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The transient X-ray source MAXI J1810-222 was discovered in 2018 and has been active ever since. A long combined radio and X-ray monitoring campaign was performed with ATCA and Swift respectively. It has been proposed that MAXI J1810-222 is a relatively distant black hole X-ray binary, albeit showing a very peculiar outburst behaviour. Here, we report on the spectral study of this source making use of a large sample of NICER observations performed between 2019 February and 2020 September. We detected a strong spectral absorption feature at $\sim$1 keV, which we have characterised with a physical photoionisation model. Via a deep scan of the parameters space, we obtained evidence for a spectral-state dependent outflow, with mildly relativistic speeds. In particular, the soft and intermediate states point to a hot plasma outflowing at 0.05-0.15 $c$. This speeds rule-out thermal winds and, hence, they suggest that such outflows could be radiation pressure or (most likely) magnetically-driven winds. Our results are crucial to test current theoretical models of wind formation in X-ray binaries., 6 pages, 10 figures, accepted for publication in MNRAS Letter

We construct an efficient dynamic group signature (or more generally an accountable ring signature) from isogeny and lattice assumptions. Our group signature is based on a simple generic construction that can be instantiated by cryptographically hard group actions such as the CSIDH group action or an MLWE-based group action. The signature is of size $$O(\log N)$$ O ( log N ) , where N is the number of users in the group. Our idea builds on the recent efficient OR-proof by Beullens, Katsumata, and Pintore (Asiacrypt’20), where we efficiently add a proof of valid ciphertext to their OR-proof and further show that the resulting non-interactive zero-knowledge proof system is online extractable. Our group signatures satisfy more ideal security properties compared to previously known constructions, while simultaneously having an attractive signature size. The signature size of our isogeny-based construction is an order of magnitude smaller than all previously known post-quantum group signatures (e.g., 6.6 KB for 64 members). In comparison, our lattice-based construction has a larger signature size (e.g., either 126 KB or 89 KB for 64 members depending on the satisfied security property). However, since the $$O(\cdot )$$ O ( · ) -notation hides a very small constant factor, it remains small even for very large group sizes, say $$2^{20}$$ 2 20 .

Furnariida (i.e. ovenbirds, woodcreepers and antbirds) cover diverse ecologies and locomotor habits, ranging from strictly terrestrial to climbing birds, with different degrees of acrobatic performances. We know that this variety of locomotor modes is linked to different limb morpho-functional adaptations in other climbing clades of birds, such as woodpeckers and nuthatches. Here, we link the morphological variations to ecological categories, such as different locomotor habits and a gradient of acrobatic performances, in a phylogenetically informed analysis. We used a high-density three-dimensional (3D) geometric morphometric approach on foot bones (tarsometatarsus and all toes) of 55 specimens from 39 species of Furnariida. We found a significant correlation between acrobatic performances and foot bone shapes, partly explained by the phylogenetic relationship between species. Dendrocolaptidae show specific anatomical features, linked to their acrobatic locomotor habits. More specifically, we found that: (1) foot bones are more robust amongst climbing Furnariida, (2) the spread between toes is wider amongst highly acrobatic Furnariida, (3) dermal syndactyly between digits II and III is linked to special osteological features interpreted as functional osteological syndactyly in woodcreepers (tail-assisted climbers) and (4) the hallux claw is straighter than other claws in climbing Furnariida. Our study demonstrates that climbing Furnariida evolved common foot adaptations with subtle phenotypic variations depending on their climbing performances, refining our understanding of how evolution shapes interactions amongst structure, function and ecological traits.

Due to the high nutritional value as well as the appreciated sensory characteristic Citrus crop is one of the most popular fruits over the world. Albedo and flavedo are commonly discarded as waste and could represent an important by-product of food industry. In a circular economy contest we carried out a characterization of albedo and flavedo of Citrus limon var pompia (pompia) followed by the evaluation of antioxidant potential and cytotoxic activity. The chemical analysis showed the presence of several functional ingredients such as the flavanones, naringin, neohesperidin, nereriocitrin and hesperidin while quinic acid resulted the main phenolic acid detected. The flavedo extract exerted a complete inhibition of the cholesterol oxidative process from 25 μg of extract. Pompia extracts showed an inhibition of lipid oxidation in the β-carotene-linoleate system with an activity equivalent to about 0.31% (albedo) and 0.34% (flavedo) of the BHT activity, while the antiradical activity resulted equivalent to that of 62.90% (albedo) and 60.72% (flavedo) of the trolox activity. Finally, all extracts did not show any cytotoxic effect on differentiated Caco-2 cells by the AlamarBlue assay while exhibited, by MTT assay, a significant decrease in colon cancer Caco-2 cell viability.

Variability is a powerful tool to investigate properties of X-ray binaries (XRB), in particular for Ultraluminous X-ray sources (ULXs) that are mainly detected in the X-ray band. For most ULXs the nature of the accretor is unknown, although a few ULXs have been confirmed to be accreting at super-Eddington rates onto a neutron star (NS). Monitoring these sources is particularly useful both to detect transients and to derive periodicities, linked to orbital and super-orbital modulations. Here we present the results of our monitoring campaign of the galaxy NGC 925, performed with the Neil Gehrels Swift Observatory. We also include archival and literature data obtained with Chandra, XMM-Newton and NuSTAR. We have studied spectra, light-curves and variability properties on days to months time-scales. All the three ULXs detected in this galaxy show flux variability. ULX-1 is one of the most luminous ULXs known, since only 10% of the ULXs exceed a luminosity of $\sim$5$\times$10$^{40}$ erg s$^{-1}$, but despite its high flux variability we found only weak spectral variability. We classify it as in a hard ultraluminous regime of super-Eddington accretion. ULX-2 and ULX-3 are less luminous but also variable in flux and possibly also in spectral shape. We classify them as in between the hard and the soft ultraluminous regimes. ULX-3 is a transient source: by applying a Lomb-Scargle algorithm we derive a periodicity of $\sim$ 126 d, which could be associated with an orbital or super-orbital origin., Comment: 14 pages, 7 figures, Accepted for publication in MNRAS

We consider the discretization of elliptic boundary-value problems by variational physics-informed neural networks (VPINNs), in which test functions are continuous, piecewise linear functions on a triangulation of the domain. We define an a posteriori error estimator, made of a residual-type term, a loss-function term, and data oscillation terms. We prove that the estimator is both reliable and efficient in controlling the energy norm of the error between the exact and VPINN solutions. Numerical results are in excellent agreement with the theoretical predictions., Comment: 14 pages, 3 figures

Regular sports activities are associated with multiple physical and psychological health benefits. However, sports also may lead to injuries and the development of osteoarthritis (OA). This systematic review investigated the association between sports activity, sports type, and the risk of developing OA.A systematic review was performed by assessing studies that have investigated the risk of OA development in sports. Data extracted included general information, study design, number of participants, related body mass index, sports type, and assessment of OA. The methodological quality of the studies was assessed using the Newcastle-Ottawa Scale.A total of 63 studies were included in this systematic review. The overall Newcastle-Ottawa Scale score was 6.46±1.44 demonstrating a good methodological quality of the articles included in the present study. A total of 628,036 participants were included, with a mean follow-up of 8.0±8.4 years. The mean age of the included athletes was 45.6±15.8, with a mean body mass index of 24.9±2.3 kg/m 2 .Football and soccer players seem to be at higher risk for the development of OA, although the injury status of the joint should be considered when assessing the risk of OA. High equipment weight and increased injury risk also put military personnel at a higher risk of OA, although elite dancing leads to more hip labral tears. Femoroacetabular impingement was also often diagnosed in ice-hockey players and ballet dancers.

