Search

Measurement of the dwell time and moving speed of a high-activity iridium-192 (Ir-192) source used for high-dose-rate (HDR) brachytherapy is important for estimating the precise dose delivery to a tumor. For this purpose, we used a cerium-doped yttrium aluminum perovskite (YA1OGamma photon imaging was conducted using the gamma camera in list mode for the Ir-192 source of HDR brachytherapy with fixed dwell times and positions. The acquired list-mode images were sorted to millisecond-order interval time sequential images to evaluate the dwell time at each position. Time count rate curves were derived to calculate the dwell time at each source position and moving speed of the source.We could measure the millisecond-order time sequential images for the Ir-192 source. The measured times for the preset dwell times of 2 s and 10 s were 1.98 to 2.00 s full width at half maximum (FWHM) and 10.0 s FWHM, respectively. The dwell times at the first dwell position were larger than those at other positions. We also measured the moving speeds of the source after the dwells while moving back to the afterloader and found the speed increased with the distance from the edge of the field of view to the last dwell position.We conclude that millisecond-order time sequential imaging of the Ir-192 source is possible by using a gamma camera and is useful for evaluating the dwell times and moving speeds of the Ir-192 source.

Proton-induced secondary-electron-bremsstrahlung (SEB) imaging is a promising method for estimating the ranges of particle beam. However, SEB images do not directly represent dose distributions of particle beams. In addition, the ranges estimated from measured images were deviated because of limited spatial resolutions of the developed x-ray camera as well as statistical noise in the images. To solve these problems, we proposed a method for predicting high-resolution dose images from SEB images with various count level using a deep learning (DL) approach for range and width verification.In this study, we adopted the double U-Net model, which is a previously proposed deep convolutional network model. The first U-Net model in the double U-Net model was used to denoise the SEB images with various count level. The first U-Net model for denoising was trained on 8000 pairs of SEB images with various count level and noise-free images which were created by a sophisticated in-house developed model function. The second U-Net model for dose prediction was trained using 8000 pairs of denoised SEB images from the first U-Net model and high-resolution dose images generated by Monte Carlo simulation.For both simulation and measurement data, the trained DL model could successfully predict high-resolution dose images which showed a clear Bragg peak and no statistical noise. The difference of the range and width was less than 2.1 mm, even from the SEB images measured with a decrease in the number of irradiated protons to less than 11% of 3.2 × 10High-resolution dose images from measured and simulated SEB images were successfully predicted by using the trained DL model for protons. Our proposed DL model was feasible to predict dose images accurately even with smaller number of irradiated protons.

High-resolution imaging of alpha particles is required in the detection of alpha radionuclides in cells or small organs for the development of radio-compounds for targeted alpha-particle therapy or other purposes. We developed an ultrahigh resolution, real time alpha-particle imaging system for observing the trajectories of alpha particles in a scintillator. The developed system is based on a magnifying unit and a cooled electron multiplying charge-coupled device (EM-CCD) camera, combined with a 100-µm-thick Ce-doped Gd3Al2Ga3O12 (GAGG) scintillator plate. Alpha particles from an Am-241 source were irradiated to the GAGG scintillator and imaged with the system. Using our system, we measured the trajectories of the alpha particles having different shapes in real time. In some of these measured trajectories, the line shapes of the alpha particles that flew in the GAGG scintillator were clearly observed. The lateral profiles of the alpha-particle trajectories were imaged with widths of ~ 2 µm. We conclude that the developed imaging system is promising for research on targeted alpha-particle therapy or other alpha particle detections that require high spatial resolution.

The authors have requested that this preprint be removed from Research Square.

Prompt X-ray imaging using a low-energy X-ray camera is a promising method for observing the beam shape from outside the subject. However, such imaging has so far been conducted only on static images with relatively long acquisition times without any energy information. Consequently, we performed list-mode prompt X-ray imaging using a newly developed data acquisition system combined with a pinhole YAP(Ce) camera during irradiation of a water phantom with carbon ions. Prompt X-ray imaging was conducted in list mode with a 1-ms time stamp and 128-channel energy bins during irradiation of a water phantom with 241.5 MeV/n carbon ions. After the imaging, list-mode data were sorted to obtain the time-sequential prompt X-ray images and those with different energies. From the images with different energies, we found the energy spectra were different depending on the areas in the images, and the reduction of the background fraction was possible. From the short time-sequential prompt X-ray images, we could even observe the differences in the images depending on the acquisition times, as well as the spill and ripple shapes of the carbon ion beam.

