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1. Consequences of General Anesthesia in Infancy on Behavior and Brain Structure

Author

Salaün, Jean-Philippe, Chagnot, Audrey, Cachia, Arnaud, Poirel, Nicolas, Datin-Dorrière, Valérie, Dujarrier, Cléo, Lemarchand, Eloïse, Rolland, Marine, Delalande, Lisa, Gressens, Pierre, Guillois, Bernard, Houdé, Olivier, Levard, Damien, Gakuba, Clément, Moyon, Marine, Naveau, Mikael, Orliac, François, Orliaguet, Gilles, Hanouz, Jean-Luc, Agin, Véronique, Borst, Grégoire, Vivien, Denis, Hôpital Côte de Nacre [CHU Caen], CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Physiopathologie et imagerie des troubles neurologiques (PhIND), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Normandie Université (NU), Laboratoire de psychologie du développement et de l'éducation de l'enfant (LaPsyDÉ - UMR 8240), Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de psychologie du développement et de l'éducation de l'enfant (LaPsyDÉ), Normandie Université (NU)-Normandie Université (NU)-Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), University of Manchester [Manchester], Thèses d'exercice et mémoires - UFR de Médecine Montpellier-Nîmes, Université de Montpellier (UM), Maladies neurodéveloppementales et neurovasculaires (NeuroDiderot (UMR_S_1141 / U1141)), Laboratoire de psychologie de Caen Normandie (LPCN), Normandie Université (NU)-Normandie Université (NU), Service de Soins Intensifs [CHU Caen], Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Unité Support CYCERON, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Centre National de la Recherche Scientifique (CNRS), GIP Cyceron (Cyceron), Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Evaluation thérapeutique et pharmacologie périnatale et pédiatrique (EA_7323), Université Paris Descartes - Paris 5 (UPD5), Etablissement français du sang - Normandie (EFS), and Institut Blood and Brain @ Caen-Normandie [Caen] (BB@C)

Subjects
[SCCO]Cognitive science, Anesthesiology and Pain Medicine, [SCCO.NEUR]Cognitive science/Neuroscience, [SCCO.PSYC]Cognitive science/Psychology, [SHS.PSY]Humanities and Social Sciences/Psychology
Abstract

International audience

Published
2022
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3. S167. ANATOMICAL CONNECTIVITY OF THE VISUOSPATIAL ATTENTIONAL NETWORK IN SCHIZOPHRENIA: A DTI-BASED TRACTOGRAPHY STUDY

Author

Sonia Dollfus, Poirel Nicolas, and Leroux Elise

Subjects
Poster Session III, biology, business.industry, Superior longitudinal fasciculus, biology.organism_classification, Lateralization of brain function, White matter, Abstracts, Psychiatry and Mental health, medicine.anatomical_structure, Fasciculus, Fractional anisotropy, Medicine, Inferior longitudinal fasciculus, business, Neuroscience, Tractography, Diffusion MRI
Abstract

Background In healthy controls (HCs), the visuospatial attentional network consists of fronto-parietal bundles distributed across both hemispheres, but the anatomical organization of this network remains largely unknown in patients with schizophrenia (SZPs). Using diffusion tensor imaging (DTI)-based tractography, we investigated both white matter integrity and the volume of visuospatial attentional pathways in the right and left hemispheres (RH and LH), as well as their structural asymmetry in SZPs and HCs and hypothesized that SZPs would have WM pathway alterations and abnormal structural asymmetry. Methods This study included 34 SZPs and 69 HCs. Integrity parameters (fractional anisotropy [FA], radial and mean diffusivity [RD and MD]) and volume were calculated in each fasciculus of this network: the three branches of the superior longitudinal fasciculus (SLFI–III), the inferior longitudinal fasciculus, and the inferior fronto-occipital fasciculus in the RH and LH. Results In SLFII and SLFIII, compared to RH and LH values for SZPs, HCs presented increased FA and/or decreased RD/MD in RH and/or LH. Both SZPs and HCs presented increased FA and decreased RD/MD in the RH compared to the LH in the SLFIII, whereas only HCs had this pattern in the SLFII. Volumes did not differ between groups. Discussion To our knowledge, this study is the first to describe the structural hemispheric lateralization/organization of the visuospatial attentional network in SZPs. Our main findings are disrupted structural connectivity in the SLFII associated with abnormal anatomical asymmetry in patients, which could be a substrate of attentional deficits.

Published
2018
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4. The impacts of examples on creative design : explaining fixation and stimulation effects

Author

Agogué, Marine, Kazakçı, Akın, Hatchuel, Armand, Le Masson, Pascal, Weil, Benoit, Poirel, Nicolas, Cassotti, Mathieu, Agogue, Marine, Centre de Gestion Scientifique i3 ( CGS i3 ), MINES ParisTech - École nationale supérieure des mines de Paris-PSL Research University ( PSL ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de psychologie du développement et de l'éducation de l'enfant ( LaPsyDÉ - UMR 8240 ), Université de Caen Normandie ( UNICAEN ), Normandie Université ( NU ) -Normandie Université ( NU ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Centre National de la Recherche Scientifique ( CNRS ), Centre de Gestion Scientifique i3 (CGS i3), MINES ParisTech - École nationale supérieure des mines de Paris-PSL Research University (PSL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de psychologie du développement et de l'éducation de l'enfant (LaPsyDÉ - UMR 8240), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-MINES ParisTech - École nationale supérieure des mines de Paris, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)

Subjects
creative behavior, design fixation, fixation effect,design fixation,creative behavior, fixation effect, [SHS.GESTION]Humanities and Social Sciences/Business administration, [ SHS.GESTION ] Humanities and Social Sciences/Business administration, [SHS.GESTION] Humanities and Social Sciences/Business administration
Abstract

Converging evidences have indicated that the ability to generate creative ideas could be limited by recently activated knowledge such as examples of solutions. However, neuroimaging studies have recently demonstrated that exposure to examples did not systematically lead to fixation and could on the contrary have a stimulation effect on creativity. Our hypothesis is that there are two types of examples that C-K theory helps to characterize: (1) restrictive examples that do not change the definition or the attributes of the object, and (2) expansive examples that modify its identity by adding unexpected attributes. In two studies, we explored the impact of restrictive and expansive examples on a creative task. We then hypothesized that the introduction of an example during the task would provoke participants to propose solutions of a higher originality when the provided example was expansive. In contrast, when the provided example was restrictive, we hypothesized that the originality of the solutions would be reduced. Results confirmed that solutions proposed by the group exposed to restrictive example are less original than those given by groups exposed to expansive examples.

Published
2014

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