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1. Left gastric vein embolization during TIPS placement for acute variceal bleeding has no effect on bleeding recurrence: Results of a multicenter study

Author

Paul Calame, Mathieu Rostam, Louis d'Alteroche, Alexandre Malakhia, Jean-Paul Cervoni, Delphine Weil, Vincent Di Martino, Olivier Sutter, Michel Greget, Jean-Romain Risson, Mathilde Vionnet, Antoine Bouvier, Fatima-Zohra Mokrane, Julien Ghelfi, Panteleimon Papadopoulos, Christian Sangel, Agnes Rodes, Jean Goupil, Eric Delabrousse, Frederic Douane, Romaric Loffroy, Olivier Chevallier, Thomas Hebert, Antoine Boizet, Ayoub Guerrab, Nicolas Raynaud, Pierre-Quentin Carbillet, Victor Dumas, Stéphane Velasco, Bruno Lapuyade, Marie-Annaig Pey, Emanuele Boatta, Pierre De Marini, Jules Cœur, and Pierre Verdot

Subjects
Radiological and Ultrasound Technology, Radiology, Nuclear Medicine and imaging, General Medicine
Published
2023
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4. Towards $5\mu \mathrm{m}$ interconnection pitch with Die-to-Wafer direct hybrid bonding

Author

Emilie Bourjot, Noura Nadi, Frank Fournel, Loic Sanchez, Severine Cheramy, Nicolas Raynaud, C. Castan, Alice Bond, Pascal Metzger, and N. Bresson

Subjects
Bonding process, Interconnection, Materials science, business.industry, visual_art, Electronic component, visual_art.visual_art_medium, Optoelectronics, Wafer, business, Die (integrated circuit)
Abstract

Die-to-wafer direct hybrid bonding process is foreseen as a key enabler of heterogeneous 3D integration. Hybrid bonding technologies were first developed on W2W assembly reaching 3D interconnection pitch of $1\mu\mathrm{m}$ . Recently, CEA-Leti demonstrated the feasibility of DTW direct hybrid bonding at $10\mu\mathrm{m}$ with a specific die bonder (NEO HB) developed by SET Corporation. In this paper, the last improvements of DTW hybrid bonding process flow and die bonder alignment capability are presented. Main results showed an alignment capability improved to $ which enables bonding of die with $ interconnection pitch. Finally, multi-interconnection pitch bondings on a wafer were achieved with Cu pitches varying from $5\mu\mathrm{m}$ to $10\mu \mathrm{m}$ .

Published
2021
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5. Mechanical Thrombectomy for Acute Ischemic Stroke Amid the COVID-19 Outbreak: Decreased Activity, and Increased Care Delays

