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Polygene of the pathogenesis of osteoporosis and the number of factors influencing structure and functions of bone tissue challenge researches to further studies. Estrogen receptor alpha (ERalpha) gene polimorphism influences the transduction of the signal to the bone cells.The study aimed to establish the frequency of occurrence of Pvull and Xbal gene polymorphism of estrogen receptor alpha in a group of children and adolescents from north-eastern Poland with diagnosed and treated cancer.In the study of gene polymorphism a group of 205 children (113 boys) treated in Department of Pediatric Oncology and its' Outpatient Department in Bialystok was compared with a control group of 70 healthy children (38 boys) from the same part of Poland. Gene polymorphism was established using polymerase chain reaction (PCR) and Pvull and Xbal enzymes.In both groups heterozygots were prevalent (Pp - 49.27% and 51.43% Xx - 53.17% and 48.57%). The most often occurring genotype was px, and the rarest was pX genotype (1.46% in the study group).The influence of ERalpha polymorphism should be taken into account among the negative factors influencing the development of osteoporosis, especially in the case of prolonged lack or minimal physical activity.

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An epoxy-anhydride formulation used for the coating of electrical devices was modified with a commercially available hyperbranched poly(ester-amide), HybraneS2200, in order to improve the thermal degradability of the resulting thermoset and thus facilitate the recovery of substrate materials after use of the component. The curing kinetics of the unmodified and modifiedformulationswerestudied in detail with differential scanning calorimetry,Fourier transform infrared spectroscopyand rheology. The results suggest that S2200 gets incorporated into the network structure and the curing kinetics are accelerated by the presence of hydroxyl groups from S2200.