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The effect of the dietary level of selenium on lethal and renal toxicity of cis-diamminedichloroplatinum (cis-DDP) was investigated using mice fed diets containing 4 different concentrations of selenium (0.009, 0.1, 0.4 or 1.0 ppm) for 6 weeks starting at 4 weeks of age. The groups of mice fed the diets containing 0.009 and 0.1 ppm of selenium showed higher sensitivity to the lethal toxicity caused by a single subcutaneous administration of cis-DDP (32 mumol/kg) than the other groups. The renal toxicity of cis-DDP, indicated by increases in blood urea nitrogen (BUN), serum creatinine and urinary activity of N-acetylglucosaminidase (NAG), was significantly enhanced by a decrease in dietary selenium level. These results suggest that the dietary level of selenium affects the manifestation of lethal and renal toxicity of cis-DDP.

A protective effect of preadministration of the metals Cu, Bi, Zn, Hg, Cd, Ni or Co, against lethal toxicity of cis-diamminedichloroplatinum (Cisplatin; CDDP) was observed in mice. However, the protective effect seems not always to correlate with metallothionein (MT) levels in the liver and kidney of mice treated with one of these metals, suggesting possible participation in this protection of mechanisms other than MT induction by the preadministered metals.