2 results on '"Schroder, Helmut"'
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2. Leisure time physical activity is associated with improved HDL functionality in high cardiovascular risk individuals: a cohort study
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Ángel M. Alonso-Gómez, Miquel Fiol, Jordi Salas-Salvadó, Montserrat Fitó, Enrique Gómez-Gracia, Olga Castañer, José Lapetra, Helmut Schröder, Camille Lassale, María Trinidad Soria-Florido, Dolores Corella, Álvaro Hernáez, Ramon Estruch, Emilio Ros, Miguel Ángel Martínez-González, Lluis Serra-Majem, Xavier Pintó, [Hernaez, Alvaro] Hosp del Mar Med Res Inst IMIM, Barcelona, Spain, [Soria-Florido, Maria Trinidad] Hosp del Mar Med Res Inst IMIM, Barcelona, Spain, [Castaner, Olga] Hosp del Mar Med Res Inst IMIM, Barcelona, Spain, [Schroder, Helmut] Hosp del Mar Med Res Inst IMIM, Barcelona, Spain, [Fito, Montserrat] Hosp del Mar Med Res Inst IMIM, Barcelona, Spain, [Lassale, Camille] Hosp del Mar Med Res Inst IMIM, Barcelona, Spain, [Hernaez, Alvaro] August Pi i Sunyer Biomed Res Inst IDIBAPS, Barcelona, Spain, [Estruch, Ramon] August Pi i Sunyer Biomed Res Inst IDIBAPS, Barcelona, Spain, [Hernaez, Alvaro] Inst Salud Carlos III, CIBER Pathophysiol Obes & Nutr CIBEROBN, Madrid, Spain, [Castaner, Olga] Inst Salud Carlos III, CIBER Pathophysiol Obes & Nutr CIBEROBN, Madrid, Spain, [Pinto, Xavier] Inst Salud Carlos III, CIBER Pathophysiol Obes & Nutr CIBEROBN, Madrid, Spain, [Estruch, Ramon] Inst Salud Carlos III, CIBER Pathophysiol Obes & Nutr CIBEROBN, Madrid, Spain, [Salas-Salvado, Jordi] Inst Salud Carlos III, CIBER Pathophysiol Obes & Nutr CIBEROBN, Madrid, Spain, [Corella, Dolores] Inst Salud Carlos III, CIBER Pathophysiol Obes & Nutr CIBEROBN, Madrid, Spain, [Alonso-Gomez, Angel] Inst Salud Carlos III, CIBER Pathophysiol Obes & Nutr CIBEROBN, Madrid, Spain, [Angel Martinez-Gonzalez, Miguel] Inst Salud Carlos III, CIBER Pathophysiol Obes & Nutr CIBEROBN, Madrid, Spain, [Ros, Emilio] Inst Salud Carlos III, CIBER Pathophysiol Obes & Nutr CIBEROBN, Madrid, Spain, [Serra-Majem, Lluis] Inst Salud Carlos III, CIBER Pathophysiol Obes & Nutr CIBEROBN, Madrid, Spain, [Fiol, Miguel] Inst Salud Carlos III, CIBER Pathophysiol Obes & Nutr CIBEROBN, Madrid, Spain, [Lapetra, Jose] Inst Salud Carlos III, CIBER Pathophysiol Obes & Nutr CIBEROBN, Madrid, Spain, [Gomez-Gracia, Enrique] Inst Salud Carlos III, CIBER Pathophysiol Obes & Nutr CIBEROBN, Madrid, Spain, [Fito, Montserrat] Inst Salud Carlos III, CIBER Pathophysiol Obes & Nutr CIBEROBN, Madrid, Spain, [Lassale, Camille] Inst Salud Carlos III, CIBER Pathophysiol Obes & Nutr CIBEROBN, Madrid, Spain, [Pinto, Xavier] Hosp Univ Bellvitge, Lhospitalet De Llobregat, Spain, [Estruch, Ramon] Hosp Clin Barcelona, Barcelona, Spain, [Ros, Emilio] Hosp Clin Barcelona, Barcelona, Spain, [Salas-Salvado, Jordi] Univ Rovira & Virgili, Hosp Univ St Joan de Reus, Reus, Spain, [Corella, Dolores] Univ Valencia, Valencia, Spain, [Alonso-Gomez, Angel] Univ Basque Country, UPV EHU, Bioaraba Hlth Res Inst, Leioa, Spain, [Angel Martinez-Gonzalez, Miguel] Univ Navarra, Pamplona, Spain, [Angel Martinez-Gonzalez, Miguel] Harvard TH Chan Sch Publ Hlth, Boston, MA USA, [Schroder, Helmut] Inst Salud Carlos III, CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain, [Serra-Majem, Lluis] Univ Las Palmas Gran Canaria, Las Palmas Gran Canaria, Spain, [Fiol, Miguel] Hosp Son Espases, Balearic Isl Hlth Res Inst, Palma De Mallorca, Balearic Island, Spain, [Lapetra, Jose] Dist Sanitario Atenc Primaria Sevilla, Seville, Spain, [Gomez-Gracia, Enrique] Univ Malaga, Malaga, Spain, [Lassale, Camille] UCL, Dept Epidemiol & Publ Hlth, London, England, Beatriu de Pinos postdoctoral programme of the Government of Catalonia's Secretariat for Universities and Research of the Ministry of Economy and Knowledge, Agencia de Gestio d'Ajuts Universitaris i de Recerca AGAUR, Instituto de Salud Carlos III, and FEDER funds
