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RPS3, a universal core component of the 40S ribosomal subunit, interacts with mRNA at the entry channel. Whether RPS3 mRNA-binding contributes to specific mRNA translation and ribosome specialization in mammalian cells is unknown. Here we mutated RPS3 mRNA-contacting residues R116, R146 and K148 and report their impact on cellular and viral translation. R116D weakened cap-proximal initiation and promoted leaky scanning, while R146D had the opposite effect. Additionally, R146D and K148D displayed contrasting effects on start-codon fidelity. Translatome analysis uncovered common differentially translated genes of which the downregulated set bears long 5’UTR and weak AUG context, suggesting a stabilizing role during scanning and AUG selection. We identified an RPS3-dependent regulatory sequence (RPS3RS) in the sub-genomic 5’UTR of SARS-CoV-2 consisting of a CUG initiation codon and a downstream element that is also the viral transcription regulatory sequence (TRS). Furthermore, RPS3 mRNA-binding residues are essential for SARS-CoV-2 NSP1-mediated inhibition of host translation and for its ribosomal binding. Intriguingly, NSP1-induced mRNA degradation was also reduced in R116D cells, indicating that mRNA decay occurs in the ribosome context. Thus, RPS3 mRNA-binding residues have multiple translation regulatory functions and are exploited by SARS-CoV-2 in various ways to influence host and viral mRNA translation and stability.

Increasing evidence suggests that ribosome composition and modifications contribute to translation control. Whether direct mRNA binding by ribosomal proteins regulates the translation of specific mRNA and contributes to ribosome specialization has been poorly investigated. Here, we used CRISPR–Cas9 to mutate the RPS26 C-terminus (RPS26dC) predicted to bind AUG upstream nucleotides at the exit channel. RPS26 binding to positions −10 to −16 of short 5′ untranslated region (5′UTR) mRNAs exerts positive and negative effects on translation directed by Kozak and Translation Initiator of Short 5′UTR (TISU), respectively. Consistent with that, shortening the 5′UTR from 16 to 10 nt diminished Kozak and enhanced TISU-driven translation. As TISU is resistant and Kozak is sensitive to energy stress, we examined stress responses and found that the RPS26dC mutation confers resistance to glucose starvation and mTOR inhibition. Furthermore, the basal mTOR activity is reduced while AMP-activated protein kinase is activated in RPS26dC cells, mirroring energy-deprived wild-type (WT) cells. Likewise, the translatome of RPS26dC cells is correlated to glucose-starved WT cells. Our findings uncover the central roles of RPS26 C-terminal RNA binding in energy metabolism, in the translation of mRNAs bearing specific features and in the translation tolerance of TISU genes to energy stress.

The imagined universe of the people of Late Antiquity was heavily populated by gods. Even the broader philosophical trends and monotheistic foundation of Judaism and Christianity had failed to entirely diminish their power. How then did Jews and Christians cope with such a backdrop presence of “other gods”? Earlier research suggested that Jewish attitudes, which found their way into early Christian sources as well, fluctuate between accommodation and rejection. Following analysis of Jewish and Christian Late Antique literary traditions dealing with gods, and more specifically, goddesses, this article aims to demonstrate that such “fluctuation” resulted – in addition to the extreme positions – in a variety of middle of the road strategies. These strategies point to a keen harmonizing impulse to absorb—via domestication—motifs with mythic religious vitality from the broader cultural repository.

We suggest that individuals with obsessive-compulsive disorder (OCD) experience difficulty accessing their internal states, including their feelings, emotions, preferences, and motivations. Instead, they rely on proxies to inform them of these states—that is, discernible substitutes in the form of fixed rules and rituals, observable behavior, and indexes. The Seeking Proxies for Internal States (SPIS) model of OCD proposes that compulsions, obsessions, indecision, and doubt result from seeking and using such proxies. The SPIS model not only accounts for these OCD symptoms but also sheds new light on normal processes of action control, metacognition, decision-making, and introspection.

