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1. Correction: Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

Author

Roseann E. Peterson, EM Byrne, M J Owen, Sven Cichon, Gcb Sinnamon, Jian Yang, Stephan Ripke, Andreas J. Forstner, Stephanie H. Witt, TM Air, Isaac S. Kohane, M. Rietschel, Tõnu Esko, Jakob Grove, Eske M. Derks, Hans-Jörgen Grabe, Christine Søholm Hansen, Hualin S. Xi, Kenneth I. Berger, A. C. Heath, Henry Völzke, Manuel Mattheisen, Bernard Ng, Hamdi Mbarek, Stefan Kloiber, Jodie N. Painter, Marianne Giørtz Pedersen, Jerome C. Foo, Carsten Horn, Yang Wu, Alexander Viktorin, Hilary K. Finucane, Paf Madden, Lili Milani, Katharina Domschke, Yun Li, Bernard T. Baune, I. Jones, M. M. Nöthen, Atf Beekman, Eric Jorgenson, Matthew Hotopf, Christopher Rayner, Giorgio Pistis, Stanley I. Shyn, J.H. Smit, A Abdellaoui, N. G. Martin, Paul F. O'Reilly, Enrico Domenici, Daphna Levinson, John P. Rice, Thomas Werge, Ling Shen, Catherine Schaefer, Andrea Danese, Jonathan Marchini, Na Cai, Michel G. Nivard, Scott D. Gordon, Shantel Weinsheimer, Steven P. Hamilton, G. Homuth, Yunpeng Wang, David M. Hougaard, Andres Metspalu, Nese Direk, Gonneke Willemsen, Francis M. Mondimore, J-J Hottenga, M. Gill, S. E. Medland, Donald M. Lyall, Peter Hoffmann, Merete Nordentoft, Udo Dannlowski, Stacy Steinberg, Tfm Andlauer, Ian J. Deary, Caroline Hayward, Cathryn M. Lewis, Penelope A. Lind, Nancy L. Pedersen, David J. Porteous, Hogni Oskarsson, D.I. Boomsma, Evelin Mihailov, Thorgeir E. Thorgeirsson, Evangelos Vassos, Rudolf Uher, Gary Davies, Gerome Breen, KW Choi, Christopher Hübel, Carol Kan, Sara A. Paciga, Kirstin L. Purves, Torben Hansen, Jri Coleman, Naomi R. Wray, Erin C. Dunn, Engilbert Sigurdsson, Bradley T. Webb, Jorge A. Quiroz, van, Hemert, Am, Christel M. Middeldorp, Jonas Bybjerg-Grauholm, Robert A. Schoevers, Maciej Trzaskowski, Jing Shi, Ole Mors, Alexander Teumer, Fernando S. Goes, S-A Bacanu, James B. Potash, David J. Smith, Niamh Mullins, EB Binder, J Bryois, Dean F. MacKinnon, Arolt, Daniel Umbricht, Andrew M. McIntosh, P. B. Mortensen, Anders D. Børglum, Futao Zhang, Susanne Lucae, W. Maier, Eva C. Schulte, Jens Treutlein, Carsten Bøcker Pedersen, Henning Tiemeier, Grant W. Montgomery, Trubetskoy, Thomas G. Schulze, Martin Preisig, Bwjh Penninx, TB Bigdeli, Thalia C. Eley, Shing Wan Choi, Robert Maier, E Agerbo, Katherine E. Tansey, P. McGuffin, James A. Knowles, de, Geus, Ejc, Franziska Degenhardt, Jane H. Christensen, Julia Kraft, Enrique Castelao, Ian B. Hickie, Helena Gaspar, Danielle Posthuma, K. Stefansson, Gregory E. Crawford, Wesley K. Thompson, Kas Davis, Jana Strohmaier, Henriette N. Buttenschøn, Margarita Rivera, Josef Frank, Van der Auwera S, Fabian Streit, Erik Pettersson, Peter M. Visscher, Donald J. MacIntyre, Qingqin S. Li, Rick Jansen, Conor V. Dolan, Matthias Nauck, Barbara Maughan, Escott-Price, Glyn Lewis, Patrick K.E. Magnusson, Henning Teismann, DePaulo, Saira Saeed Mirza, Sara Mostafavi, Kenneth S. Kendler, Matthew Traylor, Brien P. Riley, Roy H. Perlis, Patrick J. McGrath, Bertram Müller-Myhsok, Mark Adams, David M. Howard, Lucía Colodro-Conde, Lisa Hall, Divya Mehta, Nyholt, Y. Milaneschi, Jordan W. Smoller, M Baekvad-Hansen, Marcus Ising, M O'Donovan, Warren W. Kretzschmar, Baptiste Couvy-Duchesne, Wouter J. Peyrot, P. A. Thomson, P.F. Sullivan, Stefan Herms, Clarke T, Ffh Kiadeh, Jürgen Wellmann, Lisa Jones, A.G. Uitterlinden, Per Qvist, Z. Kutalik, Hreinn Stefansson, Myrna M. Weissman, and N. Craddock