Journal of orthopaedic surgery and research 18, 350 (2023). doi:10.1186/s13018-023-03841-2, Published by Biomed Central, London

We present results from radio and X-ray observations of the X-ray transient MAXI J1810-222. The nature of the accretor in this source has not been identified. In this paper, we show results from a quasi-simultaneous radio and X-ray monitoring campaign taken with the Australia Telescope Compact Array (ATCA), the Neil Gehrels Swift observatory X-ray telescope (XRT), and the Swift Burst Alert Telescope (BAT). We also analyse the X-ray temporal behaviour using observations from the Neutron star Interior Composition Explorer (NICER). Results show a seemingly peculiar X-ray spectral evolution of MAXI J1810-222 during this outburst, where the source was initially only detected in the soft X-ray band for the early part of the outburst. Then, ~200 days after MAXI J1810-222 was first detected the hard X-ray emission increased and the source transitioned to a long-lived (~1.5 years) bright, harder X-ray state. After this hard state, MAXI J1810-222 returned back to a softer state, before fading and transitioning again to a harder state and then appearing to follow a more typical outburst decay. From the X-ray spectral and timing properties, and the source's radio behaviour, we argue that the results from this study are most consistent with MAXI J1810-222 being a relatively distant ($\gtrsim$6 kpc) black hole X-ray binary. A sufficiently large distance to source can simply explain the seemingly odd outburst evolution that was observed, where only the brightest portion of the outburst was detectable by the all-sky X-ray telescopes., Comment: 15 pages, 8 figures, 5 tables, accepted for publication in MNRAS

The seismology data archive at Istituto Nazionale di Geofisica e Vulcanologia (INGV), a node of the EIDA federation, currently holds more than 100 TB of seismological waveform data. To guarantee a robust qualitatively superior service needs full care of every step about curation preservation and dissemination of data.It starts from seismic network inventory management and requires keeping track of all station and network related information and metadata.Our system has a modular design, whenever possible, by leveraging existing open-source solutions as a customized Tuleap implementation to realize the ticketing system, for injecting and tracking the changes and managing the station’s faults. The station metadata and channel responses are managed using the XML database eXist-db to store StationXML documents natively and a new implementation of the fdsnws-station based on it. Then GUI leverages Grafana creating a dashboard to present an overview of the system status of all components.Then we have deployed an semiautomatic sanity check of data to apply our policies and quality assessment before archive data using a rule managerOur policy for preservation is to make a replication (synchronized copy) at a new storage archive in Naples and a backup in the tape library.After all these steps we are ready to disseminate data through webservices and websites (https://eida.ingv.it/).To complete the service for users we are adding significant computational resources and an adequate processing and analysis framework combining Apache Spark, and ObsPy, creating a "computational archive" where storage resources and computational resources converge., The 28th IUGG General Assembly (IUGG2023) (Berlin 2023)

Background: Communicating bad news is of great interest in the geriatric field, but few works have considered the physician’s point of view in this regard. Objectives: The aim of this study was to explore possible differences related to physicians’ gender and work experience in how a terminal diagnosis is disclosed to older patients. Methods: Study participants were 420 Italian physicians (277 M, 143 F) working in clinical medicine (58.2%), surgery (33.3%), or other medical departments (8.5%). They completed an anonymous multiple-choice questionnaire that investigated various issues associated with communicating bad news to terminally ill older patients. Results: Men had more work experience than women (55.6% vs. 44.8% had worked for ≥23 years) and were more likely to work in surgery departments, while more women worked in clinical medicine. Most physicians declared that terminally ill older patients, if mentally competent, should always (14.4%) or generally (64.3%) be directly and openly informed of their condition. With no difference in gender, length of work experience, or specialty area, 36.9% of physicians thought that this was a human right and 18% that it would improve the patient’s quality of life. Where older patients were alone, male physicians were more likely than female (30.2% vs. 8.9%) to always communicate bad news directly to them. More than 70% of physicians, especially those with longer work experience, declared that they always or often took enough time to inform the patient. Female physicians and those working in clinical medicine were more likely to need psychological help when deciding to break bad news, but only a smaller proportion declared to have received it. Conclusions: Gender and work experience may influence how physicians communicate with patients and how often they seek psychological support.

African swine fever (ASF) is a devastating disease, resulting in the high mortality of domestic and wild pigs, spreading quickly around the world. Ensuring the prevention and early detection of the disease is even more crucial given the absence of licensed vaccines. As suggested by the European Commission, those countries which intend to provide evidence of freedom need to speed up passive surveillance of their wild boar populations. If this kind of surveillance is wellregulated in domestic pig farms, the country-specific activities to be put in place for wild populations need to be set based on wild boar density, hunting bags, the environment, and financial resources. Following the indications of the official EFSA opinion 2021, a practical interpretation of the strategy was implemented based on the failure probabilities of wrongly declaring the freedom of an area even if the disease is still present but undetected. This work aimed at providing a valid, applicative example of an exit strategy based on two different approaches: the first uses the wild boar density to estimate the number of carcasses need to complete the exit strategy, while the second estimates it from the number of wild boar hunted and tested. A practical free access tool, named WBC-Counter, was developed to automatically calculate the number of needed carcasses. The practical example was developed using the ASF data from Sardinia (Italian island). Sardinia is ASF endemic from 43 years, but the last ASFV detection dates back to 2019. The island is under consideration for ASF eradication declaration. The subsequent results provide a practical example for other countries in approaching the EFSA exit strategy in the best choices for its on-field application

Knee surgery, sports traumatology, arthroscopy : KSSTA (2022). doi:10.1007/s00167-022-07258-y, Published by Springer, Berlin ; Heidelberg

Introduction Reverse oblique intertrochanteric fractures are classified by the Orthopaedic Trauma Association [OTA]/[AO] as 31A3, and account for up to one-third of all hip fractures, and 2–23% of all trochanteric fractures. The treatment of choice of those fractures is intramedullary nailing as it decreases soft tissue damage and permits early weight bearing. Material and methods A retrospective comparative study was conducted on patients surgically treated for 31A3 fractures from October 2018 to January 2022 in a high-volume regional referral centre. All the patients had been treated with intramedullary nailing. Results The selected group included 11 males (16%) and 59 females (84%), with a mean age of 83.6 years (range 61 to 96 years). A Trigen Intertan Nail was the most frequent choice of intramedullary nailing in 33 patients (47%), an Elos Long nail was chosen in 19 cases (27%), while a ZNN nail was used in 18 patients (26%). The mean time between admission and surgery was 2.5 days, with a mean Hb value of 10.5 g/dl reported preoperatively. Conclusion Patients treated with an Intertan nail reported the lowest TAD, CALTAD, and TALCALTAD mean radiographic values, and the lowest rate of Hb loss and blood transfusions.

