Author: "Rossi Giuseppe" / Language: undetermined - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"Rossi Giuseppe"' showing total 44 results

Start Over Author "Rossi Giuseppe" Language undetermined

44 results on '"Rossi Giuseppe"'

1. sj-pdf-1-tmj-10.1177_03008916231153698 – Supplemental material for Acute myeloid leukemia: Incidence, transplantation and survival through Italian administrative healthcare data

Author: Calabria, Silvia, Ronconi, Giulia, Dondi, Letizia, Piccinni, Carlo, Pedrini, Antonella, Esposito, Immacolata, Addesi, Alice, Rossi, Giuseppe, Ferrara, Felicetto, Venditti, Adriano, and Martini, Nello
Subjects: Medicine
Abstract: Supplemental material, sj-pdf-1-tmj-10.1177_03008916231153698 for Acute myeloid leukemia: Incidence, transplantation and survival through Italian administrative healthcare data by Silvia Calabria, Giulia Ronconi, Letizia Dondi, Carlo Piccinni, Antonella Pedrini, Immacolata Esposito, Alice Addesi, Giuseppe Rossi, Felicetto Ferrara, Adriano Venditti and Nello Martini in Tumori Journal
Published: 2023
Full Text: View/download PDF

2. sj-pdf-1-tmj-10.1177_03008916231153698 – Supplemental material for Acute myeloid leukemia: Incidence, transplantation and survival through Italian administrative healthcare data

Author: Calabria, Silvia, Ronconi, Giulia, Dondi, Letizia, Piccinni, Carlo, Pedrini, Antonella, Esposito, Immacolata, Addesi, Alice, Rossi, Giuseppe, Ferrara, Felicetto, Venditti, Adriano, and Martini, Nello
Subjects: Medicine
Abstract: Supplemental material, sj-pdf-1-tmj-10.1177_03008916231153698 for Acute myeloid leukemia: Incidence, transplantation and survival through Italian administrative healthcare data by Silvia Calabria, Giulia Ronconi, Letizia Dondi, Carlo Piccinni, Antonella Pedrini, Immacolata Esposito, Alice Addesi, Giuseppe Rossi, Felicetto Ferrara, Adriano Venditti and Nello Martini in Tumori Journal
Published: 2023
Full Text: View/download PDF

3. SCRIVERE OGGI ALL’UNIVERSITÀ. Atti del Convegno di studi – Università degli Studi di Milano 6-7 maggio 2019

Author: Marina Brambilla, Valentina Crestani, Carla Marello, Alina Masla, Michele Daloiso, Benoît Monginot, Sibylle Orlandi, Margaret Rose, Francesca Gatta. , Contributi di Michela Dota, Giuseppe Polimeni, Massimo Prada, Giuliana Fiorentino, Alessio Ricci, Eugenio Salvatore, Laura Clemenzi, Fabio Ruggiano, Silvia Demartini, Daniele D’Aguanno, Claudia Tarallo, Fabio Rossi, Giuseppe Sergio, Clara Bulfoni
Abstract: Scrivere oggi all’Università Atti del Convegno di studi –Università degli Studi di Milano 6-7 maggio 2019 A cura di Michela Dota, Giuseppe Polimeni, Massimo Prada
Published: 2020
Full Text: View/download PDF

4. Percutaneous irreversible electroporation in combination with radiofrequency ablation in the treatment of non-resectable hepatocellular carcinoma: A case report

Author: Rossi Giuseppe, Ragone Enrico, Sanges Federica, and Scarica Sabrina
Subjects: medicine.medical_specialty, Percutaneous, Resectable Hepatocellular Carcinoma, Radiofrequency ablation, law, business.industry, General Engineering, Medicine, Irreversible electroporation, Radiology, business, law.invention
Abstract: Introduction: There are more option of treatments of hepatocellular carcinoma (HCC), that is currently the sixth most common cancer worldwide. As only 10–20% of patients are candidates for surgery (resection or transplantation), ablative therapies such as Radiofrequency (RF) and Microwave (MW) ablation are both widely used techniques, but tumors adjacent to heat-sensitive structures such as the gallbladder, major bile ducts, portal vein, and hepatic veins are difficult to destroy. Irreversible electroporation (IRE) is a new non-thermal ablation technique for pancreatic and liver tumors that generates electrical fields leading to cell death through apoptosis. In this way IRE prevents collateral damage to other tissues, such as blood vessels, bile ducts, nerves, gallbladder and other vital organs which often occur in thermal ablation techniques. Case Report: We report the treatment of an inoperable HCC with a maximum diameter of 40 mm in left lobe at the 4th hepatic segment, adjacent to the gallbladder in a 75-year-old female with hepatitis C–related cirrhosis. It was used for the first time a dual thermal and nonthermal ablative technique: ultrasound–guided irreversible electroporation ablation (IRE) following ultrasound–guided radiofrequency ablation (RFA) in the same session. We got complete response at 1, 3 and 6 months follow-up without evidenced of local tumor progression or metastatic disease. Conclusion: Combination therapy plays an important role in the treatment of unresectable HCC, because near vital structures, but additional research is necessary to assess further the safety, efficacy and long-term outcomes for this combination therapy.
Published: 2018
Full Text: View/download PDF

5. The Long Wave of Prohibition: Alcohol Trade Laws in the US

Author: Rossi , Giuseppe
Abstract: Il saggio offre una panoramica della regolazione del commercio di alcoolici negli USA, partendo dalle origini del Temperance Movement sino ad oggi, ed alcuni spunti di comparazione con il diritto dell’UE. Viene sottolineata la persistenza dell’influenza del Proibizionismo sull’attuale disciplina, nell’ottica di sottolineare l’importanza del clima culturale sulle scelte regolatorie relative ad alcoolici e sostanze psicotrope., Cibo e diritto. Una prospettiva comparata. Volume 2
Published: 2020
Full Text: View/download PDF

6. Reasons for initiating long-acting antipsychotics in psychiatric practice: findings from the STAR Network Depot Study

Author: Barbui, Corrado, Bertolini, Federico, Bartoli, Francesco, Calandra, Carmela, Callegari, Camilla, Carrà, Giuseppe, D’Agostino, Armando, Lucii, Claudio, Martinotti, Giovanni, Mastromo, Daniele, Moretti, Daniele, Monzani, Emiliano, Porcellana, Matteo, Prestia, Davide, Ostuzzi, Giovanni, Nose, Michela, Purgato, Marianna, Turrini, Giulia, Mazzi, Maria, Angela, Papola, Davide, Gastaldon, Chiara, Terlizzi, Samira, Piccoli, Alberto, Ruggeri, Mirella, De Fazio, Pasquale, Magliocco, Fabio, Caroleo, Mariarita, Raffaele, Gaetano, D'Agostino, Armando, Ostinelli, Edoardo, Giuseppe, Chirico, Margherita, Cavallotti, Simone, Bolognesi, Simone, Debolini, Sara, Pierantozzi, Elisa, Fargnoli, Francesco, Del Zanna, Maria, Giannini, Alessandra, Luccarelli, Livia, De Capua, Alberto, Annese, Pasqua, Maria, Cerretini, Massimiliano, Tozzi, Fiorella, Magnani, Nadia, Cardamone, Giuseppe, Bardicchia, Francesco, Facchi, Edvige, Soscia, Federica, Zotos, Spyridon, Biancosino, Bruno, Zonta, Filippo, Pompei, Francesco, Zizolfi, Daniele, Poloni, Nicola, Ielmini, Marta, Caselli, Ivano, Giana, Edoardo, Buzzi, Aldo, Emanuele, Diurni, Marcello, Milano, Anna, Sani, Emanuele, Calzolari, Roberta, Bortolaso, Paola, Piccinelli, Marco, Cazzamalli, Sara, Caterina, Alberini, Gabro, Piantanida, Silvia, Costantini, Chiara, Paronelli, Chiara, Di Caro, Angela, Moretti, Valentina, Gozzi, Mauro, D'Ippolito, Chiara, Barbanti Silva, Veronica, Papalini, Alessandro, Corbo, Mariangela, Campese, Ornella, Fiori, Federica, Lorusso, Marco, Di Capro, Lucia, Viceconte, Daniela, Mancini, Valerio, Suraniti, Francesco, Signorelli, Maria, Salvina, Rossi, Eugenio, Lupoli, Pasqualino, Menchetti, Marco, Terzi, Laura, Boso, Marianna, Risaro, Paolo, De Paoli, Giuseppe, Catania, Cristina, Tarricone, Ilaria, Caretto, Valentina, Storbini, Viviana, Emiliani, Roberta, Balzarro, Beatrice, Carra, Giuseppe, Tabacchi, Tommaso, Nava, Roberto, Bono, Adele, Provenzi, Milena, Brambilla, Giulia, Aspesi, Flora, Tremolada, Martina, Castagna, Gloria, Bava, Mattia, Verrengia, Enrica, Lucchi, Sara, Oriani, Maria, Ginevra, Barchiesi, Michela, Pacetti, Monica, Aguglia, Andrea, Magni, Laura, Rosa, Rossi, Giuseppe, Beneduce, Rossella, Tura, Giovanni, Battista, Laffranchini, Laura, Ferrato, Farida, Restaino, Francesco, Limosani, Ivan, Ghio, Lucio, Ferro, Maurizio, Parise, Vincenzo, Fricchione, Balletta, Giovanni, Addeo, Lelio, De Vivo, Elisa, Di Benedetto, Rossella, Pinna, Federica, Carpiniello, Bernardo, Spano, Mariangela, Giacomin, Marzio, Pecile, Damiano, Mattei, Chiara, Fabrici, Elisabetta, Pascolo, Panarello, Sofia, Peresson, Giulia, Vitucci, Claudio, Bonavigo, Tommaso, Perini, Giovanni, Boschello, Filippo, Strizzolo, Stefania, Gardellin, Francesco, Di Giannantonio, Massimo, Fizzotti, Carlo, Cossetta, Edoardo, Di Gregorio, Luana, Sozzi, Francesca, Boncompagni, Giancarlo, La Barbera, Daniele, Colli, Giuseppe, Laurenzi, Sabrina, Luca, Maria, Crocamo, Carlo, Barbui, C, Bertolini, F, Bartoli, F, Calandra, C, Callegari, C, Carrà, G, D'Agostino, A, Lucii, C, Martinotti, G, Mastromo, D, Moretti, D, Monzani, E, Porcellana, M, Prestia, D, and Ostuzzi, G
Subjects: medicine.medical_specialty, psychiatric practice, lcsh:RC435-571, Treatment adherence, viruses, medicine.medical_treatment, antipsychotic, long-acting injectable, prescribing attitudes, survey, immune system diseases, lcsh:Psychiatry, medicine, Psychiatry, Antipsychotic, prescribing attitude, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), Original Research, business.industry, lcsh:RM1-950, virus diseases, lcsh:Therapeutics. Pharmacology, Long acting, Psychology (miscellaneous), business
Abstract: Background: Long acting injectable (LAI) antipsychotics have been claimed to ensure treatment adherence and possibly reduce the daily burden of oral formulations. So far, only surveys investigating the theoretical prescribing attitudes of clinicians have been employed. On this basis, we aimed to investigate reasons for prescribing LAIs in a real-world, unselected sample of patients. Methods: The STAR Network Depot Study is an observational, multicentre study consecutively enrolling adults initiating a LAI over a 12-months period. Clinical severity was assessed with the Brief Psychiatric Rating Scale, and patient’s attitude toward medications with the Drug Attitude Inventory 10 items. Psychiatrists recorded reasons for LAI prescribing for each study participant. Responses were grouped into six non-mutually exclusive categories: aggressiveness, patient engagement, ease of drug taking, side-effects, stigma, adherence. Results: Of the 451 patients included, two-thirds suffered from chronic psychoses. Improving patient engagement with the outpatient psychiatric service was the most common reason for prescribing LAIs (almost 80% of participants), followed by increasing treatment adherence (57%), decreasing aggressiveness (54%), and improving ease of drug taking (52%). After adjusting for confounders, logistic regression analyses showed that reasons for LAI use were associated with LAI choice (e.g. first-generation LAIs for reducing aggressiveness). Conclusion: Despite the wide availability of novel LAI formulation and the emphasis on their wider use, our data suggest that the main reasons for LAI use have remained substantially unchanged over the years, focusing mostly on improving patient’s engagement. Further, clinicians follow implicit prescribing patterns when choosing LAIs, and this may generate hypotheses for future experimental studies.
Published: 2020

7. Supplemental Material, sj-doc-1-ear-10.1177_0145561320981447 - Alteration of Smell and Taste in Asymptomatic and Symptomatic COVID-19 Patients in Sicily, Italy

Author: Bianco, Maria Rita, Modica, Domenico M., Drago, Gaetano D., Azzolina, Alfio, Mattina, Gianfranco, Natale, Massimo De, Rossi, Giuseppe, Amata, Marta, Canzoneri, Gaspare, Manganaro, Giovanni, Gregorio, Francesco Di, Russo, Rosario, Pricoco, Salvatore, Saita, Vincenzo, and Allegra, Eugenia
Subjects: 110315 Otorhinolaryngology, FOS: Clinical medicine
Abstract: Supplemental Material, sj-doc-1-ear-10.1177_0145561320981447 for Alteration of Smell and Taste in Asymptomatic and Symptomatic COVID-19 Patients in Sicily, Italy by Maria Rita Bianco, Domenico M. Modica, Gaetano D. Drago, Alfio Azzolina, Gianfranco Mattina, Massimo De Natale, Giuseppe Rossi, Marta Amata, Gaspare Canzoneri, Giovanni Manganaro, Francesco Di Gregorio, Rosario Russo, Salvatore Pricoco, Vincenzo Saita and Eugenia Allegra in Ear, Nose & Throat Journal
Published: 2020
Full Text: View/download PDF