The past decade has witnessed the creation of a new international tax regime. The original international tax regime was created a century ago by the League of Nations. Until the 1980s, it functioned reasonably well and prevented most instances of double taxation and double non-taxation by allocating cross-border income between home and host jurisdictions based on a compromise reached in 1923. However, since the advent of globalization in the 1980s and digitalization in the 1990s, the original international tax regime ceased to function as intended. The main problems were the increased mobility of capital related to increased intangibility and digitalization, together with a relaxation of capital controls and increased tax competition. These developments posed a problem for countries that wished to leave their borders open to reap the benefits of globalization and to engage in tax competition to attract investment. The outcome was a significant fall in tax revenues that threatened the social safety net of the modern welfare state. The trilemma of open borders, tax competition, and satisfying voters’ demand for social insurance culminated in the financial crisis of 2008–09, where many countries were forced to implement austerity measures at the same time that parliamentary hearings, leaks, and media reports revealed that rich individuals and large corporations were paying very little tax on cross-border income. The results over the past decade have been the creation of a new international tax regime designed to curb both tax evasion by the rich and tax competition among countries seeking to attract business activity within their borders by granting various preferential tax provisions to multinational enterprises. The key question going forward is how the new international tax regime will deal with international (in)equity, i.e. the economic digital divide. In what follows, I will first discuss the decline of the original international tax regime from 1980 to 2009, then the creation of the new international tax regime from 2010 on, and finally the implications of the new international tax regime for the economic digital divide.

Multistage sequential decision-making scenarios are commonly seen in the healthcare diagnosis process. In this paper, an active learning-based method is developed to actively collect only the necessary patient data in a sequential manner. There are two novelties in the proposed method. First, unlike the existing ordinal logistic regression model which only models a single stage, we estimate the parameters for all stages together. Second, it is assumed that the coefficients for common features in different stages are kept consistent. The effectiveness of the proposed method is validated in both a simulation study and a real case study. Compared with the baseline method where the data is modeled individually and independently, the proposed method improves the estimation efficiency by 62\%-1838\%. For both simulation and testing cohorts, the proposed method is more effective, stable, interpretable, and computationally efficient on parameter estimation. The proposed method can be easily extended to a variety of scenarios where decision-making can be done sequentially with only necessary information.

This study investigated whether students’ academic motivation during the Hyflex learning modality have a significant relationship with parental autonomy support, parental involvement, and academic achievement and the level of parental autonomy support, parental involvement, Academic Achievement among college Student Motivation during HyFlex Learning Modality. A sample of 100 college students of National University- Baliwag participated to complete a series of questionnaires, Pearson Correlation was used to attain the relationship bet ween the variables that was used. The result of the study found that the college students’ Parental Autonomy Support, Parental Involvement, and their Academic Achievement, when combined, significantly predicts the dependent variable level of Academic Motivation during Hyflex Learning Modality (F [3, 96] = 4.744, p = .004). This implies that the null hypothesis (Ho) is rejected; thus, there is a significant relationship between the parental autonomy support, parental involvement, academic achievement of college students and their academic motivation during Hyflex learning modality when taken as a whole. The implies that among parents, providing better emotional and mental support, on top of the material supports could affect positively the academic achievements of college students. Based on these results, parents would benefit by considering different approach that suits the educational needs of the college students by providing autonomous support and becoming more physically and emotionally involved.

