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An improved understanding of the computed tomographic (CT) features for malignant versus benign oral tumors would be helpful for guiding prognosis and treatment planning decisions in dogs. This retrospective, multi-center, observational study compared the CT features of malignant and benign tumors in 28 dogs with 31 oral masses. Malignant tumors were present in 20 dogs, including malignant melanoma (n = 14), squamous cell carcinoma (SCC, n = 4), adenocarcinoma (n = 1), and fibrosarcoma (n = 1). Eight dogs had benign tumors, including giant cell granuloma (n = 2), peripheral odontogenic fibroma (n = 2), acanthomatous ameloblastoma (n = 2), plasmacytoma (n = 1), and oncocytoma (n = 1). Common CT features of malignant tumors included heterogeneous enhancement, tumor invasion into the adjacent bone, tooth loss, and ipsilateral mandibular lymphadenopathy. Malignant tumors were significantly larger than benign tumors. Bone lysis was found in benign tumors (n = 4) such as acanthomatous ameloblastoma, giant cell granuloma, and plasmacytoma. The bone lysis was a well-defined geographic area regardless of malignancy and tumor type. In periosteal reactions, amorphous patterns were seen in both malignant (n = 2) and benign tumors (n = 2); the latter subgroup also showed solid patterns. Bone expansion (n = 2) was identified in malignant melanoma and acanthomatous ameloblastoma. Findings supported a diagnosis of possible malignancy for dogs with oral tumors having the following CT characteristics: large size, heterogeneous contrast enhancement pattern, bone lysis, tooth loss, and ipsilateral lymphadenopathy. However, there was a considerable overlap of CT findings among the different types of oral tumors and between benign and malignant tumors. Histological evaluation therefore remains necessary for definitive diagnosis.

Odontogenic lesions are well described in domestic cats, but published literature describing these lesions in nondomestic felids is limited. This study reports oral lesions in 109 captive, non-domestic felids. Ten cases of odontogenic lesions were diagnosed, including 9 with fibromatous epulis of periodontal ligament origin (FEPLO) and one odontogenic cyst in a cougar. FEPLO was common in lions. FEPLO did not recur after surgical removal in any of the 3 cases for which follow-up information was available. Increased occurrences of oral papillomas in snow leopards and eosinophilic granulomas in tigers were identified, which is consistent with the reported literature. With the exception of oral papillomas in snow leopards and FEPLO in lions, the spectrum of oral lesions in nondomestic felids was similar to what is reported in domestic cats, with squamous cell carcinoma being the most common oral malignancy, and stomatitis/gingivitis/glossitis accounting for approximately one third of all cases. Rare diagnoses with one case each included hemangioma, fibrosarcoma, melanoma, cleft palate, and glossal amyloidosis.

A case of peripheral ossifying fibroma (POF) in the anterior mandible of a 63-year-old woman is described. The 17 x 23 x 16mm nodular mass was sessile, displaced teeth and had a non-ulcerated, pink surface. Due to the variations in radiographic, clinical and pathological appearance, initially the diagnosis of peripheral odontogenic fibroma was reached. Complex nomenclature and variation in clinical, radiological and pathological appearance of POF and similar masses is discussed.

Objectives Peripheral odontogenic fibroma (POF) is a relatively rare odontogenic tumor of the gingiva. Although its histological differential diagnosis from fibrous epulis (FE) is important, no study has reported the differences in their expression of immunohistochemical markers. Here, we compared the expression of tumor markers that are frequently used for the differential diagnosis of fibroproliferative lesions between POF and FE. Methods Forty cases were selected, including 20 POF and 20 FE cases. CD34, B cell lymphoma (Bcl)-2, and Ki-67 were used as markers for immunohistochemical examination. The positive cell ratio was calculated, and Mann-Whitney U test was performed for statistical analysis. Results POF and FE were negative for CD34 expression but showed Bcl-2 and Ki-67 expression. The ratio of Bcl-2- and Ki-67-positive cells was significantly higher in POF than in FE (p Conclusions POF is CD34 negative, and Bcl-2 and Ki-67 positive-cell ratio differs between POF and FE, suggesting that these proteins may serve as immunohistochemical markers for the differential diagnosis of POF.

In neoplasms Peripheral Odontogenic Tumors(POT) are one of the rare to occur on gingiva, among them, Peripheral Odontogenic Fibroma (POdF) is the most common. A plethora of lesions sharing similar clinical features, makes the diagnosis difcult. POdF is a benign, slow-growing, smooth, exophytic, painless lesion but it may show diverse clinical presentation as erythematous, lobulated, rapidly growing mass which might be tender on palpation overlapping the features with various inammatory gingival conditions to even a gingival squamous cell carcinoma.This results into diagnostic enigma. Histopathologoical examination plays a vital role in these type of cases. Discussed here is a case of POdF mimicking gingival squamous cell carcinoma. Histopathological investigation showed presence of odontogenic epithelium and dystrophic calcication which are the pathognomonic features of POdF. After surgical removal,POdF is seen to recur but, the exact recurrence rate cannot be estimated due to scarcity of reported cases.