8. Monitoring of coffee tree growth through crop surface models and MGVRI with images obtained with RPA

Author: ARAUJO E SILVA FERRAZ, Gabriel, Luana Mendes dos Santos, Marco Thulio Andrade, Letícia Aaparecida Gonçalves Xavier, Diogo Tubertini Maciel, FERREIRA PONCIANO FERRAZ, Patricia, Rossi, Giuseppe, and Barbari, Matteo
Subjects: Precision Agriculture, plant height, remote sensing, UAS, index vegetation
Published: 2019

9. Physical proprieties of alternative bedding materials for dairy cattle

Author: FERREIRA PONCIANO FERRAZ, Patricia, Rossi, Giuseppe, Conti, Leonardo, ARAUJO E SILVA FERRAZ, Gabriel, Leso, Lorenzo, and Barbari, Matteo
Subjects: Bulk density, dairy cows, Miscanthus, porosity, straw, water holding capacity
Published: 2019

10. La Libreria Mediceo-Laurenziana

Author: Rossi, Giuseppe Ignazio
Abstract: Scelta di architetture antiche e moderne della citt�� di Firenze, 4,2
Published: 2017
Full Text: View/download PDF

11. A new Risk-Adjusted Bernoulli CUSUM chart for monitoring binary health data

Author: Rossi, Giuseppe, DEL SARTO, Simone, and Marchi, Marco
Published: 2016

12. The use of anthracycline at first-line compared to alkylating agents or nucleoside analogs improves the outcome of salvage treatments after relapse in follicular lymphoma The REFOLL study by the Fondazione Italiana Linfomi

Author: Rossi, Giuseppe, Marcheselli, Luigi, Dondi, Alessandra, Bottelli, Chiara, Tucci, Alessandra, Luminari, Stefano, Arcaini, Luca, Merli, Michele, Pulsoni, Alessandro, Boccomini, Carola, Puccini, Benedetta, Micheletti, Moira, Martinelli, Giovanni, Rossi, Andrea, Zilioli, Vittorio Ruggero, Bozzoli, Valentina, Balzarotti, Monica, Bolis, Silvia, Cabras, Maria Giuseppina, and Federico, Massimo
Subjects: Male, Salvage Therapy, Nucleosides, Kaplan-Meier Estimate, Middle Aged, Disease-Free Survival, Antibodies, Monoclonal, Murine-Derived, Treatment Outcome, follicular lymphoma, Italy, Recurrence, Antineoplastic Combined Chemotherapy Protocols, Humans, Anthracyclines, Female, Rituximab, anthracyclines, retrospective studies, rituximab, treatment outcome, salvage therapy, Antineoplastic Agents, Alkylating, Lymphoma, Follicular, Aged, Retrospective Studies
Abstract: Follicular lymphoma (FL) patients experience multiple remissions and relapses and commonly receive multiple treatment lines. A crucial question is whether anthracyclines should be used at first-line or whether they would be better "reserved" for relapse and whether FL outcome can be optimized by definite sequences of treatments. Randomized trials can be hardly designed to address this question. In this retrospective multi-institutional study, time-to-next-treatment after first relapse was analyzed in 510 patients who had received either alkylating agents- or anthracycline- or nucleoside analogs-based chemotherapy with/without rituximab at first-line and different second-line therapies. After a median of 42 months, median time-to-next-treatment after relapse was 41 months (CI95%:34-47 months). After adjustment for covariates, first-line anthracycline-based chemotherapy with/without rituximab was associated with better time-to-next-treatment after any salvage than alkylating agents-based chemotherapy with/without rituximab or nucleoside analogs-based chemotherapy with/without rituximab (HR:0.74, P = 0.027). The addition of rituximab to first-line chemotherapy had no significant impact (HR:1.22, P = 0.140). Autologs stem cell transplantation performed better than any other salvage treatment (HR:0.53, P 0.001). First-line anthracycline-based chemotherapy significantly improved time-to-next-treatment even in patients receiving salvage autologs stem cell transplantation (P = 0.041). This study supports the concept that in FL previous treatments significantly impact on the outcome of subsequent therapies. The outcome of second-line treatments, either with salvage chemoimmunotherapy or with autologs stem cell transplantation, was better when an anthracycline-containing regimen was used at first-line.
Published: 2014

13. Autologous stem cell transplantation with in vivo purged progenitor cells shows long-term efficacy in relapsed/refractory follicular lymphoma

Author: Arcaini, Luca, Morello, Lucia, Tucci, Alessandra, Rusconi, Chiara, Ladetto, Marco, Rattotti, Sara, Bonfichi, Maurizio, Bottelli, Chiara, Gabutti, Cristina, Bernasconi, Paolo, Varettoni, Marzia, Gotti, Manuel, Troletti, Daniela, Guerrera, Maria Luisa, Fiaccadori, Valeria, Sciarra, Roberta, Ferretti, Virginia Valeria, Alessandrino, Emilio Paolo, Rossi, Giuseppe, and Morra, Enrica
Subjects: Murine-Derived, Adult, Male, Lymphoma, Gene Expression, Transplantation, Autologous, Antibodies, Aged, Anthracyclines, Antibodies, Monoclonal, Murine-Derived, Cyclophosphamide, Female, Hematopoietic Stem Cell Mobilization, Humans, Lymphoma, Follicular, Middle Aged, Neoplasm Grading, Prednisone, Prospective Studies, Proto-Oncogene Proteins c-bcl-2, Recurrence, Rituximab, Survival Analysis, Treatment Outcome, Vincristine, Antineoplastic Combined Chemotherapy Protocols, Hematopoietic Stem Cell Transplantation, Hematology, Monoclonal, Transplantation, Follicular, Autologous
Abstract: High-dose chemotherapy with autologous stem cell transplantation (ASCT) has been shown effective in the control of relapsed/refractory follicular lymphoma. We evaluate the long-term outcome of patients with relapsed or refractory follicular lymphoma treated with ASCT with in vivo purged progenitors cells. We report the long-term results of a prospective multicenter phase 2 trial on 124 relapsed/refractory follicular lymphoma patients treated with a program of anthracycline-based debulking chemotherapy, immunochemotherapy, mobilization of in vivo purged PBSC followed by ASCT. Median age was 52 years; 14% of patients had grade 3A histology. Debulking chemotherapy produced CR in 16% and PR in 71%, while 13% of patients progressed. After rituximab, cyclophosphamide, vincristine, prednisone (R-COP), CR was obtained in 60% and PR in 35%; 118 patients successfully mobilized PBSC and 117 proceeded to ASCT. The harvest in all the 32 molecularly informative patients was bcl-2 negative. TRM was 0%. The 5-year PFS was 54% and the 5-year OS was 83%. After a median f-up of 6.7 years (range 1.5-13.6), 54% are still in CR. These data show that prolonged PFS is achievable in relapsed/refractory patients with high dose autologous transplantation of in vivo purged progenitor cells.
Published: 2014

14. [Equity of access to percutaneous transluminal coronary angioplasty (PTCA) among patients with acute myocardial infarction in Tuscany Region (Central Italy), 2001-2008]

Author: Falcone, Manuele, Del Sarto, Simone, Forni, Silvia, Pepe, Pasquale, Marchi, Marco, and Rossi, Giuseppe
Subjects: Adult, Aged, 80 and over, Male, Angioplasty, Coronary, Myocardial Infarction, Middle Aged, Health Services Accessibility, Young Adult, Italy, 80 and over, Humans, Female, Angioplasty, Balloon, Coronary, Balloon, Aged
Abstract: assessing the equity in the access to the percutaneous transluminal coronary angioplasty (PTCA) and in its time trend among patients with ST-elevation acute myocardial infarction.observational study based on regional administrative data: Hospital Discharge Registry, Health Registry, and 2001 Census data. Two indexes were used as deprivation measure: deprivation status at small area level (as proxy of the individual deprivation) and deprivation status at Local Health Agency level. The residence in a mountain municipality was used as extra measure of contextual deprivation.patients with first emergency hospital admission for acute myocardial infarction (AMI) with ST-elevation, resident in Tuscany Region (Central Italy) and hospitalized during the period 2001-2008.relative risk (RR) of the PTCA utilization.multivariate analysis by multilevel multiple logistic regression showed a significant lower PTCA utilization in females (RR: 0.91, p0.0001), in patients with high deprivation status at Local Health Agency level (RR: 0.71, p0.0001), in residents in a mountain municipality (RR: 0.90, p0.0001), and in patients with comorbidity (RR: 0.98, p =0.006; RR: 0.87, p0.0001; RR: 0.69, p0.0001 for Charlson comorbidity index equal to 1, 2, ≥3, respectively). The PTCA utilization over time has grown significantly (p0.0001), from 26.6% in 2001 to 57.4% in 2008. This increase was more pronounced in patients with high deprivation status at Local Health Agency level (RR: 4.01, p0.0001 for year 2008 vs. 2001), with consequent reduction of the initial differential with respect to patients with low deprivation status at Local Health Agency level (RR: 0.40, p0.0001 in 2001 and RR: 0.93, p =0.114 in 2008). However, the differential associated with gender and residence in a mountain municipality persisted over time.In Tuscany during the period 2001-2008 a significant reduction of the differential in the PTCA utilization associated with the deprivation status at Local Health Agency level was observed. This finding could be explained by the diffusion and organization of suitable invasive cardiology units in the region, the organizational models of care, the different propensity to the PTCA utilization by the referral hospitals.
Published: 2014

15. Randomized Phase II Trial on Primary Chemotherapy with High-Dose Methotrexate Alone or Associated with High-DoseCytarabine for Patients with Primary CNS Lymphoma (IELSG #20 Trial): Tolerability, Activity and Event-Free Survival Analysis

Author: Ferreri Andres J. M., Reni Michele, Foppoli Marco, Marteili Maurizio, Siakantaris Marina, Frezzato Maurizio, Cabras Maria Giuseppina, Fabbri Alberto, Corazzelli Gaetano, Ilariucci Fiorella, Rossi Giuseppe, Soffietti Riccardo, Stelitano Caterina, Vallisa Daniele, Zaja Francesco, Gelemur Marta, Aondio Gian Marco, Avvisati Giuseppe, Balzarotti Monica, Brandes Alba, Costa Maria Joao, Gomez Henry, Guarini Attilio, Pinotti Graziella, Rigacci Luigi, Uhlmann Catrina, Angelopoulou Maria, Tirindelli Maria, Naso Virginia, Franzin Alberto, ANZALONE, NICOLETTA EMANUELA, Ponzoni Maurilio, Zucca Emanuele, Caligaris Cappio Federico, Cavalli Franco, Ferreri Andres, J. M., Reni, Michele, Foppoli, Marco, Marteili, Maurizio, Siakantaris, Marina, Frezzato, Maurizio, Cabras Maria, Giuseppina, Fabbri, Alberto, Corazzelli, Gaetano, Ilariucci, Fiorella, Rossi, Giuseppe, Soffietti, Riccardo, Stelitano, Caterina, Vallisa, Daniele, Zaja, Francesco, Gelemur, Marta, Aondio Gian, Marco, Avvisati, Giuseppe, Balzarotti, Monica, Brandes, Alba, Costa Maria, Joao, Gomez, Henry, Guarini, Attilio, Pinotti, Graziella, Rigacci, Luigi, Uhlmann, Catrina, Angelopoulou, Maria, Tirindelli, Maria, Naso, Virginia, Franzin, Alberto, Anzalone, NICOLETTA EMANUELA, Ponzoni, Maurilio, Zucca, Emanuele, Caligaris Cappio, Federico, and Cavalli, Franco
Published: 2008

16. La 'devolution' dell'antitrust. Prime riflessioni intorno al 'libro bianco' sulla modernizzazione

Author: Frignani Aldo, Gentile Enrico, and Rossi Giuseppe
Abstract: The white paper on modernisation by the EC Commission provides for a survey of the problems arising out of the obsoleteness of regulation n. 17/62, and some proposals to modify the current system of application of art. 81.3 of the Treaty. The most relevant of such proposals is the introduction of a system of "directly applicable exception", under which the agreements which satisfy the requirements for the exemption will be held valid ever since they are entered into without any decision by the Commission being needed. Though the proposal is based on sound reasons, many questions are left unanswered. The Authors analyse the white paper with some criticism, wondering whether the proposal is apt to reach its aim or not.
Published: 2000
Full Text: View/download PDF

17. NONLINEAR ANALYSIS OF AN HISTORICAL BUILDING UNDER EARTHQUAKE LOADING

Author: Clemente, Paolo, Buffarini, Giacomo, Saitta, Fernando, Rossi, Giuseppe, Bongiovanni, Giovanni, Rinaldis, Dario, Rinaldis, D., Clemente, P., Buffarini, G., Bongiovanni, Giovanni, and Saitta, F.
Abstract: Palazzo Marchesale in San Giuliano di Puglia (Italy) is an old masonry structure hosting the new City Hall. It is quite complex and is characterized by several parts with different height and foundation levels, and includes an internal court. After the 2002 earthquake (2 shocks of ML=5.4 and ML=5.3, respectively), the building was retrofitted and seismic joints were realized between the different buildings, in order to regularize its dynamic behaviour. The structure has been considered for seismic monitoring in the framework of a research project funded by the Office for the reconstruction of San Giuliano di Puglia. Therefore a permanent accelerometric array has been designed and installed. It was tested by deploying also a temporary array in different configurations and recording ambient vibrations and weak motion effects. The experimental results have been used to set up a finite element model, which was used to pursue a nonlinear analysis to evaluate the seismic safety of the structure.
Published: 2014
Full Text: View/download PDF