HYPOTHESIS: Computed tomography (CT) density measurement can be used to objectively distinguish otosclerosis from normal bone and to determine histologic grades of otosclerosis. BACKGROUND: Otosclerosis can be seen on CT as subtle radiolucent areas. An objective radiologic measurement that corresponds to known otosclerosis pathology may improve diagnostic accuracy, and could be used as a radiologic biomarker for otosclerosis grade. METHODS: A blinded, randomized evaluation of both histologic grade on histopathology slides and CT density measurement was performed on 78 human temporal bone specimens (31 with otosclerosis and 47 controls) that had undergone high-resolution multi-detector CT prior to histologic processing. Assessments were performed at 11 regions of interest (ROIs) in the otic capsule for each specimen. RESULTS: The CT density measurement mean (Hounsfield Units) ± standard deviation for all ROIs (#1-#9) was 2245 ± 854 for grade 0 (no otosclerosis, n=711), 1896 ±317 for grade 1 (inactive otosclerosis, n=109), and 1632 ±255 for grades 2 and 3 combined (mixed/active otosclerosis, n=35). There was a strong inverse correlation of CT density to histologic grade at ROIs #1–5 (ANOVA, p

This article focuses on the changing cultural, social, and ideological characteristics of the central Sephardi Rabban Yochanan Ben-Zakai synagogue in Jerusalem, as a lens reflecting social and ideological processes of the local Sephardi community during the first half of the twentieth century. These included the community's attempts to consolidate its cultural uniqueness and civic identity vis-à-vis the surrounding and evolving spirits—within the Jewish community and outside it; its struggles with the local Ashkenazi community over historical and legal hegemony; its changing and evolving attitude toward the Ottoman and British Empires; and its gradual yet distinct adoption of the Jewish national framework. The article is based on an in-depth study of the archives of the Sephardi Commission (Va'ad Ha'eda HaSepharadit) in Jerusalem, as well as literary and scholarly sources and the local Jewish press of the time.

We present a randomized algorithm for generating standard set-valued tableaux by extending the Green-Nijenhuis-Wilf hook walk algorithm. In the case of asymptotically rank two partitions, we use this algorithm to give a fully polynomial almost uniform sampler (FPAUS) for standard set-valued tableaux. This FPAUS is then used to construct a fully polynomial randomized approximation scheme (FPRAS) for counting the number of standard set-valued tableaux for such shapes. We also construct a FPAUS and FPRAS for standard set-valued tableaux when either the size of the partition or the difference between the maximum value and the size of the partition is fixed. Our methods build on the work of Jerrum-Valiant-Vazirani and provide a framework for constructing FPAUS's and FPRAS's for other counting problems in algebraic combinatorics., 20 pages

We studied and found that the populations of two gastropod species in the inter-tidal zone of the Red Sea at Eilat demonstrate a predominantly dextral chirality of their shells. We identified lateralization sinistral/dextral shell torsion for 675 live Tenguella granulata (left = 114, 16.9%; right = 561, 83.1%) and 405 Clanculus pharaonius (left = 102, 25.2%; right = 303, 74.8%). In both cases, we found differences between sinistral and dextral shell torsions for Tenguella granulata and Clanculus pharaonius. The ecological and evolutionary consequences of individuals with sinistral chirality are unclear, but there are indications that it is a directional rather than stochastic process.

A watchman path is a path such that a direct line of sight exists between each point in some region and some point along the path. Here, we study the online watchman path problem outside a convex polygon, i.e., in $\mathbb{R}^2\setminus \Omega$, where $\Omega$ is a convex polygon that is not known in advance. We present an algorithm for the exploration of the region outside the polygon. We prove that the presented algorithms guarantees a $\approx 22.77$ competitive ratio compared to the optimal offline watchman path.