Summary: Fibromatous epulis is a rare tumour in horses which is analogous to the same condition in dogs and peripheral odontogenic fibromas in man. The nomenclature is varied throughout the veterinary literature, but these tumours are most correctly known as peripheral odontogenic fibromas. Although these lesions are benign, they have a high recurrence rate in other species, so wide local excision is important to give the best possible prognosis.

Peripheral odontogenic fibroma (POF) is an uncommon finding in the mouth of cats. Few cases have been reported in the literature. The present report describes an adolescent, male-castrated domestic shorthair cat with POFs at the rostral upper and lower jaws that were treated via marginal excision including removal of underlying bone. Despite the high incidence of recurrence reported in the literature, recheck examinations up to 11 months postoperatively did not show regrowth of the gingival masses. Thus, marginal excision including removal of underlying bone appears to be a viable treatment option for POF in cats.

Background: The incidence and frequency of odontogenic cysts and tumors depends on the different geographic location. Odontogenic cysts and tumors are lesions that arise from the tooth apparatus or its remnants. The purpose of this study was to determine the prevalence of odontogenic cysts and tumors over a period of 5 years 9 months and to compare our results with other published studies. Aim and Objective: The purpose of this study was to evaluate the prevalence of odontogenic cysts and tumors diagnosed at the Department of Oral Pathology, M.M. College of Dental Sciences & Research, Mullana (Ambala) and to compare the results with findings in the literature. Materials and Method: Data of odontogenic cysts and tumors diagnosed during 2014 to 2019 (till September) w4ere collected from the files of the Oral Pathology Department, M.M. College of Dental Sciences & Research, Mullana (Ambala). Results: Out of the total 71 cases of odontogenic cysts, most prevalent odontogenic cysts were found to be radicular cysts (n=42, %= 59.1%), followed by dentigerous cysts (n=17, %=23.9%) and odontogenic keratocyst (n=12, %=16.9%). Among the odontogenic tumors out of 49 cases reported, the most prevalent was ameloblastoma (n=28, %=57.1%) followed by, ameloblastic fibroma (n=06, %=12.2%), odontoma (n=05,%=10.2%), adenomatoid odontogenic tumor (n=03, %=6.1%), peripheral odontogenic fibroma (n=02, %=4.08%), ameloblastic carcinoma (n=02, %=4.08%), odontogenic fibroma (n=02, %=4.08%) and odontogenic myxofibroma (n=01, %=2.04%). The anterior and posterior portion of the body of mandible was the most common site for both odontogenic cysts and tumors. The age group for odontogenic cysts ranged from 07 to 72 years of age, whereas for the odontogenic cysts the range was 10 to 75 years of age. The male to female ratio for the odontogenic cysts was 1:1.2, whereas for the odontogenic tumors it was found to be having more female predilection with the ratio of 1:1.3. Conclusion: The prevalence of odontogenic cysts was similar to that reported in the literature, with incidence of radicular cysts seen most frequently. In case of odontogenic tumors the findings vary to the reported literature with ameloblastoma being more commonly reported.

To present the clinical presence, histopathological features, and management of a rare peripheral odontogenic fibroma (POF) case. A 32-year-old male patient was referred to the clinic complaining of a localized gingival enlargement of the anterior maxillary region. Initial periodontal treatment was delivered and the patient was informed about proper oral hygiene. After the initial periodontal treatment, the lesion was surgically excised while preserving the marginal line. POF was diagnosed based on clinical and histopathological findings. Normal mechanical oral hygiene was established in the postoperative period. No recurrence was observed during this follow-up period, and the patient was included in the maintenance phase. POF was treated with local excision and the prognosis was excellent. Regular follow-ups are very important for such patients after surgery. How to cite this article: Alan R, Can B, Kilinc F. Peripheral Odontogenic Fibroma: A Rare Case Report. Int Dent Res 2018;8(1):45-9. Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.

The extraosseous/peripheral odontogenic fibroma (E/POF) is a benign mesenchymal odontogenic tumour found on the gingival surface with clinical characteristics identical to those of reactive lesions. A histopathological analysis is the only method for determining the difference between reactive lesions and these neoplastic lesions, whose recurrence potential varies between 38.9% and 50%, highlighting the importance of correct diagnosis. The following report describes an E/POF case with a clear cells component, as well as a long-term follow-up treatment, which we emphasise due to its potential for recurrence.