Significant evolutionary shifts in locomotor behaviour often involve comparatively subtle anatomical transitions. For dinosaurian and avian evolution, medial overhang of the proximal femur has been central to discussions. However, there is an apparent conflict with regard to the evolutionary origin of the dinosaurian femoral head, with neontological and palaeontological data suggesting seemingly incongruent hypotheses. To reconcile this, we reconstructed the evolutionary history of morphogenesis of the proximal end of the femur from early archosaurs to crown birds. Embryological comparison of living archosaurs (crocodylians and birds) suggests the acquisition of the greater overhang of the femoral head in dinosaurs results from additional growth of the proximal end in the medial-ward direction. On the other hand, the fossil record suggests that this overhang was acquired by torsion of the proximal end, which projected in a more rostral direction ancestrally. We reconcile this apparent conflict by inferring that the medial overhang of the dinosaur femoral head was initially acquired by torsion, which was then superseded by mediad growth. Details of anatomical shifts in fossil forms support this hypothesis, and their biomechanical implications are congruent with the general consensus regarding broader morpho-functional evolution on the avian stem.

Cancer is a complex disease including approximately 200 different entities that can potentially affect all body tissues. Among the conventional treatments, radiotherapy and chemotherapy are most often applied to different types of cancers. Despite substantial advances in the development of innovative antineoplastic drugs, cancer remains one of the most significant causes of death, worldwide. The principal pitfall of successful cancer treatment is the intrinsic or acquired resistance to therapeutic agents. The development of more effective or synergistic therapeutic approaches to improve patient outcomes and minimize toxicity has become an urgent issue.

Background: The anterior talofibular ligament and the calcaneofibular ligament are 2 of the most frequently injured structures in sports, being damaged in 30% to 45% of all sports injuries. Most reconstructive procedures are successful but can deteriorate with time and can lead to low-grade radiographic degeneration. Methods: We operated on 26 consecutive patients from 2001 to 2008 who had failed previous surgical procedures for the lateral ligamentous complex of the ankle, with an average of 104 (range, 75-140) months. Results: The overall functional rating was excellent in 14 ankles, good in 10, fair in 1, and poor in 1. Twenty-four patients (92.3%) were satisfied with the procedure and 15 (57.7%) were able to return to their preinjury level of activity. Local complications were detected in 2 patients who presented with skin necrosis; 1 patient developed severe reflex sympathetic dystrophy. Conclusion: Revision surgery for the management of failure after surgical treatment of chronic lateral ankle instability is under debate, and the literature is devoid of clinical studies with long-term follow-up. The technique described offers a high rate of long-term excellent and good results, with a low rate of complications and a good rate of return to preinjury level. Level of Evidence: Level IV, retrospective case series.

Soft Ultra-Luminous X-ray (ULXs) sources are a subclass of the ULXs that can switch from a supersoft spectral state, where most of the luminosity is emitted below 1 keV, to a soft spectral state with significant emission above 1 keV. In a few systems, dips have been observed. The mechanism behind this state transition and the dips nature are still debated. To investigate these issues, we obtained a long XMM-Newton monitoring campaign of a member of this class, NGC 247 ULX-1. We computed the hardness-intensity diagram for the whole dataset and identified two different branches: the normal branch and the dipping branch, which we study with four and three hardness-intensity resolved spectra, respectively. All seven spectra are well described by two thermal components: a colder ($kT_{\rm bb}$ $\sim$ 0.1-0.2 keV) black-body, interpreted as emission from the photo-sphere of a radiatively-driven wind, and a hotter ($kT_{\rm disk}$ $\sim$ 0.6 keV) multicolour disk black-body, likely due to reprocessing of radiation emitted from the innermost regions. In addition, a complex pattern of emission and absorption lines has been taken into account based on previous high-resolution spectroscopic results. We studied the evolution of spectral parameters and the flux of the two thermal components along the two branches and discuss two scenarios possibly connecting the state transition and the dipping phenomenon. One is based on geometrical occultation of the emitting regions, the other invokes the onset of a propeller effect., 13 pages, accepted by MNRAS on 2021/08/16

Dolphin morbillivirus (DMV) is a pathogen of great concern in free-ranging cetaceans. Confirmation and staging of morbillivirus infections rely on histology and immunohistochemistry (IHC), following molecular detection. As at the present time no specific antibodies (Abs) against DMV are available, two heterologous Abs have been used worldwide for the examinations of morbillivirus infections of cetaceans. One is a monoclonal Ab (MoAb) prepared against the N protein of canine distemper virus (CDV), whereas the other is a polyclonal Ab raised in rabbits against rinderpest virus (RPV). Both Abs are known to show cross-reactivity with DMV. In this study we compared the labelling quality and the neuroanatomical distribution of staining with these two Abs by means of IHC analysis. To this end, serial sections of the target organs from ten free-ranging stranded cetaceans, previously diagnosed as being infected with DMV by PCR and/or serology, were subjected to IHC. The brain, lungs and lymph nodes of one animal were found to be positive with both Abs. From two other animals, the brain and the spleen, respectively, tested positive only with the polyclonal Ab. In the positive brain tissues, multifocal immunostaining was observed, with similar staining location and extent, with the two antibodies tested. Our results suggest that the polyclonal anti-RPV Ab might have a stronger binding activity to DMV than the anti-CDV MoAb. Nevertheless, the elaboration and use of specific anti-DMV Abs might be essential to guarantee conclusive results in diagnostic and pathogenetic investigations.

Sexual dimorphism is challenging to detect among fossils, due to a lack of statistical representativeness. The Angeac-Charente Lagerstätte (France) represents a remarkable “snapshot” from a Berriasian (Early Cretaceous) ecosystem and offers a unique opportunity to study intraspecific variation among a herd of at least 61 coeval ornithomimosaurs. Herein, we investigated the hindlimb variation across the best-preserved specimens from the herd through 3D Geometric Morphometrics and Gaussian Mixture Modelling. Our results based on complete and fragmented femora evidenced a dimorphism characterized by variations in the shaft curvature and the distal epiphysis width. Since the same features vary between sexes among modern avian dinosaurs, crocodilians, and more distant amniotes, we attributed this bimodal variation to sexual dimorphism based on the extant phylogenetic bracketing approach. Documenting sexual dimorphism in fossil dinosaurs allows a better characterization and accounting of intraspecific variations, which is particularly relevant to address ongoing taxonomical and ecological questions relative to dinosaur evolution.

