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1. Salute to a giant ... Robert Geoffrey Edwards

Author

Ahuja, Kamal, Bennett, Fiona, Cohen, Jacques, Edwards, Ruth, Pritchard, Huw, Silver, Ann, Sirlin, Julio, Slee, John, Abse, Dannie, Ashwood-Smith, M. J., Bavister, Barry, Bedford, J. Michael, Beier, Henning M., Bronson, Richard, Cattanach, Bruce, Daniel, Joseph C., Dawes, Edwin A., Ferguson-Smith, Malcolm, Gardner, Richard, Griffin, Dave, Hunter, R. H. F., Johnson, Martin, Jones, Howard, Lunenfeld, Bruno, Mittwoch, Ursula, Moor, Robert, Rankin, Barbara, Schally, Andrew V., Sharpe, David J., Simpson, David, Yanagimachi, Ryuzo Yana, Alexandre, Henri, Bhargava, Pushpa M., Dexter, Alan, Diedrich, Klaus, Emperaire, Jean-Claude, Findlay, Alan, Fishel, Simon, Fox, Norma Lynn, Goddard, Hester, Gomel, Victor, Gore-Langton, Robert E., Gosden, Roger, Iritani, A., Koskimies, Aarne I., Macdonald, Grace, Menezo, Yves, Mettler, Liselotte, Monk, Marilyn, Mori, Takahide, Mortimer, David, Papaioannou, Virginia E., Racowsky, Catherine, Surani, Azim, Trounson, Alan, Blerkom, Jonathan, Vincent, Paul, Walters, Eurof, Webster, John, Williams, Peter, Aboulghar, M., Barri, Pedro N., Benagiano, Giuseppe, Blackwell, Caroline, Bolton, Virginia N., Brinsden, Peter R., Bustillo, Maria, Coulam, Carolyn, Chaouat, Gerard, Crosignani, Piergiorgio, Gardner, David, Gianaroli, Luca, Hamberger, Lars, Hartshorne, Geraldine, Hollands, Peter, Howles, Colin, Illmensee, Karl, Jauniaux, Eric, Kini, Dee, Lee, Sammy, Lees, Martin, Leese, Henry, Mathews, Thomas, Moate, Elaine, Nygren, Karl, Colin Ockleford, Palermo, Gianpiero D., Pandiyan, N., Rizk, Botros, Rosenwaks, Zev, Sallam, Hassan, Sathananthan, A. Henry, Saunders, Douglas M., Simpson, Joe Leigh, Sunde, Arne, Tan, Seang Lin, Ulloa-Aguirre, Alfredo, Gosden, Lucinda Veeck, Veiga, Anna, Albertini, David F., Alikani, Mina, Balaban, Basak, Thornhill, Alan, Beard, Helen K., Ben-Shlomo, Izhar, Borini, Andrea, Carrell, Douglas, Jonge, Christopher, Eichenlaub-Ritter, Ursula, Fleming, Steven, Geber, Selmo, Gerris, Jan, Golombok, Susan, Leather, Dame Suzi, Nagy, Zsolt Peter, Nielsen, H. Ingolf, Oehninger, Sergio, Olivennes, Francois, Patrizio, Pasquale, Paulson, Richard J., Polak Fried, Ester, Pool, Thomas B., Risquez, Francisco, Sauer, Mark V., Sciarra, John J., Basuray, Rita, Boiso, Irene, Bose, Chinmoy K., Cryan, Bob, Falconer, Anthony, Hansis, Christoph, Kahraman, Semra, Ko, Minoru S. H., Korsak, Vladislav, Loeffler, Frank, Ludwig, Michael, Magli, M. Cristina, Robertson, John A., Roche, Lady Alexandra, Thornhill, A., Wallberg-Henriksson, Harriet, Woo, George, and Ivf, Canada