OBJECTIVE Mounting evidence indicates the detrimental impact of posttraumatic stress following childbirth (PTS-FC). Nevertheless, research on preventive strategies is scarce. We recently reported that ultrasound visual biofeedback during second stage of labor was associated with immediate beneficial medical outcomes (increased pushing efficacy, decreased perineal tearing), as well as greater feelings of maternal connectedness toward her newborn immediately postlabor. The current study assessed the potential longer-term psychological benefits of these outcomes in buffering risk for PTS-FC. The study follows up the previously reported sample to examine the longitudinal clinical effect of the visual biofeedback intervention on symptoms of acute stress at 2 days postpartum and subsequent symptoms of PTS-FC at 1 month postpartum. METHOD A sample of 26 nulliparous women received visual biofeedback and was compared to a group of women receiving standard obstetrical coaching. Maternal feelings of connectedness and acute stress symptoms were assessed 2 days postpartum and PTS-FC was assessed 1 month postpartum. RESULTS Double-mediation analyses revealed a significant indirect relation between visual biofeedback and decreased PTS-FC symptoms 1 month postpartum. The relation was significantly mediated by increased feelings of maternal connectedness immediately postpartum, which in turn was associated with decreased symptoms of acute stress 2 days postpartum. CONCLUSIONS These results suggest that the visual biofeedback intervention during childbirth may decrease risk for PTS-FC. Importantly, findings suggest the preventive potential of fostering feelings of maternal connectedness toward her newborn to reduce symptoms of PTS-FC. (PsycINFO Database Record (c) 2020 APA, all rights reserved).

The introduction of the minimum tax in Pillar II of the Organization for Economic Cooperation and Development (OECD)/G20/Inclusive Forum(IF) framework was generally seen as a response to the US Tax Cuts and Jobs Act (TCJA) of 2017. The TCJA included both a minimum tax on outbound income (the Global Intangible Low-Taxed Income, or ‘GILTI’) and a minimum tax on inbound income (the Base Erosion Anti-Avoidance Tax, or ‘BEAT’). These were seen as the precursors to the Income Inclusion Rule (IIR) and the Under Tax Payments Rule (UTPR). Thus, unlike Pillar I which was perceived as a device to impose more tax on the US digital giants, Pillar II was seen as more consistent with US tax policy. This story is true to some extent, but the relationship between the US and Pillar II is more complicated. Pillar II was the culmination of years of efforts to implement the single tax principle (STP), which has its origins in the 1920s but was not the guiding principle of US tax policy for a long period before the TCJA. Moreover, the TCJA does not fully implement Pillar II, and it is unclear whether the US can in fact do so. In this article, the authors first discuss the relationship between the TCJA and Pillar II, then the possible US responses to Pillar II, and finally what would happen if the US does not implement Pillar II. In general, if Pillar II is not implemented in the US, the tax consequences are likely to be increased double taxation as well as a shift in revenues from the US to foreign jurisdictions. GloBE, pillar 2, TCJA

This recommendation document follows the mission of the World Association of Perinatal Medicine (WAPM) in collaboration with the Perinatal Medicine Foundation (PMF). We aim to bring together groups and individuals throughout the world for standardization to implement the ultrasound evaluation in labor ward and improve the clinical management of labor. Ultrasound in labor can be performed using a transabdominal or a transperineal approach depending upon which parameters are being assessed. During transabdominal imaging, fetal anatomy, presentation, liquor volume, and placental localization can be determined. The transperineal images depict images of the fetal head in which calculations to determine a proposed fetal head station can be made.

To describe the DISCO protocol (Dilation, Steroid injection, and post-operative Cough Exercise); a novel treatment for posterior glottic stenosis (PGS). Restoring glottic mobility in PGS is a major challenge. In orthopedic and plastic surgery, post-operative physical therapy is associated with improved motion range and flexibility; yet, this principle was never applied to laryngeal surgery.A retrospective cohort of PGS adult patients, treated by the DISCO protocol during 2018-2020. DISCO involves the following: scar release, glottic dilation, and steroid injection, followed by post-operative cough as glottic physical therapy. Maximal glottic opening angle (MGOA), relative glottic opening area (RGOA), and relative glottic insufficiency area (RGIA) were calculated before and post-operatively.Seventeen patients were included; PGS etiology was post-intubation (n = 10), post-irradiation (n = 3), both (n = 1) and joint sclerosis (n = 3). Six patients also had additional airway disorders. Sixteen patients were tracheostomy-dependent. 2 (12%), 8 (47%) and 7 (41%) patients had type II, III and IV stenosis, respectively. Surgery included scar release, dilation and steroid injection alone in 7 patients; and additional unilateral sub-mucosal arytenoidectomy in 10. The mean follow-up was 17.5 months. There were no major complications. Successful outcomes (e.g., decannulation or permanent capping) were achieved in 14 (82%) patients with some restoration of joint movement. None had a persistent voice or swallowing complaints. Both MGOA and RGOA increased in all patients (p 0.001). RGIA remained unchanged (p = 0.878).The DISCO protocol is a novel, effective and safe approach for PGS correction that can be easily applied. It can restore vocal fold mobility and may expand the glottic airway without causing glottic insufficiency.4 Laryngoscope, 2022.