Nowadays 360° cameras, capable to capture full environments in a single shot, are increasingly being used in a variety of Extended Reality (XR) applications that require specific Diminished Reality (DR) techniques to conceal selected classes of objects. In this work, we present a new data-driven approach that, from an input 360° image of a furnished indoor space automatically returns, with very low latency, an omnidirectional photorealistic view and architecturally plausible depth of the same scene emptied of all clutter. Contrary to recent data-driven inpainting methods that remove single user-defined objects based on their semantics, our approach is holistically applied to the entire scene, and is capable to separate the clutter from the architectural structure in a single step. By exploiting peculiar geometric features of the indoor environment, we shift the major computational load on the training phase and having an extremely lightweight network at prediction time. Our end-to-end approach starts by calculating an attention mask of the clutter in the image based on the geometric difference between full and empty scene. This mask is then propagated through gated convolutions that drive the generation of the output image and its depth. Returning the depth of the resulting structure allows us to exploit, during supervised training, geometric losses of different orders, including robust pixel-wise geometric losses and high-order 3D constraints typical of indoor structures. The experimental results demonstrate that our method provides interactive performance and outperforms current state-of-the-art solutions in prediction accuracy on available commonly used indoor panoramic benchmarks. In addition, our method presents consistent quality results even for scenes captured in the wild and for data for which there is no ground truth to support supervised training.

The ASTRI Mini-Array is an international collaboration led by the Italian National Institute for Astrophysics (INAF) and devoted to the imaging of atmospheric Cherenkov light for very-high gamma-ray astronomy. The project is deploying an array of 9 telescopes sensitive above 1 TeV. In this contribution, we present the architecture of the software that covers the entire life cycle of the observatory, from scheduling to remote operations and data dissemination. The high-speed networking connection available between the observatory site, at the Canary Islands, and the Data Center in Rome allows for ready data availability for stereo triggering and data processing.

Due to marine mammals’ demonstrated susceptibility to SARS-CoV-2, based upon the homology level of their angiotensin-converting enzyme 2 (ACE2) viral receptor with the human one, alongside the global SARS-CoV-2 occurrence and fecal contamination of the river and marine ecosystems, SARS-CoV-2 infection may be plausibly expected to occur also in cetaceans, with special emphasis on inshore species like bottlenose dolphins (Tursiops truncatus). Moreover, based on immune and inflammatory responses to SARS-CoV-2 infection in humans, macrophages could also play an important role in antiviral defense mechanisms. In order to provide a more in-depth insight into SARS-CoV-2 susceptibility in marine mammals, we evaluated the presence of SARS-CoV-2 and the expression of ACE2 and the pan-macrophage marker CD68. Aliquots of tissue samples, belonging to cetaceans stranded along the Italian coastline during 2020-2021, were collected for SARS-CoV-2 analysis by real-time PCR (RT-PCRT) (N = 43) and Immunohistochemistry (IHC) (N = 59); thirty-two aliquots of pulmonary tissue sample (N = 17 Tursiops truncatus, N = 15 Stenella coeruleoalba) available at the Mediterranean Marine Mammal Tissue Bank (MMMTB) of the University of Padua (Legnaro, Padua, Italy) were analyzed to investigate ACE2 expression by IHC. In addition, ACE2 and CD68 were also investigated by Double-Labeling Immunofluorescence (IF) Confocal Laser Microscopy. No SARS-CoV-2 positivity was found in samples analyzed for the survey while ACE2 protein was detected in the lower respiratory tract albeit heterogeneously for age, gender/sex, and species, suggesting that ACE2 expression can vary between different lung regions and among individuals. Finally, double IF analysis showed elevated colocalization of ACE2 and CD68 in macrophages only when an evident inflammatory reaction was present, such as in human SARS-CoV-2 infection.

The Orfeus European Integrated Data Archive (EIDA) provides a federated approach to the dissemination of seismological waveform data and ensures access to 12 regional seismological data centers—the EIDA nodes. The Istituto Nazionale di Geofisica e Vulcanologia (INGV) is one of the founding partners of this EIDA federation and manages the EIDA data distribution node in Italy. INGV has actively managed the smaller MedNet archive since 1990 and adopted a more comprehensive and systematic approach to seismological data archiving since 2007. The Italian EIDA node data archive currently totals 90 TBytes of waveform data available for download, originating from 25 networks and 974 stations, provided by INGV, MedNet, or contributed by various partner institutions. Geographically, it covers mainly Italy and some stations from the Mediterranean region. The archive is currently growing at a rate of approximately 11 TB/yr. INGV recently strengthened its data management capabilities, resources, and infrastructure to effectively respond to the growing scale of station inventory, archive, and volumes of delivered data, and to acknowledge increasing attention toward open data sharing, appropriate attribution, and FAIR principles (Findability, Accessibility, Interoperability, and Reuse), as well as higher demands on data quality and expectations of the scientific user community. To this end, it established a dedicated internal unit in charge of all relevant activities related to the Italian EIDA node. In this article, we address key aspects of the EIDA node in Italy such as evolution and status of the seismological waveform archive, and we describe the technical, organizational, and operational setup of data and service management. We also outline ongoing activities and future evolutions aiming to further increase the quality of services, data availability, data and metadata quality, resilience, and sustainability.

The Istituto Nazionale di Geofisica e Vulcanologia (INGV) is an Italian research institution with focus on earth sciences. Moreover, the INGV is the operational center for seismic surveillance and earthquake monitoring in Italy and is a part of the civil protection system as a center of expertise on seismic, volcanic, and tsunami risks.INGV operates the Italian National Seismic Network and other networks at national scale and is a primary node of the European Integrated Data Archive for archiving and distributing strong-motion and weak-motion seismic recordings. In the control room in Rome, INGV staff performs seismic surveillance and tsunami warning services; in Catania and Naples, the control rooms are devoted to volcanic surveillance. Volcano monitoring includes locating earthquakes in the regions around the Sicilian (Etna, Eolian Islands, and Pantelleria) and the Campanian (Vesuvius, Campi Fregrei, and Ischia) active volcanoes. The tsunami warning is based on earthquake location and magnitude (M) evaluation for moderate to large events in the Mediterranean region and also around the world. The technologists of the institute tuned the data acquisition system to accomplish, in near real time, automatic earthquake detection, hypocenter and magnitude determination, and evaluation of several seismological products (e.g., moment tensors and ShakeMaps). Database archiving of all parametric results is closely linked to the existing procedures of the INGV seismic surveillance environment and surveillance procedures. Earthquake information is routinely revised by the analysts of the Italian seismic bulletin. INGV provides earthquake information to the Department of Civil Protection (Dipartimento di Protezione Civile) to the scientific community and to the public through the web and social media. We aim at illustrating different aspects of earthquake monitoring at INGV: (1) network operations; (2) organizational structure and the hardware and software used; and (3) communication, including recent developments and planned improvements.

