16 results on '"Pieper, P.G."'
Search Results
2. Pregnancy outcome in women with repaired versus unrepaired isolated ventricular septal defect
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Yap, S.C., Drenthen, W., Pieper, P.G., Moons, P., Mulder, B.J., Vliegen, H.W., Dijk, A.P.J. van, Meijboom, F.J., Jaddoe, V.W., Steegers, E.A.P., Boersma, E., Roos-Hesselink, J.W., Graduate School, ACS - Amsterdam Cardiovascular Sciences, Cardiology, and Cardiovascular Centre (CVC)
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ventricular septal defect ,CONGENITAL HEART-DISEASE ,congenital, hereditary, and neonatal diseases and abnormalities ,pre-eclampsia ,Cardiovascular diseases [NCEBP 14] ,pregnancy ,Congenital heart disease - Abstract
Contains fulltext : 89661.pdf (Publisher’s version ) (Closed access) OBJECTIVE: To compare the risks of pregnancy complications in women with repaired and unrepaired isolated ventricular septal defect (VSD). DESIGN: A retrospective multicentre study. SETTING: Tertiary centres in the Netherlands and Belgium. METHODS: Women were identified using two congenital heart disease registries. Eighty-eight women were identified who had experienced 202 pregnancies, including 46 miscarriages and nine terminations of pregnancy. Information on each completed pregnancy (n = 147; unrepaired VSD, n = 104; repaired VSD, n = 43) was obtained using medical records and telephone interviews. Data from the Generation R database (prospective cohort study; n = 9667) were used to determine the background risk (controls). Odds ratios and 95% CI were estimated using general estimation equation analysis adjusted for multiple pregnancies per woman, maternal age and parity status. MAIN OUTCOME MEASURES: Adjusted odds ratios (AORs) for developing pregnancy complications in relation to corrective status. RESULTS: Pregnancies in women with an unrepaired VSD were associated with a higher risk of pre-eclampsia (AOR 4.59, 95% CI 2.01-10.5, P < 0.001) compared with controls. No differences were observed when comparing women with repaired VSD and controls. Pregnancies in women with repaired VSD were associated with a higher risk of premature labour (AOR 4.02, 95% CI 1.12-14.4, P = 0.03) and small-for-gestational-age (SGA) births (AOR 4.09, 95% CI 1.27-13.2, P = 0.02) compared with women with unrepaired VSD. CONCLUSIONS: Women with unrepaired VSD are at increased risk of pre-eclampsia, which suggests that it is not a benign condition. In addition, women with repaired VSD are at increased risk of premature labour and SGA births compared with women with unrepaired VSD. 01 mei 2010
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- 2010
3. Comparison of pregnancy outcomes in women with repaired versus unrepaired atrial septal defect
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Yap, S.C., Drenthen, W., Meijboom, F.J., Moons, P., Mulder, B.J., Vliegen, H.W., Dijk, A.P.J. van, Jaddoe, V.W., Steegers, E.A.P., Roos-Hesselink, J.W., Pieper, P.G., Graduate School, ACS - Amsterdam Cardiovascular Sciences, Cardiology, and Cardiovascular Centre (CVC)
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CONGENITAL HEART-DISEASE ,pre-eclampsia ,Cardiovascular diseases [NCEBP 14] ,LONG-TERM ,SURGICAL-TREATMENT ,mental disorders ,atrial septal defect ,pregnancy ,Arrhythmias ,FOLLOW-UP ,congenital heart disease ,PROSPECTIVE MULTICENTER - Abstract