Gold wire is commonly used for quality assurance (QA) of the neutron beam in a boron neutron capture therapy (BNCT) system. It is set in water and irradiated with the neutron beam, and then 412-keV gamma photons from the activated gold wire are measured by a semiconductor detector. Since this procedure takes time and labor, a more efficient method is desired. To reduce the time and labor to measure the radioactivity of an activated gold wire, we carried out imaging of 412-keV gamma photons from the activated gold wire using a developed high-energy gamma camera. After the gold wire was set in the depth direction in a water-filled phantom and irradiated with neutron beams using the BNCT system, gamma photon imaging was conducted with the developed high-energy gamma camera. On the measured image, a depth profile was set to obtain the neutron distribution, and this was compared with the profile sequentially measured with a semiconductor detector. An image of the 412-keV gamma photons was obtained with an imaging time of 1.5 hours. The estimated depth profile of the neutron beam from the gamma camera image closely matched that measured with a semiconductor detector. Imaging of the gamma photons emitted from the activated gold wire was possible, and it offers an efficient method to measure the thermal neutron distribution of the BNCT system. This method has the potential to reduce the time and labor for QA of a BNCT system.

Purpose Although the imaging of luminescence emitted in water during irradiation of protons and carbon ions is a useful method for range and dose estimations, the intensity of the images is relatively low due to the low photon production of the luminescence phenomenon. Therefore, a relatively long time is required for the imaging. Since a fluorescent dye, fluorescein, may increase the intensity of the optical signal, we measured the luminescence images of water with different concentrations of fluorescein during irradiation of protons and carbon ions and compared the results with those by measurements with water. Methods A cooled charge‐coupled device (CCD) camera was used for imaging a water phantom with different concentrations of fluorescein from 0.0063 to 0.025 mg/cm3, in addition to a water phantom without fluorescein during irradiation of 150‐MeV protons and 241.5‐MeV/n carbon ions. Results For both protons and carbon ions, the intensity of the luminescence images increased as the concentration of fluorescein increased. With a fluorescein concentration of 0.025 mg/cm3, the intensities increased to more than 10 times those of water for both protons and carbon ions. Although the shape of the depth profiles of luminescence images of water with fluorescein appeared similar to that of water for protons, those for carbon ions were different from those of water due to the increase in the Cherenkov light component at shallow depths by the decrease in the angular dependencies of the Cherenkov light. Conclusion We confirmed the increase in intensity of the luminescence of water by adding fluorescein for particle ions. With a small amount of Cherenkov light contamination in the images, such as protons, the relative distributions of the luminescence images with fluorescein were similar to that of water and will be used for range or dose determination in a short time.

The accurate measurement of the 3D dose distribution of carbon-ion beams is essential for safe carbon-ion therapy. Although ionization chambers scanned in a water tank or air are conventionally used for this purpose, these measurement methods are time-consuming. We thus developed a rapid 3D dose-measurement tool that employs a silver-activated zinc sulfide (ZnS) scintillator with lower linear energy transfer (LET) dependence than gadolinium-based (Gd) scintillators; this tool enables the measurement of carbon-ion beams with small corrections. A ZnS scintillator sheet was placed vertical to the beam axis and installed in a shaded box. Scintillation images produced by incident carbon-ions were reflected with a mirror and captured with a charge-coupled device (CCD) camera. A 290 MeV/nucleon mono-energetic beam and spread-out Bragg peak (SOBP) carbon-ion passive beams were delivered at the Gunma University Heavy Ion Medical Center. A water tank was installed above the scintillator with the water level remotely adjusted to the measurement depth. Images were recorded at various water depths and stacked in the depth direction to create 3D scintillation images. Depth and lateral profiles were analyzed from the images. The ZnS-scintillator-measured depth profile agreed with the depth dose measured using an ionization chamber, outperforming the conventional Gd-based scintillator. Measurements were realized with smaller corrections for a carbon-ion beam with a higher LET than a proton. Lateral profiles at the entrance and the Bragg peak depths could be measured with this tool. The proposed method would make it possible to rapidly perform 3D dose-distribution measurements of carbon-ion beams with smaller quenching corrections.

