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We argue that in the context of string theory a large number N of connected degenerate vacua that mix will lead to a ground state with much lower energy, essentially because of the standard level repulsion of quantum theory for the wavefunction of the Universe. We imagine a history where initial quantum fluctuations give an energy density $\sim m_{susy}^2m_{Pl}^2$, but the universe quickly cascades to an energy density $\sim m_{susy}^2m_{Pl}^2/N$. Then at various phase transitions there are large contributions to the energy density and rearrangement of levels, followed again by a rapid cascade to the ground state or near it. If this mechanism is correct, the ground state of the theory describing our world would be a superposition of a large number of connected string vacua,with shared superselection sets of properties such as three families etc. The observed value of the cosmological constant in terms of the Planck mass, the scale of supersymmetry breaking and the number of connected string vacua., Comment: 8 pages

A brief review of string theory on group manifolds is given, and comparisons are then drawn between Minkowski space, SU(2), and SU(1,1) = AdS_3. The proof of the no-ghost theorem is outlined, assuming a certain restriction on the representation content for bosonic and fermionic strings on SU(1,1). Some possible connections with the AdS/CFT correspondence are mentioned. (Based on invited talk by JME at Trieste Conference on Super 5-branes and Physics in (5+1)-dimensions.), Comment: 10 pages, LaTeX

In this paper we perform a detailed investigation of the Dirichlet eight-brane of the Type IIA string theory, when the effects of gravity are included. In particular, consider what happens when one allows the ten-form field strength $F_{10}$ to vary discontinuously across the worldvolume of the brane. Since the ten-form is constant on each side of the brane ($d*F_{10} = 0$), a variation in the bulk term $\int F_{10}*F_{10}$ gives rise to a net pressure acting on the surface of the brane. This means that the infinite `planar' eight-brane is no longer a static configuration with these boundary conditions. Instead, a static configuration is found only when the brane `compactifies' to the topology of an eight-sphere, $S^8$. These spherical eight-branes are thus bubbles which form boundaries between different phases of the massive Type IIA supergravity theory. While these bubbles are generically unstable and will want to expand (or contract), we show that in certain cases there is a critical radius, $r_c$, at which the (inward) tension of the brane is exactly counterbalanced by the (outward) force exerted by the pressure terms. Intuitively, these `compactified' branes are just spherical bubbles where the effective cosmological constant jumps by a discrete amount as you cross a brane worldsheet. We argue that these branes will be unstable to various semi-classical decay processes. We discuss the implications of such processes for the open strings which have endpoints on the eight-brane., Comment: 24 pages REVTeX plus 2 figures

We investigate non-abelian gaugings of WZNW models. When the gauged group is semisimple we are able to present exact formulae for the dual conformal field theory, for all values of the level $k$. The results are then applied to non-abelian target space duality in string theory, showing that the standard formulae are quantum mechanically well defined in the low energy limit if the gauged group is semisimple., Comment: 17 pages uuencoded Z-compressed latex

5'-Rapid amplification of cDNA ends, done on poly(A)+ RNA from human U87 cells, was used to identify 420 bp of novel 5' sequence of a PDE4B cAMP-specific phosphodiesterase (PDE). This identified an open reading frame encoding a putative 721-residue 'long-form' PDE4B splice variant, which we term HSPDE4B3. HSPDE4B3 differs from the two known PDE4B forms by virtue of its unique 79-residue N-terminal region, compared with the unique N-terminal regions of 94 and 39 residues found in HSPDE4B1 and HSPDE4B2 respectively. In transfected COS7 cells the two long forms, HSPDE4B1 and HSPDE4B3, had molecular masses of approx. 104 and approx. 103 kDa respectively. Expressed in COS-7 cells, the three HSPDE4B isoforms were found in the high-speed supernatant (cytosol) fraction as well as both the high-speed pellet (P2) and low-speed pellet (P1) fractions. All isoforms showed similar Km values for cAMP hydrolysis (1.5-2.6 microM). The maximal activities of the soluble cytosolic activity of the two long forms were very similar, whereas that of the short form, HSPDE4B2, was approx. 4-fold higher. Particulate-associated HSPDE4B1 and HSPDE4B2 were less active (approx. 40%) than their cytosol forms, whereas particulate HSPDE4B3 was similar in activity to its cytosolic form. Particulate and cytosolic forms of HSPDE4B1 and HSPDE4B3 were similarly inhibited by rolipram {4-[3-(cyclopentoxyl)-4-methoxyphenyl]-2-pyrrolidone}, the selective inhibitor of PDE4 (IC50 0.05-0.1 microM), whereas particulate-associated HSPDE4B2 was profoundly (approx. 10-fold) more sensitive (IC50 0.02 microM) to rolipram inhibition than its cytosolic form (IC50 0.2 microM). The various particulate-associated HSPDE4B isoforms showed very different susceptibilities to solubilization with the detergent Triton X-100 and high NaCl concentration. A novel cDNA, called pRPDE74, was obtained by screening a rat olfactory lobe cDNA library. This contained an open reading frame encoding a 721-residue protein that showed approx. 96% amino acid identity with HSPDE4B3 and is proposed to reflect the rat homologue of this human enzyme and is thus called RNPDE4B3. Alternative splicing of mRNA generated from both the human and rat PDE4B genes produces long and short splice variants that have unique N-terminal splice regions. It is suggested that these alternatively spliced regions determine changes in the maximal catalytic activity of the isoforms, their susceptibility to inhibition by rolipram and mode of interaction with particulate fractions.