18. Investigation on rainfall extremes events trough a geoadditive model

Author: Chiara Bocci, ENRICA CAPORALI, Alessandra Petrucci, and Rossi, Giuseppe
Published: 2012

19. A Simple Risk-Adjusted CUSUM chart for monitoring binary health data

Author: Rossi, Giuseppe, DEL SARTO, Simone, and Marchi, Marco
Published: 2012

20. Ricovero avicolo polifunzionale per l'allevamento libero

Author: Barbari, Matteo, Monti, Massimo, Rossi, Giuseppe, and Simonini, Stefano
Subjects: Ricoveri avicoli, allevamento estensivo, autocostruzione
Published: 2011

21. Approximate Poisson CUSUM charts for the monitoring of time series with time-varying mean

Author: Rossi, Giuseppe, DEL SARTO, Simone, and Marchi, Marco
Published: 2010

22. Accounting for both electron--lattice and electron--electron coupling in conjugated polymers: minimum total energy calculations on the Hubbard--Peierls hamiltonian

Author: Rossi, Giuseppe
Subjects: Condensed Matter (cond-mat), FOS: Physical sciences, Condensed Matter
Abstract: Minimum total energy calculations, which account for both electron--lattice and electron--electron interactions in conjugated polymers are performed for chains with up to eight carbon atoms. These calculations are motivated in part by recent experimental results on the spectroscopy of polyenes and conjugated polymers and shed light on the longstanding question of the relative importance of electron--lattice vs. electron--electron interactions in determining the properties of these systems., Comment: 6 pages, Plain TeX, FRL-PSD-93GR2
Published: 1993
Full Text: View/download PDF

23. Peripheral Stem Cell Mobilization with Chemotherapy + G-CSF Priming in a Large Series of Patients with Lymphoma Candidates to Autologous Transplantation. An Analysis of Baseline and Ongoing Predictors of Failure or Suboptimal Stem Cell Collection

Author: Andrea Castelli, Rossi Giuseppe, Enrico Morello, Liliana Baushi, Alessandro Levis, Annamaria Nosari, Umberto Vitolo, Camillo Almici, Gianluca Gaidano, Gianmatteo Pica, Angelo Michele Carella, Francesco Ripamonti, Flavia Salvi, Luca Arcaini, Enrica Morra, and Barbara Botto
Subjects: Oncology, medicine.medical_specialty, Chemotherapy, Mobilization, Cyclophosphamide, business.industry, medicine.medical_treatment, Immunology, Follicular lymphoma, Cell Biology, Hematology, medicine.disease, Biochemistry, Fludarabine, Autologous stem-cell transplantation, Internal medicine, medicine, Cytarabine, Autologous transplantation, business, medicine.drug
Abstract: Abstract 2149 Poster Board II-126 Background Autologous stem cell transplantation (ASCT) is a potentially curative treatment for lymphoma. Adequate stem cell (SC) collection is possible in the majority of cases but poor mobilization remains a major issue in some patients (pts). New agents were recently developed which may improve the rate of SC mobilization. Aims A retrospective analysis was conducted on a large series of lymphoma pts candidates to ASCT in order to identify factors influencing SC mobilization outcome. Potential early markers of poor mobilization were also evaluated. Patients and methods A total of 415 attempts of PBSC collection consecutively performed at 7 Italian centres in 388 pts affected by lymphoma were analyzed. Their median age was 52. A collection of less than 2×106 CD34+ cells/kg was defined as “mobilization failure” and of more than 5×106 CD34+ cells/kg as “good mobilization”. The following parameters were analysed for correlation with mobilization outcome: lymphoma diagnosis, disease status at mobilization, type of mobilizing chemotherapy, bone marrow infiltration at collection, n° of previous lines of therapy, prior use of fludarabine, alkylating agents or radiotherapy. The ratio between circulating CD34+cells/nL and total WBC/μL on the first day of CD34+ count (SCratio) was also analysed, trying to predict mobilization failure. Both univariate and multivariate statistical analyses were performed with SPSS package 13.0. Results Lymphoma diagnosis was diffuse large B cell/Burkitt in 38%, follicular in 10%, mantle in 13%, Hodgkin in 26%, T or NK/T in 6%, and other in 7% of cases. Disease status at apheresis was CR in 25%, chemosensitive in 49% and refractory in 26%. Mobilization was attempted during first-line therapy in 14%, in 37% during second-line and in 26% at third- or subsequent lines of therapy. Fludarabine, alkylating agents and extended-fields radiotherapy had been used prior to mobilization in 5%, 73% and 13% of cases respectively. Marrow infiltration by lymphoma was present in 17,7% and 7,7% of patients had failed a prior mobilization attempt. In 99% of cases (411/415) mobilizing therapy included chemotherapy and G-CSF. Two pts received AMD3100 and 2 G-CSF. Several chemotherapy programs were used for mobilization. For analysis purposes they were grouped as follows: single-agent cyclophosphamide (CTX) in 62 (15,1%); high-dose cytarabine, either single agent or in combination (HD-ARAC) in 143 (34,8%), etoposide-containing regimens in 119 (30,0%), and platinum containing regimens in 108 cases (26,3%). Mobilization failure occurred in 14% (59/415) whereas a good mobilization was obtained in 72% of cases. At univariate analysis mobilization failure was significantly associated with the use of single-agent CTX as mobilizer (p=0.000), with the n° of prior lines of treatment (p=0.006) and with failure of a previous mobilization attempt (p=0.000) whereas a diagnosis of follicular lymphoma (FL) was associated with a reduced risk of mobilization failure (p=0.007). Multivariate analysis confirmed FL as protective factor for mobilization failure (p=0.008) and single agent CTX and a higher n° of prior treatment lines as negative predictive factors (p=0.000 and 0.033 respectively). A “good mobilization” was significantly predicted at univariate analysis by HD-ARAC use as mobilizer (p=0,004) whereas single-agent CTX (p=0.000), n° of prior lines of therapy (p=0.005), prior fludarabine (p=0.035) or alkylating agents (p=0.003) were adverse predictors. Multivariate analysis confirmed HD-ARAC as independent predictive factor for good mobilization (p=0.031) and single-agent CTX and n° of prior lines of therapy as independent negative predictive factors (p=0.000 and 0.003 respectively). A SCratio of less than 10 on the first day of CD34+ count was associated with an increased risk of poor mobilization (p=0.000 risk estimate 0.638). Conclusions In this large series of pts with lymphoma the standard policy of SC mobilization was the use of chemotherapy + G-CSF. Nevertheless collection failed in a significant proportion of cases (14 %) and only 72% of cases reached an optimal SC collection. Predictive factors for mobilization outcome included disease and treatment history, type of lymphoma and type of mobilizing chemotherapy. These data provide the framework to rationally explore the use of new mobilizing agents in patients with lymphoma undergoing SC mobilization with chemotherapy and G-CSF. Disclosures: No relevant conflicts of interest to declare.
Published: 2009
Full Text: View/download PDF

24. Notas bibliográficas

Author: Asensio, Eugenio, Seco, Manuel, Rossi, Giuseppe Carlo, Porqueras MAyo, A., Sánchez Alonso, B., Criado del Val, M., Alvar, Manuel, Ares Montes, José, Llorente, Antonio, de Riquer, Martín, and de Balbín, Rafael
Published: 1957
Full Text: View/download PDF

25. RITUXIMAB AND INFUSIONAL CYCLOPHOSPHAMIDE, DOXORUBICIN AND ETOPOSIDE (CDE) IN COMBINATION WITH HAART: A SAFE AND HIGHLY ACTIVE REGIMEN IN HIV-RELATED NON-HODGKIN'S LYMPHOMAS (NHL)

Author: Michele Spina, Vaccher, Emanuela, Lleshi, Arben, Morra, Aldo, Rossi, Giuseppe, Jaeger, Ulrich, Sparano, Joseph, and Tirelli, Umberto

26. Parent-child Interaction Treatment for Preschoolers with Feeding Disorders

Author: Maestro, Sandra, Cordella, Maria Rosaria, Curzio, Olivia, Intorcia, Claudia, CLAUDIA ROVERSI, Rossi, Giuseppe, Scardigli, Silvia, Silvestri, Virginia, and Calderoni, Sara
Subjects: Feeding and Eating Disorders, Male, Treatment Outcome, Child, Preschool, Humans, Family Therapy, Female, Parent-Child Relations, Child
Abstract: This study examined the immediate outcome of Feeding Disorders (FD) in preschoolers referred to the family treatment program Cerco Asilo.21 children (mean age [SD=1]: 39 months [1]; range 9-65 months) with a diagnosis of FD were included in the treatment for 24 weeks. Specifically, seven subjects were diagnosed with Infantile Anorexia (IA), nine subjects with Sensory Food Aversion (SFA), and five subjects with Feeding Disorder of Caregiver-Infant Reciprocity (FDCIR).The great majority of patients with SFA and with FDCIR resolved the FD, whereas children with IA did not respond well to the treatment.The study's main limitations are the relatively small sample size, and the lack of a control group.Findings suggest that changes in the parentchild relationship could generally promote FD resolution, other than IA. These data may have implications for clinical practice suggesting the need to develop ad hoc intervention protocols tailored to children with IA and their families.

27. [Mortality in the area around Massa-Carrara 10 years after ANIC-Agricoltura and Farmoplant chemical plants were shut down]

Author: Minichilli, Fabrizio, Bartolacci, Simone, Buiatti, Eva, Pierini, Anna, Rossi, Giuseppe, and Fabrizio Bianchi

28. Successful NBCA embolization of a T2 aneurysmal bone cyst

Author: Mavrogenis, Andreas F., Andrea Angelini, Rossi, Giuseppe, Rimondi, Eugenio, Guerra, Giovanni, Ruggieri, Pietro, Mavrogenis AF, Angelini A, Rossi G, Rimondi E, Guerra G, and Ruggieri P
Subjects: Bone Cysts, Aneurysmal, Adolescent, Aneurysmal bone cyst, Angiography, Digital Subtraction, Humans, Female, Embolization, Therapeutic, spine, artificial embolism, Thoracic Vertebrae
Abstract: Surgically accessible aneurysmal bone cysts (ABC) have traditionally been treated with curettage. Selective arterial embolization was initially proposed as a preoperative adjuvant to reduce peroperative bleeding. Currently, the role of embolization has been extended to the definitive treatment of aneurysmal bone cyst of the spine in children, as well as to other locations in the skeleton. The authors describe the technique in a 15-year-old girl with a T2 aneurysmal bone cyst. Digital subtraction angiography was performed for tumor vascular mapping, followed by selective arterial embolization with N-butyl 2 cyanoacrylate (NBCA). Because of persistent local pain, repeat embolization was done at 8 months. Pain relief and progressive ossification of the lesion were now observed. At 4-year follow-up, the patient was asymptomatic, with complete ossification of the lesion. Selective arterial embolization (SAE) is a minimally invasive, safe and effective procedure for the permanent occlusion of the pathological feeding vessels of spinal ABC. It should be considered as the treatment of choice for lesions difficult to access with surgery, especially in young patients. Careful pre-embolization vascular mapping of the lesion, operator's experience and use of NBCA are the keys to success.

29. Directional detection of light dark matter from three-phonon events in superfluid He-4

Author: Caputo, Andrea, Esposito, Angelo, Piccinini, Fulvio, Polosa, Antonio D., and Rossi, Giuseppe
Subjects: Strong interactions, Particle Physics, Exotic Hadron Spectroscopy, evaporation
Abstract: We present the analysis of a new signature for light dark matter detection with superfluid He4: the emission of three phonons. We show that, in a region of mass below the MeV, the kinematics of this process can offer a way to reconstruct the dark matter interaction vertex while providing background rejection via coincidence requirements and directionality. We develop all the theoretical tools to deal with such an observable, and compute the associated differential distributions.

30. Advanced Neuroimaging Study of Molecularly Defined Hereditary Spastic Paraplegias (HSPs)

Author: Martinuzzi, Andrea, Domenico Montanaro, Martino, Nicola, Hlavata, Hana, Rossi, Giuseppe, Paparella, Gabriella, Peruch, Francesca, Rossetto, Maria G., Baratto, Alessandra T., and Bassi, Maria T.