Dose distribution measurements of high-energy X-rays from medical linear accelerators (LINAC) in water are important for quality control (QC) of the system. Although Cherenkov-light imaging is a useful method for measuring the high-energy X-ray dose distribution, depth profiles have an underestimated dose at increased depths due to the angular dependency of the Cherenkov light generated in water. In this study, we use a linear polarizer to separate the majority of polarized components from the majority of unpolarized components of Cherenkov-light images in water and then use this information to correct for angular dependencies.A water phantom, a cooled charge-coupled device (CCD) camera, and a polarizer were installed in a black box. Then, the water phantom was irradiated from the upper side with 6 or 10 MV X-rays, and the Cherenkov light generated in water was imaged with the polarizer axis at both parallel and perpendicular orientations to the beam. By using these images from the two orientations relative to the beam, we corrected the angular dependency of the Cherenkov light.By subtracting the images measured with the polarizer perpendicular to the beams from the images measured with the polarizer parallel to the beams, we could obtain images with only the polarized components. Using these images, we could calculate the images with non-polarized components that had similar depth profiles to those calculated with a planning system. The average difference between corrected depth profiles and those calculated with the planning system was less than 1%, while that between uncorrected depth profiles and the planning system was more than 8.3% in depths of water from 20 to 100 mm.We conclude that the use of the polarizer has the potential to improve the accuracy of dose distribution in Cherenkov-light imaging of water using high-energy X-rays.

Although real-time imaging of the high-activity iridium-192 (Ir-192) source position during high-dose-rate (HDR) brachytherapy using a high-energy gamma camera system is a promising approach, the energy window was not optimized for spatial resolution or scatter fraction.By using a list-mode data-acquisition system that can acquire energy information of a cerium-doped yttrium aluminum perovskite (YA1OThe spatial resolution was highest for the central energy of the window at ∼300 keV. The scatter fraction was also smallest for the central energy of the window at ∼300 keV, and the scatter fraction was more than 48 % smaller than that for the full energy window.We clarified that the spatial resolution can be improved and the scatter fraction can be reduced through optimizing the energy window of the YAP(Ce) gamma camera by setting the central energy of the window to ∼300 keV for HDR brachytherapy.

Although the luminescence images of water and an acrylic block during irradiation of proton and carbon ion beams were measured recently, they were not measured for helium ions. Because the mass of helium ions is four times that of protons and one-third that of carbon ions, different results from protons or carbon ions will be obtained by luminescence imaging. We measured the luminescence images of water and an acrylic block during irradiation of helium ion beams. Imaging was conducted using a cooled charge-coupled device (CCD) camera during the irradiation of helium ion pencil beams at three different energies to a water phantom and an acrylic block in addition to mini-beams of helium ions at four different energies. From the measured luminescence images during irradiation of helium ion pencil beams, we could estimate the ranges of the beams for water and the acrylic block. In the luminescence images of the acrylic block during irradiation of mini-beams of helium ions, we observed the luminescence of mini-beams with Bragg peaks in the images. Luminescence imaging of water and an acrylic block during the irradiation of helium ion beams was possible and could be used for range determination of the beams.

Purpose We developed a novel and simple method to measure the source positions in applicators directly for high-dose-rate (HDR) brachytherapy based on Cherenkov emission imaging, and evaluated the performance. Methods The light emission from plastic applicators used in cervical cancer treatments, irradiated by an 192 Ir γ-ray source, was captured using a charge-coupled device camera. Moreover, we attached plastics of different shapes, including tapes, tubes, and plates to a metal applicator, to use as screens for the Cherenkov imaging. We determined the source positions and dwell intervals from the light profiles along with the applicator and compared these with preset values and dummy marker measurements. Results The source positions and dwell intervals measured from the light images were comparable to the dummy marker measurements and preset values. The distance from the applicator tip to the first source positions agreed with the dummy marker measurements within 0.2 mm for the plastic tandem. The dwell intervals measured using the Cherenkov method agreed with the preset values within 0.6 mm. The distances measured with three plastic types on the metal applicator also agreed with the dummy marker measurements within 0.2 mm. The dwell intervals measured using the plastic tape agreed with the preset values within 0.7 mm. Conclusions The proposed method should be suitable for rapid and easy quality assurance (QA) investigations in HDR brachytherapy, as it enables source position using a single image. The method allows for real-time, filmless measurements of the source positions to be obtained and is useful for rapid feedback in QA procedures.