A 10 yr old intact female German shepherd dog presented with a large peripheral odontogenic fibroma and malignant melanoma on her lower jaw. The tumor was resected with a unilateral subtotal rostral hemimandibulectomy. After the mandible was removed, it was devitalized intraoperatively by freezing it in liquid nitrogen. It was subsequently reimplanted. New bone tissue formed in the gap between the frozen bone and the host bone. The regenerated bone contained osteocytes, osteoblasts, and blood vessels. The cosmetic appearance of the dog was preserved. The dog had normal mastication. The malignant melanoma recurred rostral of the left canine tooth at 159 days after the reconstruction surgery. A subtotal hemimandibulectomy was consequently performed. This is the first reported case of mandibular reconstruction using a liquid nitrogen-treated autograft in a dog with oral tumors.

Peripheral ossifying fibroma (POF) is by far the most common of the reactive fibro-osseous processes affecting the gingiva.1 Histologically, POF shows a wide spectrum, the types and patterns of calcification and ossification varying in both amount and appearance, mostly depending on the stage of development, although the diagnosis is straightforward nevertheless.1 Here we describe two rare findings in mature lesions of POF: transepithelial elimination (TEE) of bony sequestrae (case 1) and multiple inclusions of odontogenic epithelium in the intervening fibrous stroma (case 2). Our working hypotheses were that case 1 gave rise to florid pseudoepitheliomatous hyperplasia (PEH) that could have been potentially misdiagnosed as squamous cell carcinoma (SCC), whereas case 2 showed overlap of microscopic features with peripheral odontogenic fibroma (POdF), making the differential diagnosis challenging. This article is protected by copyright. All rights reserved.

There appears to be similarities between the clinical appearances of different types of gingival overgrowths. The WHO type peripheral odontogenic fibroma (POdF) is an unusual benign odontogenic neoplasma of the gingiva. It is considered to be an extraosseous counterpart of the central odontogenic fibroma (COF). Among all biopsy specimens, POdF comprehend only upto 0.05%. Odontogenic fibromas are rare but still they provide a noteworthy diagnostic and therapeutic challenge. Along with clinical, radiographic appearance, and histologic features, a sound knowledge on biologic behavior of rare gingival overgrowths would ensure an accurate diagnosis of tumor pathology. We present here a case report of POdF that occurred in a young female patient in anterior interdental region displacing the tooth. Platelet rich fibrin (PRF) was used to stimulate soft tissue healing. Two year follow up showed satisfactory healing with no recurrence.

Peripheral odontogenic fIbroma (POF) is a rare odontogenic tumor. It resembles clinically with other peripheral exophytic lesions like pyogenic granuloma, peripheral ossifying fibroma, and peripheral giant cell granuloma. Hence, needs to be differentiated from such other lesions. Histopathological examination being the only diagnostic approach for peripheral odontogenic fibroma, which can provide a basis for treatment and prognosis evaluation. This case report presents a rare clinical case of a 14-year-old female patient with a palatal overgrowth along the maxillary incisors, which was diagnosed as peripheral odontogenic fibroma.

Pathological dental conditions in zoo animals are frequently encountered, although under-reported in the veterinary literature. Teeth fractures are commonly encountered in carnivores and often require specialised endodontic intervention. This paper describes gingivectomy of a peripheral odontogenic fibroma of the left maxillary gingivae; crown lengthening of the left mandibular canine; and pulpectomies of complicated crown fractures of the left maxillary canine tooth (204), left mandibular canine tooth (304) and left third maxillary incisor (203) in an adult jaguar (Panthera onca). Follow-on dental examination at 18 months and postoperative radiographs at 24 months found no evidence of further dental pathology. Dental examination and prophylaxis are essential components of the examination procedure. There are limited opportunities to make routine clinical assessments in zoo animals. The availability of specialised materials, equipment and specialised veterinary assistance are limitations as relevant to zoological dentistry today as when described by Fowler in 1986.

Congenital granular cell epulis (CGCE) is an uncommon lesion of unclear pathogenesis. It occurs predominantly in female newborns with a predilection site of the maxillary alveolar ridge. The mass enlarges prenatally but the growth arrests after birth. Histologically, CGCE is characterized by a proliferation of polygonal cells with eosinophilic, granular cytoplasm and eccentric, bland-appearing nuclei. It closely resembles adult granular cell tumor (GCT) microscopically and S-100 immunostain is often helpful in distinguishing the two (S-100-positive in GCT and S-100-negative in CGCE). Clinically, the lesion should also be distinguished from entities such as infantile myofibroma, rhabdomyoma, melanotic neuroectodermal tumor of infancy, peripheral odontogenic fibroma, and neurofibroma. CGCE demonstrates an excellent prognosis and has not been associated with any syndromes/genetic defects or malignant transformation. Clinicians and pathologists should be familiar with this rare entity and its differential diagnosis for accurate diagnosis and management.