Author

Basile Kerleroux, Thibaut Fabacher, Nicolas Bricout, Martin Moïse, Benoit Testud, Sivadji Vingadassalom, Héloïse Ifergan, Kévin Janot, Arturo Consoli, Wagih Ben Hassen, Eimad Shotar, Julien Ognard, Guillaume Charbonnier, Vincent L’Allinec, Alexis Guédon, Federico Bolognini, Gaultier Marnat, Géraud Forestier, Aymeric Rouchaud, Raoul Pop, Nicolas Raynaud, François Zhu, Jonathan Cortese, Vanessa Chalumeau, Jérome Berge, Simon Escalard, Grégoire Boulouis, Cyril Chivot, Riyad Hanafi, Anne Pasco, Jean-Baptiste Girot, Alessandra Biondi, Fortunato Di Caterino, Panagiotis Primikiris, Giovanni Vitale, Louise Bonnet, Florent Gariel, Xavier Barreau, Sabrina Debruxelles, Ludovic Lucas, Patrice Menegon, Stéphane Olindo, Mathilde Poli, Pauline Renou, Sharmila Sagnier, Igor Sibon, Louis Veunac, Jean-Christophe Gentric, Charlotte Barbier, Marion Boulanger, Julien Cogez, Sophie Guettier, Romain Schneckenburger, Emmanuel Touze, Mariette Delaitre, Pablo Lebendinsky, Mariano Musacchio, Frédéric Ricolfi, Pierre Thouant, François Caparros, Barbara Casolla, Lucie Della Schiava, Nelly Dequatre, Hilde Henon, Marco Pasi, Apolline Kazemi, Fouzi Bala, Laurent Estrade, Charbel Mounayer, Susanna Saleme, Francisco Macian-Montoro, Omer Eker, François Cotton, Karine Blanc-Lasserre, Serkan Cakmak, Tae-Hee Cho, Laurent Derex, Anne-Claire Lukaszewicz, Laura Mechtouff, Norbert Nighoghossian, Frédéric Philippeau, Roberto Riva, Francis Turjman, Anne-Evelyne Vallet, Xavier Carle, Philippe Dory-Lautrec, Anthony Reyre, Jean-François Hak, Hervé Brunel, Amel Benali, François-Louis Collemiche, Cyril Dargazanli, Frederico Cagnazzo, Imad Derraz, Caroline Arquizan, Lucas Corti, Vincent Costalat, Nicolas Gaillard, Grégory Gascou, Pierre-Henri Lefèvre, Isabelle Mourand, Carlos Riquelme, Anne Laure Derelle, Benjamin Gory, Liang Liao, Romain Tonnelet, René Anxionnat, Mathieu Bonnerot, Serge Bracard, Marc Braun, Lisa Humbertjean, Jean-Christophe Lacour, Gioia Mione, Sophie Planel, Sébastien Richard, Nolwenn Riou-Comte, Emmanuelle Schmitt, Romain Bourcier, Lili Detraz, Hubert Desal, Pierre-Louis Alexandre, Benjamin Daumas-Duport, Cédric Lenoble, Monica Roy, Oghuzan Coskun, Frederico Di Maria, Bertrand Lapergue, Georges Rodesch, Adrien Wang, David Weisenburger-Lile, Sergio Zimatore, Nadia Ajili, Géraldine Buard, Serge Evrard, Lucas Gorza, Julie Gratieux, Morgan Leguen, Sylvie Marinier, Fernando Pico, Roxanna Poll, Haja Rakotoharinandrasana, Philippe Tassan, Maya Tchikviladze, François Delvoye, Solène Hebert, Raphaël Blanc, Gabriele Ciccio, Jean-Philippe Desilles, Benjamin Maier, Mikael Mazighi, Michel Piotin, Hocine Redjem, Stanislas Smajda, Malek Ben Maacha, Ovide Corabianu, Thomas De Broucker, Olivier Ille, Eric Manchon, Michael Obadia, Mickael Obadia, Igor Raynouard, Roxanne Peres, Candice Sabben, Didier Smadja, Guillaume Taylor, Laurie-Anne Thion, Augustin Lecler, Laurent Spelle, Christian Denier, Jildaz Caroff, Olivier Chassin, laurent Spelle, Laura Venditti, Armand Aymard, Jean Betty, Vittorio Civelli, Michael Eliezer, Matteo Fantoni, Emmanuel Houdart, Marc-Antoine Labeyrie, Jean-Pierre Saint Maurice, Erwah Kalsoum, Aurelien Pacini, Chawkat Ramadane, Titien Tuilier, Adrien Villain, Frédéric Clarencon, Vincent Degos, Ahmed Elhfnawy, Mahmoud Elhorany, Stéphanie Lenck, Kevin Premat, Nader-Antoine Sourour, Sonia Alamowitch, Flore Baronnet, Sophie Crozier, Sandrine Deltour, Anne Leger, Charlotte Rosso, Nadya Pyatigorskaya, Christine Rodriguez Regent, Denis Trystram, Olivier Naggara, Pierre Seners, Guillaume Turc, Myriam Edjlali, Rémi Agbonon, Mohammed Alotaibi, Antoine Sonchet, Catherine Oppenheim, Jean François Meder, Joseph Benzakoun, Laurence Legrand, Cédric Fauché, Stéphane Velasco, Pierre François Manceau, Sebastien Solène Soize Moulin, François Eugene, Jean-Christophe Ferre, Christophe Paya, Jean-Yves Gauvrit, Sophie Langnier-Lemercier, Maria Lassale, helene Raoult, thomas Ronziere, Clément Tracol, Stéphane Vannier, Julien Burel, Julien Le Moal, Chrysanthi Papagiannaki, Mohamed Aggour, Marina Sachet, Claire Boutet, Remy Beaujeux, Anca Hasiu, Monica Manisor, Dan Mihoc, Stéphane Kremer, Charles Arteaga, Sébastien Gazzola, Jean Darcourt, Christophe Cognard, Fabrice Bonneville, Anne Christine Januel, Jean-Marc Olivot, Nicolas Raposo, Alain Viguier, Richard Bibi, Fakhreddine Boustia, Denis Herbreteau, Igor Maldonado, and Ana-Paula Narata

