Search

Supplemental material, sj-docx-1-eso-10.1177_23969873231156260 for Sex and gender differences in acute stroke care: metrics, access to treatment and outcome. A territorial analysis of the Stroke Code System of Catalonia by Yolanda Silva, Laura Sánchez-Cirera, Mikel Terceño, Laura Dorado, Adrián Valls, Marina Martínez, Sònia Abilleira, Marta Rubiera, Helena Quesada, Laura Llull, Ana Rodríguez-Campello-Campello, Joan Martí-Fàbregas, Laia Seró, Francisco Purroy, Iago Payo, Sònia García, David Cánovas, Jurek Krupinski, Natalia Mas, Ernest Palomeras, Dolores Cocho, Maria Àngels Font, Esther Catena, Elsa Puiggròs, Claudia Pedroza, Gemma Marín, Dolors Carrión, Xavier Costa, Mari Cruz Almendros, Ivan Torres, Carla Colom, John Alejandro Velasquez, Gloria Diaz, Xavier Jiménez, Teresa Subirats, Anna Deulofeu, Verónica Hidalgo, Mercè Salvat-Plana and Natalia Pérez de la Ossa in European Stroke Journal

Supplemental material, sj-docx-1-wso-10.1177_17474930221089772 for First pass effect in posterior circulation occlusions: Analysis from the CICAT registry by Mikel Terceño, Yolanda Silva, Saima Bashir, Ángel Chamorro, Natalia Pérez de la Ossa, María Hernandez-Pérez, Carlos Castaño, Pol Camps-Renom, Denisse Wenger, Pere Cardona, Carlos Molina, Ana Rodríguez-Campello, David Cánovas, Francisco Purroy, Mercè Salvat-Plana and Joaquín Serena in International Journal of Stroke

Supplemental material, ESO901616 Supplemental material for Influence of time to admission to a comprehensive stroke centre on the outcome of patients with intracerebral haemorrhage by Luis Prats-Sánchez, Marina Guasch-Jiménez, Ignasi Gich, Elba Pascual-Goñi, Noelia Flores, Pol Camps-Renom, Daniel Guisado-Alonso, Alejandro Martínez-Domeño, Raquel Delgado-Mederos, Ana Rodríguez-Campello, Angel Ois, Alejandra Gómez-Gonzalez, Elisa Cuadrado-Godia, Jaume Roquer and Joan Martí-Fàbregas in European Stroke Journal

Supplemental material, sj-pdf-1-wso-10.1177_1747493020976247 for Impact of general anesthesia on posterior circulation large vessel occlusions after endovascular thrombectomy by Mikel Terceño, Yolanda Silva, Saima Bashir, Víctor A Vera-Monge, Pere Cardona, Carlos Molina, Ángel Chamorro, Natalia P de la Ossa, María Hernández-Pérez, Mariano Werner, Pol Camps-Renom, Ana Rodríguez-Campello, David Cánovas, Francisco Purroy, Joaquín Serena and on behalf of the Catalan Stroke Code and Reperfusion Consortium (Cat-SCR) in International Journal of Stroke

Supplemental material, sj-pdf-1-wso-10.1177_1747493020976247 for Impact of general anesthesia on posterior circulation large vessel occlusions after endovascular thrombectomy by Mikel Terceño, Yolanda Silva, Saima Bashir, Víctor A Vera-Monge, Pere Cardona, Carlos Molina, Ángel Chamorro, Natalia P de la Ossa, María Hernández-Pérez, Mariano Werner, Pol Camps-Renom, Ana Rodríguez-Campello, David Cánovas, Francisco Purroy, Joaquín Serena and on behalf of the Catalan Stroke Code and Reperfusion Consortium (Cat-SCR) in International Journal of Stroke

[Rationale] Ischemic stroke is among the leading causes of adult disability. Part of the variability in functional outcome after stroke has been attributed to genetic factors but no locus has been consistently associated with stroke outcome. [Objective] Our aim was to identify genetic loci influencing the recovery process using accurate phenotyping to produce the largest GWAS (genome-wide association study) in ischemic stroke recovery to date. [Methods and Results] A 12-cohort, 2-phase (discovery-replication and joint) meta-analysis of GWAS included anterior-territory and previously independent ischemic stroke cases. Functional outcome was recorded using 3-month modified Rankin Scale. Analyses were adjusted for confounders such as discharge National Institutes of Health Stroke Scale. A gene-based burden test was performed. The discovery phase (n=1225) was followed by open (n=2482) and stringent joint-analyses (n=1791). Those cohorts with modified Rankin Scale recorded at time points other than 3-month or incomplete data on previous functional status were excluded in the stringent analyses. Novel variants in PATJ (Pals1-associated tight junction) gene were associated with worse functional outcome at 3-month after stroke. The top variant was rs76221407 (G allele, β=0.40, P=1.70×10−9). [Conclusions] Our results identify a set of common variants in PATJ gene associated with 3-month functional outcome at genome-wide significance level. Future studies should examine the role of PATJ in stroke recovery and consider stringent phenotyping to enrich the information captured to unveil additional stroke outcome loci. Genetic contribution to functional outcome and disability after stroke (GODS) project, Fundació Marató-TV3 Grant 2011 (76/C/2011), Recercaixa’13; Generación Project, Instituto de Salud Carlos III; GENISIS (Genetics of Early Neurological InStability After Ischemic Stroke) project, National Institutes of Health (NIH); National Institute of Neurological Disorders and Stroke Stroke Genetics Network (SiGN) Project, NIH.

