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The objective of current study was to fabricate PEG based hydrogels cross linked with monomer i.e. acrylic acid and 2, Acrylamide-2-methyl propane sulfonic acid (AMPS) in aqueous media. N,N'-Methylenebisacrylamide (MBA) was used as cross linker while ammonium per sulfate was added in reaction as initiator. Sodium bicarbonate was used as to create pores in hydrogel making the formulations superporous. Ivabradine hydrochloride as model drug was loaded into prepared hydrogel formulation. FTIR confirmed the compatibility of Polyethylene glycol with acrylic acid and AMPS. Thermal stability of PEG based hydrogels was confirmed by DSC and TGA techniques. Prepared hydrogels showed pH dependent swelling behavior. Presence of AMPS caused excellent swelling of hydrogels due to its polyelectrolyte nature while in case of acrylic acid dense cross linking cause comparatively less swelling of acrylic acid based hydrogels. Sol–gel fraction was determined to find out unreacted and uncross linked portion of each formulation. Invitro release study confirmed controlled release of loaded drug from PEG based polymeric matrices. Release kinetics suggested that drug release from hydrogel matrix followed solvent diffusion swelling mechanism.

We describe five members of a consanguineous Pakistani family (Family I) plus two affected children from families of different ethnic origins presenting with neurodevelopmental disorders with overlapping features. All affected individuals from families have intellectual disability (ID), ranging from mild to profound, and reduced motor and cognitive skills plus variable features including short stature, microcephaly, developmental delay, hypotonia, dysarthria, deafness, visual problems, enuresis, encopresis, behavioural anomalies, delayed pubertal onset and facial dysmorphism. We first mapped the disease locus in the large family (Family I), and by exome sequencing identified homozygous ZNF407 c.2814_2816dup (p.Val939dup) in four affected members where DNA samples were available. By exome sequencing we detected homozygous c.2405G>T (p.Gly802Val) in the affected member of Family II and compound heterozygous variants c.2884C>G (p.Arg962Gly) and c.3642G>C (p.Lys1214Asn) in the affected member of Family III. Homozygous c.5054C>G (p.Ser1685Trp) has been reported in two brothers with an ID syndrome. Affected individuals we present did not exhibit synophrys, midface hypoplasia, kyphosis, 5th finger camptodactyly, short 4th metatarsals or limited knee mobility observed in the reported family.

We describe five members of a consanguineous Pakistani family (Family I) plus two affected children from families of different ethnic origins presenting with neurodevelopmental disorders with overlapping features. All affected individuals from families have intellectual disability (ID), ranging from mild to profound, and reduced motor and cognitive skills plus variable features including short stature, microcephaly, developmental delay, hypotonia, dysarthria, deafness, visual problems, enuresis, encopresis, behavioural anomalies, delayed pubertal onset and facial dysmorphism. We first mapped the disease locus in the large family (Family I), and by exome sequencing identified homozygous ZNF407 c.2814_2816dup (p.Val939dup) in four affected members where DNA samples were available. By exome sequencing we detected homozygous c.2405GT (p.Gly802Val) in the affected member of Family II and compound heterozygous variants c.2884CG (p.Arg962Gly) and c.3642GC (p.Lys1214Asn) in the affected member of Family III. Homozygous c.5054CG (p.Ser1685Trp) has been reported in two brothers with an ID syndrome. Affected individuals we present did not exhibit synophrys, midface hypoplasia, kyphosis, 5th finger camptodactyly, short 4th metatarsals or limited knee mobility observed in the reported family.

Objective: The main purpose of study is to evaluate the cause / etiology of scabies. It was expected that this study would be helpful in identifying the cause of scabies, management and prevention of scabies in international students. Research was descriptive in nature. In research, we used tabulation method for interpretation and objectively exalted every possibility to find out accuracy in getting result to maximum extent. Methods: We used survey method for collection of data from selected population by questioner method. We selected students of MBBS from Yangtze University for our selected research purpose by using systemic sampling method in selection of our samples, including male and female. We selected 32 students from our sampled population and divided into two groups. i.e. 16 students for each group. And collected data of members of diseased and normal group. Results: As international students have to live in hostels, dormitories and apartments together. So, due to overcrowding and poor hygienic conditions international students suffer from scabies. In our diseased group 15 out 16 students diagnosed scabies so, prevalence is 93.75%. After practicing general and specific management, our patients started to recover from scabies within a week (5-7 days). CONCLUSION: We concluded that cause behind itching and rashes are Sarcoptes scabiei which causes scabies. Sarcoptes scabiei is responsible causing Type I and Type IV hypersensitivity which is responsible for itching. Scabies mite live in keratin layer of epidermis and feed there, causing itching and rashes because of initiating HSR. We can investigate and visualize the scabies mites in burrows by Ink test and by microscopy examination. After application of Sulphur ointment and concomitant use of disinfectant to surrounding of the patient (with clothes, rooms, fomites, furniture) the duration of recovery is within 6 days (n=15, p=0.19). Keywords: Sulphur Ointment, Rashes, Itching, Scabies, Hypersensitivity, Streptococcus Pyogens, Bacterial Infection