Subjects
Male, 2019-20 coronavirus outbreak, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Mechanical Thrombolysis, Pneumonia, Viral, 030204 cardiovascular system & hematology, medicine.disease_cause, Brain Ischemia, Time-to-Treatment, 03 medical and health sciences, Betacoronavirus, 0302 clinical medicine, Patient Admission, Pandemic, Medicine, Humans, Prospective Studies, Acute ischemic stroke, Pandemics, Coronavirus, Aged, Advanced and Specialized Nursing, Aged, 80 and over, business.industry, SARS-CoV-2, Outbreak, COVID-19, Middle Aged, 3. Good health, Mechanical thrombectomy, Hospitalization, Stroke, Emergency medicine, Female, Neurology (clinical), France, Cardiology and Cardiovascular Medicine, business, Coronavirus Infections, Delivery of Health Care, 030217 neurology & neurosurgery, Procedures and Techniques Utilization
Abstract

Background and Purpose: The efficiency of prehospital care chain response and the adequacy of hospital resources are challenged amid the coronavirus disease 2019 (COVID-19) outbreak, with suspected consequences for patients with ischemic stroke eligible for mechanical thrombectomy (MT). Methods: We conducted a prospective national-level data collection of patients treated with MT, ranging 45 days across epidemic containment measures instatement, and of patients treated during the same calendar period in 2019. The primary end point was the variation of patients receiving MT during the epidemic period. Secondary end points included care delays between onset, imaging, and groin puncture. To analyze the primary end point, we used a Poisson regression model. We then analyzed the correlation between the number of MTs and the number of COVID-19 cases hospitalizations, using the Pearson correlation coefficient (compared with the null value). Results: A total of 1513 patients were included at 32 centers, in all French administrative regions. There was a 21% significant decrease (0.79; [95%CI, 0.76–0.82]; P P P R 2 −0.51; P =0.04). Patients treated during the COVID outbreak were less likely to receive intravenous thrombolysis and to have unwitnessed strokes (both P Conclusions: Our study showed a significant decrease in patients treated with MTs during the first stages of the COVID epidemic in France and alarming indicators of lengthened care delays. These findings prompt immediate consideration of local and regional stroke networks preparedness in the varying contexts of COVID-19 pandemic evolution.

Published
2020

6. Mechanical Thrombectomy for Acute Ischemic Stroke Amid the COVID-19 Outbreak in France: Decreased Activity, and Increased Care Delays

Author

Alexis Guédon, Julien Ognard, Géraud Forestier, Nicolas Bricout, Basile Kerleroux, Guillaume Charbonnier, Martin Moise, Wagih Ben Hassen, Simon Escalard, Gregoire Boulouis, Gaultier Marnat, Aymeric Rouchaud, Nicolas Raynaud, Raoul Pop, Jérôme Berge, Vanessa Chalumeau, Arturo Consolli, Sivadji Vingadassalom, Benoit Testud, Héloïse Ifergan, Eimad Shotar, Vincent L'Allinec, Jonathan Cortese, Kevin Janot, Federico Bolognini, François Zhu, and Thibaut Fabacher

Subjects
Mechanical thrombectomy, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), business.industry, Emergency medicine, Epidemiology, medicine, Outbreak, medicine.disease, business, Acute ischemic stroke, Stroke
Published
2020
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7. MT-DRAGON score for outcome prediction in acute ischemic stroke treated by mechanical thrombectomy within 8 hours

Author

Apolline Kazemi, Wassim H. Farhat, Marc Ferrigno, Wagih Ben Hassen, Mathieu Zuber, Catherine Oppenheim, Charlotte Cordonnier, Hilde Hénon, Pierre Seners, Guillaume Turc, Nicolas Raynaud, Sébastien Soize, Laurence Legrand, Martin Bretzner, Nicolas Bricout, Olivier Naggara, and Gregoire Boulouis

Subjects
Male, medicine.medical_specialty, Time Factors, Mechanical Thrombolysis, 030204 cardiovascular system & hematology, Brain Ischemia, 03 medical and health sciences, 0302 clinical medicine, Fibrinolytic Agents, Modified Rankin Scale, Internal medicine, Occlusion, medicine, Humans, Derivation, Prospective Studies, Stroke, Acute ischemic stroke, Aged, Aged, 80 and over, business.industry, General Medicine, Middle Aged, medicine.disease, Prognosis, Magnetic Resonance Imaging, Mechanical thrombectomy, Treatment Outcome, Cohort, Surgery, Administration, Intravenous, Female, Neurology (clinical), business, Outcome prediction, 030217 neurology & neurosurgery
Abstract