31. Low High-Density Lipoprotein Cholesterol and Abnormal Glucose Control in Idiopathic Left Ventricular Dysfunction

Author: Neglia, Danilo, Sampietro, Tiziana, Vecoli, Cecilia, Liga, Riccardo, Rossi, Giuseppe, Filidei, Elena, Bigazzi, Federico, Patricia Iozzo, Giannessi, Daniela, L Abbate, Antonio, and Rovai, Daniele

32. ABC Subtype, TP53 Mutation and BCL2 Overexpression are Associated with a Worse Outcome in Untreated Poor-Risk Young Diffuse Large B-Cell Lymphoma: Results from the Frontline Phase III BIO-DLBCL04 Study of the Fondazione Italiana Linfomi

Author: Chiappella, Annalisa, Agostinelli, Claudio, Ladetto, Marco, Evangelista, Andrea, Martelli, Maurizio, Angelucci, Emanuele, Balzarotti, Monica, Riccardo Bomben, Cabras, Maria Giuseppina, Diop, Fary, Fabbri, Marco, Gotti, Manuel, Melle, Federica, Merli, Francesco, Motta, Giovanna, Nassi, Luca, Novero, Domenico, Righi, Simona, Rossi, Davide, Rossi, Giuseppe, Stelitano, Caterina, Gattei, Valter, Gaidano, Gianluca, Pileri, Stefano A., and Vitolo, Umberto

33. Safety and Activity of a Dose-Dense Short-Term Chemoimmunotherapy in HIV-Positive Patients with Burkitt Lymphoma (HIV-BL pts): Final Results of the Carmen Phase II Trial

Author: Ferreri, Andres J. M., Michele Spina, Cattaneo, Chiara, Verga, Luisa, Allione, Bernardino, Ferrari, Daris, Rigacci, Luigi, Fumagalli, Luca, Donadoni, Giovanni, Lleshi, Arben, Sassone, Marianna, Rossi, Giuseppe, and Re, Alessandro

34. Bone marrow characteristics predict outcome in a multicenter cohort of primary immune thrombocytopenia patients treated with thrombopoietin analogs

Author: Raffaella Pasquale, Giuseppe Rossi, Nicola Vianelli, Silvia Cantoni, Mariella D'Adda, Marco Ruggeri, Bruno Fattizzo, Monica Carpenedo, Giuseppe Auteri, Doriana Gramegna, Sergio Siragusa, Mariasanta Napolitano, Dario Consonni, Wilma Barcellini, Fattizzo, Bruno, Pasquale, Raffaella, Carpenedo, Monica, Cantoni, Silvia, Auteri, Giuseppe, Gramegna, Doriana, D'Adda, Mariella, Napolitano, Mariasanta, Consonni, Dario, Ruggeri, Marco, Siragusa, Sergio, Rossi, Giuseppe, Vianelli, Nicola, and Barcellini, Wilma
Subjects: Male, Oncology, medicine.medical_specialty, Recombinant Fusion Proteins, Eltrombopag, Bone Marrow Cells, Immune Thrombocytopenic Purpura, Receptors, Fc, Benzoates, chemistry.chemical_compound, Internal medicine, medicine, Humans, Online Only Articles, Thrombopoietin, Retrospective Studies, Purpura, Thrombocytopenic, Idiopathic, Romiplostim, business.industry, Retrospective cohort study, romiplostim, Hematology, Middle Aged, Immune thrombocytopenia, Clinical trial, Hydrazines, medicine.anatomical_structure, chemistry, Cohort, Pyrazoles, Female, Bone marrow, eltrombopag, business, Follow-Up Studies, medicine.drug
Abstract: It is well established that immune thrombocytopenia (ITP) results from increased immune mediated platelet destruction (anti-platelets antibodies, autoreactive T cells, and reduction of regulatory T cells) along with impaired production in the bone marrow.1 The latter has been attributed to both cellular and humoral mediators that cause suppression of megakaryocyte production and maturation.2 Current standard first line therapy consists of corticosteroids, with or without intravenous Ig, achieving about 70-80% response rate. However, a consistent proportion of patients would relapse after corticosteroid discontinuation or tapering, and requires further therapy. ...
Published: 2019
Full Text: View/download PDF

35. Selective arterial embolization as neoadjuvant treatment in hip pseudotumors

Author: Andrea Sambri, Giuseppe Bianchi, Giuseppe Rossi, Mehmet Ali Tokgöz, Davide Maria Donati, Tokgöz, Mehmet Ali, Sambri, Andrea, Rossi, Giuseppe, Bianchi, Giuseppe, and Donati, Davide Maria
Subjects: Male, medicine.medical_specialty, medicine.medical_treatment, Arthroplasty, Replacement, Hip, Operative Time, Blood Loss, Surgical, Group B, Granuloma, Plasma Cell, Young Adult, medicine, Humans, Orthopedics and Sports Medicine, Embolization, Young adult, Aged, Retrospective Studies, Aged, 80 and over, medicine.diagnostic_test, business.industry, Arterial Embolization, Selective arterial embolization, Rehabilitation, Angiography, Magnetic resonance imaging, Retrospective cohort study, Middle Aged, Arthroplasty, Embolization, Therapeutic, Magnetic Resonance Imaging, Neoadjuvant Therapy, Surgery, Female, Radiology, business, Tomography, X-Ray Computed, Pseudotumor of hip
Abstract: Objectives This study aims to investigate the significance of selective arterial embolization (SAE) as neoadjuvant for the treatment of pseudotumor (PT) associated with hip arthroplasty and present our case series including all the known bearing techniques. Patients and methods This retrospective study included 16 patients (9 males, 7 females; mean age 75.5 years; range, 55 to 87 years) affected by hip PT. Seven patients were treated only surgically without any adjuvant treatment (group A), while nine patients were performed preoperative SAE (group B). Pseudotumors were grouped according to magnetic resonance imaging and computed tomography (CT) classifications. Durations of all operations and number of blood units given intra- and postoperatively were recorded. Results Although embolization did not change the amount of intraoperative bleeding (p=0.619), a common vascular network leading to PT was observed in all patients in angiography. Group A's mean duration of operation was shorter than group B (p=0.03); however, this condition was attributed to larger and more complex lesions of patients who underwent embolization. According to CT classification, blood loss was more and duration of operation was longer in severe stages (p=0.046 and p=0.035, respectively). Conclusion Successful demonstration of vascular network in patients with PT strengthens the idea that SAE technique may be used particularly in severe cases according to CT classification. Our findings suggest that PT may develop in all commonly used bearings.
Published: 2019

36. The efficacy of lenalidomide combination therapy in heavily pretreated non-Hodgkin lymphoma patients: an Italian observational, multicenter, retrospective study

Author: Alberto Fabbri, Pier Luigi Zinzani, Luigi Rigacci, Maria Cristina Cox, Pier Paolo Fattori, Lisa Argnani, Umberto Vitolo, Liliana Devizzi, Sergio Storti, Francesco Zaja, Giuseppe Rossi, Alice Di Rocco, Zinzani, Pier Luigi, Rigacci, Luigi, Cox, Maria Cristina, Devizzi, Liliana, Fabbri, Alberto, Zaja, Francesco, Di Rocco, Alice, Rossi, Giuseppe, Storti, Sergio, Fattori, Pier Paolo, Argnani, Lisa, and Vitolo, Umberto
Subjects: Adult, Male, Oncology, Cancer Research, medicine.medical_specialty, Combination therapy, Lenalidomide, Treatment, Non Hodgkin lymphoma, 03 medical and health sciences, 0302 clinical medicine, Hematology, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Aged, Retrospective Studies, Aged, 80 and over, The efficacy of lenalidomide combination therapy in heavily pretreated non-Hodgkin lymphoma patients: an Italian observational, multicenter, retrospective study, business.industry, Lymphoma, Non-Hodgkin, Remission Induction, Retrospective cohort study, Middle Aged, Survival Analysis, Thalidomide, Treatment Outcome, Italy, 030220 oncology & carcinogenesis, Hodgkin lymphoma, Female, Observational study, business, 030215 immunology, medicine.drug
Abstract: not available
Published: 2016
Full Text: View/download PDF

37. Interim Positron Emission Tomography Response–Adapted Therapy in Advanced-Stage Hodgkin Lymphoma: Final Results of the Phase II Part of the HD0801 Study

Author: Caterina Stelitano, Alessandro Levis, Antonio Castagnoli, Gian Mauro Sacchetti, Daniela Gioia, Giovannino Ciccone, Vincenzo Pavone, Umberto Vitolo, Lisa Argnani, Ercole Brusamolino, Maurizio Bonfichi, Andrea Evangelista, Flavia Salvi, Roberto Freilone, Pier Luigi Zinzani, Gianluca Gaidano, Armando Santoro, Umberto Ricardi, Francesco Zaja, Giuseppe Rossi, Chiara Rusconi, Luigi Rigacci, Monica Tani, Eugenio Borsatti, Alessandro Pulsoni, Antonella Anastasia, Alessandro Broccoli, Patrizia Pregno, Zinzani, PIER LUIGI, Broccoli, Alessandro, Gioia, Daniela Maria, Castagnoli, Antonio, Ciccone, Giovannino, Evangelista, Andrea, Santoro, Armando, Ricardi, Umberto, Bonfichi, Maurizio, Brusamolino, Ercole, Rossi, Giuseppe, Anastasia, Antonella, Zaja, Francesco, Vitolo, Umberto, Pavone, Vincenzo, Pulsoni, Alessandro, Rigacci, Luigi, Gaidano, Gianluca, Stelitano, Caterina, Salvi, Flavia, Rusconi, Chiara, Tani, Monica, Freilone, Roberto, Pregno, Patrizia, Borsatti, Eugenio, Sacchetti, Gian Mauro, Argnani, Lisa, Levis, Alessandro, and Zinzani, Pier Luigi
Subjects: Male, Cancer Research, Time Factors, Adolescent, Adult, Aged, Antineoplastic Combined Chemotherapy Protocols, Disease Progression, Disease-Free Survival, Female, Hodgkin Disease, Humans, Italy, Kaplan-Meier Estimate, Middle Aged, Neoplasm Staging, Patient Selection, Predictive Value of Tests, Risk Assessment, Risk Factors, Salvage Therapy, Treatment Outcome, Young Adult, Drug Substitution, Positron-Emission Tomography, Stem Cell Transplantation, Oncology, Salvage therapy, Predictive Value of Test, Evaluable Patient, chemistry.chemical_compound, 0302 clinical medicine, Medicine, Vinblastine, 030220 oncology & carcinogenesis, Radiology, Human, medicine.drug, medicine.medical_specialty, Time Factor, Dacarbazine, Bleomycin, 03 medical and health sciences, Antineoplastic Combined Chemotherapy Protocol, business.industry, Risk Factor, Surgery, Transplantation, Regimen, chemistry, ABVD, business, 030215 immunology
Abstract: Purpose The clinical impact of positron emission tomography (PET) evaluation performed early during first-line therapy in patients with advanced-stage Hodgkin lymphoma, in terms of providing a rationale to shift patients who respond poorly onto a more intensive regimen (PET response-adapted therapy), remains to be confirmed. Patients and Methods The phase II part of the multicenter HD0801 study involved 519 patients with advanced-stage de novo Hodgkin lymphoma who received an initial treatment with doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) and who underwent an early ifosfamide-containing salvage treatment followed by stem-cell transplantation if they showed a positive PET evaluation after two cycles of chemotherapy (PET2). The primary end point was 2-year progression-free survival calculated for both PET2-negative patients (who completed a full six cycles of ABVD treatment) and PET2-positive patients. Overall survival was a secondary end point. Results In all, 103 of the 512 evaluable patients were PET2 positive. Among them, 81 received the scheduled salvage regimen with transplantation, 15 remained on ABVD (physician’s decision, mostly because of minimally positive PET2), five received an alternative treatment, and two were excluded because of diagnostic error. On intention-to-treat analysis, the 2-year progression-free survival was 76% for PET2-positive patients (regardless of the salvage treatment they received) and 81% for PET2-negative patients. Conclusion Patients with advanced-stage Hodgkin lymphoma for whom treatment was at high risk of failing appear to benefit from early treatment intensification with autologous transplantation, as indicated by the possibility of successful salvage treatment in more than 70% of PET2-positive patients through obtaining the same 2-year progression-free survival as the PET2-negative subgroup.
Published: 2016
Full Text: View/download PDF

38. Percutaneous management of bone metastases: state of the art, interventional strategies and joint position statement of the Italian College of MSK Radiology (ICoMSKR) and the Italian College of Interventional Radiology (ICIR)