BNT162b2 messenger RNA (mRNA) COVID-19 vaccine administered during pregnancy was found to produce a strong maternal immunoglobulin (IgG) response which crosses the placenta to the newborn. Our aim was to evaluate maternal and neonatal SARS-CoV-2 IgG antibody levels at birth, following a COVID-19 booster vaccine during the third trimester.A prospective cohort study including women admitted to delivery ward at least 7 days after their BNT162b2 (Pfizer/BioNTech) booster vaccination without a prior clinical COVID-19 infection. SARS-CoV-2 IgG antibodies levels were measured in maternal blood upon admission to delivery and in the umbilical blood within 30 min following delivery. The correlation between antibody titers, feto-maternal characteristics, maternal side effects following vaccination, and time interval from vaccination to delivery were analyzed.Between September to November 2021, high antibody levels were measured in all 102 women and 93 neonatal blood samples, at a mean ± standard deviation duration of 7.0 ± 2.9 weeks after the third vaccine. We found positive correlation between maternal and neonatal antibodies (r = 0.73, 95% confidence interval [CI] 0.61 to 0.81, p 0.001), with neonatal titers approximately 1.4 times higher compared to maternal titers. In the multivariable analysis maternal antibody levels dropped by -7.2% (95% CI -12.0 to -2.3%, p = 0.005) for each week that passed since the receipt of the third vaccine dose. In contrary, systemic side effects after the third vaccine were associated with higher maternal antibody levels of 52.0% (95% CI 4.7 to 120.8%, p = 0.028). Also, for each 1 unit increase in maternal body mass index, maternal antibody levels increased by 3.6% (95% CI 0.4 to 6.9%, p = 0.025).BNT162b2 mRNA COVID-19 booster dose during the third trimester of pregnancy was associated with strong maternal and neonatal responses as reflected by maternal and neonatal SARS-CoV-2 IgG antibody levels measured at birth. These findings support the administration of the COVID-19 booster to pregnant women to restore maternal and neonatal protection during the ongoing pandemic.

Purpose: Morgagni hernias account for less than 5% of congenital diaphragmatic hernias. They are characteristically retrosternal and bilateral, with right-sided predominance. An association between Trisomy 21 and diaphragmatic hernias resembling Morgagni hernia has been reported, but the effect of cardiac surgery on its formation has not been investigated. The purpose of this study was to determine whether there is a higher incidence of anterior diaphragmatic hernias in children with Trisomy 21 after cardiac surgery. Methods: We compared the prevalence of anterior diaphragmatic hernias in 92 patients with Trisomy 21 who underwent cardiac surgery with its prevalence in two control groups - children without Trisomy 21 who underwent cardiac surgery, and children with Trisomy 21 who did not undergo cardiac surgery, 100 patients in each. All available CXRs of all children underwent revision for the presence of an anterior diaphragmatic hernia by a pediatric radiologist. Results: Within the study group, four cases of an anterior diaphragmatic hernia were detected, all upon presentation to the emergency room due to breathing difficulties. No cases of an anterior diaphragmatic hernia were found in the two control groups (P = 0.0094) Conclusions: A high index of suspicion for an anterior diaphragmatic hernia should be maintained in children with Trisomy 21 who have undergone cardiac surgery and present with breathing difficulty. If CXR findings are uncertain, UGI series and\or CT should be performed. In light of our findings, the surgical technique has been modified in patients with DS in our medical center.