Peripheral odontogenic fibroma (POF) is defined as a benign neoplasm of the jaws of odontogenic ectomesenchymal origin. It is considered an uncommon neoplasm that affects patients in a wide age group, with certain predominance in girls and women. It appears as a firm, slow-growing, and usually sessile mass that affects the gingiva, is of firm consistency, and is covered by apparently normal mucosa. The objective of this study was to report a case of FOP in a 17-year-old male patient with a localized gingival swelling in the region of the left canine. It was present for 3 years and had slowly grown, causing displacement of the teeth. Radiography of the involved area did not reveal bone loss. The lesion was removed by surgical excision, and the POF was diagnosed based on clinical and histopathologic findings. Regular follow-ups are very important for such patients after surgery.

The use of the term “fibroma” for any soft-tissue lesion or gingival lesion by general practitioners has led to inadequate diagnosis of quite a few rare entities. The occurrence of gingival lesions in adolescent female patients is a routine clinical finding. The site of occurrence of such a lesion is of prime significance, as the rarity of these lesions is determined by the site and size of the lesion. On the other hand, the dilemma over the diagnosis of peripheral ossifying fibroma (POF) versus peripheral odontogenic fibroma still continues. Commonly used synonyms for POF include calcifying fibroblastic granuloma, peripheral fibroma with calcification, peripheral cementifying fibroma, and calcifying or ossifying fibrous epulis. The present case report deals with the management of a unique case of POF between two maxillary central incisors in an adolescent female child patient, followed up to 2-year postsurgical excision.

The purpose of the study is to document a rare case of a peripheral odontogenic fibroma with associated cervical and coronal tooth resorption in a 38 year old woman. Histopathological features are described, the clinical management outlined and follow-up observations over 27 years detailed. The exophytic firm lesion, coral pink in appearance, located on the labial aspect of a maxillary right lateral incisor was excised, fixed in formalin and prepared for histological evaluation. The resorption cavity and adjacent soft tissue were treated by the topical application of trichloroacetic acid prior to restoration with a glass-ionomer cement and subsequent root canal treatment. Histologically, the body of the lesion was characterized by the presence of odontogenic epithelium embedded in a mature fibrous stroma. Areas of dystrophic calcification could also be identified. The features were consistent with a diagnosis of a peripheral odontogenic fibroma. The clinical result of treatment assessed 27 years postoperatively showed no evidence of recurrence of the peripheral odontogenic fibroma. External cervical and coronal tooth resorption can, on rare occasions, prove to be a clinical feature associated with peripheral odontogenic fibroma. Treatment of the tumour mass and the resorptive lesion can provide a successful outcome.

Historically, the classification of localized gingival fibrous lesions has been inconsistent, leading to multiple naming schemes and confusion among pathologists. Currently, lesions are broadly grouped into localized hyperplastic lesions and true neoplasms. Although some cases are clearly defined histologically (i.e., peripheral ossifying fibroma, peripheral odontogenic fibroma), another set of "reactive" fibrous lesions exhibit overlapping histologic features including nondistinctive fibrosis and inflammation. This group can exhibit recurrence, classically related to a local stimulus. However, when local factors are absent, recurrence suggests inherent neoplastic potential. Herein, we describe 2 recurrent fibrous gingival masses, one of which reportedly recurred 3 times with no obvious inciting agent. The histologic appearance of both lesions was similarly distinctive but not well classifiable, while the immunohistochemical profile indicated divergent lesions. This highlights the need for further study of recurrent gingival fibrous lesions to better predict independent growth potential.

Peripheral odontogenic fibroma is considered a gingival tumor characterized by a proliferation of relatively cellular fibrous or fibromyxomatous connective tissue which exhibits variable amounts of odontogenic epithelium and sometimes foci of calcification in the form of dentinoid, cementicles, or bone. It is considered the extraosseous counterpart of central odontogenic fibroma. This lesion usually is presented as a focal swelling in the gingiva, occurring in a wide age range, and the anterior region of the gingiva is the most frequent anatomic site. Conservative local excision is the treatment frequently adopted and its recurrence rate varies widely, and its biologic behavior is still unknown. In this study, the authors discuss 3 cases of peripheral odontogenic fibroma, and present their clinical and histopathological features and management.

PERIPHERAL ODONTOGENIC FIBROMA: AN UNUSUAL CASE ABSTRACT Peripheral odontogenic fibroma (POF) is a benign odontogenic neoplasm of fibroblastic origin characterized by relatively mature collagenous fibrous tissue and varying amounts of odontogenic epithelium. The lesions are treated by conservative surgical excision. However, it is considered to be with a potential to recur. This paper presents a peripheral odontogenic fibroma case report and emphasizes the accurate diagnosis and importance of patient follow-up. Keywords: Peripheral odontogenic fibroma, benign neoplazm, periodontal surgery PERIFERIAL ODONTOJENIK FIBROMA: NADIR BIR OLGU OZET Periferal odontojenik fibroma (POF) degisik miktarlarda odontojenik epitel ve kismen olgun kollojenoz fibroz doku icermesiyle karekterize fibroblastik orjinli benign odontojenik neoplazmdir. Lezyonlar konservatif cerrahi eksizyonla tedavi edilir. Bununla birlikte tekrar olusma potansiyeliyle dikkate alinir. Bu makale periferal odontojenik fibroma olgusu takdim etmekte ve dogru tani ve hasta takibinin onemini vurgulamaktadir. Anahtar Kelimeler: Periferial odontojenik fibroma, benign neoplazm, periodontal cerrahi

Peripheral ossifying fibroma (POF) occurs as a gingival overgrowth. The purpose of this article is to present a case of POF, briefly reviewing the current literature on this condition and emphasize the importance of inclusion of this lesion into list of all the pathologies, specially the gingival overgrowths. A case report of peripheral ossifying fibroma (POF) is reported in young adolescent which comprises the growth that occurred in the mandibular anterior region with displacement of anterior teeth, its satisfactory management and literature review. POF represents a reactive benign lesion of connective tissue and is not the soft tissue counterpart of ossifying fibroma and is also not related to peripheral odontogenic fibroma. Careful clinical examination and histopathology findings should be correlated to conclude the final diagnosis. Treatment consists of surgical excision with periodic follow-ups to observe any recurrence.

The differential diagnosis of exophytic gingival lesions include peripheral odontogenic fibroma, peripheral giant cell granuloma, pyogenic granuloma, and peripheral ossifying fibroma (POF). The peripheral odontogenic broma, the peripheral counterpart of the central dontogenic fibroma, is neoplastic, whereas the othrs are generally regarded reactive in nature. The roliferative activity of the reactive lesions are conidered to be initiated by local irritants occurring in he gingival crevice or associated with adjacent teeth. hese irritants stimulate the gingival fibers of the eriodontal ligament, a specialized periosteal tissue, r the periosteum itself. Depending on the tissue timulated, these fibrous growths may contain bone nd/or cementum. The POF has been described by many names, includng ossifying fibroid epulis, peripheral fibroma with alcification, calcifying fibroplastic granuloma, and eripheral odontogenic fibroma. Gardner convincingly argued that the term peripheral odontogenic fibroma be reserved for those lesions that are neoplastic and have characteristic odontogenic epithelium. This diagnosis would include only those lesions that meet the World Health Organization criteria. He also reinforced the concept that the POF is not the peripheral variant of the central ossifying fibroma, a true neoplasm, but a distinct non-neoplastic inflammatory proliferation. POF occurs more frequently in female than in male individuals, is more common in the maxilla, and generally presents as a painless mass smaller than 2 cm. Occasionally larger lesions have been reported in the literature. The generally ac

Central odontogenic fibroma has been defined as a benign odontogenic tumor, representing the intraosseous counterpart of a peripheral odontogenic fibroma. The odontogenic fibroma is a rare tumor. Differential diagnosis of radiolucent lesions in the molar-premolar region of mandible which involve impacted tooth may include central odontogenic fibroma, hyperplastic dental follicle, dentigerous cyst, unicystic ameloblastoma, and keratocystic odontogenic tumor. We describe an example of a small central odontogenic fibroma mimicking hyperplastic dental follicle and dentigerous cyst, resulting in uneruption of a primary tooth.

Objective—To characterize clinicopathologic features of the most common odontogenic tumors and focal fibrous hyperplasia (FFH) in dogs. Design—Retrospective case series. Animals—152 dogs evaluated for oral tumors of possible odontogenic origin at the William R. Pritchard Veterinary Medical Teaching Hospital of the University of California-Davis between 1995 and 2005. Procedures—Information was collected from records, including dog breed, age, reproductive status, and location of lesion in the oral cavity. Histologic slides pertaining to each dog were reviewed by 3 investigators. Data regarding clinicopathologic features of the 3 most common lesions (canine acanthomatous ameloblastoma [CAA], peripheral odontogenic fibroma [POF], and FFH) were summarized. Results—152 dogs with odontogenic tumors or FFH were identified. Sixty-eight (45%) dogs had CAA, 47 (31 %) had POF, 24 (16%) had FFH, and 13 (9%) had other odontogenic tumors. Canine acanthomatous ameloblastoma was present most commonly in the rostral aspect of the mandible, with POF and FFH more common in the rostral aspect of the maxilla. Males and females were equally represented among dogs with CAA and FFH. Castrated males were overrepresented among dogs with POF. Golden Retrievers, Akitas, Cocker Spaniels, and Shetland Sheepdogs were overrepresented among dogs with CAA. No breed predisposition was detected for FFH or POF. Dogs with FFH had a greater mean age at initial evaluation than did dogs with CAA or POF. Conclusions and Clinical Relevance—CAA, POF, and FFH have distinct clinical patterns that may help clinicians and pathologists identify such lesions more readily.