Author: Giuseppe Rossi, Nicola Burdi, Jean Betsy Chiang, Bruno Beomonte Zobel, Francesco Arrigoni, Federico Bruno, Luigi Zugaro, Carlo Masciocchi, Daniele Santini, Carmine Zoccali, Silvia Squarza, Maurizio Cariati, Roberto Luigi Cazzato, Antonio Barile, Raffaella Niola, Chiara Floridi, Giovanni Luca Gravina, Alessandro Napoli, Umberto G. Rossi, Massimo Venturini, Luca Maria Sconfienza, Rosario Francesco Grasso, Alberto Aliprandi, Roberto Cioni, Anna Maria Ierardi, Alberto Bazzocchi, Gianpaolo Carrafiello, Andrea Giovagnoni, Julien Garnon, Mario Di Staso, Roberto Biagini, Aldo Victor Giordano, Salvatore Masala, Stefano Marcia, Francesco De Cobelli, Marina Carotti, Afshin Gangi, Antonio Basile, Enzo Silvestri, Giuseppe Tonini, Marco Varrassi, Sergio Carducci, Emanuele Boatta, Cazzato, Roberto Luigi, Arrigoni, Francesco, Boatta, Emanuele, Bruno, Federico, Chiang, Jean Betsy, Garnon, Julien, Zugaro, Luigi, Giordano, Aldo Victor, Carducci, Sergio, Varrassi, Marco, Beomonte Zobel, Bruno, Bazzocchi, Alberto, Aliprandi, Alberto, Basile, Antonio, Marcia, Stefano, Masala, Salvatore, Grasso, Rosario Francesco, Squarza, Silvia, Floridi, Chiara, Ierardi, Anna Maria, Burdi, Nicola, Cioni, Roberto, Napoli, Alessandro, Niola, Raffaella, Rossi, Giuseppe, Rossi, Umberto Geremia, Venturini, Massimo, De Cobelli, Francesco, Carotti, Marina, Gravina, Giovanni Luca, Di Staso, Mario, Zoccali, Carmine, Biagini, Roberto, Tonini, Giuseppe, Santini, Daniele, Carrafiello, Gianpaolo, Cariati, Maurizio, Silvestri, Enzo, Sconfienza, Luca Maria, Giovagnoni, Andrea, Masciocchi, Carlo, Gangi, Afshin, Barile, Antonio, Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, and Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Position statement, medicine.medical_specialty, Radiology, Nuclear Medicine and Imaging, Percutaneous, medicine.medical_treatment, Skeletal-related event, [SDV.CAN]Life Sciences [q-bio]/Cancer, Bone Neoplasms, Bone Neoplasm, Radiology, Interventional, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Nuclear Medicine and Imaging, medicine, Humans, Radiology, Nuclear Medicine and imaging, Medical physics, Neuroradiology, Curative intent, Interventional radiology, medicine.diagnostic_test, Interventional, business.industry, Bone metastasis, Skeletal-related events, Italy, General Medicine, medicine.disease, Radiation therapy, 030220 oncology & carcinogenesis, Bone metastasi, Palliative intent, business, Radiology, Human
Abstract: Interventional radiology provides local management of bone metastases (BM) with a palliative intent in most cases, or with a curative intent in selected patients. Its role has rapidly expanded in the last decade, offering new treatment solutions often in combination with surgery, radiation therapy and medical treatments. The aim of the present paper is to increase awareness, acceptance and adoption of interventional radiology procedures for the treatment of BM; and to present the joint position of the Italian College of Musculoskeletal Radiology and the Italian College of Interventional Radiology.
Published: 2018
Full Text: View/download PDF

39. AISF position paper on HCV in immunocompromised patients

Author: Gabriele Missale, Mauro Viganò, Marco Astegiano, Mauro Salizzoni, C. Chialà, Angelo Pera, Patrizia Racca, Massimo Di Maio, Mario Salomone, M. Puoti, Simone Parisi, Paolo Bironzo, M. Rendina, Carla Pasquina, Clodoveo Ferri, Luisa Pasulo, Rita Tozzi, A. Tucci, Pietro Lampertico, Emanuele Angelucci, Bruno Daniele, Patrizia Burra, Franco Riccardini, Marco Lagget, Fabio Salvatore Macaluso, Davide Giuseppe Ribaldone, Luca Miele, Clara Lisa Peroni, Raffaele Bruno, Anna Linda Zignego, Ambrogio Orlando, Giovanni Battista Gaeta, Giuseppe Montrucchio, Daniela Libertucci, Massimo Marignani, Agostino Colli, Enrico Fusaro, Antonio Craxì, Giorgio Maria Saracco, Barbara Imperatrice, Paolo Caraceni, Luisa Giaccone, Chiara Baratelli, Giuliano Torre, Luigi Biancone, Elisabetta De Gasperi, Mario Rizzetto, Maria Grazia Clemente, Francesco Paolo Russo, Aldo Giacardi, Riccardo Volpes, Edoardo G. Giannini, Daniele Curci, Rossella Della Valle, Salvatore Petta, Pierluigi Toniutto, Alessandro Busca, Pietro Vajro, Giorgio Verme, Chiara Mazzarelli, Paolo Grossi, Maria Chiara Ditto, Lorella Orsucci, Umberto Vitolo, Alberto Mella, Salvatore Madonia, Federica Cavallo, Maria Giuseppina Cabras, Stefano Bonora, Massimiliano Conforti, Vito Di Marco, Mario Pirisi, Giuseppe Cariti, Marta Coscia, Giuseppina Brancaccio, L. Scaglione, Stefano Fagiuoli, Alfredo Marzano, Stefano Cusinato, Roberto Minutolo, Giuseppe Rossi, Enrico Brignardello, Maurizia Rossana Brunetto, Marzano A., Angelucci E., Astegiano M., Baratelli C., Biancone L., Bironzo P., Brancaccio G., Brunetto M.R., Bruno R., Burra P., Cabras M.G., Caraceni P., Chiala C., Clemente M.G., Colli A., Daniele B., De Gasperi E., Di Marco V., Ditto M.C., Fagiuoli S., Ferri C., Gaeta G.B., Grossi P.A., Imperatrice B., Lampertico P., Macaluso F.S., Madonia S., Marignani M., Mazzarelli C., Mella A., Missale G., Parisi S., Pasulo L., Puoti M., Rendina M., Ribaldone D., Rossi G., Toniutto P., Tucci A., Vajro P., Vigano M., Volpes R., Zignego A.L., Giannini E.G., Miele L., Russo F.P., Petta S., Bonora S., Brignardello E., Busca A., Cariti G., Cavallo F., Conforti M., Coscia M., Craxi A., Curci D., Cusinato S., Di Maio M., Valle R.D., Fusaro E., Giacardi A., Giaccone L., Lagget M., Libertucci D., Minutolo R., Montrucchio G., Orlando A., Orsucci L., Pasquina C., Pera A., Peroni C.L., Pirisi M., Racca P., Riccardini F., Rizzetto M., Salizzoni M., Salomone M., Saracco G.M., Scaglione L., Torre G., Tozzi R., Vitolo U., Verme G., Angelucci, E, Astegiano, M, Baratelli, C, Biancone, L, Bironzo, P, Brancaccio, G, Brunetto, M, Bruno, R, Burra, P, Cabras, M, l Caraceni, P, Chialà, C, Clemente, M, Colli, A, Daniele, B, De Gasperi, E, Di Marco, V, Ditto, M, Fagiuoli, S, Ferri, C, Gaeta, G, Grossi, P, Imperatrice, B, Lampertico, P, Macaluso, F, Madonia, S, Marignani, M, Mazzarelli, C, Mella, A, Missale, G, Parisi, S, Pasulo, L, Puoti, M, Rendina, M, Ribaldone, D, Rossi, G, Toniutto, P, Tucci, A, Vajro, P, Viganò, M, Volpes, R, Zignego, A, Giannini, E, Miele, L, Russo, F, Petta, S, Bonora, S, Brignardello, E, Busca, A, Cariti, G, Cavallo, F, Conforti, M, Coscia, M, Craxì, A, Curci, D, Cusinato, S, Di Maio, M, Valle, R, Fusaro, E, Giacardi, A, Giaccone, L, Lagget, M, Libertucci, D, Minutolo, R, Montrucchio, G, Orlando, A, Orsucci, L, Pasquina, C, Pera, A, Peroni, C, Pirisi, M, Racca, P, Riccardini, F, Rizzetto, M, Salizzoni, M, Salomone, M, Saracco, G, Scaglione, L, Torre, G, Tozzi, R, Vitolo, U, Verme, G, Marzano, Alfredo, Angelucci, Emanuele, Astegiano, Marco, Baratelli, Chiara, Biancone, Luigi, Bironzo, Paolo, Brancaccio, Giuseppina, Brunetto, Maurizia Rossana, Bruno, Raffaele, Burra, Patrizia, Cabras, Maria Giuseppina, Caraceni, Paolo, Chialà, Claudia, Clemente, Maria Grazia, Colli, Agostino, Daniele, Bruno, De Gasperi, Elisabetta, Di Marco, Vito, Ditto, Maria Chiara, Fagiuoli, Stefano, Ferri, Clodoveo, Gaeta, Giovanni Battista, Grossi, Paolo Antonio, Imperatrice, Barbara, Lampertico, Pietro, Macaluso, Fabio Salvatore, Madonia, Salvatore, Marignani, Massimo, Mazzarelli, Chiara, Mella, Alberto, Missale, Gabriele, Parisi, Simone, Pasulo, Luisa, Puoti, Massimo, Rendina, Maria, Ribaldone, Davide, Rossi, Giuseppe, Toniutto, Pierluigi, Tucci, Alessandra, Vajro, Pietro, Viganò, Mauro, Volpes, Riccardo, Zignego, Anna Linda, Giannini, Edoardo G., Miele, Luca, Russo, Francesco Paolo, Petta, Salvatore, Bonora, Stefano, Brignardello, Enrico, Busca, Alessandro, Cariti, Giuseppe, Cavallo, Federica, Conforti, Massimiliano, Coscia, Marta, Craxì, Antonio, Curci, Daniele, Cusinato, Stefano, Di Maio, Massimo, Valle, Rossella Della, Fusaro, Enrico, Giacardi, Aldo, Giaccone, Luisa, Lagget, Marco, Libertucci, Daniela, Minutolo, Roberto, Montrucchio, Giuseppe, Orlando, Ambrogio, Orsucci, Lorella, Pasquina, Carla, Pera, Angelo, Peroni, Clara Lisa, Pirisi, Mario, Racca, Patrizia, Riccardini, Franco, Rizzetto, Mario, Salizzoni, Mauro, Salomone, Mario, Saracco, Giorgio Maria, Scaglione, Luca, Torre, Giuliano, Tozzi, Rita, Vitolo, Umberto, Verme, Giorgio, and Ditto, MARIA CHIARA
Subjects: medicine.medical_specialty, Transplant Recipient, Comorbidity, Antiviral Agents, Organ transplantation, 03 medical and health sciences, Immunocompromised Host, 0302 clinical medicine, Internal medicine, Neoplasms, medicine, Immunocompromised patient, Humans, Chronic, Intensive care medicine, Antiviral Agent, Hepatology, business.industry, Gastroenterology, Hepatitis C, Chronic, medicine.disease, Hepatitis C, Organ transplant, HCV, Immunocompromised patients, Transplant Recipients, Immunocompetence, Italy, 030220 oncology & carcinogenesis, HCV, Immunocompromised patients, Organ transplant, Position paper, Neoplasm, 030211 gastroenterology & hepatology, business, Direct acting, Human
Abstract: This report summarizes the clinical features and the indications for treating HCV infection in immunocompromised and transplanted patients in the Direct Acting Antiviral drugs era.
Published: 2018

40. Intrafollicular Epstein-Barr virus-positive large B cell lymphoma. A variant of 'germinotropic' lymphoproliferative disorder

Author: Claudio Agostinelli, Murad H. M. Essatari, Anna Gazzola, Giovannino Massarelli, Fabio Facchetti, Giuseppe Rossi, Vilma Pellegrini, Luisa Lorenzi, William Vermi, Silvia Lonardi, Simona Fisogni, Stefano Pileri, Lorenzi, Luisa, Lonardi, Silvia, Essatari, Murad H. M., Pellegrini, Vilma, Fisogni, Simona, Gazzola, Anna, Agostinelli, Claudio, Vermi, William, Rossi, Giuseppe, Massarelli, Giovannino, Pileri, Stefano A., and Facchetti, Fabio
Subjects: Male, 0301 basic medicine, B cell lymphoma, Epstein-Barr virus, Germinotropic, Aged, Epstein-Barr Virus Infections, Female, Germinal Center, Humans, Immunohistochemistry, Immunophenotyping, In Situ Hybridization, Fluorescence, Lymphoma, Large B-Cell, Diffuse, Middle Aged, Phenotype, Polymerase Chain Reaction, 2734, Medicine (all), Molecular Biology, Cell Biology, Pathology, Lymphoma, CD30, medicine.disease_cause, 0302 clinical medicine, Epstein-Barr Virus Infection, immune system diseases, hemic and lymphatic diseases, B-cell lymphoma, In Situ Hybridization, Epstein-Barr viru, General Medicine, BCL6, Diffuse, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Human, medicine.medical_specialty, Lymphoproliferative disorders, Biology, Fluorescence, Virus, Pathology and Forensic Medicine, 03 medical and health sciences, Large B-Cell, medicine, B cell, medicine.disease, Epstein–Barr virus, 030104 developmental biology
Abstract: Germinotropic lymphoproliferative disorders were previously described as localized disorders associated with coinfection by human herpes virus 8 and Epstein-Barr virus and characterized by good clinical outcome. We report the clinical, morphological, phenotypical, and molecular features of three cases of a hitherto unreported variant of Epstein-Barr virus (EBV)-positive, human herpes virus 8 (HHV8)-negative large B cell lymphoma with exclusive intrafollicular localization. All cases occurred in elderly individuals (63, 77, and 65 years old; one male, two females) without obvious immunedeficiency, who presented with high stage disease. Lymph nodes showed an effaced nodular architecture with abnormal B follicles colonized by EBV+ large, pleomorphic atypical cells, including Reed-Sternberg-like cells, showing an activated B cell phenotype (CD10-FOXP1-Bcl6-IRF4+ or CD10-FOXP1+Bcl6+IRF4+) and intense expression of CD30. No monoclonal light-chain restriction was detected by immunohistochemistry or in situ hybridization, and IGH rearrangement was polyclonal; notably, EBV clonality was detectable in one case. Lymphoma cells in all cases showed diffuse expression of the c-Myc protein, while Bcl2 was dim or negative; moreover, the strong expression of phosphorylated-STAT3 in tumor cell nuclei suggested activation of the JAK-STAT pathway. FISH analysis was performed in two cases and showed no translocations of BCL2, BCL6, MYC, and PAX5 genes. Response to treatment was poor in 2/3 patients: one died after 18 months, one is alive with disease after 12 months. The intrafollicular EBV-positive large B cell lymphoma expands the spectrum of EBV-associated lymphoproliferative disorders in immunocompetent individuals.
Published: 2016
Full Text: View/download PDF

