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2. Safety of treatments for inflammatory bowel disease: Clinical practice guidelines of the Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD)

Author

Aratari, Annalisa, Bossa, Fabrizio, Cappello, Maria, Cassinotti, Andrea, Chiriatti, Alberto, Fiorino, Gionata, Formica, Vincenzo, Guidi, Luisa, Losco, Alessandra, Mocciaro, Filippo, Onali, Sara, Pastorelli, Luca, Pica, Roberta, Principi, Mariabeatrice, Renna, Sara, Ricci, Chiara, Rispo, Antonio, Rogai, Francesca, Sarmati, Loredana, Scaldaferri, Franco, Spina, Luisa, Tambasco, Rosy, Testa, Anna, Viscido, Angelo, Biancone, Livia, Annese, Vito, Ardizzone, Sandro, Armuzzi, Alessandro, Calabrese, Emma, Caprioli, Flavio, Castiglione, Fabiana, Comberlato, Michele, Cottone, Mario, Danese, Silvio, Daperno, Marco, D'Incà, Renata, Frieri, Giuseppe, Fries, Walter, Gionchetti, Paolo, Kohn, Anna, Latella, Giovanni, Milla, Monica, Orlando, Ambrogio, Papi, Claudio, Petruzziello, Carmelina, Riegler, Gabriele, Rizzello, Fernando, Saibeni, Simone, Scribano, Maria Lia, Vecchi, Maurizio, Vernia, Piero, Meucci, Gianmichele, Rugge, Massimo, Biancone, Livia, Annese, Vito, Ardizzone, Sandro, Armuzzi, Alessandro, Calabrese, Emma, Caprioli, Flavio, Castiglione, Fabiana, Comberlato, Michele, Cottone, Mario, Danese, Silvio, Daperno, Marco, D'Incà, Renata, Frieri, Giuseppe, Fries, Walter, Gionchetti, Paolo, Kohn, Anna, Latella, Giovanni, Milla, Monica, Orlando, Ambrogio, Papi, Claudio, Petruzziello, Carmelina, Riegler, Gabriele, Rizzello, Fernando, Saibeni, Simone, Scribano, Maria Lia, Vecchi, Maurizio, Vernia, Piero, Meucci, Gianmichele, Rugge, Massimo, Aratari, Annalisa, Bossa, Fabrizio, Cappello, Maria, Cassinotti, Andrea, Chiriatti, Alberto, Fiorino, Gionata, Formica, Vincenzo, Guidi, Luisa, Losco, Alessandra, Mocciaro, Filippo, Onali, Sara, Pastorelli, Luca, Pica, Roberta, Principi, Mariabeatrice, Renna, Sara, Ricci, Chiara, Rispo, Antonio, Rogai, Francesca, Sarmati, Loredana, Scaldaferri, Franco, Spina, Luisa, Tambasco, Rosy, Testa, Anna, Viscido, Angelo, Biancone, L, Annese, V, Ardizzone, S, Armuzzi, A, Calabrese, E, Caprioli, F, Castiglione, F, Comberlato, M, Cottone, M, Danese, S, Daperno, M, D'Inca, R, Frieri, G, Fries, W, Gionchetti, P, Kohn, A, Latella, G, Milla, M, Orlando, A, Papi, C, Petruzziello, C, Riegler, G, Rizzello, F, Saibeni, S, Scribano, Ml, Vecchi, M, Vernia, P, and Meucci, G

Subjects
Guidelines, Inflammatory bowel disease, Medical treatments, Safety, Adrenal Cortex Hormones, Aminosalicylic Acid, Anti-Bacterial Agents, Antibodies, Monoclonal, Humanized, Cyclosporine, Drug Therapy, Combination, Female, Humans, Inflammatory Bowel Diseases, Italy, Mercaptopurine, Methotrexate, Pregnancy, Randomized Controlled Trials as Topic, Treatment Outcome, Tumor Necrosis Factor-alpha, Evidence-Based Medicine, Hepatology, Gastroenterology, Disease, Guideline, Adrenal Cortex Hormone, chemistry.chemical_compound, 0302 clinical medicine, Monoclonal, 030212 general & internal medicine, Humanized, Settore MED/12 - Gastroenterologia, Ulcerative colitis, Combination, 030211 gastroenterology & hepatology, Human, medicine.drug, medicine.medical_specialty, Antibodies, Vedolizumab, 03 medical and health sciences, Drug Therapy, Internal medicine, Anti-Bacterial Agent, medicine, Intensive care medicine, business.industry, medicine.disease, digestive system diseases, Rifaximin, Metronidazole, chemistry, Etiology, business, Medical treatment
Abstract

Inflammatory bowel diseases are chronic conditions of unknown etiology, showing a growing incidence and prevalence in several countries, including Italy. Although the etiology of Crohn's disease and ulcerative colitis is unknown, due to the current knowledge regarding their pathogenesis, effective treatment strategies have been developed. Several guidelines are available regarding the efficacy and safety of available drug treatments for inflammatory bowel diseases. Nevertheless, national guidelines provide additional information adapted to local feasibility, costs and legal issues related to the use of the same drugs. These observations prompted the Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD) to establish Italian guidelines on the safety of currently available treatments for Crohn's disease and ulcerative colitis. These guidelines discuss the use of aminosalicylates, systemic and low bioavailability corticosteroids, antibiotics (metronidazole, ciprofloxacin, rifaximin), thiopurines, methotrexate, cyclosporine A, TNFα antagonists, vedolizumab, and combination therapies. These guidelines are based on current knowledge derived from evidence-based medicine coupled with clinical experience of a national working group.

Published
2017
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5. Early Post-Operative Endoscopic Recurrence in Crohn's Disease Patients: Data From a Large Prospective Italian Multicenter Cohort

Author

Orlando, Ambrogio, Mocciaro, Filippo, Scimeca, Daniela, Rispo, Antonio, Scribano, Maria Lia, Testa, Anna, Aratari, Annalisa, Bossa, Fabrizio, Tambasco, Rosy, Angelucci, Erika, Onali, Sara, Cappello, Maria, Fries, Walter, Renata D'Incà, Martinato, Matteo, Castiglione, Fabiana, Papi, Claudio, Annese, Vito, Gionchetti, Paolo, Rizzello, Fernando, Vernia, Piero, Biancone, Livia, Kohn, Anna, and Cottone, Mario

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