HighlightsTwo methods (VPM and HVM) are proposed to improve the hydraulic system efficiency of agricultural tractors.VPM and HVM both target reducing the power loss at the flow control valve of the hydraulic system.The solutions are presented conceptually and then numerically modeled, and VPM is tested on an actual tractor.Results show that the VPM solution achieves 6.7% power saving, while HVM achieves 15.6% power saving.Abstract. Load sensing (LS) is a dominant fluid power actuation technology in mobile machines, particularly in construction and agriculture. It has the advantage of guaranteeing good controllability in systems with multiple actuators while promoting higher energy efficiency. Several variants of LS systems have been proposed over the years, and research on cost-effective methods to further increase their efficiency is still of interest for original equipment manufacturers (OEMs) and the fluid power community. This article presents two solution, referred to as variable pump margin (VPM) and hybrid variable margin (HVM), suitable to improve the energy efficiency in pre-compensated LS systems such as those used in agricultural tractors. Both methods allow either downsizing the control valves or reducing the power consumption over the working range. Compared to a standard LS system, the VPM solution lowers the pump pressure using an electronic proportional pressure-reducing valve (ep-PRV), while the HVM solution uses a second ep-PRV in the compensator’s pilot line to further minimize the pressure differential across the LS valve. Simulation and experimental results show that, among the main working conditions, the VPM solution on average achieved 6.7% power saving over the standard LS system, while the model predicted an average improvement of 15.6% for the HVM solution. Keywords: Efficiency, Experiments, Hydraulic, Load sensing, Modeling, Pump.

African swine fever (ASF) is a devastating disease, resulting in the high mortality of domestic and wild pigs, spreading quickly around the world. Ensuring the prevention and early detection of the disease is even more crucial given the absence of licensed vaccines. As suggested by the European Commission, those countries which intend to provide evidence of freedom need to speed up passive surveillance of their wild boar populations. If this kind of surveillance is well-regulated in domestic pig farms, the country-specific activities to be put in place for wild populations need to be set based on wild boar density, hunting bags, the environment, and financial resources. Following the indications of the official EFSA opinion 2021, a practical interpretation of the strategy was implemented based on the failure probabilities of wrongly declaring the freedom of an area even if the disease is still present but undetected. This work aimed at providing a valid, applicative example of an exit strategy based on two different approaches: the first uses the wild boar density to estimate the number of carcasses need to complete the exit strategy, while the second estimates it from the number of wild boar hunted and tested. A practical free access tool, named

Whether sport participation is a risk factor for osteoarthritis (OA) development or progression is controversial. Mechanical overload, injuries, genetics, and acquired disorders concur to the onset of OA, with high variability between sports and participants. This study investigated the association between participation in specific sports and the risk of developing knee and hip OA in athletes at different ages. We hypothesized that young athletes who are exposed to high levels of physical activities have a greater risk of developing OA.This systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed, Google scholar, EMABSE, and Web of Science were accessed in October 2021. No time constrains were used for the search. All the published clinical studies reporting data about relationship between physical activity, OA, and age were included.The Newcastle-Ottawa Scale resulted in a final score ≥7 for all studies, attesting good quality of the methodological assessment. Data from 27,364 patients were retrieved. The mean age was 48.2±16.7 years. In all, 21.8% were women.Our systematic review suggests an association between high levels of physical activities and knee and hip OA in men younger than 50 years. People who practice intense physical activity, such as professional athletes or heavy workers, are more prone to develop early-onset OA.

Joint overload and sport-related injuries may accelerate the development of osteoarthritis (OA). A systematic review of the literature was performed to establish the risk of athletes to develop premature OA compared with nonathletes.This systematic review was conducted according to the PRISMA guidelines. PubMed, Google scholar, Embase, and Web of Science databases were accessed in June 2021. All the published clinical studies investigating OA onset in athletes versus nonathletes were considered. Studies reporting data on secondary and/or post-traumatic OA were excluded.Data from 32 articles (20,288 patients) were retrieved. The mean age was 67.8±10.0 years and the mean body mass index was 25.0±2.5 kg/m2. 74% (6859 patients) of the athletes suffered from premature OA. Of them, 21% were active in soccer, 11% in handball, 11% in ice-hockey, 3% in football, and 0.3% in rugby. 26% of the athletes reported no significant differences in OA progression compared with healthy controls. Of these athletes, 47% were runners, 5% dancers, and 1% triathletes.Certain sports, such as soccer, handball, ice-hockey, and rugby are more likely to be associated with premature knee and hip OA. Conversely, runners and ballet dancers do not evidence significant increase in OA. Moderate and recreational exposure to aerobic sports does not accelerate the development of OA.

