 to inhibit tumor growth

Published
2023
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10. PD-1-expressing tumor-infiltrating T cells are a favorable prognostic biomarker in HPV-associated head and neck cancer

Author

Rinat Rotem-Yehudar, Patrick Bruneval, Cécile Alanio, Daniel Olive, Emeline Levionnois, Françoise Quintin-Colonna, Mevyn Nizard, Thi Tran, Wolf H. Fridman, Nathalie Merillon, Cordelia Van Ryswick, Hélène Péré, Coralie L. Guerin, François M. Lemoine, Alain Gey, Ludger Johannes, Cécile Badoual, Federico Sandoval, Ali Si-Mohamed, Eric Tartour, Nadine Benhamouda, Estelle Dransart, Stéphane Oudard, Nicolas Besnier, Stéphane Hans, Daniel Brasnu, Béatrix Barry, Patrice Ravel, Sebastien Albert, and Anne Chauvat

Subjects
Oncology, Cancer Research, medicine.medical_specialty, T-Lymphocytes, Programmed Cell Death 1 Receptor, Fluorescent Antibody Technique, Lymphocyte Activation, Flow cytometry, Mice, Immune system, Lymphocytes, Tumor-Infiltrating, T-Lymphocyte Subsets, Internal medicine, medicine, Carcinoma, Biomarkers, Tumor, Tumor Microenvironment, Animals, Humans, medicine.diagnostic_test, business.industry, Head and neck cancer, Papillomavirus Infections, Cancer, FOXP3, medicine.disease, Flow Cytometry, Prognosis, Blockade, Mice, Inbred C57BL, Head and Neck Neoplasms, Carcinoma, Squamous Cell, Female, Cancer vaccine, business
Abstract

Head and neck cancers positive for human papillomavirus (HPV) have a more favorable clinical outcome than HPV-negative cancers, but it is unknown why this is the case. We hypothesized that prognosis was affected by intrinsic features of HPV-infected tumor cells or differences in host immune response. In this study, we focused on a comparison of regulatory Foxp3+ T cells and programmed death-1 (PD-1)+ T cells in the microenvironment of tumors that were positive or negative for HPV, in two groups that were matched for various clinical and biologic parameters. HPV-positive head and neck cancers were more heavily infiltrated by regulatory T cells and PD-1+ T cells and the levels of PD-1+ cells were positively correlated with a favorable clinical outcome. In explaining this paradoxical result, we showed that these PD-1+ T cells expressed activation markers and were functional after blockade of the PD-1–PD-L1 axis in vitro. Approximately 50% of PD-1+ tumor-infiltrating T cells lacked Tim-3 expression and may indeed represent activated T cells. In mice, administration of a cancer vaccine increased PD-1 on T cells with concomitant tumor regression. In this setting, PD-1 blockade synergized with vaccine in eliciting antitumor efficacy. Our findings prompt a need to revisit the significance of PD-1–infiltrating T cells in cancer, where we suggest that PD-1 detection may reflect a previous immune response against tumors that might be reactivated by PD-1/PD-L1 blockade. Cancer Res; 73(1); 128–38. ©2012 AACR.

Published
2012

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