1. Complex Enterally Tube-Fed Community Patients Display Stable Tolerance, Improved Compliance and Better Achieve Energy and Protein Targets with a High-Energy, High-Protein Peptide-Based Enteral Tube Feed: Results from a Multi-Centre Pilot Study
- Author
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A. Owen, Carrie Wills, J. Davies, Rourke Thomas, Lily Miller, Susan Price, Rose Talbot, Kristina Stanley, Anna Lumsdon, Adrienne McCallum, Rachel Watson, Carolyn Day, Julie Barker, Sam Crease, Michelle Barry, Benjamin Green, Chloé McMurray, Mary Phillips, Lyndsey Tomlinson, Susan Duff, Nicola Cunningham, Sarah Maria Brook, Siobhan Oldham, Rebecca J. Stratton, Anna Julian, Lisa Green, Samm Morris, Jennifer Thomas, Carys Robinson, Gary P. Hubbard, Katy Sorensen, Carole-Anne Fleming, and Alice Williams
- Subjects
Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Abdominal pain ,Constipation ,Nausea ,Pilot Projects ,lcsh:TX341-641 ,compliance ,Gastroenterology ,Enteral administration ,Article ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Bloating ,Internal medicine ,medicine ,Humans ,enteral nutrition ,Prospective Studies ,Aged ,030109 nutrition & dietetics ,Nutrition and Dietetics ,business.industry ,Incidence (epidemiology) ,Middle Aged ,United Kingdom ,peptide ,Compliance (physiology) ,Parenteral nutrition ,gastrointestinal tolerance ,Patient Compliance ,Female ,030211 gastroenterology & hepatology ,Dietary Proteins ,medicine.symptom ,Energy Intake ,Peptides ,protein ,business ,lcsh:Nutrition. Foods and food supply ,energy ,Food Science - Abstract
This pilot study evaluated a high-energy, high-protein, peptide-based, (medium-chain triglycerides) MCT-containing enteral tube feed (Nutrison Peptisorb Plus HEHP®, Nutricia Ltd., Trowbridge, BA14 0XQ, UK.) containing 1.5 kcal/mL and 7.5 g protein/100 mL. Fifteen community-based, enterally tube-fed adults (42 (SD 16.3) years) received the intervention feed daily for 28 days, with gastrointestinal tolerance, compliance and nutrient intake assessed at baseline and after the intervention period. Incidence and intensity of constipation (p = 0.496), nausea (p = 1.000), abdominal pain (p = 0.366) and bloating (p = 0.250) remained statistically unchanged, yet the incidence and intensity of diarrhoea improved significantly after receiving the intervention feed (Z = &minus, 2.271, p = 0.023). Compliance with the intervention feed was significantly greater compared to the patient&rsquo, s baseline regimens (99% vs. 87%, p = 0.038). Compared to baseline, use of the intervention feed enabled patients to significantly increase total energy (1676 kcal/day (SD 449) to 1884 kcal/day (SD 537), p = 0.039) and protein intake (73 g/day (SD 17) to 89 g/day (SD 23), p = 0.001), allowing patients to better achieve energy (from 88% to 99%, p = 0.038) and protein (from 101% to 121%, p <, 0.001) requirements. This pilot study demonstrates that a high-energy, high-protein, peptide-based, MCT-containing enteral tube feed maintains gastrointestinal tolerance and improves compliance, energy and protein intake in complex, enterally tube-fed, community-based adult patients, though more work is recommended to confirm this.
- Published
- 2020