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An evidence-based systematic review of acai (Euterpe oleracea) by the Natural Standard Research Collaboration consolidates the safety and efficacy data available in the scientific literature using a validated, reproducible grading rationale. This article includes written and statistical analysis of clinical trials, plus a compilation of expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing.

An evidence-based systematic review of cinnamon (Cinnamomum spp.), including written and statistical analysis of scientific literature, expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing, by the Natural Standard Research Collaboration is discussed in this monograph.

The function of fixational eye movements, the tiny involuntary eye movements or 'retinal jitters' that occur when we fix our gaze on something, has been a matter of debate since they were first recognized in the 1950s. Using a combination of psychophysical experiments with statistical analysis of the visual signals entering the eye to counteract the visual effects of the eye movements, Rucci et al. show that without them, perception of fine-grained information is reduced. This suggests that fixational eye movements are part of a strategy used by the brain to extract fine details of visual information. Our eyes are constantly in motion. Even during visual fixation, small eye movements continually jitter the location of gaze1,2,3,4. It is known that visual percepts tend to fade when retinal image motion is eliminated in the laboratory5,6,7,8,9. However, it has long been debated whether, during natural viewing, fixational eye movements have functions in addition to preventing the visual scene from fading10,11,12,13,14,15,16,17. In this study, we analysed the influence in humans of fixational eye movements on the discrimination of gratings masked by noise that has a power spectrum similar to that of natural images. Using a new method of retinal image stabilization18, we selectively eliminated the motion of the retinal image that normally occurs during the intersaccadic intervals of visual fixation. Here we show that fixational eye movements improve discrimination of high spatial frequency stimuli, but not of low spatial frequency stimuli. This improvement originates from the temporal modulations introduced by fixational eye movements in the visual input to the retina, which emphasize the high spatial frequency harmonics of the stimulus. In a natural visual world dominated by low spatial frequencies, fixational eye movements appear to constitute an effective sampling strategy by which the visual system enhances the processing of spatial detail.

Following Good Pharmacovigilance Practices Module XVI, two complementary studies were performed that included process and outcome measurements of the effectiveness of physician education on metabolic monitoring of patients receiving quetiapine. A multinational survey of 800 European Union physicians was utilized to assess the receipt of educational materials and also to assess the degree of monitoring as reported by physicians. Recall of receipt of educational materials ranged from 16.0 to 69.0% across the participating countries; however, physicians reported that 64.5% of patients were being monitored, with the majority reporting performance of three or more of four key metabolic-monitoring activities. Higher rates of monitoring were reported by those who reported receiving materials. Assessment of outcomes in a separate retrospective analysis of electronic medical record data showed lower levels of monitoring performed by specialist physicians. The monitoring activities observed were assessed as acceptable on the basis of the established performance of UK physicians, who are incentivized to deliver preventive screening.

An evidence-based systematic review of active hexose correlated compound (AHCC) by the Natural Standard Research Collaboration consolidates the safety and efficacy data available in the scientific literature using a validated, reproducible grading rationale. This article includes written and statistical analysis of clinical trials, plus a compilation of expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing.

An evidence-based systematic review of rosemary (Rosmarinus officinalis), including written and statistical analysis of scientific literature, expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing.