41. Post-remission intensive treatment after induction chemotherapy is feasible in selected elderly patients with acute myeloid leukemia and age ≥75 years: a retrospective analysis of the Rete Ematologica Lombarda

Author: Francesca Guidotti, Fabio Ciceri, Marianna Rossi, Matteo Carrabba, Enrica Morra, Chiara Pagani, Erika Borlenghi, Massimo Bernardi, Armando Santoro, Elisabetta Todisco, Nicola Stefano Fracchiolla, Valentina Mancini, Laura Marbello, Giuseppe Rossi, Patrizia Zappasodi, Bernardi, Massimo, Zappasodi, Patrizia, Fracchiolla, Nicola, Marbello, Laura, Todisco, Elisabetta, Pagani, Chiara, Carrabba, Matteo, Rossi, Marianna, Guidotti, Francesca, Mancini, Valentina, Santoro, Armando, Borlenghi, Erika, Ciceri, Fabio, Morra, Enrica, and Rossi, Giuseppe
Subjects: Male, medicine.medical_specialty, Myeloid, MEDLINE, Disease-Free Survival, Follow-Up Studie, Retrospective Studie, Internal medicine, medicine, Retrospective analysis, Humans, Intensive care medicine, Survival rate, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Myeloid leukemia, Induction chemotherapy, Retrospective cohort study, Hematology, Induction Chemotherapy, medicine.disease, Survival Rate, Leukemia, Leukemia, Myeloid, Acute, medicine.anatomical_structure, Female, business, Human, Follow-Up Studies
Published: 2015

42. Pre-chemotherapy risk factors for invasive fungal diseases: prospective analysis of 1,192 patients with newly diagnosed acute myeloid leukemia (SEIFEM 2010-a multicenter study)

Author: Caira, M., Candoni, A., Verga, L., Busca, A., Delia, M., Nosari, A., Caramatti, C., Castagnola, C., Cattaneo, C., Fanci, R., Chierichini, A., Melillo, L., Mitra, M. E., Picardi, M., Potenza, L., Salutari, P., Vianelli, N., Facchini, L., Cesarini, M., De Paolis, M. R., Di Blasi, R., Farina, F., Venditti, A., Ferrari, A., Garzia, M., Gasbarrino, C., Invernizzi, R., Lessi, F., Manna, A., Martino, B., Nadali, G., Offidani, M., Paris, L., Pavone, V., Rossi, G., Spadea, A., Specchia, G., Trecarichi, E. M., Vacca, A., Cesaro, S., Perriello, V., Aversa, F., Tumbarello, M., Pagano, L., Ragionieri, R., Orsola Malpighi, O. S., Antoniazzi, F., Storti, S., Luppi, M., Pagliuca, S., Rossetti, E., Da Vià, M., Di Caprio, L., Majolino, I., Cascavilla, N., Turri, G., Fanin, Renato, Sorveglianza Epidemiologica Infezioni Fungine in Emopatie Maligne, Caira, Morena, Candoni, Anna, Verga, Luisa, Busca, Alessandro, Delia, Mario, Nosari, Annamaria, Caramatti, Cecilia, Castagnola, Carlo, Cattaneo, Chiara, Fanci, Rosa, Chierichini, Anna, Melillo, Lorella, Mitra, Maria Enza, Picardi, Marco, Potenza, Leonardo, Salutari, Prassede, Vianelli, Nicola, Facchini, Luca, Cesarini, Monica, De Paolis, Maria Rosaria, Di Blasi, Roberta, Farina, Francesca, Venditti, Adriano, Ferrari, Antonella, Garzia, Mariagrazia, Gasbarrino, Cristina, Invernizzi, Rosangela, Lessi, Federica, Manna, Annunziata, Martino, Bruno, Nadali, Gianpaolo, Offidani, Massimo, Paris, Laura, Pavone, Vincenzo, Rossi, Giuseppe, Spadea, Antonio, Specchia, Giorgina, Trecarichi, Enrico Maria, Vacca, Adriana, Cesaro, Simone, Perriello, Vincenzo, Aversa, Franco, Tumbarello, Mario, and Pagano, Livio
Subjects: Myeloid, Male, Antifungal Agents, invasive fungal diseases, Mycose, Risk Factors, Epidemiology, Antineoplastic Combined Chemotherapy Protocols, Antifungal Agent, Prospective Studies, Prospective cohort study, Univariate analysis, leukemia, Myeloid leukemia, Hematology, Environmental exposure, Articles, Middle Aged, Prognosis, Survival Rate, Leukemia, Leukemia, Myeloid, Acute, Female, Case-Control Studie, Human, Adult, medicine.medical_specialty, Prognosi, risk factors, acute myeloid leukemia, Neutropenia, Acute, Settore MED/17 - MALATTIE INFETTIVE, Aged, Case-Control Studies, Follow-Up Studies, Humans, Mycoses, Neoplasm Staging, Immunocompromised Host, Follow-Up Studie, Internal medicine, medicine, Antineoplastic Combined Chemotherapy Protocol, Performance status, business.industry, Risk Factor, medicine.disease, Surgery, Prospective Studie, Settore MED/15 - MALATTIE DEL SANGUE, Fungal Disease, business
Abstract: Correct definition of the level of risk of invasive fungal infections is the first step in improving the targeting of preventive strategies. We investigated the potential relationship between pre-hospitalization exposure to sources of fungi and the development of invasive fungal infections in adult patients with newly diagnosed acute myeloid leukemia after their first course of chemotherapy. From January 2010 to April 2012, all consecutive acute myeloid leukemia patients in 33 Italian centers were prospectively registered. Upon first admission, information about possible pre-chemotherapy risk factors and environmental exposure was collected. We recorded data regarding comorbid conditions, employment, hygienic habits, working and living environment, personal habits, hobbies, and pets. All invasive fungal infections occurring within 30 days after the first course of chemotherapy were recorded. Of the 1,192 patients enrolled in this study, 881 received intensive chemotherapy and were included in the present analysis. Of these, 214 developed an invasive fungal infection, including 77 proven/probable cases (8.7%). Of these 77 cases, 54 were proven/probable invasive mold infections (6.1%) and 23 were proven yeast infections (2.6%). Upon univariate analysis, a significant association was found between invasive mold infections and age, performance status, diabetes, chronic obstructive pulmonary disease, smoking, cocaine use, job, hobbies, and a recent house renovation. Higher body weight resulted in a reduced risk of invasive mold infections. Multivariate analysis confirmed the role of performance status, job, body weight, chronic obstructive pulmonary disease, and house renovation. In conclusion, several hospital-independent variables could potentially influence the onset of invasive mold infections in patients with acute myeloid leukemia. Investigation of these factors upon first admission may help to define a patient's risk category and improve targeted prophylactic strategies. (Clinicaltrial.gov: NCT01315925)
Published: 2015

43. Metachronous osteoblastoma of the spine and osteoid osteoma of the femur

Author: Giuseppe Rossi, Costantino Errani, Giancarlo Facchini, Ugo Albisinni, Alberto Righi, Daniel Vanel, Davide Maria Donati, Errani, Costantino, Facchini, Giancarlo, Rossi, Giuseppe, Vanel, Daniel, Righi, Alberto, Albisinni, Ugo, and Donati, Davide
Subjects: musculoskeletal diseases, Osteoid osteoma, medicine.medical_specialty, Unusual case, business.industry, Case Report, General Medicine, musculoskeletal system, medicine.disease, osteoid osteoma, Osteoblastoma, medicine, Femur, Radiology, osteoblastoma, business
Abstract: Osteoblastoma (OBL) and osteoid osteoma (OO) are usually solitary tumours, and are only rarely multicentric. Herein, we report an unusual case in which a typical OBL of the spine was followed by an OO of the femur after a disease-free interval of 5 years. We believe that our unique case represents the first report of a metachronous OBL and an OO, and this presentation may confirm the close correlation between these two rare entities.
Published: 2015
Full Text: View/download PDF

44. Postoperative continuous positive airway pressure to prevent pneumonia, re-intubation, and death after major abdominal surgery (PRISM): a multicentre, open-label, randomised, phase 3 trial