Few cases of myelomonocytic leukemia associated with neurological signs have been described in dogs; none have been related to intraparenchymal spinal cord infiltration by neoplastic cells. This short communication describes a case of acute myelomonocytic leukemia subtype M4 in a dog with spinal cord infiltration. A 3-year-old male Golden Retriever was presented with a history of hyperthermia, lymphadenomegaly, leukocytosis with circulating blast cells, anemia and thrombocytopenia, and acute onset paraplegia. Immunophenotyping of peripheral blood by flow cytometry was consistent with acute myelomonocytic leukemia subtype M4. The dog was euthanized because of clinical deterioration and unfavourable prognosis. Postmortem examination revealed multi-organ neoplastic infiltration, including the spinal cord. To our knowledge, this is the first case of acute myelomonocytic leukemia subtype M4 in a dog with spinal cord infiltration. Our findings hold importance for including myelomonocytic leukemia in the differential diagnosis of patients with neurological signs due to spinal cord localisation.In der Literatur werden nur wenige Fälle myelomonozytärer Leukämien bei Hunden beschrieben, die mit neurologischen Symptomen assoziiert sind. Keine dieser Fälle stehen in Zusammenhang mit einer intraparenchymatösen Rückenmarksinfiltration durch neoplastische Zellen. Das Ziel dieser Kurzmitteilung ist die Beschreibung eines Falles einer akuten myelomonozytären Leukämie Subtyp M4 mit Rückenmarksinfiltration bei einem Hund. Ein 3 Jahre alter, männlicher Golden Retriever wurde vorberichtlich mit Hyperthermie, Lymphadenomegalie, Leukozytose mit zirkulierenden Blasten, Anämie und Thrombozytopenie und akuter Paraplegie vorstellig. Anhand einer Immunphänotypisierung des peripheren Blutes mittels Durchflusszytometrie wurde eine akute myelomonozytäre Leukämie Subtyp M4 nachgewiesen. Der Hund wurde aufgrund klinischer Verschlechterung und ungünstiger Prognose euthanasiert. Die postmortale Untersuchung zeigte eine neoplastische Infiltration multipler Organe einschließlich des Rückenmarks. Nach unserem Wissen ist dies der erste Fall einer akuten myelomonozytären Leukämie Subtyp M4 mit Rückenmarksinfiltration bei einem Hund. Bei Patienten mit akuter neurologischer Symptomatik mit Lokalisation im Rückenmark sollte eine Leukämie als eine Differenzialdiagnose mit einbezogen werden.Peu de cas de leucémie myélomonocytaire associés à des signes neurologiques ont été décrits chez le chien ; aucun n’était lié à une infiltration intraparenchymateuse de la moelle épinière par des cellules néoplasiques. Cette courte communication décrit un cas de leucémie aiguë myélomonocytaire de sous-type M4 chez un chien avec infiltration de la moelle épinière. Un Golden Retriever mâle de 3 ans a été présenté avec une anamnèse d’hyperthermie, de lymphadénomégalie, de leucocytose avec des cellules blastiques circulantes, d’anémie et de thrombocytopénie et de paraplégie d’apparition aiguë. L’immunophénotypage du sang périphérique par cytométrie de flux était compatible avec une leucémie myélomonocytaire aiguë de sous-type M4. Le chien a été euthanasié en raison de la détérioration de son état clinique et du pronostic défavorable. L’examen post-mortem a révélé une infiltration néoplasique multi-organique, y compris la moelle épinière. À notre connaissance, il s’agit du premier cas de leucémie aiguë myélomonocytaire de sous-type M4 chez un chien avec infiltration de la moelle épinière. Nos résultats sont importants pour inclure la leucémie myélomonocytaire dans le diagnostic différentiel chez les patients présentant des signes neurologiques dus à une localisation médullaire.La letteratura riporta solo pochi casi di leucemia mielomonocitica nei cani associata a segni neurologici e nessuno di questi casi è associato a un’infiltrazione intraparenchimatosa del midollo spinale da parte di cellule neoplastiche. Lo scopo di questa breve relazione è di descrivere un caso di leucemia mielomonocitica acuta di sottotipo M4 con infiltrazione del midollo spinale in un cane. Un golden retriever maschio di 3 anni è stato presentato con ipertermia, linfoadenomegalia, leucocitosi con blasti circolanti, anemia, trombocitopenia e paraplegia acuta. L’immunofenotipizzazione del sangue periferico mediante citometria a flusso ha rivelato una leucemia mielomonocitica acuta di sottotipo M4. Il cane è stato sottoposto ad eutanasia a causa del deterioramento clinico e della prognosi sfavorevole. L’esame post-mortem ha rivelato l’infiltrazione neoplastica di più organi, compreso il midollo spinale. A nostra conoscenza, questo è il primo caso di leucemia mielomonocitica acuta di sottotipo M4 in un cane con infiltrazione del midollo spinale. I nostri risultati sono importanti per includere la leucemia mielomonocitica nella diagnosi differenziale dei pazienti con segni neurologici con localizzazione del midollo spinale.

Artificial intelligence provides a vast opportunity and conquest of the science of knowledge. Twenty-first-century medicine will be characterized by an extraordinary ability to access and process medical information to provide patient-specific, timely, and effective clinical decision support. The knowledge gained by patient care experience and clinicians' expertise has led to many clinical care advances. Access to a large volume of data, along with ever-growing information and knowledge of diseases, can allow us to optimize diagnoses and management strategies by using advances in machine learning and artificial intelligence. Changing the medical culture from only relying on the experts to use medical informatics advances to improve the experts' clinical judgment would be an uphill battle. It is necessary to overcome the clinicians' traditional training to empower them into moving in the data science, statistics, and artificial intelligence era. As the incorporation of artificial intelligence in clinical practice seems inevitable, a thorough understanding of its capacities and flaws is essential to the emergence of a new clinical practice world. This review paper describes some of the nuances of past, current, and future clinical decision support systems and artificial intelligence's impact on this process.

The continuity of monitoring operations at national earthquake centers during crisis is an important challenge. In 2020, because of the COronaVIrus Disease 2019 (COVID-19) health emergency, monitoring centers all over the world faced new, unexpected problems. In Italy, the Istituto Nazionale di Geofisica e Vulcanologia (INGV) has the duty to perform earthquake and volcano monitoring, seismic surveillance and tsunami alerting, and maintaining effective communication with the National Civil Protection agency and the public. During the lockdown, that started on 9 March 2020, INGV set up a series of sanitary and organizational measures and improved the technological infrastructures in the control room in Rome for remote use of software for seismic network monitoring, seismic surveillance, and tsunami alerting. Our main goal was to protect the researchers and technicians on duty as much as possible and develop the remote use of software tools necessary to perform service activities when needed to limit the presence in the control room to the essential. In the first month of lockdown, we implemented the organizational controls, the health aids, and the tools for remote surveillance and alerting, and gave online training courses for about 100 shift workers. At the end of March 2020, most of the technicians, researchers, and tsunami experts on duty were able to access the new monitoring tools from home. During these months, the shifts in the control room were done in person and we performed remote seismic surveillance and tsunami alerting only during the weekly disinfections of the control room and at the beginning of each week. The tools developed during the COVID health emergency are going to be useful in the future especially in the case of other emergencies including the occurrence of a strong earthquake.

When a pairing $$e: {\mathbb {G}}_1 \times {\mathbb {G}}_2 \rightarrow {\mathbb {G}}_{T}$$ e : G 1 × G 2 → G T , on an elliptic curve E defined over a finite field $${\mathbb {F}}_q$$ F q , is exploited for an identity-based protocol, there is often the need to hash binary strings into $${\mathbb {G}}_1$$ G 1 and $${\mathbb {G}}_2$$ G 2 . Traditionally, if E admits a twist $${\tilde{E}}$$ E ~ of order d, then $${\mathbb {G}}_1=E({\mathbb {F}}_q) \cap E[r]$$ G 1 = E ( F q ) ∩ E [ r ] , where r is a prime integer, and $${\mathbb {G}}_2={\tilde{E}}({\mathbb {F}}_{q^{k/d}}) \cap {\tilde{E}}[r]$$ G 2 = E ~ ( F q k / d ) ∩ E ~ [ r ] , where k is the embedding degree of E w.r.t. r. The standard approach for hashing into $${\mathbb {G}}_2$$ G 2 is to map to a general point $$P \in {\tilde{E}}({\mathbb {F}}_{q^{k/d}})$$ P ∈ E ~ ( F q k / d ) and then multiply it by the cofactor $$c=\#{\tilde{E}}({\mathbb {F}}_{q^{k/d}})/r$$ c = # E ~ ( F q k / d ) / r . Usually, the multiplication by c is computationally expensive. In order to speed up such a computation, two different methods—by Scott et al. (International conference on pairing-based cryptography. Springer, Berlin, pp 102–113, 2009) and by Fuentes-Castaneda et al. (International workshop on selected areas in cryptography)—have been proposed. In this paper we consider these two methods for BLS pairing-friendly curves having $$k \in \{12,24,30,42,48\}$$ k ∈ { 12 , 24 , 30 , 42 , 48 } , providing efficiency comparisons. When $$k=42,48$$ k = 42 , 48 , the application of Fuentes et al. method requires expensive computations which were infeasible for the computational power at our disposal. For these cases, we propose hashing maps that we obtained following Fuentes et al. idea.