ObjectivesThe MRI-DRAGON score includes clinical and MRI parameters and demonstrates a high specificity in predicting 3 month outcome in patients with acute ischemic stroke (AIS) treated with intravenous tissue plasminogen activator (IV tPA). The aim of this study was to adapt this score to mechanical thrombectomy (MT) in a large multicenter cohort.MethodsConsecutive cases of AIS treated by MT between January 2015 and December 2017 from three stroke centers were reviewed (n=1077). We derived the MT-DRAGON score by keeping all variables of the MRI-DRAGON score (age, initial National Institutes of Health Stroke Scale score, glucose level, pre-stroke modified Rankin Scale (mRS) score, diffusion weighted imaging-Alberta Stroke Program Early CT score ≤5) and considering the following variables: time to groin puncture instead of onset to IV tPA time and occlusion site. Unfavorable 3 month outcome was defined as a mRS score >2. Score performance was evaluated by c statistics and an external validation was performed.ResultsAmong 679 included patients (derivation and validation cohorts, n=431 and 248, respectively), an unfavorable outcome was similar between the derivation (51.5%) and validation (58.1%, P=0.7) cohorts, and was significantly associated with all MT-DRAGON parameters in the multivariable analysis. The c statistics for unfavorable outcome prediction was 0.83 (95%CI 0.79 to 0.88) in the derivation and 0.8 (95%CI 0.75 to 0.86) in the validation cohort. All patients (n=55) with an MT-DRAGONscore ≥11 had an unfavorable outcome and 60/63 (95%) patients with an MT-DRAGON score ≤2 points had a favorable outcome.ConclusionThe MT-DRAGON score is a simple tool, combining admission clinical and radiological parameters that can reliably predict 3 month outcome after MT.

Published
2019

8. New Flip-Chip Bonder Dedicated To Direct Bonding For Production Environment

Author

Severine Cheramy, A. Jouve, Frank Fournel, N. Bresson, Loic Sanchez, Nicolas Raynaud, and Pascal Metzger

Subjects
Development environment, Interconnection, Computer science, Hardware_INTEGRATEDCIRCUITS, Process (computing), Dice, Direct bonding, Throughput (business), Vertical integration, Automotive engineering, Flip chip
Abstract

3D vertical integration of components is today an industrial reality. To reduce pitch of interconnection between the dice, the hydrid bonding technique, offering sub-10 $\mu$m interconnection pitch, is widely demonstrated for Wafer-to-Wafer bonding. Die-to-Wafer direct bonding remains today more challenging due to additional particle contamination and handling complexity but presents interesting assets.The purpose of this paper is to demonstrate the performance of a fully automated Die-to-Wafer bonder, SET FC1, specifically designed for direct bonding dedicated to production. After a description of the process and the elements developed specially for this process, it will be demonstrated that an accuracy of ± 1 $\mu$m can be reached today with a throughput up to several hundred dice per hour. If progresses still need to be done, the particle contamination is low enough to enable demonstration of oxide/oxide Die-to-Wafer direct bonding. Considering the results obtained until now, industrialization appears feasible.

Published
2018
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9. Numerical approximation of stiff transmission problems by mixed finite element methods

Author

Daniela Capatina-Papaghiuc and Nicolas Raynaud

Subjects
Numerical Analysis, Cauchy stress tensor, Applied Mathematics, Uniform convergence, Numerical analysis, Geometry, Finite element method, Computational Mathematics, Numerical approximation, Transmission (telecommunications), Modeling and Simulation, Applied mathematics, Analysis, Mathematics
Abstract

On s'interesse a l'approximation des problemes de transmission raide par methodes d'elements finis mixtes. On etablit un resultat de convergence uniforme en e, le petit parametre quand le pas de discretisation tend vers 0, prouvant ainsi la robustesse de la methode. Le probleme discret est ensuite resolu numeriquement via une methode hybride, car le mauvais conditionnement de la matrice rend impraticable l'algorithme standard d'Uzawa. Les resultats numeriques montrent une convergence optimale en O(h) pour le tenseur des contraintes et pour le deplacement anti-plane. En conclusion, contrairement aux methodes primales conformes, les methodes mixtes echappent au verrouillage numerique, et ceci independamment de triangulation.

Published
1998
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