Author: Rupert Pearse, Marco Ranieri, Tom Abbott, Mari-Liis Pakats, Edoardo Piervincenzi, Akshaykumar Patel, Brennan Kahan, Andrew Rhodes, Priyanthi Dias, Russell Hewson, Ib Jammer, Michelle Chew, Cesar Aldecoa, Reitze Rodseth, Bruce Biccard, Tim Stephens, Sara Payne, David Hepworth, Soeren Pischke, Joerund Asvall, John Hausken, Shaman Jhanji, Martin Rooms, Neil Flint, Dawn Hales, Tamas Szakmany, Andrew Leitch, Savino Spadaro, Davide Chiumello, Paul Johnston, Joyce Yeung, Guglielmo Tellan, Tonny Veenith, Josep Macmillan, Pierpaolo Terragni, Caroline Sander, Vidya Kasipandian, Tahania Ahmad, Aaron Lee, Marcello Tammaro, Danny McAuley, Simon Skene, Ravinder Vohra, Matt Wilson, Mark Edwards, Ewen Griffiths, Naomi Pritchard, Claudia Filippini, Tor Aasmundstad, Einar Aksnes, Lise-Merete Alpers, Andreas Barratt-Due, Anita Dahl, Linda Feldt, Elisa Figari, Eva Flåten, Karen Granheim, Minna Hagring, Håkon Haugaa, Gisle Kjoesen, Inge Klaevahaugen, Harald Lenz, Marianne Myhre, Hilde Orrem, Emily Stitt, Tor Inge Toennessen, Samuel Al-Kadhimi, Robert Anker, Mihaela Balint, Lauren Barraclough, Ethel Black, Matt Clayton, Leonora Conneely, Zara Edwards, Alex Eeles, Matthew Evans, Michelle Gerstman, Nicole Greenshields, Eleanor Harvey, Aoife Hegarty, Natalie Hester, Jenna Hutchinson, Ramanathan Kasivisvanathan, Helen Lawrence, Veronica Marsh, Laura Matthews, Francesca Mazzola, Jamie McCanny, Ben Morrison, Michelle O'Mahony, Ching Ling Pang, David Parkinson, Katrina Pirie, Ravishankar Rao Baikady, Louisa Shovel, Lorna Smith, Kate Tatham, Peter Thomas, Sophie Uren, Susanna Walker, Alasdair Wills, Prematie Andreou, Alex Howson, Jasmin Kaur, Adam Lewszuk, Esther Molina, Nirmalabaye Ramsamy, Emma Roberts, Vanessa Amaral, Salma Begum, Soliana Bekele, Richard Cashmore, Carmen Correia, Steven Dunkley, Maria Fernandez, Alexander Fowler, Amaia Garcia, Maria Della Giovampaola, Kathryn Greaves, Bethan Griffiths, Ryan Haines, Richard Haslop, Ying Hu, Sarah Hui, Marta Januszewska, Vasi Manon, Tim Martin, Shaun May, Annamaria Minicozzi, Edyta Niebrzegowska, Monica Oliveira, Katherine Pates, Filipa Santos, Tasnin Shahid, Paolo Simili, Alastair Somerville, Emily Subhedar, Ruzena Uddin, Sophie Walker, Yize Wan, Jan Whalley, Parjam Zolfaghari, Una Gunter, Gemma Hodkinson, Gwenllian Howe, Valentina Baratozzi, Giulia Casotto, Giulia Darai, Erica Ferrari, Giovanni Mistraletti, Valentina Palmaverdi, Stefano Furlani, Paolo Priani, Riccardo Ragazzi, Marco Salmaso, Marco Verri, Carlo Volta, Chris Nutt, Emma McKay, Orla O'Neill, Jaimin Patel, Katie Atterbury, Sarah Ballinger, Natalie Carling, Kaytie Ellis, Jo Gresty, Teresa Melody, Jade Monk, Chloe Norman, Eleanor Reeves, Julia Sampson, Peter Sutton, Marie Thomas, Amy Bamford, Colin Bergin, Ronald Carrera, Lauren Cooper, Liesl Despy, Karen Ellis, Emma Fellows, Stephanie Goundry, Samantha Harkett, Peter Ip, Tracy Mason, Christopher McGhee, Aisling McLaughlin, Aoife Neal, Martin Pope, Stephanie Porter, Hazel Smith, Catherine Snelson, Elaine Spruce, Ylenia Vigo, Arlo Whitehouse, Tony Whitehouse, Maria Donatiello, Sergio Gazzanelli, Mario Mezzapesa, Martina Savino, Giacomo Settesoldi, Gudrun Kunst, Sian Birch, Louise Greig, Harriet Noble, Evita Pappa, Bethany Penhaligon, Andrea Cossu, Leda Floris, Davide Piredda, Alberto Racca, Olof Brattstrom, Bente Heggelund, Magnus Flodberg, Sandra Månsson, Mamoona Ahmed, Jonathan Allen, Paula Bell, Roman Genetu, Julia Glennon, Janice Hanley, Katy Jenner, Summayyah Jogi, Parisa Mahjoob, Clare McGovern, Anthony Murphy, Roonak Nazari, Jacki Routledge, Trishna Uttamlal, Sinead Ward, Giorgio Iotti, Raffaella Picchioni, Silvia Poma, Paolo Navalesi, Andrea Bruni, Brunella De Leonardis, Eugenio Garofalo, Panna Patel, Carol McArthur, Karen Burns, Steven Peters, Giuseppe Foti, Serena Calcinati, Alice Grassi, Silvia Villa, John Berridge, Muthuraj Kanakaraj, Hazel Cahill, Greg Forshaw, Andy Gibson, Lia Grainger, Kate Howard, Katherine James, Zoe Murphy, Helen Sweeting, Rebecca Tait, Danielle Wilcock, David Yates, Sean Cope, Ashley Allan, Rebecca Betts, Sarah Cornell, Julie Sheriff, Lindsey Woods, Giacomo Grasselli, Matteo Brioni, Luigi Castagna, Richard von Rahden, Zane Farina, Samantha Green, Simphiwe Gumede, Chantal Rajah, Arisha Ramkillawan, Susan Moug, David Alcorn, Carol Dalton, Natalie Dickinson, Jennifer Edwards, Steven Henderson, Erin McIlveen, Richard Ramsaran, Joanne Bell, Lorna Fleming, Kathleen Monks, Jane Parker, Sean Stamper, Jo Stokes-Denson, Elisa Elías, Yessica Guerra, Jesus Rico-Feijoo, Carlos Kidel, Helder Filipe, Gretchelle Asis, Yvonne Gleeson, Alice Harvey, Christine Jackson, Margaret McNeil, Sara Mingo, Glykeria Pakou, Manuel Pinto, Stephen Wright, Maite Babio-Galan, David Buckley, Verity Calder, Ahmad Chishti, Joseph Cosgrove, Katherine Cullen, Leigh Dunn, Matthew Faulds, Jonathan Fortune, Matthew Gardner, Abigail Harrison, Carole Hays, Gerry Jones, Caroline Macfie, Iain Mccullagh, Ian Nesbitt, Suzanne O'Neil, Catherine Phoenix, Girish Rangaswamy, Craig Samson, Carmen Scott, Tara Shrestha, Rita Singh, Graham Soulsby, Jon Walton, Kimberley Zwiggelaar, Ceri Lynch, Heidi Clarke, Bethan Deacon, Helen Ivatt, Leanne Jones, Ahmed Latif, Shaun Oram, Chris Perman, Lisa Roche, Rowan Duys, Margot Flint, Kamal Bhagwan, Ettienne Coetzee, Ivan Joubert, Felipe Montoya-Pelaez, Pradeep Navsaria, Guy Picken, Owen Porrill, Grant Strathie, Thembinkosi Zungu, Sireesha Aluri, Simon Chau, Deborah Cooper, Mishell Cunningham, Allison Daniels, Susan Hope, Alice Nicholson, Laura Walker, Antonino Giarratano, Giuseppe Accurso, Santi Raineri, Giuseppe Tricoli, Richard Innes, Patricia Doble, Joanne Hutter, Corinne Pawley, Moira Tait, Mark Hamilton, Edward Andrade, Veronica Barnes, Claire Dalton, Carlos Delgado, Sarah Farnell-Ward, Helen Farrah, Geraldine Gray, Luisa Howlett, Gipsy Joseph, Monika Krupa, Susannah Leaver, Joao Macedo, Karen Maher, Johannes Mellinghoff, Rachel Oguntimehin, Joel Pereira, Frances Robinson, Christine Ryan, Nirav Shah, Paula Shirley, Alexandra Torborg, Thuli Biyase, Leanne Drummond, Belinda Kusel, Mbalenhle Mbuyisa, Sivuyisiwe Solala, Jenna Taylor, Adanma Ezihe-Ejiofor, Maame Aduse-Poku, Gary Colville, Louise Davies, Soo Kang, Alex Phillips, Justin Kirk-Bayley, Leigh Kelliher, Paula Carvelli, Gokce Daysal, Matthew Dickinson, Nancileigh Doyle, Christina Hughes, Laura Montague, Elizabeth Potter, Armorel Salberg, Sheena Sibug, Sinduja Sivarajan, Milo Thomson, Nichola Wakeford, Monica Rocco, Daniela Alampi, Daniel Conway, Richard Clark, Jashmin Maria, Fiona Pomeroy, Tanviha Quraishi, Abigail Williams, Srikanth Chukkambotla, Caroline Aherne, Donna Harrison-Briggs, Jill Fitchett, Stephen Duberley, Andrea Zanoni, Daniela Cardinale, Claudia Righi, Mark Blunt, Tracy Fuller, Ruth Hodgson, Melissa Rosbergen, Andrew Brennan, Louise Akeroyd, Victoria Boardman, Christopher Bull, Mike Carrick, Ian Chadderton, Sarah Cooper, Sarah Goellner, Laura Graham, Carl Ilyas, James King, Muhammad Laklouk, Tom Lawton, Christopher Macrow, Michael Munro, Adam Neep, Martin Northey, Victoria Peacock, Kate Pye, Lydia Radley, James Sira, Beth Smithson, Stuart Syddall, David Tooth, Thomas White, Sindre Hoel, Elin Aakre, Monica Bakke, Tone Hoivik, Arystarch Makowski, Harry Alcock, Sean Cardoso, Samantha Coetzee, Mary Everett, Mohamed Ibrahim, Christina Kouridaki, Vongayi Ogbeide, Elisabetta Bertellini, Valentina Bertolotti, Antonio Buono, Maria Fanigliulo, Ram Kumar, Nicole Richards, Alisha Allana, Samantha Bacciarelli, Helen Barker, Jessica De Bois, Isabel Bradley, Jennifer Crooks, Peter Daum, Alex Feben, Lizzie Gannon, Sarah Kipling, Andrew Peetamsingh, Charlotte Quamina, Sahiba Sethi, Harry Sivadhas, Kathryn Sollesta, Andrew Swain, Evalyn Tan, Joan Willis, Maggie Zou, Julius Cranshaw, Nina Barratt, Katie Bowman, Debbie Branney, Maria Letts, Sally Pitts, Christopher Day, Sarah Benyon, Sara Eddy, Adam Green, Anna Grice, Sinéad Kelly, Daisy Mackle, Victor Mariano, Linda Park, Pauline Sibley, William Spencer, Elena Bignami, Valentina Bellini, Francesco Forfori, Maria Curci, Alessandra Leo, Matthew Jackson, Jennifer Awolesi, Sheila Hodgkinson, Alissa Kent, Dee Leonard, Claire Stapleton, Clare Tibke, Farhad Alexander-Sefre, Lorraine Campey, Kathryn Hall, Jennifer Spimpolo, Malin Nilsson, Helen Didriksson, Emma Hamilton, Mandy Carnahan, Chris Mowatt, Jo Stickley, Antonio Corcione, Giuseppe Rossi, Hege Fladby, Nina Andersen, Gunhild Bjoernå, Mads Reite, Linda Roertveit, Philipp Seidel, Glenn Arnold, Melissa Benavente, Anjalee Chattersingh, Nyasha Chironga, Gillian Hornzee, Joyce Kibaru, Ihtisham Malik, Laura McLeavy, Byiravey Pathmanathan, Florence Prior, Rhea Strudwick, Marios Vezyrgiannis, Aneeta Sinha, Sheeba Babu, Bisanth Batuwitage, Zoe Daly, Katharine Ellinor, Elizabeth Hawes, Ann Holmes, Karen Hudson, Jeremy Nightingale, Alison Le Poidevin, Lindsey Roberts, Agnieszka Kubisz-Pudelko, Joanna Allison, Lucy Pippard, Vincent Hamlyn, Angie Organ, Thaventhran Prabhahar, Hayley Bridger, Lee Dvorkin, Vitul Manhas, Rachel Vincent, Shondipon Laha, Terri-Louise Cromie, Donna Doyle, Rachel Howarth, Mark Verlander, Ailsa Watt, Alexandra Williams, Massimo Antonelli, Salvatore Cutuli, Luca Montini, Juan Graterol, Benita Adams, Sarah Bean, Karen Burt, Fiona Hammonds, Suyogi Jigajinni, Laura Fulton, Stephen Kinghorn, Jost Mullenheim, Kirsty Baillie, Martyn Cain, Kerry Colling, Carol Hannaway, Ruggero Corso, Morena Calli, Carlos Ferrando, Esther Romero, Pablo Jorge-Monjas, María Soria-García, José Gómez-Herreras, Rita Rodríguez-Jiménez, Blanca De Prada-Martín, Pearse, Rupert, Ranieri, Marco, Abbott, Tom, Pakats, Mari-Lii, Piervincenzi, Edoardo, Patel, Akshaykumar, Kahan, Brennan, Rhodes, Andrew, Dias, Priyanthi, Hewson, Russell, Jammer, Ib, Chew, Michelle, Aldecoa, Cesar, Rodseth, Reitze, Biccard, Bruce, Stephens, Tim, Payne, Sara, Hepworth, David, Pischke, Soeren, Asvall, Joerund, Hausken, John, Jhanji, Shaman, Rooms, Martin, Flint, Neil, Hales, Dawn, Szakmany, Tama, Leitch, Andrew, Spadaro, Savino, Chiumello, Davide, Johnston, Paul, Yeung, Joyce, Tellan, Guglielmo, Veenith, Tonny, Macmillan, Josep, Terragni, Pierpaolo, Sander, Caroline, Kasipandian, Vidya, Ahmad, Tahania, Lee, Aaron, Tammaro, Marcello, McAuley, Danny, Skene, Simon, Vohra, Ravinder, Wilson, Matt, Edwards, Mark, Griffiths, Ewen, Pritchard, Naomi, Filippini, Claudia, Aasmundstad, Tor, Aksnes, Einar, Alpers, Lise-Merete, Barratt-Due, Andrea, Dahl, Anita, Feldt, Linda, Figari, Elisa, Flåten, Eva, Granheim, Karen, Hagring, Minna, Haugaa, Håkon, Kjoesen, Gisle, Klaevahaugen, Inge, Lenz, Harald, Myhre, Marianne, Orrem, Hilde, Stitt, Emily, Toennessen, Tor Inge, Al-Kadhimi, Samuel, Anker, Robert, Balint, Mihaela, Barraclough, Lauren, Black, Ethel, Clayton, Matt, Conneely, Leonora, Edwards, Zara, Eeles, Alex, Evans, Matthew, Gerstman, Michelle, Greenshields, Nicole, Harvey, Eleanor, Hegarty, Aoife, Hester, Natalie, Hutchinson, Jenna, Kasivisvanathan, Ramanathan, Lawrence, Helen, Marsh, Veronica, Matthews, Laura, Mazzola, Francesca, McCanny, Jamie, Morrison, Ben, O'Mahony, Michelle, Pang, Ching Ling, Parkinson, David, Pirie, Katrina, Rao Baikady, Ravishankar, Shovel, Louisa, Smith, Lorna, Tatham, Kate, Thomas, Peter, Uren, Sophie, Walker, Susanna, Wills, Alasdair, Andreou, Prematie, Howson, Alex, Kaur, Jasmin, Lewszuk, Adam, Molina, Esther, Ramsamy, Nirmalabaye, Roberts, Emma, Amaral, Vanessa, Begum, Salma, Bekele, Soliana, Cashmore, Richard, Correia, Carmen, Dunkley, Steven, Fernandez, Maria, Fowler, Alexander, Garcia, Amaia, Della