Objectives: The aim of this research work was to assess the outcome of pregnancy having complications due to gestation diabetes and this complication was well-managed by professionals. Methodology: The information regarding all singleton pregnancies with the identification of gestation diabetes retrieved retroactively from the files of patients. The duration of this research work was from December 2018 to May 2019 in endocrinology department of Mayo Hospital Lahore. The standards of O’Sullivan & NDDG (national diabetes data group) were in use for the diagnosis of the gestational diabetes. SPSS V.17 was in use for the analysis of data. Median and range were in use for the expression of the discrete as well as continuous variables. Percentages were in use for the presentation of the categorical information. Results: The occurrence of gestation diabetes mellitus was 6.10% (n: 94) among total deliveries but seventy-eight patients of GDM were the part of this research work. The rate of maternal & neonatal morbidity was 32.0% (n: 25) & 29.50% (n: 23). The average age of patients was thirty-five years with a range of 23 to 47 year of age. Majority of the patients were multipara 50.0% (n: 39). We saw the highest body mass index in the final three months of pregnancy period with an average of 32.30 (from 28.0 to 35.70). The hemoglobin of the patients was 10.70 (from 8.50 to 12.80). The rate of cesarean surgery was 25.60% (n: 20) whereas 19.20% (n: 15) patients developed the hypertension because of pregnancy. But, 14.10% (n: 11) neonates got admission in the intensive care unit of neonates because of hypoglycemia in 24.4% (n: 19). About 19.20% (n: 15) neonates were suffering from the distress of the respiration system. Conclusion: The occurrence of gestational diabetes mellitus was 6.10%. The outcome of pregnancies associated with well-controlled diabetes was also adverse with many complications. KEY WORDS: Gestation, Diabetes, Retroactive, Maternal & Neonatal Morbidity, Distress, Respiration, Hypoglycemia.

Lanthanum Zirconate (La2Zr2O7) nanoparticles (NPs) are generally used in blades of gas turbine engines to thermally insulate them and to protect them against hot and corrosive gas streams. The present research experiment was aimed to determine the effect of Lanthanum Zirconate NPs on selected aspects of behavior, serum biochemistry, complete blood count and antioxidant metabolites from vital organs of albino mice in a gender specific manner. Seven weeks old mice were administered orally with 25mg/ml solvent/Kg body weight of Lanthanum Zirconate nanoparticles for consecutive 22 days. Saline treated control groups were maintained in parallel. It was observed that neuromuscular coordination was significantly improved (P = 0.01) in NPs treated female mice while rearing frequency was significantly decreased (P = 0.004) in NPs treated male mice than their respective controls. Complete blood count analysis revelaed that NPs treated female mice had significantly reduced white blood cell (P = 0.04) and lymphocyte count (P = 0.02) than control group. It was observed that Superoxide dismutase concentrations in kidney (P = 0.04), Malonaldehyde concentrations in brain (P = 0.002), heart (P = 0.001), liver (P = 0.05) of male and in kidney (P = 0.001) of NPs treated female mice were significantly higher than their respective control groups. In conclusion, we are reporting that oral supplementation with 25mg/ml solvent/Kg body weight of Lanthanum Zirconate nanoparticles is affecting neuromuscular coordination, exploratory behavior, leukocyte count and antioxidant metabolites from vital organs in a gender specific manner with more pronounced effects in male.

Lanthanum Zirconate nanoparticles (NPs) are used in blades of gas turbine engines to thermally insulate them and to protect them against hot and corrosive gas streams. However, the information regarding their biocompatibility is limited. The present study was aimed to report the effect of Lanthanum Zirconate NPs on selected aspects of behavior, serum biochemistry, complete blood count and antioxidant parameters from vital organs of albino mice in a gender specific manner. Albino mice, seven weeks old, were orally treated with 75 mg/ml solvent/Kg body weight of Lanthanum Zirconate nanoparticles for consecutive 22 days. Saline treated control groups were maintained in parallel. It was observed that rearing frequency was significantly decreased (P = 0.01) in NPs treated male mice. Complete blood count analysis indicated that NPs treated female mice had significantly reduced white blood cells (P = 0.05) and lymphocytes count (P = 0.03). NPs treated male had significantly reduced serum cholesterol levels (P = 0.05) than control group. It was observed that Superoxide dismutase concentrations in liver (P = 0.025) and kidney (P = 0.008), Malondialdehyde concentrations in liver (P = 0.044) of female and Malondialdehyde concentrations in kidney (P

The analysis aims to identify and explain how ideology is constructed and presented through language used in two Pakistani newspapers, viz., the Nation and the Dawn. Emphasis is placed on the construction of ideology using framework of analyzing media discourse given by van Dijk (1998) thus revealing the close relationship between language and ideology. The findings indicate that lexical choices and sentence structure in written text play a fundamental role in propagation and perpetuation of implicit and dominant ideologies and that there are certain ideological differences that are yielded either tacitly or overtly in newspaper editorials. The article is divided into four sections. The first section includes the introduction of the newspaper editorial. The next two sections describe what critical discourse analysis is, framework of Van Dijk’s media discourse model, brief history of the newspaper under investigation and an analysis of the data. The last section offers concluding remarks about the association between language and ideology.