Contains fulltext : 81862.pdf (Publisher’s version ) (Closed access) OBJECTIVE: To compare the risks of complications during pregnancy in women with repaired and unrepaired atrial septal defects (ASDs) without associated complex cardiac lesions. DESIGN: A retrospective multicentre study. SETTING: Tertiary centres in the Netherlands and Belgium. POPULATION: Women with ASD without associated complex cardiac lesions. METHODS: Women were identified using two congenital heart disease registries. One hundred women were identified who had 243 pregnancies, including 49 miscarriages and six terminations of pregnancy. Detailed information on each completed pregnancy (n = 188; unrepaired ASD, n = 133; repaired ASD, n = 55) was obtained using medical records and telephone interviews. In addition, data from the Generation R database (a prospective cohort study; n = 9667) were used to determine the background risk (control group). MAIN OUTCOME MEASURES: Adjusted odds ratios (AORs) for cardiac, obstetric and neonatal events controlled for multiple pregnancies per woman using general estimating equation analysis. RESULTS: Women with an unrepaired ASD had a higher risk of neonatal events (AOR = 2.99, 95% confidence interval [CI] 1.14-7.89, P = 0.027) than women with a repaired ASD. The risk of cardiac and obstetric complications was comparable between women with unrepaired and repaired ASDs. Compared with the general population, women with an unrepaired ASD had higher risks of pre-eclampsia (AOR = 3.54, 95% CI 1.26-9.98, P = 0.017), small-for-gestational-age births (AOR = 1.95, 95% CI 1.15-3.30, P = 0.013) and fetal mortality (AOR = 5.55, 95% CI 1.77-17.4, P = 0.003). By contrast, no differences were observed when comparing women with a repaired ASD versus controls. CONCLUSIONS: Women with an unrepaired ASD are at increased risk of neonatal events in comparison with women with a repaired ASD. Compared with the general population, women with an unrepaired ASD are at increased risk of pre-eclampsia, small-for-gestational-age births and fetal mortality.
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- 2009
4. Maternal cardiac function, uteroplacental Doppler flow parameters and pregnancy outcome: a systematic review
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Kampman, M.A.M., Bilardo, C.M., Mulder, B.J., Aarnoudse, J.G., Ris-Stalpers, C., Veldhuisen, D.J. van, and Pieper, P.G.
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Other Research Radboud Institute for Health Sciences [Radboudumc 0] ,cardiovascular system - Abstract
Item does not contain fulltext OBJECTIVE: To investigate the existing evidence for a link between maternal cardiac function, abnormal uteroplacental flow and poor perinatal outcome in women with and without known cardiac disease. METHODS: PubMed and EMBASE databases were searched systematically for studies relating cardiac functional parameters and uteroplacental Doppler flow with pregnancy outcome in women with pre-existing congenital cardiac disease and women without known cardiac disease. Only studies based on echocardiography were included. RESULTS: From 1732 citations, 10 articles were included. In women with known congenital heart disease, a relationship was found between abnormal uteroplacental Doppler flow patterns and cardiac function before and during pregnancy. Conversely, women without a history of congenital heart disease, but with abnormal uterine artery resistance and pregnancy complications, more often showed global left ventricular diastolic dysfunction (33%; P = 0.0001), impaired myocardial relaxation (72%; P < 0.0001) and left ventricular systolic dysfunction (17%; P = 0.006), even up to 1 year postpartum. CONCLUSION: There is increasing evidence for an association between pre-existing subclinical cardiac dysfunction, poor placentation (reflected by uteroplacental Doppler flow abnormalities) and poor pregnancy outcome. It may be postulated that pre-existing suboptimal cardiac performance, as a result of either congenital heart disease or a subclinical latent condition, is one of the common denominators of poor placentation, leading to poor pregnancy outcome.
