1. Serotypes and Clonal Diversity of Streptococcus pneumoniae Causing Invasive Disease in the Era of PCV13 in Catalonia, Spain
- Author
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Amo Moran, Eva del, Esteva, Cristina, Hernández Bou, Susanna, Galles, Carmen, Navarro, Marian, Sauca, Goretti, Díaz Conradi, Álvaro, Gassiot, Paula, Marti, Carmina, Larrosa, Nieves, Ciruela, Pilar, Jane, Mireia, Sá-Leao, Raquel, Muñoz-Almagro, Carmen, García García, Juan José, Catalan Study Group of Invasive Pneumococcal Disease [autoria conjunta], and Universitat de Barcelona
- Subjects
Male ,0301 basic medicine ,Serotype ,Streptococcus pneumonia ,Pulmonology ,Physiology ,lcsh:Medicine ,Pneumònia ,Vacunes ,medicine.disease_cause ,Nervous System ,Pneumococcal conjugate vaccine ,Geographical Locations ,Pneumococcal Vaccines ,0302 clinical medicine ,Medicine and Health Sciences ,Public and Occupational Health ,Immunologia ,030212 general & internal medicine ,Child ,lcsh:Science ,Cerebrospinal Fluid ,Aged, 80 and over ,Vaccines ,Multidisciplinary ,Pneumococs ,Middle Aged ,Vaccination and Immunization ,Body Fluids ,Anti-Bacterial Agents ,Europe ,Vaccination ,Pneumococcal infections ,Streptococcus pneumoniae ,Child, Preschool ,Female ,Anatomy ,Research Article ,medicine.drug ,Adult ,Catalonia ,Adolescent ,Immunology ,030106 microbiology ,Microbial Sensitivity Tests ,Serogroup ,Pneumococcal Infections ,Microbiology ,Young Adult ,03 medical and health sciences ,Molecular microbiology ,medicine ,Humans ,Espanya ,Aged ,business.industry ,lcsh:R ,Biology and Life Sciences ,Genetic Variation ,Catalunya ,Pneumonia ,medicine.disease ,Virology ,Age Groups ,Spain ,Conjugate Vaccines ,People and Places ,Multilocus sequence typing ,Population Groupings ,lcsh:Q ,Preventive Medicine ,business ,Multilocus Sequence Typing - Abstract
The aim of this study was to study the serotypes and clonal diversity of pneumococci causing invasive pneumococcal disease in Catalonia, Spain, in the era of 13-valent pneumococcal conjugate vaccine (PCV13). In our region, this vaccine is only available in the private market and it is estimated a PCV13 vaccine coverage around 55% in children. A total of 1551 pneumococcal invasive isolates received between 2010 and 2013 in the Molecular Microbiology Department at Hospital Sant Joan de Déu, Barcelona, were included. Fifty-two serotypes and 249 clonal types—defined by MLST—were identified. The most common serotypes were serotype 1 (n = 182; 11.7%), 3 (n = 145; 9.3%), 19A (n = 137; 8.8%) and 7F (n = 122; 7.9%). Serotype 14 was the third most frequent serotype in children < 2 years (15 of 159 isolates). PCV7 serotypes maintained their proportion along the period of study, 16.6% in 2010 to 13.4% in 2013, whereas there was a significant proportional decrease in PCV13 serotypes, 65.3% in 2010 to 48.9% in 2013 (p
- Published
- 2016