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2. L’incidenza del diabete tipo 1 al di sotto del primo anno di vita. Sardegna versus resto d’Italia

Author

Cherubini V, Frongia P, M. Songini, A. Ogada, F. Carle, M. Cotellessa, E. De Conciliis e. Gruppo di Studio di Diabetologia Pediatrica F. Chiarelli, U. Iannilli, R. Dhamo, A. Pinelli, GV Coppa, L. Bellu, A. R. Fifi, L. Cavallo, E. Frezza, E. Piccinno, A. Vergerio, E. Cacciari, S. Salardi, E. Angius, P. Frongia, C. Pintor, A. La Loggia, M. Cicchetti, G. Reitano, M. Mancuso, ML Arpi, M. Pocecco, G. Cerasoli, A. Verrotti, E. Altobelli, R. Vanini, L. Spallino, A. Vaccà, P. Banin, S. Toni, R. Lorini, P. Picco, A. Monaci, F. De Luca, F. Lombardo, G. Chiumello, F. Meschi, S. Bernasconi, S. Mariani, A. Franzese, O. Stoppoloni, F. Prisco, Bona, C. Monciotti, F. Cardella, M. Vanelli, G. Chiari, G. D’Annunzio, G. De Giorgi, L. Calisti, G. Zanette, E. Bartolotta, A. Crinò, L. Lucentini, I. P. Patera, G. Marietti, G. Multari, N. Sulli, A. M. Marinaro, A. Falorni, F. Cerutti, I. Rabbone, Bruno, V. Cauvin, A. Visentin, G. Tonini, E. Buratti, P. Salvatoni, L. Pinelli, IAFUSCO, Dario, Cherubini, V, Iafusco, Dario, Frongia, P, M., Songini, A., Ogada, F., Carle, M., Cotellessa, E. De Conciliis e. Gruppo di Studio di Diabetologia Pediatrica F., Chiarelli, U., Iannilli, R., Dhamo, A., Pinelli, Gv, Coppa, L., Bellu, A. R., Fifi, L., Cavallo, E., Frezza, E., Piccinno, A., Vergerio, E., Cacciari, S., Salardi, E., Angiu, P., Frongia, C., Pintor, A., La Loggia, M., Cicchetti, G., Reitano, M., Mancuso, Ml, Arpi, M., Pocecco, G., Cerasoli, A., Verrotti, E., Altobelli, R., Vanini, L., Spallino, A., Vaccà, P., Banin, S., Toni, R., Lorini, P., Picco, A., Monaci, F., De Luca, F., Lombardo, G., Chiumello, F., Meschi, S., Bernasconi, S., Mariani, A., Franzese, O., Stoppoloni, F., Prisco, Bona, C., Monciotti, F., Cardella, M., Vanelli, G., Chiari, G., D’Annunzio, G., De Giorgi, L., Calisti, G., Zanette, E., Bartolotta, A., Crinò, L., Lucentini, I. P., Patera, G., Marietti, G., Multari, N., Sulli, A. M., Marinaro, A., Falorni, F., Cerutti, I., Rabbone, Bruno, V., Cauvin, A., Visentin, G., Tonini, E., Buratti, P., Salvatoni, and L., Pinelli

Published
1999

3. HLA-DQ genotype in early onset insulin dependent diabetes mellitus

Author

F Prisco, G. Tosi, Dario Iafusco, O Stoppoloni, and Rs Accolla

Subjects
Male, Adolescent, Genotype, Endocrinology, Diabetes and Metabolism, early onset diabetes, Endocrinology, HLA-DQ beta-Chains, HLA-DQ Antigens, Diabetes mellitus, HLA-DQ, medicine, Humans, Age of Onset, Child, Early onset, HLA-DQ Antigen, business.industry, Homozygote, Infant, medicine.disease, Diabetes Mellitus, Type 1, HLA genotype, Child, Preschool, Insulin dependent diabetes, Pediatrics, Perinatology and Child Health, Immunology, early onset diabetes, HLA genotype, Female, Age of onset, business

4. Celiac Disease in Children and Adolescents with Type I Diabetes: Importance of Hypoglycemia

Author

Marina Cerruto, Stefano Tumini, Francesco Prisco, Dario Iafusco, Ornella Stoppoloni, Francesco Chiarelli, Angelika Mohn, A, Mohn, M., Cerruto, Iafusco, Dario, F., Prisco, S., Tumini, and O. STOPPOLONI AND F., Chiarelli

Subjects
Adult, Male, medicine.medical_specialty, Malabsorption, Adolescent, Glutens, medicine.medical_treatment, Disease, Hypoglycemia, Gastroenterology, Coeliac disease, Intestinal mucosa, Risk Factors, Internal medicine, Diabetes mellitus, medicine, Humans, Insulin, Child, Retrospective Studies, business.industry, Case-control study, Infant, nutritional and metabolic diseases, medicine.disease, Surgery, Celiac Disease, Kinetics, Diabetes Mellitus, Type 1, Case-Control Studies, Child, Preschool, Pediatrics, Perinatology and Child Health, Female, business
Abstract

Background Symptomatic hypoglycemia is an unavoidable problem in the treatment of type I diabetes. Celiac disease is associated with malabsorption and may therefore represent an important risk factor. Methods The frequency of symptomatic hypoglycemia in patients with type I diabetes and celiac disease (cases) was compared with those of patients who had diabetes without celiac disease (controls). For this purpose, each case was matched for age, sex, and duration of disease with one to two control patients. Indices of metabolic control (hemoglobin [Hb]A1c, frequency of hypoglycemia, and total insulin requirement) were retrieved for the 18 months before and after diagnosis of celiac disease. Results Eighteen patients (6 males and 12 females) had diagnosed celiac disease and were matched with 26 control patients (10 males and 16 females). There was no difference in age (11.0 years; range, 1.8-21.9 vs. 13.1 years; range, 2.3-22; P = 0.3) and duration of disease (8.4 years; range, 1.2-19.3 vs. 8.3 years; range, 1.1-18.7; P = 0.3) between the two groups. During the 6 months before and after diagnosis of celiac disease the cases had significantly more hypoglycemic episodes than the controls (means +/- SD; 4.5+/-4 vs. 2.0+/-2.2 episodes/months, P = 0.01). This was reflected by a progressive reduction in insulin requirement over the 12 months before diagnosis reaching a nadir at time 0 (0.6+/-0.2 vs. 0.9+/-0.3, P = 0.05). Conclusion These data suggest that underlying celiac disease is associated with an increased risk of symptomatic hypoglycemia and that the introduction of a gluten-free diet with normalization of the intestinal mucosa may reduce its frequency.

Published
2001
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