Theoretical analyses indicate that aggressive signals should positively correlate with the signallers' willingness and abilities to fight. Few experimental studies, however, have tested this prediction. In two experiments employing distinct, ecologically realistic protocols, we quantified the association between aggressive signals and fighting in fruit fly genotypes and found high positive genetic correlations between threat and fighting ( r G = 0.80 and 0.74). Our results add to the growing body of experimental work indicating that aggressive signals have relatively high informational value.

Female mate choice is a complex decision making process that involves many context-dependent factors. Understanding the factors that shape variation in female mate choice has important consequences for evolution via sexual selection. In many animals including fruit flies, Drosophila melanogaster, males often use aggressive mating strategies to coerce females into mating, but it is not clear if females’ experience with sexual aggression shapes their future behaviors. Here, we used males derived from lineages that were artificially selected to display either low or high sexual aggression toward females to determine how experience with these males shapes subsequent female mate choice. First, we verified that males from these lineages differed in their sexual behaviors. We found that males from high sexual aggression backgrounds spent more time pursuing virgin females, and had a shorter mating latency but shorter copulation duration compared with males from low sexual aggression backgrounds. Next, we tested how either a harassment by or mating experience with males from either a high or low sexual aggression backgrounds influenced subsequent female mate choice behaviors. We found that in both scenarios, females that interacted with high sexual aggression males were more likely and faster to mate with a novel male one day later, regardless of the male’s aggression level. These results have important implications for understanding the evolution of flexible polyandry as a mechanism that benefits females.

Following extensive renovation of urban areas of central Israel, and in the framework of a research project of supplying nest-boxes for urban breeding birds, especially Common Swifts Apus apus, we documented interspecific nest destruction by House Sparrows Passer domesticus. In two separate incidents the House Sparrows entered the nest chamber of the swifts and removed the eggs by puncturing them. In one, the incident occurred early enough in the breeding season and allowed the Common Swift pair to renest and successfully fledge two young.

To identify risk factors associated with accidental fetal skin lacerations (AFL) during cesarean section (CS).This retrospective cohort study was obtained from the registry of two large medical centers between 2014 and 2019. The study group comprised all newborns identified with AFL. The rates of various potential risk factors were compared between the study group and a group of CS at which no AFL had occurred (the control group).Of the 14 666 CS deliveries, 48 cases of AFL (0.33%) were documented, 52% of these following urgent CS. Compared with the control group (n = 14 618), the only risk factors associated with AFL were premature rupture of membranes (PROM) (odds ratio [OR] 5.38, 95% convidence interval [CI] 2.97-9.74) and meconium-stained amniotic fluid (OR 6.50, 95% CI 2.55-16.54). In subgroup analysis by CS urgency, no significance for these factors was noted in elective CS group; but higher rates of both PROM and meconium-stained amniotic fluid were noted in the AFL during urgent CS (OR 14.23, 95% CI 6.30-32.16 and OR 15.36, (95% CI 5.65-41.75, respectively).During urgent CS, the surgeon should bear in mind that the presence of PROM or meconium-stained amniotic fluid should prompt extra care and application of preventive measures to decrease the rates of AFL.

The mid-Middle Paleolithic (late Marine Isotope Stage 6 and Marine Isotope Stage 5) is the least documented phase of the Levantine Middle Paleolithic (MP), especially concerning flint provisioning strategies. Our study of raw material exploitation at Nesher Ramla karst sinkhole (central Coastal Plain, Israel) provides an intriguing glimpse into the decision making of mid-Middle Paleolithic hominins. In this study we focused on the identification of the provisioning strategies derived from two horizons (which we dubbed the “Pelvis Horizon” and the “Stones Horizon”) from the upper part of the Nesher Ramla sequence. We applied several analytical measures: a survey of raw material sources, material composition and typo-technological analyses of the archaeological assemblages, mainly using the chaine operatoire approach and a taphonomic-taxonomic analysis of the faunal assemblages. Our study demonstrates that different lithic provisioning strategies were practiced in each horizon. The findings for the Pelvis Horizon are particularly interesting. They offer strong evidence for hunter-gatherers’ personal toolkits associated with the provisioning of individuals strategy. The Stones Horizon, conversely, produced a mixed signal, containing evidence for both intensive in situ knapping and mobile toolkits. The faunal remains echo these differences: Compared to the Stones Horizon, the zooarchaeological assemblage of the Pelvis Horizon presents lower frequencies of bone fracturing, anthropogenic modifications, and burning. Accordingly, during the Pelvis Horizon, the site most likely functioned as an ephemeral hunting station whereas, during the Stones Horizon, it hosted a broader range of activities and longer occupations. These observations shed light on the variability of south Levantine MP mobility patterns, modes of occupation, and site function.

