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2. Role of 3β-hydroxysteroid-Δ24 reductase in mediating antiinflammatory effects of high-density lipoproteins in endothelial cells

Author

McGrath, KCY, Li, XH, Puranik, R, Liong, EC, Tan, JTM, Dy, VM, Dibartolo, BA, Barter, PJ, Rye, KA, and Heather, AK

Subjects
Oxidoreductases Acting on CH-CH Group Donors, Vascular Cell Adhesion Molecule-1, Nerve Tissue Proteins, Transfection, Cholesterol, Dietary, NF-KappaB Inhibitor alpha, Animals, Humans, RNA, Small Interfering, Infusions, Intravenous, Promoter Regions, Genetic, Cells, Cultured, Arteritis, Apolipoprotein A-I, Tumor Necrosis Factor-alpha, Gene Expression Profiling, NF-kappa B, Endothelial Cells, Atherosclerosis, I-kappa B Kinase, Disease Models, Animal, Cardiovascular System & Hematology, Gene Expression Regulation, RNA Interference, I-kappa B Proteins, Rabbits, Lipoproteins, HDL
Abstract

OBJECTIVE-: The purpose of this study was to investigate the ability of high-density lipoproteins (HDLs) to upregulate genes with the potential to protect against inflammation in endothelial cells. METHODS AND RESULTS-: Human coronary artery endothelial cells (HCAECs) were exposed to reconstituted HDLs (rHDLs) for 16 hours before being activated with tumor necrosis factor-α (TNF-α) for 5 hours. rHDLs decreased vascular cell adhesion molecule-1 (VCAM-1) promoter activity by 75% (P

Published
2009

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