Giovampaola, Maria, Greaves, Kathryn, Griffiths, Bethan, Haines, Ryan, Haslop, Richard, Hu, Ying, Hui, Sarah, Januszewska, Marta, Manon, Vasi, Martin, Tim, May, Shaun, Minicozzi, Annamaria, Niebrzegowska, Edyta, Oliveira, Monica, Pates, Katherine, Santos, Filipa, Shahid, Tasnin, Simili, Paolo, Somerville, Alastair, Subhedar, Emily, Uddin, Ruzena, Walker, Sophie, Wan, Yize, Whalley, Jan, Zolfaghari, Parjam, Gunter, Una, Hodkinson, Gemma, Howe, Gwenllian, Baratozzi, Valentina, Casotto, Giulia, Darai, Giulia, Ferrari, Erica, Mistraletti, Giovanni, Palmaverdi, Valentina, Furlani, Stefano, Priani, Paolo, Ragazzi, Riccardo, Salmaso, Marco, Verri, Marco, Volta, Carlo, Nutt, Chri, McKay, Emma, O'Neill, Orla, Patel, Jaimin, Atterbury, Katie, Ballinger, Sarah, Carling, Natalie, Ellis, Kaytie, Gresty, Jo, Melody, Teresa, Monk, Jade, Norman, Chloe, Reeves, Eleanor, Sampson, Julia, Sutton, Peter, Thomas, Marie, Bamford, Amy, Bergin, Colin, Carrera, Ronald, Cooper, Lauren, Despy, Liesl, Ellis, Karen, Fellows, Emma, Goundry, Stephanie, Harkett, Samantha, Ip, Peter, Mason, Tracy, McGhee, Christopher, McLaughlin, Aisling, Neal, Aoife, Pope, Martin, Porter, Stephanie, Smith, Hazel, Snelson, Catherine, Spruce, Elaine, Vigo, Ylenia, Whitehouse, Arlo, Whitehouse, Tony, Donatiello, Maria, Gazzanelli, Sergio, Mezzapesa, Mario, Savino, Martina, Settesoldi, Giacomo, Kunst, Gudrun, Birch, Sian, Greig, Louise, Noble, Harriet, Pappa, Evita, Penhaligon, Bethany, Cossu, Andrea, Floris, Leda, Piredda, Davide, Racca, Alberto, Brattstrom, Olof, Heggelund, Bente, Flodberg, Magnu, Månsson, Sandra, Ahmed, Mamoona, Allen, Jonathan, Bell, Paula, Genetu, Roman, Glennon, Julia, Hanley, Janice, Jenner, Katy, Jogi, Summayyah, Mahjoob, Parisa, McGovern, Clare, Murphy, Anthony, Nazari, Roonak, Routledge, Jacki, Uttamlal, Trishna, Ward, Sinead, Iotti, Giorgio, Picchioni, Raffaella, Poma, Silvia, Navalesi, Paolo, Bruni, Andrea, De Leonardis, Brunella, Garofalo, Eugenio, Patel, Panna, McArthur, Carol, Burns, Karen, Peters, Steven, Foti, Giuseppe, Calcinati, Serena, Grassi, Alice, Villa, Silvia, Berridge, John, Kanakaraj, Muthuraj, Cahill, Hazel, Forshaw, Greg, Gibson, Andy, Grainger, Lia, Howard, Kate, James, Katherine, Murphy, Zoe, Sweeting, Helen, Tait, Rebecca, Wilcock, Danielle, Yates, David, Cope, Sean, Allan, Ashley, Betts, Rebecca, Cornell, Sarah, Sheriff, Julie, Woods, Lindsey, Grasselli, Giacomo, Brioni, Matteo, Castagna, Luigi, von Rahden, Richard, Farina, Zane, Green, Samantha, Gumede, Simphiwe, Rajah, Chantal, Ramkillawan, Arisha, Moug, Susan, Alcorn, David, Dalton, Carol, Dickinson, Natalie, Edwards, Jennifer, Henderson, Steven, McIlveen, Erin, Ramsaran, Richard, Bell, Joanne, Fleming, Lorna, Monks, Kathleen, Parker, Jane, Stamper, Sean, Stokes-Denson, Jo, Elías, Elisa, Guerra, Yessica, Rico-Feijoo, Jesu, Kidel, Carlo, Filipe, Helder, Asis, Gretchelle, Gleeson, Yvonne, Harvey, Alice, Jackson, Christine, McNeil, Margaret, Mingo, Sara, Pakou, Glykeria, Pinto, Manuel, Wright, Stephen, Babio-Galan, Maite, Buckley, David, Calder, Verity, Chishti, Ahmad, Cosgrove, Joseph, Cullen, Katherine, Dunn, Leigh, Faulds, Matthew, Fortune, Jonathan, Gardner, Matthew, Harrison, Abigail, Hays, Carole, Jones, Gerry, Macfie, Caroline, Mccullagh, Iain, Nesbitt, Ian, O'Neil, Suzanne, Phoenix, Catherine, Rangaswamy, Girish, Samson, Craig, Scott, Carmen, Shrestha, Tara, Singh, Rita, Soulsby, Graham, Walton, Jon, Zwiggelaar, Kimberley, Lynch, Ceri, Clarke, Heidi, Deacon, Bethan, Ivatt, Helen, Jones, Leanne, Latif, Ahmed, Oram, Shaun, Perman, Chri, Roche, Lisa, Duys, Rowan, Flint, Margot, Bhagwan, Kamal, Coetzee, Ettienne, Joubert, Ivan, Montoya-Pelaez, Felipe, Navsaria, Pradeep, Picken, Guy, Porrill, Owen, Strathie, Grant, Zungu, Thembinkosi, Aluri, Sireesha, Chau, Simon, Cooper, Deborah, Cunningham, Mishell, Daniels, Allison, Hope, Susan, Nicholson, Alice, Walker, Laura, Giarratano, Antonino, Accurso, Giuseppe, Raineri, Santi, Tricoli, Giuseppe, Innes, Richard, Doble, Patricia, Hutter, Joanne, Pawley, Corinne, Tait, Moira, Hamilton, Mark, Andrade, Edward, Barnes, Veronica, Dalton, Claire, Delgado, Carlo, Farnell-Ward, Sarah, Farrah, Helen, Gray, Geraldine, Howlett, Luisa, Joseph, Gipsy, Krupa, Monika, Leaver, Susannah, Macedo, Joao, Maher, Karen, Mellinghoff, Johanne, Oguntimehin, Rachel, Pereira, Joel, Robinson, France, Ryan, Christine, Shah, Nirav, Shirley, Paula, Torborg, Alexandra, Biyase, Thuli, Drummond, Leanne, Kusel, Belinda, Mbuyisa, Mbalenhle, Solala, Sivuyisiwe, Taylor, Jenna, Ezihe-Ejiofor, Adanma, Aduse-Poku, Maame, Colville, Gary, Davies, Louise, Kang, Soo, Phillips, Alex, Kirk-Bayley, Justin, Kelliher, Leigh, Carvelli, Paula, Daysal, Gokce, Dickinson, Matthew, Doyle, Nancileigh, Hughes, Christina, Montague, Laura, Potter, Elizabeth, Salberg, Armorel, Sibug, Sheena, Sivarajan, Sinduja, Thomson, Milo, Wakeford, Nichola, Rocco, Monica, Alampi, Daniela, Conway, Daniel, Clark, Richard, Maria, Jashmin, Pomeroy, Fiona, Quraishi, Tanviha, Williams, Abigail, Chukkambotla, Srikanth, Aherne, Caroline, Harrison-Briggs, Donna, Fitchett, Jill, Duberley, Stephen, Zanoni, Andrea, Cardinale, Daniela, Righi, Claudia, Blunt, Mark, Fuller, Tracy, Hodgson, Ruth, Rosbergen, Melissa, Brennan, Andrew, Akeroyd, Louise, Boardman, Victoria, Bull, Christopher, Carrick, Mike, Chadderton, Ian, Cooper, Sarah, Goellner, Sarah, Graham, Laura, Ilyas, Carl, King, Jame, Laklouk, Muhammad, Lawton, Tom, Macrow, Christopher, Munro, Michael, Neep, Adam, Northey, Martin, Peacock, Victoria, Pye, Kate, Radley, Lydia, Sira, Jame, Smithson, Beth, Syddall, Stuart, Tooth, David, White, Thoma, Hoel, Sindre, Aakre, Elin, Bakke, Monica, Hoivik, Tone, Makowski, Arystarch, Alcock, Harry, Cardoso, Sean, Coetzee, Samantha, Everett, Mary, Ibrahim, Mohamed, Kouridaki, Christina, Ogbeide, Vongayi, Bertellini, Elisabetta, Bertolotti, Valentina, Buono, Antonio, Fanigliulo, Maria, Kumar, Ram, Richards, Nicole, Allana, Alisha, Bacciarelli, Samantha, Barker, Helen, De Bois, Jessica, Bradley, Isabel, Crooks, Jennifer, Daum, Peter, Feben, Alex, Gannon, Lizzie, Kipling, Sarah, Peetamsingh, Andrew, Quamina, Charlotte, Sethi, Sahiba, Sivadhas, Harry, Sollesta, Kathryn, Swain, Andrew, Tan, Evalyn, Willis, Joan, Zou, Maggie, Cranshaw, Juliu, Barratt, Nina, Bowman, Katie, Branney, Debbie, Letts, Maria, Pitts, Sally, Day, Christopher, Benyon, Sarah, Eddy, Sara, Green, Adam, Grice, Anna, Kelly, Sinéad, Mackle, Daisy, Mariano, Victor, Park, Linda, Sibley, Pauline, Spencer, William, Bignami, Elena, Bellini, Valentina, Forfori, Francesco, Curci, Maria, Leo, Alessandra, Jackson, Matthew, Awolesi, Jennifer, Hodgkinson, Sheila, Kent, Alissa, Leonard, Dee, Stapleton, Claire, Tibke, Clare, Alexander-Sefre, Farhad, Campey, Lorraine, Hall, Kathryn, Spimpolo, Jennifer, Nilsson, Malin, Didriksson, Helen, Hamilton, Emma, Carnahan, Mandy, Mowatt, Chri, Stickley, Jo, Corcione, Antonio, Rossi, Giuseppe, Fladby, Hege, Andersen, Nina, Bjoernå, Gunhild, Reite, Mad, Roertveit, Linda, Seidel, Philipp, Arnold, Glenn, Benavente, Melissa, Chattersingh, Anjalee, Chironga, Nyasha, Hornzee, Gillian, Kibaru, Joyce, Malik, Ihtisham, McLeavy, Laura, Pathmanathan, Byiravey, Prior, Florence, Strudwick, Rhea, Vezyrgiannis, Mario, Sinha, Aneeta, Babu, Sheeba, Batuwitage, Bisanth, Daly, Zoe, Ellinor, Katharine, Hawes, Elizabeth, Holmes, Ann, Hudson, Karen, Nightingale, Jeremy, Le Poidevin, Alison, Roberts, Lindsey, Kubisz-Pudelko, Agnieszka, Allison, Joanna, Pippard, Lucy, Hamlyn, Vincent, Organ, Angie, Prabhahar, Thaventhran, Bridger, Hayley, Dvorkin, Lee, Manhas, Vitul, Vincent, Rachel, Laha, Shondipon, Cromie, Terri-Louise, Doyle, Donna, Howarth, Rachel, Verlander, Mark, Watt, Ailsa, Williams, Alexandra, Antonelli, Massimo, Cutuli, Salvatore, Montini, Luca, Graterol, Juan, Adams, Benita, Bean, Sarah, Burt, Karen, Hammonds, Fiona, Jigajinni, Suyogi, Fulton, Laura, Kinghorn, Stephen, Mullenheim, Jost, Baillie, Kirsty, Cain, Martyn, Colling, Kerry, Hannaway, Carol, Corso, Ruggero, Calli, Morena, Ferrando, Carlo, Romero, Esther, Jorge-Monjas, Pablo, Soria-García, María, Gómez-Herreras, José, Rodríguez-Jiménez, Rita, and De Prada-Martín, Blanca
Subjects: Pulmonary and Respiratory Medicine, medicine.medical_treatment, Population, NO, 03 medical and health sciences, 0302 clinical medicine, CPAP, Abdomen, Settore MED/41 - ANESTESIOLOGIA, Intubation, Intratracheal, medicine, Humans, Intubation, 030212 general & internal medicine, Continuous positive airway pressure, Adverse effect, education, education.field_of_study, Continuous Positive Airway Pressure, business.industry, respiratory complications, continuous positive airway pressure, major abdominal surgery, Pneumonia, Middle Aged, medicine.disease, respiratory tract diseases, Intratracheal, Treatment Outcome, 030228 respiratory system, Respiratory failure, Anesthesia, Vomiting, medicine.symptom, Respiratory Insufficiency, business, Abdominal surgery
Abstract: BackgroundRespiratory complications are an important cause of postoperative morbidity. We aimed to investigate whether continuous positive airway pressure (CPAP) administered immediately after major abdominal surgery could prevent postoperative morbidity.MethodsPRISM was an open-label, randomised, phase 3 trial done at 70 hospitals across six countries. Patients aged 50 years or older who were undergoing elective major open abdominal surgery were randomly assigned (1:1) to receive CPAP within 4 h of the end of surgery or usual postoperative care. Patients were randomly assigned using a computer-generated minimisation algorithm with inbuilt concealment. The primary outcome was a composite of pneumonia, endotracheal re-intubation, or death within 30 days after randomisation, assessed in the intention-to-treat population. Safety was assessed in all patients who received CPAP. The trial is registered with the ISRCTN registry, ISRCTN56012545.FindingsBetween Feb 8, 2016, and Nov 11, 2019, 4806 patients were randomly assigned (2405 to the CPAP group and 2401 to the usual care group), of whom 4793 were included in the primary analysis (2396 in the CPAP group and 2397 in the usual care group). 195 (8·1%) of 2396 patients in the CPAP group and 197 (8·2%) of 2397 patients in the usual care group met the composite primary outcome (adjusted odds ratio 1·01 [95% CI 0·81-1·24]; p=0·95). 200 (8·9%) of 2241 patients in the CPAP group had adverse events. The most common adverse events were claustrophobia (78 [3·5%] of 2241 patients), oronasal dryness (43 [1·9%]), excessive air leak (36 [1·6%]), vomiting (26 [1·2%]), and pain (24 [1·1%]). There were two serious adverse events: one patient had significant hearing loss and one patient had obstruction of their venous catheter caused by a CPAP hood, which resulted in transient haemodynamic instability.InterpretationIn this large clinical effectiveness trial, CPAP did not reduce the incidence of pneumonia, endotracheal re-intubation, or death after major abdominal surgery. Although CPAP has an important role in the treatment of respiratory failure after surgery, routine use of prophylactic post-operative CPAP is not recommended.FundingNational Institute for Health Research, Barts Charity, Intersurgical, Association of Anaesthetists, and Sapienza Università di Roma.

Catalog

Books, media, physical & digital resources

See catalog results

Searchworks

Select search scope, currently: Articles Catalog books, media & more in Jio Institute collections Articles journal articles & other e-resources

Search

Search Constraints

Refine your results

Search Limiters

Topic

Publication Year Range

Journal

Database

Publisher

44 results on '"Rossi Giuseppe"'

Search Results

Catalog

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources