1. Diagnostic and molecular testing patterns in patients with newly diagnosed acute myeloid leukemia in the Connect® MDS/AML Disease Registry
- Author
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Pollyea, Daniel A, George, Tracy I, Abedi, Mehrdad, Bejar, Rafael, Cogle, Christopher R, Foucar, Kathryn, Garcia-Manero, Guillermo, Grinblatt, David L, Komrokji, Rami S, Maciejewski, Jaroslaw P, Revicki, Dennis A, Roboz, Gail J, Savona, Michael R, Scott, Bart L, Sekeres, Mikkael A, Thompson, Michael A, Kurtin, Sandra E, Louis, Chrystal U, Nifenecker, Melissa, Flick, E Dawn, Swern, Arlene S, Kiselev, Pavel, Steensma, David P, and Erba, Harry P
- Subjects
Pediatric ,molecular testing ,Rare Diseases ,Childhood Leukemia ,Pediatric Cancer ,Clinical Research ,leukemia diagnosis ,Hematology ,acute myeloid leukemia ,leukemia therapy ,registry ,diagnostic testing ,Cancer - Abstract
Diagnostic and molecular genetic testing are key in advancing the treatment of acute myeloid leukemia (AML), yet little is known about testing patterns outside of clinical trials, especially in older patients. We analyzed diagnostic and molecular testing patterns over time in 565 patients aged ≥ 55 years with newly diagnosed AML enrolled in the Connect® MDS/AML Disease Registry (NCT01688011) in the United States. Diagnostic data were recorded at enrolment and compared with published guidelines. The percentage of bone marrow blasts was reported for 82.1% of patients, and cellularity was the most commonly reported bone marrow morphological feature. Flow cytometry, karyotyping, molecular testing, and fluorescence in situ hybridization were performed in 98.8%, 95.4%, 75.9%, and 75.7% of patients, respectively. Molecular testing was done more frequently at academic than community/government sites (84.3% vs 70.2%; P 
- Published
- 2020