Ischemic stroke is associated with aging. It is possible to predict chronological age by measuring age-related changes in DNA methylation from multiple CpG sites across the genome, known as biological age. The difference between biological age and actual chronological age would indicate an individual's level of aging. Our aim was to determine the biological age of ischemic stroke patients and compare their aging with controls of the same chronological age. A total of 123 individuals, 41 controls and 82 patients with ischemic stroke were paired by chronological age, ranging from 39 to 82 years. Illumina HumanMethylation450 BeadChip array was used to measure DNA methylation in CpG sites in both groups, and biological age was estimated using methylation values of specific CpGs. Ischemic stroke patients were biologically an average 2.5 years older than healthy controls (p-value=0.010). Stratified by age tertiles, younger stroke patients (≤57 years old) were biologically older than controls (OR=1.19; 95%CI 1.00-1.41, p-value=0.046). The older groups showed no biological age differences between cases and controls, but were close to reaching the significance level. Ischemic stroke patients are biologically older than controls. Biological age should be considered as a potential new biomarker of stroke risk. This project was funded in part by the following sources: Agència de Gestió Ajuts Universitaris de Recerca (2014 SGR 1213); Spain’s Ministry of Health (Ministerio de Sanidad y Consumo) through the Carlos III Health Institute (ISCIII-FIS-FEDER-ERDF, PI12/01238, PI15/00451, PI15/00445); the Red de Investigacion Cardiovascular, Instituto de Salud Carlos III RETIC (RD12/0042/0020, RD12/0042/0013); and a RecerCaixa 2013 research grant (JJ086116). S.S-B. is funded by an iPFIS contract from Instituto de Salud Carlos III (IFI14/00007).

Objetivos: Analizar si existen diferencias dietéticas y antropométricas entre pacientes con ictus isquémico y controles de una misma población y evaluar si existen diferencias por género y subtipos de ictus. Se estudió también si los patrones dietéticos de prevención eran igual de saludables en los pacientes con ictus isquémico y en los controles. Material y métodos: Estudio prospectivo que incluyó pacientes ingresados con el diagnóstico de ictus isquémico y controles sanos. Se registraron datos demográficos, antropométricos (peso, talla y perímetro abdominal), edad, sexo y factores de riesgo vascular. En un subgrupo de sujetos se evaluaron los hábitos dietéticos mediante un cuestionario de frecuencia de alimentos validado, que registra la ingesta habitual de nutrientes durante el año previo. Se cuantificó el consumo de los macronutrientes que se han descrito asociados a un aumento de incidencia de ictus, las diferentes formas de preparar los alimentos y los hábitos alimenticios para controlar el riesgo vascular antes del ictus. Resultados: Se observó una mayor ingesta calórica en los pacientes con ictus que en los controles, de proteínas (p< 0.001; OR 1.02), de colesterol total (P=0.001; OR 1.04) y de alimentos rebozados (p=0.001; OR 1.94) y un menor consumo de yogur con lactobacilos (p=0.002; OR 0.88). Se observaron también diferencias entre los subtipos de ictus. No se constataron diferencias entre sexos respecto al consumo calórico, ingesta de nutrientes o forma de procesar los alimentos. Los controles referían una mayor propensión a seguir una dieta saludable y las mujeres con ictus isquémico estaban más concienciadas para mantener hábitos dietéticos saludables que los hombres. En el estudio univariado, el incremento del IMC no se asoció con un aumento de riesgo de ictus en mujeres o de forma global, pero fue un factor protector en hombres (p=0.03; OR 0.59 [0.37-0.94]). Estratificada por sexo, la obesidad abdominal se asoció significativamente con el riesgo de ictus en las mujeres, tanto en medidas de circunferencia de cintura (p, Objectives: To analyze if there are dietary and anthropometric differences between patients with ischemic stroke and controls of the same population and to evaluate if there are differences by gender and stroke subtypes. It was also studied whether dietary prevention patterns were equally healthy in patients with ischemic stroke and in controls. Material and methods: Prospective study that included hospitalized patients with a diagnosis of ischemic stroke and healthy controls. Demographic and anthropometric data (weight, height, and waist circumference), age, sex and vascular risk factors were recorded. In a subgroup of subjects, dietary habits were assessed using a validated food frequency questionnaire, recording the usual intake of nutrients during the previous year. The consumption of macronutrients described associated with an increase in the incidence of stroke, the different ways of preparing food and eating habits to control the vascular risk before the stroke were quantified. Results: A higher caloric intake was observed in patients with stroke than in controls, proteins (p