Purpose The aim of this study was to assess the relative frequency of peripheral odontogenic fibroma (POdF) in an Iranian population and to compare the obtained data with previous reports. Materials and Methods Archival material was retrospectively analyzed from 1967 to 2007, and all microscopic slides of lesions considered in the differential diagnosis of POdF were retrieved. A diagnosis of POdF was made according to the criteria described by the World Health Organization in 2005. Demographic data, including age, gender, site of involvement, and previous history of POdF, were recorded for all samples with a diagnosis of this neoplasm. Results Nineteen POdFs were identified, which accounted for 0.14% of the archival cases. One of these tumors was a recurrence, diagnosed 12 months earlier. All cases were of the epithelium-rich or World Health Organization histologic subtype and most tumors occurred in the mandible. No significant difference in the prevalence of POdF was found between the studied variables. Among the 18 primary neoplasms, follow-up was possible for 2 to 13 years in 6 cases, and none developed recurrence. Conclusion Similar to previous investigations, this study shows that POdFs are uncommon odontogenic lesions. Detailed information on POdF is limited because of its rarity; therefore, this study may provide additional data for further investigations and may enable better understanding of this tumor.

) was evaluated because of right-sided facial swelling and a recent history of dysphagia and stridor. The squirrel was anesthetized to allow for phys-ical examination and collection of blood samples. Physical examination revealed a fracture of the maxillary right third premolar tooth and an associated abscess. Results of hematologic and serum biochemical testing were with-in reference limits for this species. While the squirrel was anesthetized, radiographs of the skull were obtained

A retrospective analysis of 25 cases of peripheral odontogenic fibroma (World Health Organization-type) (PODF [WHO-type]) in a Taiwan Chinese population was performed at a single institution. The clinical findings, which included a wide age distribution, a female preponderance and no racial predilection, were consistent with those of previous case series reports; however, a slight preference for location in the maxilla was found in the current case series. It is noteworthy that one particularly sizable lesion was identified in a 30-year-old Chinese female who presented with a swollen mass in the right mandible that had been present for about 2 years. Intraoral examination revealed an exophytic firm mass that measured 4.5 × 4 cm, located over the right mandibular edentulous ridge from the second premolar to the second molar area. Both panoramic radiography and computerized tomography revealed multiple radiopacities within the tumor. In conclusion, the analysis of clinical data in the current case series of PODFs (WHO-type) occurring in Taiwan Chinese mostly corroborates other reports; however, an unusually large mandible lesion was noted, indicative of the apparent size that such tumors can reach unless they are surgically removed at an early stage.

The diagnostic process and interdisciplinary treatment of a healthy 12-year-old boy with impactions due to a localized peripheral odontogenic fibroma are presented. The treatment consisted of the surgical excision of the peripheral odontogenic fibroma and interceptive orthodontic treatment with an activator appliance to allow the passive eruption of the impacted teeth. Complete orthodontic treatment with fixed appliances was used later to level and coordinate the arches. This report illustrates the importance of early diagnosis and treatment of tooth impactions associated with diffuse gingival enlargement. The cooperation of various specialists in making a differential diagnosis, developing a comprehensive plan for conservative treatment, and delivering excellent care led to a successful result for this patient.

Excisional biopsies of gingival overgrowths, performed with safety margins, frequently result in mucogingival defects. These defects may produce esthetic problems and increase the chances of dentin hyperesthesia and its possibility of hindering oral hygiene.Two clinical cases are reported in which gingival overgrowths were removed by excisional biopsy, resulting in unsightly defects. The first clinical case presents an invasive approach for the treatment of a recurrent pyogenic granuloma in the anterior maxilla, and the second depicts a complete removal of a peripheral odontogenic fibroma in the posterior maxilla. In both situations, the soft-tissue defects were repaired by periodontal plastic surgery, including a laterally positioned flap and a coronally positioned flap, respectively.Periodontal plastic surgery successfully restored the defects that resulted from biopsies, and no recurrence has been noticed in the 5-year postoperative follow-up period.The combination of biopsy and periodontal plastic surgery in a one-step procedure seems to be suitable to remove gingival overgrowths in most areas of the mouth, regardless of esthetic significance. Such procedures seem to restore gingival health, encourage healing, and create both esthetics and function in the excised area.