British medical bulletin : BMB 142(1), 23-33 (2022). doi:10.1093/bmb/ldac010, Published by [Verlag nicht ermittelbar], London [u.a.]

Archosauria diversified throughout the Triassic Period before experiencing two mass extinctions near its end ∼201 Mya, leaving only the crocodile-lineage (Crocodylomorpha) and bird-lineage (Dinosauria) as survivors; along with the pterosaurian flying reptiles. About 50 years ago, the “locomotor superiority hypothesis” (LSH) proposed that dinosaurs ultimately dominated by the Early Jurassic Period because their locomotion was superior to other archosaurs’. This idea has been debated continuously since, with taxonomic and morphological analyses suggesting dinosaurs were “lucky” rather than surviving due to being biologically superior. However, the LSH has never been tested biomechanically. Here we present integration of experimental data from locomotion in extant archosaurs with inverse and predictive simulations of the same behaviours using musculoskeletal models, showing that we can reliably predict how extant archosaurs walk, run and jump. These simulations have been guiding predictive simulations of extinct archosaurs to estimate how they moved, and we show our progress in that endeavour. The musculoskeletal models used in these simulations can also be used for simpler analyses of form and function such as muscle moment arms, which inform us about more basic biomechanical similarities and differences between archosaurs. Placing all these data into an evolutionary and biomechanical context, we take a fresh look at the LSH as part of a critical review of competing hypotheses for why dinosaurs (and a few other archosaur clades) survived the Late Triassic extinctions. Early dinosaurs had some quantifiable differences in locomotor function and performance vs. some other archosaurs, but other derived dinosaurian features (e.g., metabolic or growth rates, ventilatory abilities) are not necessarily mutually exclusive from the LSH; or maybe even an opportunistic replacement hypothesis; in explaining dinosaurs’ success.

Background: Access to the liver transplant waitlist for patients with hepatocellular carcinoma (HCC) depends on tumour presentation, biology, and response to treatments. The Milan Criteria (MC) represent the benchmark for expanded criteria that incorporate additional prognostic factors. The purpose of this study was to determine the added value of skeletal muscle index (SMI) in HCC patients beyond the MC. Method: Patients with HCC that were transplanted beyond the MC were included in this retrospective multicentre study. SMI was quantified using the Computed Tomography (CT) within 3 months prior to transplantation. Cox regression models were used to identify predictors of overall survival (OS). The discriminative performance of SMI extended Metroticket 2.0 and AFP models was also assessed. Results: Out of 889 patients transplanted outside the MC, 528 had a CT scan within 3 months prior to liver transplantation (LT), of whom 176 (33%) were classified as sarcopenic. The median time between assessment of the SMI and LT was 1.8 months (IQR: 0.77–2.67). The median follow-up period was 5.1 95% CI [4.7–5.5] years, with a total of 177 recorded deaths from any cause. In a linear regression model with SMI as the dependent variable, only male gender (8.55 95% CI [6.51–10.59], P P = 0.018). Also the SMI was significant (HR 0.98 95% CI [0.96–0.99], P = 0.014). The survival difference between the lowest SMI quartile versus the highest SMI quartile was significant (log-rank: P = 0.005) with 5 year OS of 57% and 71%, respectively. Data from 423 patients, describing 139 deaths, was used for multivariate analysis. Both sarcopenia (HR 1.45 95% CI [1.02 − 2.05], P = 0.036) and SMI were (HR 0.98 95% CI [0.95–0.99], P = 0.035) significant. On the survival scale this translates to a 5 year OS difference of 11% between sarcopenia and no sarcopenia. Whereas for SMI, this translates to a survival difference of 8% between first and third quartiles for both genders. Conclusions: Overall, we can conclude that higher muscle mass contributes to a better long-term survival. However, for individual patients, low muscle mass should not be considered an absolute contra-indication for LT as its discriminatory performance was limited.

We present an end-to-end framework for histopathological analysis of whole slide images (WSIs). Our framework uses deep learning-based localization & classification of cell nuclei followed by spatial data aggregation to propagate classes of sparsely distributed nuclei across the entire slide. We use YOLO (''You Only Look Once'') for localization instead of more costly segmentation approaches and show that using HistAuGAN boosts its performance. YOLO finds bounding boxes around nuclei at good accuracy, but the classification accuracy can be improved by other methods. To this end, we extract patches around nuclei from the WSI and consider models from the SqueezeNet, ResNet, and EfficientNet families for classification. Where we do not achieve a clear separation between highest and second-highest softmax activation of the classifier, we use YOLO's output as a secondary vote. The result is a sparse annotation of the WSI, which we turn dense by using kernel density estimation. The result is a full vector of per pixel probabilities for each class of nucleus we consider. This allows us to visualize our results using both color-coding and isocontouring, reducing visual clutter. Our novel nuclei-to-tissue coupling allows histopathologists to work at both the nucleus and the tissue level, a feature appreciated by domain experts in a qualitative user study., Visual Analytics, Artificial Intelligence, Khaled Al-Thelaya, Faaiz Joad, Nauman Ullah Gilal, William Mifsud, Giovanni Pintore, Enrico Gobbetti, Marco Agus, and Jens Schneider

The ASTRI (Astrofisica con Specchi a Tecnologia Replicante Italiana) Mini-Array will be composed of nine imaging atmospheric Cherenkov telescopes at the Observatorio del Teide site. The array will be best suited for astrophysical observations in the 0.3-200 TeV range with an angular resolution of few arc-minutes and an energy resolution of 10-15\%. A core-science programme in the first four years will be devoted to a limited number of key targets, addressing the most important open scientific questions in the very-high energy domain. At the same time, thanks to a wide field of view of about 10 degrees, ASTRI Mini-Array will observe many additional field sources, which will constitute the basis for the long-term observatory programme that will eventually cover all the accessible sky. In this paper, we review different astrophysical Galactic environments, e.g. pulsar wind nebulae, supernova remnants, and gamma-ray binaries, and show the results from a set of ASTRI Mini-Array simulations of some of these field sources made to highlight the expected performance of the array (even at large offset angles) and the important additional observatory science that will complement the core-science program., Comment: Accepted for publication in Journal of High-Energy Astrophysics

