1. Imaging and clinical correlates with regorafenib in metastatic colorectal cancer
- Author
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David Cunningham, Nazim Serdar Turhal, Salvatore Siena, Alain Hendlisz, Tara Seery, Sun Young Kim, Stefano Cascinu, Eiji Oki, Khurum Khan, Christophe Tournigand, Lin Shen, Khan, K., Cascinu, S., Cunningham, D., Kim, S. -Y., Oki, E., Seery, T., Shen, L., Siena, S., Tournigand, C., Turhal, N. S., and Hendlisz, A.
- Subjects
0301 basic medicine ,Oncology ,medicine.medical_specialty ,Positron emission tomography ,Colorectal cancer ,medicine.drug_class ,Angiogenesis ,Pyridines ,Tyrosine-kinase inhibitor ,Metastasis ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Magnetic resonance imaging ,Internal medicine ,Regorafenib ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Neoplasm Metastasis ,Imagerie médicale, radiologie, tomographie ,Computed tomography ,Protein Kinase Inhibitors ,Randomized Controlled Trials as Topic ,medicine.diagnostic_test ,Neovascularization, Pathologic ,business.industry ,Metastatic colorectal cancer ,Phenylurea Compounds ,General Medicine ,medicine.disease ,Magnetic Resonance Imaging ,Cancérologie ,030104 developmental biology ,chemistry ,Response Evaluation Criteria in Solid Tumors ,030220 oncology & carcinogenesis ,Positron-Emission Tomography ,business ,Colorectal Neoplasms ,Tomography, X-Ray Computed - Abstract
In colorectal cancer (CRC), imaging is important in determining tumor stage, selecting treatment strategies, and in assessing response to therapy. However, some challenges remain with established imaging techniques, such as computed tomography, and with some commonly used response criteria, such as Response Evaluation Criteria in Solid Tumors, which measures change in size of several target lesions instead of change in tumor morphology or metabolic function. In addition, these assessments are not typically conducted until after 8 weeks of treatment, meaning that potential non-responders are often not identified in a timely manner. Regorafenib, an oral tyrosine kinase inhibitor indicated for the treatment of metastatic CRC, blocks the activity of several protein kinases involved in angiogenesis, oncogenesis, metastasis, and tumor immunity. Timely differentiation of regorafenib responders from non-responders using appropriate imaging techniques that recognize not only changes in tumor size but also changes in tumor density or vasculature, may reduce unnecessary drug-related toxicity in patients who are unlikely to respond to treatment. This review discusses the latest developments in computed tomography, magnetic resonance imaging, and positron emission tomography tumor imaging modalities, and how these aid in identifying patients with metastatic CRC who are responders or non-responders to regorafenib treatment., SCOPUS: re.j, info:eu-repo/semantics/published
- Published
- 2020