Subjects
medicine.medical_specialty, SDG 16 - Peace, business.industry, SDG 16 - Peace, Justice and Strong Institutions, MEDLINE, Nearly Every Day, medicine.disease, Biobank, Genome, Justice and Strong Institutions, Cellular and Molecular Neuroscience, Psychiatry and Mental health, medicine, Major depressive disorder, Psychiatry, business, Molecular Biology, Depression (differential diagnoses)
Abstract

Following publication of this article, the authors noticed an error in Supplementary Table 1. In the original Supplementary Table 1, one of the criteria for control participants was incorrectly given as ‘Report extensive recent symptoms of depression: less than 14 on summed response (where “not at all” = 1 and “nearly every day” = 4) to recent’. This has now been corrected to: ‘Report extensive recent symptoms of depression: less than 5 on summed response (where “not at all” = 1 and “nearly every day” = 4) to recent’.

Published
2020
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2. Polygenic scores associated with educational attainment in adults predict educational achievement and ADHD symptoms in children

Author

Sang Hong Lee, Danielle Posthuma, Debbie A Lawlor, Michael B. Miller, Igor Rudan, Jürgen Wellmann, François Bastardot, Lawrence F. Bielak, Anu Realo, William G. Iacono, Lude Franke, Matthew Kowgier, Marika Kaakinen, Helena Schmidt, Jorma Viikari, Jennifer A. Smith, David R. Van Wagoner, Elizabeth G. Holliday, Veronique Vitart, Robert F. Krueger, Pamela A. F. Madden, Jan Emmanuel De, Andrew Heath, David Cesarini, Najaf Amin, Dale R. Nyholt, Juliette Harris, Nicholas J. Timpson, George Dedoussis, Stefania Bandinelli, W. Hoffmann, Albert V. Smith, Beate St Pourcain, Stavroula Kanoni, Martin F. Elderson, Maria Dimitriou, Jouke-Jan Hottenga, Min A. Jhun, Daniel S. Evans, Marjo-Riitta Järvelin, Lei Yu, Krista Fischer, Jae Hoon Sul, Jennifer R. Harris, Brenda W.J.H. Penninx, Antti-Pekka Sarin, Ida Surakka, Arpana Agrawal, Bo Jacobsson, Klaus Berger, Matt McGue, Christopher F. Chabris, Marisa Loitfelder, Veikko Salomaa, David Schlessinger, Mina K. Chung, Erik A. Ehli, Kati Kristiansson, Eva Albrecht, Niina Eklund, Aarno Palotie, Sarah E. Medland, Reinhold E. Schmidt, Kurt Lohman, Luigi Ferrucci, Osorio Meirelles, Ivana Kolcic, Vilmundur Gudnason, Nicholas G. Martin, Tomi E. Mäkinen, Robert M. Kirkpatrick, Thomas Illig, Peter M. Visscher, Håkon K. Gjessing, Sebastian E. Baumeister, Carla A. Ibrahim-Verbaas, Per Hall, Elisabeth Widen, Panos Deloukas, Ronny Myhre, Michelle N. Meyer, Jonathan P. Beauchamp, Caroline Hayward, Eveline L. de Zeeuw, Penelope A. Lind, Erik Ingelsson, Ian J. Deary, George Davey-Smith, Dalton Conley, Peter Lichtner, Cornelia M. van Duijn, Samuli Ripatti, Dena G. Hernandez, Albert Hofman, George McMahon, Thais S. Rizzi, Wei Zhao, Patrick K.E. Magnusson, Jingmei Li, Mariza de Andrade, Ben A. Oostra, Abdel Abdellaoui, Andres Metspalu, Patricia A. Peyser, Jessica D. Faul, David C. Liewald, Christina Holzapfel, Lydia Quaye, John Barnard, Meike Bartels, Christian Gieger, John P. Rice, Christiaan de Leeuw, Patricia A. Boyle, Nicholas D. Hastie, David R. Weir, Adriaan Hofman, Astanand Jugessur, Tamara B. Harris, Catharina E. M. van Beijsterveldt, Gail Davies, H.-Erich Wichmann, Lynn Cherkas, Polasek Ozren Polasek, Harm-Jan Westra, Yongmei Liu, Jari Lahti, Matthijs J. H. M. van der Loos, Rodney J. Scott, Gérard Waeber, Peter Vollenweider, Behrooz Z. Alizadeh, Frank J. A. van Rooij, Susan M. Ring, Judith M. Vonk, Lyle J. Palmer, Alexander Teumer, John M. Starr, Antonio Terracciano, Sara Hägg, Erkki Vartiainen, David Laibson, Eco J. C. de Geus, Mika Kähönen, Marco Masala, Peng Lin, Nicolas W. Martin, André G. Uitterlinden, Dorret I. Boomsma, Harry Campbell, Sutapa Mukherjee, Konstantin Shakhbazov, Henning Tiemeier, Zó Ltan Kutalik, Grant W. Montgomery, Eva Reinmaa, Aldo Rustichini, Wouter J. Peyrot, David M. Evans, Martin Preisig, Cornelius A. Rietveld, T.J. Glasner, J Kaprio, John Attia, Pedro Marques Vidal, Sharon L.R. Kardia, Peter K. Joshi, Toshiko Tanaka, Rauli Svento, Magnus Johannesson, Terho Lethimäki, Jüri Allik, Philip L. De Jager, Antti Latvala, Marja-Liisa Nuotio, Juha Karjalainen, Henry Völzke, Roy Thurik, Rolf Holle, Kelly S. Benke, Christopher Oldmeadow, Esko Toñu Esko, Johan G. Eriksson, Alan F. Wright, Francesco Cucca, Ute Bültmann, Olli T. Raitakari, Melissa E. Garcia, Patrick J. F. Groenen, Maria M. Groen-Blokhuis, Gonneke Willemsen, Jian Yang, Lili Milani, Fernando Rivadeneira, David A. Bennett, Gudny Eiriksdottir, Katri Räikkönen, Harold Snieder, Laura J. Bierut, James J. Hudziak, James F. Wilson, Rudolf S N Fehrmann, Jaime Derringer, Gareth E. Davies, K. Petrovic, Markus Perola, Lenore J. Launer, Daniel J. Benjamin, Paul Lichtenstein, Philipp Koellinger, Andreas Mielck, Jeffrey A. Boatman, Henrik Grönberg, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Public Health Research (PHR), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Stem Cell Aging Leukemia and Lymphoma (SALL), Life Course Epidemiology (LCE), Groningen Research Institute for Asthma and COPD (GRIAC), EMGO+ - Mental Health, Biological Psychology, Methods and Techniques, Child and Adolescent Psychiatry / Psychology, Ophthalmology, and Epidemiology