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- 2015
5. Pregnancy in women with corrected tetralogy of Fallot: Occurrence and predictors of adverse events
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Balci, A., Drenthen, W., Mulder, B.J.M., Roos-Hesselink, J.W., Voors, A.A., Vliegen, H.W., Moons, P., Sollie, K.M., Dijk, A.P.J. van, Veldhuisen, D.J. van, Pieper, P.G., ZAHARA Investigators, Cardiology, ACS - Amsterdam Cardiovascular Sciences, and Cardiovascular Centre (CVC)
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Adult ,medicine.medical_specialty ,Adolescent ,Heart disease ,Offspring ,BIRTH ,NEONATAL OUTCOMES ,Young Adult ,Hyperemesis gravidarum ,Pregnancy ,Risk Factors ,Internal medicine ,medicine ,MANAGEMENT ,Humans ,RECURRENCE ,Retrospective Studies ,Tetralogy of Fallot ,REPAIR ,RISK ,ARRHYTHMIAS ,COMPLICATIONS ,PAROXYSMAL SUPRAVENTRICULAR TACHYCARDIA ,Cardiovascular diseases [NCEBP 14] ,Obstetrics ,business.industry ,Pregnancy Outcome ,Retrospective cohort study ,Odds ratio ,Middle Aged ,Prognosis ,medicine.disease ,Pregnancy Complications ,CONGENITAL HEART-DISEASE ,Cardiology ,Gestation ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background In women with corrected tetralogy of Fallot (ToF), pregnancy is associated with maternal cardiac, obstetric, and offspring complications. Our aim is to investigate the magnitude and determinants of pregnancy outcome in women with corrected ToF.Methods In this retrospective international multicenter study using 2 congenital heart disease registries, 204 women with corrected ToF were identified. Within this group, 74 women had 157 pregnancies, including 30 miscarriages and 4 terminations of pregnancy. Detailed information on each completed pregnancy (n = 123) was obtained using medical records and supplementary interviews.Results Cardiovascular events occurred during 10 (8.1%) pregnancies, mainly (supra) ventricular arrhythmias. Obstetric and offspring events occurred in 73 (58.9%) and 42 (33.9%) pregnancies, respectively, including offspring mortality in 8 (6.4%). The most important predictor was use of cardiac medication before pregnancy (odds ratio for cardiac events 11.7, 95% CI 2.2-62.7; odds ratio for offspring events 8.4, 95% CI 1.4-48.6). In pregnancies with cardiovascular events, significantly more small-for-gestational-age children were born (P value Conclusions Cardiovascular, obstetric, and offspring events occur frequently during pregnancies in women with ToF. Maternal use of cardiovascular medication is associated with pregnancy outcome, and maternal cardiovascular events during pregnancy are highly associated with offspring events. (Am Heart J 2011;161:307-13.)
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- 2011
6. Predictors of pregnancy complications in women with congenital heart disease
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Drenthen, W., Boersma, E., Balci, A., Moons, P., Roos-Hesselink, J.W., Mulder, B.J.M., Vliegen, H.W., Dijk, A.P.J. van, Voors, A.A., Yap, S.C., Veldhuisen, D.J. van, Pieper, P.G., ZAHARA Investigators, ACS - Amsterdam Cardiovascular Sciences, Cardiology, and Cardiovascular Centre (CVC)
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Adult ,Heart Defects, Congenital ,medicine.medical_specialty ,Complications ,Heart disease ,Pregnancy Complications, Cardiovascular ,Congenital heart disease Pregnancy Complications cardiac complications biventricular repair aortic-stenosis task-force outcomes risk recurrence management fertility delivery ,Risk Assessment ,BIVENTRICULAR REPAIR ,DELIVERY ,Young Adult ,Pregnancy ,Risk Factors ,Internal medicine ,MANAGEMENT ,FERTILITY ,Medicine ,Humans ,RECURRENCE ,AORTIC-STENOSIS ,Congenital heart disease ,Retrospective Studies ,CARDIAC COMPLICATIONS ,RISK ,Heart Failure ,OUTCOMES ,Framingham Risk Score ,Cardiovascular diseases [NCEBP 14] ,business.industry ,Pregnancy Outcome ,Retrospective cohort study ,Arrhythmias, Cardiac ,Middle Aged ,medicine.disease ,Premature birth ,Heart failure ,Cardiovascular agent ,Cardiology ,Small for gestational age ,Female ,Cardiology and Cardiovascular Medicine ,business ,TASK-FORCE ,Maternal Age - Abstract
Contains fulltext : 89656.pdf (Publisher’s version ) (Closed access) AIMS: Data regarding pregnancy outcome in women with congenital heart disease (CHD) are limited. METHODS AND RESULTS: In 1802 women with CHD, 1302 completed pregnancies were observed. Independent predictors of cardiac, obstetric, and neonatal complications were calculated using logistic regression. The most prevalent cardiac complications during pregnancy were arrhythmias (4.7%) and heart failure (1.6%). Factors independently associated with maternal cardiac complications were the presence of cyanotic heart disease (corrected/uncorrected) (P < 0.0001), the use of cardiac medication before pregnancy (P < 0.0001), and left heart obstruction (P < 0.0001). New characteristics