Significant evolutionary shifts in locomotor behaviour often involve comparatively subtle anatomical transitions. In particular for dinosaurian locomotor apparatus, considerable medial overhang of the proximal end of the femur has been central to discussions for their locomotion. However, there is an apparent conflict with regard to the evolutionary origin of the dinosaurian femoral head, with neontological and paleontological data suggesting seemingly incongruent hypotheses. To reconcile this, we reconstructed the evolutionary history of morphogenesis of the proximal end of the femur from early archosaurs to crown birds. Embryological comparison of living archosaurs (crocodylians and birds) suggests the acquisition of the greater overhang of the femoral head in dinosaurs results from additional growth of the proximal end in the medial-ward direction. On the other hand, the fossil comparison suggests this overhang was acquired by torsion of the proximal end, which projected to more rostral direction in ancestors. We reconcile this apparent conflict by inferring that the medial overhang of the dinosaur femoral head was initially acquired by torsion, which was then superseded by mediad growth. Details of anatomical shifts in fossil forms support this hypothesis, and their biomechanical implications are congruent with the general consensus regarding broader morpho-functional evolution on the avian stem.

The ASTRI Mini-Array (MA) is an INAF project to build and operate a facility to study astronomical sources emitting at very high-energy in the TeV spectral band. The ASTRI MA consists of a group of nine innovative Imaging Atmospheric Cherenkov telescopes. The telescopes will be installed at the Teide Astronomical Observatory of the Instituto de Astrofisica de Canarias (IAC) in Tenerife (Canary Islands, Spain) on the basis of a host agreement with INAF. Thanks to its expected overall performance, better than those of current Cherenkov telescopes' arrays for energies above \sim 5 TeV and up to 100 TeV and beyond, the ASTRI MA will represent an important instrument to perform deep observations of the Galactic and extra-Galactic sky at these energies., 19 pages, 22 figures

The ASTRI (Astrofisica con Specchi a Tecnologia Replicante Italiana) Project led by the Italian National Institute for Astrophysics (INAF) is developing and will deploy at the Observatorio del Teide a mini-array (ASTRI Mini-Array) composed of nine telescopes similar to the small-size dual-mirror Schwarzschild-Couder telescope (ASTRI-Horn) currently operating on the slopes of Mt. Etna in Sicily. The ASTRI Mini-Array will surpass the current Cherenkov telescope array differential sensitivity above a few tera-electronvolt (TeV), extending the energy band well above hundreds of TeV. This will allow us to explore a new window of the electromagnetic spectrum, by convolving the sensitivity performance with excellent angular and energy resolution figures. In this paper we describe the Core Science that we will address during the first four years of operation, providing examples of the breakthrough results that we will obtain when dealing with current open questions, such as the acceleration of cosmic rays, cosmology and fundamental physics and the new window, for the TeV energy band, of the time-domain astrophysics., Comment: Published in Journal of High Energy Astrophysics. 46 Figures, 7 Tables

We have studied the unusual time variability of an ultraluminous X-ray source in M 101, 4XMM J140314.2$+$541806 (henceforth, J1403), using Chandra and XMM-Newton data. Over the last two decades, J1403 has shown short-duration outbursts with an X-ray luminosity $\sim1-3 \times 10^{39}$ erg s$^{-1}$, and longer intervals at luminosities $\sim0.5-1 \times 10^{38}$ erg s$^{-1}$. The bimodal behaviour and fast outburst evolution (sometimes only a few days) are more consistent with an accretor/propeller scenario for a neutron star than with the canonical outburst cycles of stellar-mass black holes. If this scenario is correct, the luminosities in the accretor and propeller states suggest a fast spin ($P \approx$ 5 ms) and a low surface magnetic field ($B \sim 10^{10}$ G), despite our identification of J1403 as a high-mass X-ray binary. The most striking property of J1403 is the presence of strong $\sim$600-s quasi periodic oscillations (QPOs), mostly around frequencies of $\approx 1.3-1.8$ mHz, found at several epochs during the ultraluminous regime. We illustrate the properties of such QPOs, in particular their frequency and amplitude changes between and within observations, with a variety of techniques (Fast Fourier Transforms, Lomb-Scargle periodograms, weighted wavelet Z-transform analysis). The QPO frequency range $, Comment: 23 pages, 29 figures, 5 tables. Accepted for publication in MNRAS

Significant evolutionary shifts in locomotor behaviour often involve comparatively subtle anatomical transitions. In particular for dinosaurian locomotor apparatus, considerable medial overhang of the proximal end of the femur has been central to discussions for their locomotion. However, there is an apparent conflict with regard to the evolutionary origin of the dinosaurian femoral head, with neontological and palaeontological data suggesting seemingly incongruent hypotheses. To reconcile this, we reconstructed the evolutionary history of morphogenesis of the proximal end of the femur from early archosaurs to crown birds. Embryological comparison of living archosaurs (crocodylians and birds) suggests the acquisition of the greater overhang of the femoral head in dinosaurs results from additional growth of the proximal end in the medial-ward direction. On the other hand, the fossil comparison suggests this overhang was acquired by torsion of the proximal end, which projected to more rostral direction in ancestors. We reconcile this apparent conflict by inferring that the medial overhang of the dinosaur femoral head was initially acquired by torsion, which was then superseded by mediad growth. Details of anatomical shifts in fossil forms support this hypothesis, and their biomechanical implications are congruent with the general consensus regarding broader morpho-functional evolution on the avian stem.

Significant evolutionary shifts in locomotor behaviour often involve comparatively subtle anatomical transitions. For dinosaurian and avian evolution, medial overhang of the proximal femur has been central to discussions. However, there is an apparent conflict with regard to the evolutionary origin of the dinosaurian femoral head, with neontological and palaeontological data suggesting seemingly incongruent hypotheses. To reconcile this, we reconstructed the evolutionary history of morphogenesis of the proximal end of the femur from early archosaurs to crown birds. Embryological comparison of living archosaurs (crocodylians and birds) suggests the acquisition of the greater overhang of the femoral head in dinosaurs results from additional growth of the proximal end in the medial-ward direction. On the other hand, the fossil record suggests that this overhang was acquired by torsion of the proximal end, which projected in a more rostral direction ancestrally. We reconcile this apparent conflict by inferring that the medial overhang of the dinosaur femoral head was initially acquired by torsion, which was then superseded by mediad growth. Details of anatomical shifts in fossil forms support this hypothesis, and their biomechanical implications are congruent with the general consensus regarding broader morpho-functional evolution on the avian stem.