2. Salute to a giant ... Robert Geoffrey Edwards

Author

Ahuja, Kamal, Bennett, Fiona, Cohen, Jacques, Edwards, Ruth, Pritchard, Huw, Silver, Ann, Sirlin, Julio, Slee, John, Abse, Dannie, Ashwood-Smith, M. J., Bavister, Barry, Bedford, J. Michael, Beier, Henning M., Bronson, Richard, Cattanach, Bruce, Daniel, Joseph C., Dawes, Edwin A., Ferguson-Smith, Malcolm, Gardner, Richard, Griffin, Dave, Hunter, R. H. F., Johnson, Martin, Jones, Howard, Lunenfeld, Bruno, Mittwoch, Ursula, Moor, Robert, Rankin, Barbara, Schally, Andrew V., Sharpe, David J., Simpson, David, Yanagimachi, Ryuzo Yana, Alexandre, Henri, Bhargava, Pushpa M., Dexter, Alan, Diedrich, Klaus, Emperaire, Jean-Claude, Findlay, Alan, Fishel, Simon, Fox, Norma Lynn, Goddard, Hester, Gomel, Victor, Gore-Langton, Robert E., Gosden, Roger, Iritani, A., Koskimies, Aarne I., Macdonald, Grace, Menezo, Yves, Mettler, Liselotte, Monk, Marilyn, Mori, Takahide, Mortimer, David, Papaioannou, Virginia E., Racowsky, Catherine, Surani, Azim, Trounson, Alan, Blerkom, Jonathan, Vincent, Paul, Walters, Eurof, Webster, John, Williams, Peter, Aboulghar, M., Barri, Pedro N., Benagiano, Giuseppe, Blackwell, Caroline, Bolton, Virginia N., Brinsden, Peter R., Bustillo, Maria, Coulam, Carolyn, Chaouat, Gerard, Crosignani, Piergiorgio, Gardner, David, Gianaroli, Luca, Hamberger, Lars, Hartshorne, Geraldine, Hollands, Peter, Howles, Colin, Illmensee, Karl, Jauniaux, Eric, Kini, Dee, Lee, Sammy, Lees, Martin, Leese, Henry, Mathews, Thomas, Moate, Elaine, Nygren, Karl, Ockleford, Colin, Palermo, Gianpiero D., Pandiyan, N., Rizk, Botros, Rosenwaks, Zev, Hossam El-Din Sallam, Sathananthan, A. Henry, Saunders, Douglas M., Simpson, Joe Leigh, Sunde, Arne, Tan, Seang Lin, Ulloa-Aguirre, Alfredo, Gosden, Lucinda Veeck, Veiga, Anna, Albertini, David F., Alikani, Mina, Balaban, Basak, Thornhill, Alan, Beard, Helen K., Ben-Shlomo, Izhar, Borini, Andrea, Carrell, Douglas, Jonge, Christopher, Eichenlaub-Ritter, Ursula, Fleming, Steven, Geber, Selmo, Gerris, Jan, Golombok, Susan, Leather, Dame Suzi, Nagy, Zsolt Peter, Nielsen, H. Ingolf, Oehninger, Sergio, Olivennes, Francois, Patrizio, Pasquale, Paulson, Richard J., Polak Fried, Ester, Pool, Thomas B., Risquez, Francisco, Sauer, Mark V., Sciarra, John J., Basuray, Rita, Boiso, Irene, Bose, Chinmoy K., Cryan, Bob, Falconer, Anthony, Hansis, Christoph, Kahraman, Semra, Ko, Minoru S. H., Korsak, Vladislav, Loeffler, Frank, Ludwig, Michael, Magli, M. Cristina, Robertson, John A., Roche, Lady Alexandra, Thornhill, A., Wallberg-Henriksson, Harriet, and Woo, George

3. Isolation and characterization of adrenocortical progenitors involved in the adaptation to stress

Author

Martin Werdermann, Charlotte Steenblock, Maria F. Rubin de Celis, Ilona Berger, Alice Santambrogio, Mirko Peitzsch, Cynthia L. Andoniadou, Verena Pawolski, Luis F. Delgadillo Silva, Ana Brennand, Andrew V. Schally, Stefan R. Bornstein, University of Zurich, and Schally, Andrew V

Subjects
0301 basic medicine, Isolation (health care), Cellular differentiation, 10265 Clinic for Endocrinology and Diabetology, 610 Medicine & health, Adrenocorticotropic hormone, Biology, Mice, stress, 03 medical and health sciences, Adrenocorticotropic Hormone, Stress, Physiological, medicine, Animals, Homeostasis, Progenitor cell, Cells, Cultured, progenitors, 1000 Multidisciplinary, Multidisciplinary, Adrenal cortex, Adrenal gland, Stem Cells, Cell Differentiation, Cell Biology, Biological Sciences, Nestin, Adaptation, Physiological, Cell biology, cortex, 030104 developmental biology, medicine.anatomical_structure, adrenal, Adrenal Cortex, Stem cell, Adaptation
Abstract

Significance Humans are constantly confronted with multiple stressors, to which the bodily response and adaptation are essential. The adrenal gland plays a major role in the response to physiological challenges. Maintenance of the adrenal is partly accomplished by proliferation and differentiation of adult progenitors and stem cells in the cortex and medulla. In this study, we have isolated and characterized a subpopulation of adrenocortical progenitors, which are interconnected with adrenomedullary stress-dependent progenitors. Under stress, the adrenocortical progenitors are also activated and they mobilize, giving rise to steroidogenic cells. Our findings demonstrate the coordinated action of stress-inducible stem cells to ensure tissue remodeling and cellular and functional adaptation to stress., The adrenal gland is a master regulator of the human body during response to stress. This organ shows constant replacement of senescent cells by newly differentiated cells. A high degree of plasticity is critical to sustain homeostasis under different physiological demands. This is achieved in part through proliferation and differentiation of adult adrenal progenitors. Here, we report the isolation and characterization of a Nestin+ population of adrenocortical progenitors located under the adrenal capsule and scattered throughout the cortex. These cells are interconnected with progenitors in the medulla. In vivo lineage tracing revealed that, under basal conditions, this population is noncommitted and slowly migrates centripetally. Under stress, this migration is greatly enhanced, and the cells differentiate into steroidogenic cells. Nestin+ cells cultured in vitro also show multipotency, as they differentiate into mineralocorticoid and glucocorticoid-producing cells, which can be further influenced by the exposure to Angiotensin II, adrenocorticotropic hormone, and the agonist of luteinizing hormone-releasing hormone, triptorelin. Taken together, Nestin+ cells in the adult adrenal cortex exhibit the features of adrenocortical progenitor cells. Our study provides evidence for a role of Nestin+ cells in organ homeostasis and emphasizes their role under stress. This cell population might be a potential source of cell replacement for the treatment of adrenal insufficiency.

Published
2019

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