were mechanical valve replacement (P = 0.0014), and systemic (P = 0.04) or pulmonary atrioventricular valve regurgitation related with the underlying (moderately) complex CHD (P = 0.03). A new risk score for cardiac complications is proposed. The most prevalent obstetric complications were hypertensive complications (12.2%). No correlation of maternal characteristics with adverse obstetric outcome was found. The most prevalent neonatal complications were premature birth (12%), small for gestational age (14%), and mortality (4%). Cyanotic heart disease (corrected/uncorrected) (P = 0.0003), mechanical valve replacement (P = 0.03), maternal smoking (P = 0.007), multiple gestation (P = 0.0014), and the use of cardiac medication (P = 0.0009) correlated with adverse neonatal outcome. CONCLUSION: In our tertiary CHD cohort, cardiac, obstetric, and neonatal complications were frequently encountered, and (new) correlations of maternal baseline data with adverse outcome are reported. A new risk score for adverse cardiac complications is proposed, although prospective validation remains necessary. 01 september 2010
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- 2010
7. Outcome of pregnancy in women with congenital heart disease: a literature review
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Drenthen, W., Pieper, P.G., Roos-Hesselink, J.W., Lottum, W.A. van, Voors, A.A., Mulder, B.J.M., Dijk, A.P.J. van, Vliegen, H.W., Yap, S.C., Moons, P., Ebels, T., and Veldhuisen, D.J. van
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Cardiovascular diseases [NCEBP 14] ,Heart, lung and circulation [UMCN 2.1] - Abstract
Contains fulltext : 52390.pdf (Publisher’s version ) (Closed access) A search of peer-reviewed literature was conducted to identify reports that provide data on complications associated with pregnancy in women with structural congenital heart disease (CHD). This review describes the outcome of 2,491 pregnancies, including 377 miscarriages (15%) and 114 elective abortions (5%). Important cardiac complications were seen in 11% of the pregnancies. Obstetric complications do not appear to be more prevalent. In complex CHD, premature delivery rates are high, and more children are small for gestational age. The offspring mortality was high throughout the spectrum and was related to the relatively high rate of premature delivery and recurrence of CHD.
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- 2007
8. Ritme en geleidingsstoornissen
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Roos - Hesselink, Jolien, Bink-Boelkens, MThE, Mulder, B.J.M., Pieper, P.G., Meijboom, F.J., Hamer, J.P.M., and Cardiology
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- 2006
9. Congenitaal gecorrigeerde transpositie van de grote arteriën
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Roos - Hesselink, Jolien, Mulder, B.J.M., Pieper, P.G., Meijboom, F.J., Hamer, J.P.M., and Cardiology
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- 2006
10. Univentriculair hart en de fontan-circulatie
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Meijboom, FJ (Folkert), Bogers, Ad, Mulder, B.J.M., Pieper, P.G., Meijboom, F.J., Hamer, J.P.M., Cardiology, and Cardiothoracic Surgery
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- 2006
11. Tetralogie van Fallot
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Meijboom, FJ (Folkert), Vliegen, HW, Mulder, B.J.M., Pieper, P.G., Meijboom, F.J., Hamer, J.P.M., and Cardiology
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- 2006
12. Congenitaal gecorrigeerde transpositie van de grote arteriën
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Roos - Hesselink, Jolien, Mulder, B.J.M., Pieper, P.G., Spitaels, S.E.C., and Cardiology
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- 1999
13. Ritme- en geleidingsstoornissen
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Roos - Hesselink, Jolien, Bink-Boelkens, MThE, Mulder, B.J.M., Pieper, P.G., Spitaels, S.E.C., and Cardiology
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- 1999
14. De Fontan-circulatie
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Meijboom, FJ (Folkert), Bogers, Ad, Mulder, B.J.M., Pieper, P.G., Spitaels, S.E.C., Pediatrics, and Cardiothoracic Surgery
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- 1999
15. Transpositie van de grote arteriën
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Spitaels, SEC (Silja), Bogers, Ad, Mulder, B.J.M., Pieper, P.G., Spitaels, S.E.C., Cardiology, and Cardiothoracic Surgery
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- 1999
16. Tetralogie van Fallot
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Spitaels, SEC (Silja), Bogers, Ad, Mulder, B.J.M., Pieper, P.G., Spitaels, S.E.C., Cardiology, and Cardiothoracic Surgery
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- 1999
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