Objective. This study sought to determine the relative frequency of odontogenic tumors in a Nigerian population and to compare these data with previous reports. Study design. Records of patients seen at the Lagos University Teaching Hospital between January 1980 and December 2003, with histologic diagnosis of odontogenic tumors (based on World Health Organisation classification, 1992), were analyzed. Results. Odontogenic tumors constituted 9.6% of all the biopsies of oral and jaw lesions seen within the period under study. Three hundred and eight (96.6%) were intraosseous, and 11 (3.4%) were peripheral (peripheral odontogenic fibroma = 7; peripheral myxoma = 3; peripheral ameloblastoma = 1). The mean age of patients was 29.9 6 15.6 years (range, 4-85 years). Among these cases, 96.6% of the tumors were benign and 3.4% were malignant. Ameloblastoma with predilection for the mandible was the most frequent odontogenic tumor (63%), followed by adenomatoid odontogenic tumor (AOT) (7.5%), myxoma (6.5%), calcifying epithelial odontogenic cyst (5.3%), and odontogenic fibroma (5.3%). More cases of malignant odontogenic tumors were seen than cases of calcifying epithelial odontogenic tumor and odontomas. The mean ages of patients with AOT, ameloblastic fibroma, and odontoma were significantly lower than those with ameloblastoma (P \ .05). No significant difference was found between the mean ages of patients with benign odontogenic tumors and those with malignant odontogenic tumors (P = .058). Conclusions. Odontogenic tumors, especially ameloblastoma, are not considered rare among Nigerians, whereas odontoma, regarded as the most frequent odontogenic tumor in North and South America, is rare. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005;99:191-5) Odontogenic tumors (OT) are a group of heterogenous lesions derived from epithelial and/or mesenchymal

A case of peripheral odontogenic fibroma occurring in the posterior region of the maxilla in a 7-year-old girl is presented. The patient was referred to our hospital because of a painless swelling in the buccal gingiva at 6 1. Physical examination revealed a localized elastic-hard tumor, with no radiological abnormalities in the adjacent alveolar bone. A biopsy specimen showed proliferation of fibroblastic cells in the submucosal layer. With the patient under general anesthesia, the tumor was resected subperiosteally, and the underlying bone surface was smoothened with a bur. Histologically, the lesion was composed of cellular fibrous connective tissue with scattered regions of cellular strands interwoven with less cellular areas and islands of odontogenic epithelium. The final diagnosis was peripheral odontogenic fibroma. Specific staining demonstrated that the tumor stroma contained large amounts of oxytalan fibers and tenascin. A positive reaction for tenascin was found to be a valuable pathohistological marker that could distinguish between peripheral odontogenic fibroma and calcifying fibrous epulis.As of about 9 years after the operation, there has been no evidence of recurrence.

Background Neoplastic lesions of the mammary gland, lymph nodes, or oral cavity in African pygmy hedgehogs (Atelerix albiventris) are common in captive animals. Chemotherapy and radiotherapy protocols have not yet been established for the African pygmy hedgehog. Thus, surgical resection is the current treatment of choice in this species. Case presentation A 5-year-old male African pygmy hedgehog showed multiple erythematous, round small tumors located in the oral cavity, on both sides of maxilla. The treatment of choice was surgical resection of tumors using a surgical knife under general anesthesia. Excised neoplastic lesions were diagnosed as peripheral odontogenic fibroma by histopathology. Six months after surgery relapse of tumors in the oral cavity was not observed. Conclusions The treatment adopted in this case report is safe for the patient and provides the best solution for mild proliferative lesions of the oral cavity. To our knowledge this is the first report of surgical resection of oral tumors (peripheral odontogenic fibroma) in the African pygmy hedgehog.

Analysis of case records of 46 patients with peripheral odontogenic fibroma (1967-95) diagnosed in the Division of Stomatology, Institute for Medical Research, Kuala Lumpur, disclosed a relatively young age of onset (mean, 32.2 years; range 5 months-64 years; peak incidence second decade of life), a slight female preponderance (M:F ratio 1:1.3), no racial predilection, a slight bias towards location in the mandible (52%) and a wide histomorphological range. All cases were treated by simple excision. Follow-up records were generally not available, so we do not know what the recurrence rate is.

This report describes the case of a 12-year-old girl who presented with diffuse enlargements of the anterior gingiva in both jaws. The clinical diagnosis was an inflammatory hyperplasia, but gingivectomy samples from all involved sites showed similar histological features consistent with odontogenic fibroma. Another peculiar finding was generalised mottled enamel. This is the fifth case of a diffuse clinical variant of peripheral odontogenic fibroma documented in the literature.

Objective: To perform a comparative study of the cellular proliferation in the peripheral and central fibromas. Material and Methods: Immunohistochemistry for PCNA and the AgNOR technique were performed in 9 cases of peripheral odontogenic fibroma (POF), in 4 cases of odontogenic fibroma (OdF), in 8 cases of peripheral ossifying fibroma (PEOF) and 7 cases of ossifying fibroma (OsF). The Kruskal-Wallis and Mann-Whitney tests were used for the statistical analyses. Results: Mesenchymal component of the central lesions presented a higher mean number of AgNOR per nucleus and PCNA index than did the peripheral lesions (P≤0.05). The mean number of AgNOR per nucleus in the epithelial component proved to be higher in the OdF than in the POF (P≤0.05). The mesenchymal and epithelial components presented similar mean numbers of AgNOR per nucleus and PCNA index in the OdF, as well as a similar mean number of AgNOR per nucleus in the POF. Conclusions: The mesenchymal component may well play a role in the differences between the biological behaviour of the central lesions as compared to the peripheral lesions. Moreover, considering that the epithelial and mesenchymal components in odontogenic fibromas presented a similar proliferation index, more research is warranted to understand the true role of the epithelial components, which are believed to be inactive in nature, as well as in the development and biological behaviour of these lesions.