Subjects
Netherlands Twin Register (NTR), Multifactorial Inheritance, genetic association, genotype, Academic achievement, Educational achievement, single nucleotide polymorphism, genetic variability, Genetics (clinical), Netherlands, child, article, symptom, academic achievement, Psychiatry and Mental health, priority journal, achievement test, Regression Analysis, Psychology, SDG 4 - Quality Education, Clinical psychology, Adult, phenotype, effect size, attention deficit disorder, gene frequency, educational status, Cellular and Molecular Neuroscience, reading, study skills, mental disorders, Genetics, medicine, Humans, ADHD, Attention deficit hyperactivity disorder, Achievement test, controlled study, human, Association (psychology), Genetic association, attention disturbance, language, School performance, medicine.disease, arithmetic, major clinical study, Polygenic scores, Educational attainment, gene linkage disequilibrium, Attention Deficit Disorder with Hyperactivity, Study skills
Abstract

The American Psychiatric Association estimates that 3 to 7 per cent of all school aged children are diagnosed with attention deficit hyperactivity disorder (ADHD). Even after correcting for general cognitive ability, numerous studies report a negative association between ADHD and educational achievement. With polygenic scores we examined whether genetic variants that have a positive influence on educational attainment have a protective effect against ADHD. The effect sizes from a large GWA meta-analysis of educational attainment in adults were used to calculate polygenic scores in an independent sample of 12-year-old children from the Netherlands Twin Register. Linear mixed models showed that the polygenic scores significantly predicted educational achievement, school performance, ADHD symptoms and attention problems in children. These results confirm the genetic overlap between ADHD and educational achievement, indicating that one way to gain insight into genetic variants responsible for variation in ADHD is to include data on educational achievement, which are available at a larger scale. (C) 2014 Wiley Periodicals, Inc.

Published
2014
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