The Levantine Middle Paleolithic period displays significant archaeological variability across a series of cave and open-air sites encompassing ca. 200,000 years. Faunal remains are an important source of knowledge regarding hunting and mobility patterns but have mostly been studied in the deep stratigraphic sequences of the Levantine caves. This research addresses questions of hunting, carcass transport, butchery patterns and use of space as they occurred at the Middle Paleolithic open-air site of Nesher Ramla in central Israel. The site is an eight-meter-thick sequence within a karst sinkhole, dating to MIS6/5. We conducted the first detailed taphonomic and zooarchaeological study at the site, focusing on a sample from Unit III, which is a thin layer with dense lithics and faunal remains, combustion features, manuports, and ochre. Our results reveal an anthropogenic accumulation that is dominated by aurochs, equid, and tortoise remains. The large ungulates’ (aurochs) skeletal-element representation is biased in favor of meat- and fat-rich body parts, coupled with abundant evidence of dismemberment, filleting and marrow extraction. These parts were imported to the sinkhole for processing and consumption. Tortoises are abundant. The lithic assemblages exhibit high frequency of retouched tools and low typological diversity and are characterized by high visibility of personal toolkit components. Coupled with use-wear analysis that suggests low spectrum of activities and massive occurrence of hammerstones, anvils and manuports, these characteristics indicate that the Unit III occupation represents an intensive camp centering on aurochs processing and butchering.

This paper focuses on new findings from Middle Paleolithic Geula Cave, Israel, located in the northern part of Mt. Carmel. The cave, consists of several small chambers that are remnants of a larger cave system, initially excavated between 1958 and 1964. The occupation at the cave was ascribed to Middle Paleolithic modern humans. In 2016, a salvage excavation was conducted in areas of the cave that were not previously explored. Analyses of the new excavation revealed a consistency in lithic technology throughout the new excavation areas, with an emphasis on Levallois production using mainly bidirectional and centripetal core preparation modes. The faunal study identified intensive hyena and porcupine activities in small chambers, probably at the back part of the cave, while fractured bones in association with flint artifacts were found at what appears as the living area in the cave. Luminescence ages indicated that Geula Cave was occupied as early as 175 ka, but that the major occupation was from 120 to 100 ka. The major occupation at Geula chronologically overlaps with the Skhul and Qafzeh Caves thus reinforcing the notion that Homo sapiens dominated the southern Levant during early MIS 5. This study demonstrates the importance of reinvestigating and reevaluating past excavated prehistoric sites and their contents to enhance our understanding of the regional, cultural and biological history.

This article presents a qualitative study of nineteen Palestinian female students in Israel. In doing so, it promotes a context-informed approach in social work education, which takes into account power relations, issues of gender, and socio-political and socio-cultural backgrounds. The students participated in a context-informed course held at Ruppin Academic Center in Israel. The findings focus on two contexts in the students’ lives: (1) their socio-cultural background, which includes their family and cultural space; and (2) the socio-political context, which includes majority-minority relations. A discussion on the intersection of these two spheres follows. Whereas students felt the socio-political realm was blind to their identity as Palestinian female students, they felt that the course was like their ‘home’ in terms of language and identity.