This article is based on a review of the literature and the study of pathology sections obtained from various veterinary pathology laboratories. Epulis is a non-specific, clinical designation for a localized, exophytic growth on the gingiva. Four reactive epulides occur in human beings, namely focal fibrous hyperplasia (fibrous epulis), pyogenic granuloma, peripheral giant cell granuloma (giant cell epulis), and peripheral ossifying fibroma (calcifying fibrous epulis). The first three also occur in dogs but only focal fibrous hyperplasia appears to be common. The peripheral ossifying fibroma has not yet been reported in dogs. Odontogenic tumors occurring on the gingiva (i.e., as epulides) are referred to as peripheral odontogenic tumors. Three types have been reported in dogs. One, the common fibromatous epulis, is equivalent to the rare peripheral odontogenic fibroma in human beings. Another, the acanthomatous epulis, appears to be a form of ameloblastoma but differs from the peripheral ameloblastoma in human beings in that it invades bone; its biological behavior is therefore that of the human intraosseous ameloblastoma. The third, a rare lesion, has been referred to in the veterinary literature as a calcifying epithelial odontogenic tumor, although it is not the canine counterpart of the human CEOT. The term, amyloid-producing odontogenic tumor, has been suggested as being appropriate for this lesion.

Odontogenic tumours are considered to be relatively rare; however, several histologically distinct types have been identified in dogs. The more common canine odontogenic tumours are peripheral odontogenic fibroma and canine acanthomatous ameloblastoma. The expression of cytokeratins (CKs) has been established for the human dental germ and odontogenic tumours. The aim of the present study was to describe the immunohistochemical expression of a panel of CKs in the epithelium of the canine dental germ, normal gingiva and odontogenic tumours arising in this species. Samples from 20 odontogenic tumours, 12 tooth germs and three normal gingival tissues were obtained. Each sample was stained with haematoxylin and eosin and subjected to immunohistochemistry for CK expression. The typical expression pattern of CKs in the odontogenic epithelium and gingiva of dogs was CK14 and CK5/6. CKs 7, 8, 18 and 20 were generally absent from the canine dental germ, gingiva and odontogenic tumours. Dogs and man therefore exhibit similar CK expression in the odontogenic epithelium.

espanolEl fibroma periferico odontogenico es una lesion tumoral de la submucosa oral o del ligamento periodontal causado por irritacion cronica como traumatismos locales, cuerpos extranos y calculo o ciertos factores que transforman el tejido conectivo de las mucosas en tejido fibroso. Es de crecimiento lento, asintomatico y en ocasiones involuciona cuando se eliminan los factores causales. El tratamiento consta de escision quirurgica y curetaje de la base de la lesion para evitar recurrencias. Se presenta un caso clinico en el servicio de Estomatologia y cirugia oral de una Universidad en Cartagena Colombia, de un paciente de 36 anos de edad, masculino y sistemicamente sano con impresion clinica de fibroma periferico odontogenico ubicado en el tercio anterior derecho de paladar duro, ulcerado y asintomatico de un ano de evolucion. Se ejecutan diversos estudios paraclinicos como radiografias panoramicas, periapicales y oclusales para descartar afeccion a estructuras oseas. Previo a la firma de un consentimiento informado se realizo procedimiento quirurgico que consto de la escision quirurgica de la lesion para posterior analisis histopatologico que confirmo el diagnostico. EnglishThe peripheral odontogenic fibroma is a tumor of the oral submucosa, or periodontal ligament caused by chronic irritation, local trauma, dental calculus foreign agents or certain agents that may transform the connective tissue of the mucous membranes in fibrous tissue. It is like slow growing, asymptomatic and sometimes regress when the etiologic factors are eliminated. Treatment consists of surgical excision and curettage of the base of the lesion to prevent recurrence. In this paper is presented a clinical case in the service of oral surgery and stomatology of a University in Cartagena Colombia, in a 36 years old patient, male and systemically healthy with clinical impression of peripheral odontogenic fibroma located in the anterior third of right palate hard, ulcers and asymptomatic one years of evolution. It was tested different studies, such as panoramic radiographs, periapical and occlusal, for discard condition involving hard tissues. Before signing an informed consent was performed surgical procedure that consisted of surgical excision of the lesion for subsequent histopathological analysis that confirmed the diagnosis.