- Subjects
Epidemiology ,Events ,Leisure time ,physical activity ,030204 cardiovascular system & hematology ,Cohort Studies ,chemistry.chemical_compound ,0302 clinical medicine ,Risk Factors ,Validation ,High-density-lipoprotein ,Ampk ,0303 health sciences ,biology ,Cholesterol ,Cardiovascular Diseases ,lipids (amino acids, peptides, and proteins) ,Cardiology and Cardiovascular Medicine ,Cohort study ,Adult ,lifestyle ,Activity questionnaire ,medicine.medical_specialty ,HDL function ,Cardiovascular health ,Physical activity ,03 medical and health sciences ,Leisure Activities ,Internal medicine ,Cholesterylester transfer protein ,medicine ,Humans ,Hdl functionality ,Exercise ,030304 developmental biology ,business.industry ,Protein ,Cholesterol, HDL ,biomarkers ,Lifestyle ,Heart-disease ,Cholesterol Ester Transfer Proteins ,chemistry ,Diabetes Mellitus, Type 2 ,Heart Disease Risk Factors ,biology.protein ,business ,Biomarkers - Abstract
Aims Physical activity has consistently been shown to improve cardiovascular health and high-density lipoprotein-cholesterol levels. However, only small and heterogeneous studies have investigated the effect of exercise on high-density lipoprotein functions. Our aim is to evaluate, in the largest observational study to date, the association between leisure time physical activity and a range of high-density lipoprotein functional traits. Methods The study sample consisted of 296 Spanish adults at high cardiovascular risk. Usual leisure time physical activity and eight measures of high-density lipoprotein functionality were averaged over two measurements, one year apart. Multivariable linear regression models were used to explore the association between leisure time physical activity (exposure) and each high-density lipoprotein functional trait (outcome), adjusted for cardiovascular risk factors. Results Higher levels of leisure time physical activity were positively and linearly associated with average levels over one year of plasma high-density lipoprotein-cholesterol and apolipoprotein A-I, paraoxonase-1 antioxidant activity, high-density lipoprotein capacity to esterify cholesterol and cholesterol efflux capacity in individuals free of type 2 diabetes only. The increased cholesterol esterification index with increasing leisure time physical activity reached a plateau at around 300 metabolic equivalents.min/day. In individuals with diabetes, the relationship with cholesteryl ester transfer protein followed a U-shape, with a decreased cholesteryl ester transfer protein activity from 0 to 300 metabolic equivalents.min/day, but increasing from there onwards. Increasing levels of leisure time physical activity were associated with poorer high-density lipoprotein vasodilatory capacity. Conclusions In a high cardiovascular risk population, leisure time physical activity was associated not only with greater circulating levels of high-density lipoprotein-cholesterol, but also with better markers of high-density lipoprotein functionality, namely cholesterol efflux capacity, the capacity of high-density lipoprotein to esterify cholesterol and paraoxonase-1 antioxidant activity in individuals free of diabetes and lower cholesteryl ester transfer protein activity in individuals with type 2 diabetes.
- Published
- 2019
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