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Background: Pecha Kucha presentation is the new promising approach to student learning in the classroom that improve students’ student speaking skills, motivates the learning process, increases creativity, and enhances student engagement in learning. Pecha Kucha presentation originated from the Japanese word “chit chat” which represents a fast-paced presentation used in different discipline. It involves 20 slides, each shown in 20 seconds making a total of 6 minutes and 40 seconds. The study will assess the role of Pecha Kucha presentation on presentation preparation knowledge, presentation skills and learning satisfaction among nursing students in Tanzania. Methods: The study proposes to employ uncontrolled quasi experimental study design with quantitative approach among 230 nursing students at University of Dodoma using purposeful and stratified sampling techniques. The study proposes to use the interviewer administered questionnaire to assess study variables when using Pecha Kucha presentation format to prepare and present their assignments of project works. The study will involve training of research assistants, pre-assessment of study variables, training and demonstration of Pecha Kucha presentations format to study participants, assigning topic to the study participants, submission and evaluation of participants assignments, participants presentations using Pecha Kucha format, post-intervention assessment of variables, data analysis using SPSS version 25 and reporting Discussion: This study will address and complement the global need to invest in nursing to prepare competent nurses and midwives to solve complex health challenges through critical thinking, analysis, collaboration, and effective communication. Also, the study will address the need for WHO to increase the number of nurses and midwives with knowledge and skills to handle global economic and primary health care challenges, by ensuring all people have equal opportunity and access to health care. The study will inform policy makers, health training institutions, educators on new engaging and innovative nursing student presentation approach that enhance student creativity, critical thinking skills and consequently meaningful learning which are good indicators of learning while equipping them with survival and life skills in the 21st century to meeting the global economy and job opportunities. Trial registration: Not applicable as this is not a trial

Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key metabolic enzymes that convert isocitrate to alpha-ketoglutarate (alphaKG). Somatic point mutations in IDH1/2 that are found in rare distinct subsets of cancers confer a gain of function in cancer cells which results in the accumulation and secretion in vast excess of the oncometabolite D-2-hydroxyglutarate (D-2HG). Overproduction of D-2HG interferes with cellular metabolism and epigenetic regulation, contributing to oncogenesis. High levels of D-2HG inhibit alphaKG-dependent dioxygenases including histone, DNA and RNA demethylases, resulting in histone, DNA and RNA hypermethylation and cell differentiation blockade. In addition, D-2HG is a biomarker suitable for the detection of IDH1/2 mutations at diagnosis, and is also predictive of clinical response. The U.S. Food and Drug Administration (FDA) approved ivosidenib, a mutant-IDH1 enzyme inhibitor, for patients with relapsed or refractory IDH1-mutated acute myeloid leukemia (AML) in 2018, and also as front-line therapy for newly diagnosed elderly patients 75 years or older or who are ineligible to receive intensive chemotherapy in 2019. Ivosidenib represents a novel drug class for targeted therapy in AML.

Presentation at the IEEE International Microwave Symposium. TechnicalSession 203AB, Presented by Dr A. Pothier,June 12th 2018,Philadelphia, USA.

Presentation at IEEE IMBioC conference. Technical Session 201C. Presented by Dr A. Pothier.Philadelphia, USA, June 15th 2018.

Conference of 2013 8th European Microwave Integrated Circuits Conference, EuMIC 2013 - Held as Part of 16th European Microwave Week, EuMW 2013 ; Conference Date: 6 October 2013 Through 8 October 2013; Conference Code:102384; International audience; A solution to mitigate the dielectric charging and to improve reliability of RF MEMS switches is the replacement of the commonly used dielectrics with others that allow fast draining of the injected charges. One of the materials that have been successfully incorporated is diamond. The present paper presents both the charging and discharging process characteristics in MEMS having nanocrystalline diamond dielectric films. The study is performed by monitoring the charging and discharging current transient in MIM capacitors and the shift of the bias for minimum up state capacitance before and after progressively increasing stressing time tests. The results reveal that diamond is very promising material to improve the device reliability.

International audience; (M.M.) † These authors contributed equally to this work. Abstract: Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Despite the progress of new treatments, the risk of recurrence, morbidity, and death remains significant and the long-term adverse effects in survivors are substantial. The fraction of cancer stem-like cells (CSCs) because of their self-renewal ability and multi-lineage differentiation potential is critical for tumor initiation, growth, and resistance to therapies. For the development of new CSC-targeted therapies, further in-depth studies are needed using enriched and stable MB-CSCs populations. This work, aimed at identifying the amount of CSCs in three available human cell lines (DAOY, D341, and D283), describes different approaches based on the expression of stemness markers. First, we explored potential differences in gene and protein expression patterns of specific stem cell markers. Then, in order to identify and discriminate undifferentiated from differentiated cells, MB cells were characterized using a physical characterization method based on a high-frequency dielectrophoresis approach. Finally, we compared their tumorigenic potential in vivo, through engrafting in nude mice. Concordantly, our findings identified the D283 human cell line as an ideal model of CSCs, providing important evidence on the use of a commercial human MB cell line for the development of new strategic CSC-targeting therapies.