Background Multiple myeloma (MM) is the second most common hematological malignancy in the U.S., and is characterized by bone pain, appetite loss, fatigue, and treatment-related symptoms. These symptoms can have potentially devastating effects on patients' health-related quality of life (HRQoL). While several instruments are available to evaluate the symptomatic profile and HRQoL of MM patients, it is unclear whether their conceptual coverages are adequate in the relapsed or refractory (R/R) setting. In order to address this concern, we conducted a qualitative study in R/R MM patients and compared the results to the conceptual frameworks of three instruments available for use in this population. Methods Qualitative concept elicitation (CE) interviews were conducted with MM patients in the U.S. Patients were considered eligible for participation if they were at least 18 years of age, fluent in U.S. English, currently receiving treatment for MM considered to be R/R, and had an ECOG Performance Status of 0-2. Patients who were receiving first-line therapy for their cancer; were mentally or legally incapable of consenting to the study; or had a concurrent diagnosis or condition that would interfere with their ability to participate in the study were excluded. Interviews were conducted according to a semi-structured interview guide. Questions were open-ended and focused primarily on patients' disease- and treatment-related symptoms and how those symptoms impacted their lives. Targeted follow-up questions were used to elicit additional information when appropriate. Interviews lasted approximately 60 minutes and were audio recorded; all interview recordings were transcribed and de-identified. Qualitative data were analyzed using a grounded theory approach that combined semi-quantitative and qualitative methods. The concepts reported by patients were evaluated for saturation and subsequently compared with the conceptual frameworks of the EORTC QLQ-C30 and QLQ-MY20, FACT-MM, and MDASI-MM instruments. Results A total of 15 MM patients (age range = 56 to 89 years; mean age = 68.8±10.4 years) participated in the CE interviews and were included in analysis. Most patients were white (n=13, 86.7%), and about half were male (n=8, 53.3%). Two-thirds of the sample had some form of college education (i.e., certificate, two- to four-year college degree, or graduate degree). Most were married (n=11, 73.3%), and all but one reported living with family or friends (n=14, 93.93%). Patients were most commonly retired (n=8, 53.3%). Time since diagnosis ranged from 1 to 7 years, with a mean of 3.2±2.0 years. Just over half of the participants (n=8, 53.3%) had stage 3 MM at diagnosis. Eight patients (53.3%) were on second line treatment, six patients (40.0%) on third line treatment, and one patient (6.7%) on seventh line treatment. A total of 27 disease-related symptom concepts were reported by MM patients. Of those, the most commonly reported were tiredness (n=8, 53.5%), back pain (n=4, 26.7%), lack of energy (n=3, 20.0%), pain (location not specified) (n=3, 20.0%), shortness of breath (n=3, 20.0%), and weakness (n=3, 20.0%). The remaining 21 symptom concepts were reported by ≤2 patients each (≤13.3%). A total of 43 disease-related HRQoL impacts were reported by MM patients during CE interviews. The most commonly reported were work (n=6, 40.0%), thinking about cancer (n=5, 33.3%), exercise (n=4, 26.7%), social activities (n=4, 26.7%), household activities (n=4, 26.7%), and financial (n=4, 26.7%). Saturation was reached for 22 MM symptoms and 35 HRQoL impacts, and was questionable for 4 symptoms and 11 impacts. Overall, of the 10 disease-related symptom concepts reported by >1 MM patient, 7 (70.0%) were covered by the QLQ-C30 and MY-20, 5 (50.0%) by the FACT-MM, and 6 (60.0%) by the MDASI-MM. Of the 28 disease-related impacts reported by >1 MM patient, 15 (53.6%) were covered by the QLQ-C30 and MY-20, 11 (39.3%) by the FACT-MM, and 9 (32.1%) by the MDASI-MM. Conclusions These findings indicate that the majority of symptoms reported by R/R MM patients are captured by the existing EORTC QLQ-C30 and QLQ-MY20 instruments. A non-trivial gap in conceptual coverage is evident, however, which suggests that there remains room for improvement in assessing the experience of this patient population. Additional patient recruitment is ongoing to ensure saturation, and to further evaluate the need for a fit-for-purpose measure. Disclosures: Trask: Sanofi: Employment. Taylor:Adelphi Values: Employment. Shields:Adelphi Values: Employment. Gallagher:Sanofi: Employment. Mehta:Sanofi: Employment. Foley:Adelphi Values: Employment. Olude:Adelphi Values: Employment. Lamoureux:Adelphi Values: Employment. Iovin:Adelphi Values: Employment. Hsu:Sanofi: Employment.

Molecular-modeling studies on the photochromism of 2-(2,4-dinitrobenzyl)pyridine (α-DNBP), a compound whose synthesis has been previously reported in this Journal, focus on the hydrogen atom migratory distances and the energies for the two very different tautomers arising from the photo-induced proton transfers. Students use these distances to determine the most likely sequence for tautomerization and to explain the relatively slow rate of reversion of the final photoproduct to the original form. They also measure the total energies of the original compound and the two tautomers and examine changes in the geometries that accompany the hydrogen atom migrations. The reason a non-photochromic form of α-DNBP can be found is explained by citing the specific geometric requirements for photochromism in the solid state of an optimal polymorph. The molecular modeling clearly demonstrates the importance of crystal geometric restraints in both the optimal polymorph and the two, diverse photoproducts arising from pho...