We developed a Gd2Si2O7 (GPS) scintillator-based alpha imaging detector and demonstrated its effectiveness by evaluating the actual Pu particle and 222Rn progeny. The GPS scintillator plate was prepared by a sintering method. The outer dimensions of the GPS scintillator plate were $5\times 5$ cm, and the scintillator layer was approximately $50~\mu \text{m}$ on a 3-mm-thick high-transparency glass. The plate was optically coupled to a position-sensitive photomultiplier tube (Hamamatsu H8500, Hamamatsu, Japan) with silicone grease. The developed imaging detector exhibited good uniformity; Pu particle activities were accurately evaluated at 14 different positions and the difference in activity was within ±6%. The radon-222 progeny counts were reduced by 65.3% by applying an energy window. Although the Pu/222Rn progeny activity ratio was 1/51, the Pu particle was successfully identified among the 222Rn progeny within the 5-min measurement time. The imaging detector has an excellent ability for detecting Pu among the 222Rn progeny. Thus, this detector is useful for alpha contamination monitoring in high-radon-background environments.

Purpose The luminescence images of water during the irradiation of carbon-ions provide useful information such as the ranges and the widths of carbon-ion beams. However, measured luminescence images show higher intensities in shallow depths and wider lateral profiles than those of the dose distributions. These differences prevent the luminescence imaging of water from being applied to a quality assurance for carbon-ion therapy. We assumed that the differences were due to the contaminations of Cerenkov-light from the secondary electrons of carbon-ions as well as the prompt gamma photons in the measured image. In this study, we applied a correction method to a luminescence image of water during the irradiation of carbon-ion beams. Methods We estimated the distribution of the Cerenkov-light in water during the irradiation of carbon-ions by Monte Carlo simulation and subtracted the simulated Cerenkov-light from the depth and lateral profiles of the measured luminescence image for 241.5 MeV/u-carbon-ions. Results With these corrections, we successfully obtained depth and lateral profiles whose distributions are almost identical to the dose distributions of carbon-ions. The high intensities in the shallow depth areas decreased and the Bragg peak intensity increased. The beam widths of the measured images approached those of the ionization chamber. Conclusions These results indicate that the luminescence imaging of water with our proposed correction has potential to be used for dose distribution measurements for carbon-ion therapy dosimetry.

Recently, we found that the decay times between $\alpha $ particles and $\gamma $ photons were different for the recently developed scintillators. We also noticed that $\alpha - \beta $ ratios were different for these scintillators. We expect that there might be a relation between these two properties. Thus, we measured the $\alpha - \beta $ ratios and the decay time differences between $\alpha $ particles and $\gamma $ photons for the newly developed scintillators and investigated the relationship between them. We measured the $\alpha - \beta $ ratios and decay times for five scintillators: (LaGd)2Si2O7 (LaGPS), Gd2Si2O7 (GPS), ceramic Gd3Al2Ga3O12(GGAG), ceramic (YGd)3(GaAl)5O12:Ce (YGAG), and single-crystal Gd3Al2Ga3O12 (GAGG). After the measurements, we estimated the correlation between the $\alpha - \beta $ ratios and the decay time differences between $\alpha $ particles and $\gamma $ photons. Among these scintillators, as the $\alpha - \beta $ ratios increased, decay time differences decreased with the correlation coefficient ( $R^{2}$ ) of more than 0.8. We conclude that there was a negative correlation between $\alpha - \beta $ ratios and the decay time differences between $\alpha $ particles and $\gamma $ photons for the measured newly developed scintillators.

Optical imaging of ionizing radiation is a possible method for dose distribution measurements. However, it is not clear whether the imaging method is also applicable to neutrons. To clarify this, we performed the imaging of neutrons in water from boron neutron capture therapy (BNCT) systems. Such systems require efficient distribution measurements of neutrons for quality assessment (QA) of the beams.A water-filled phantom was irradiated from the side with an epithermal neutron beam, in which a lithium-containing zinc sulfate (Li-ZnS(Ag)) plate was set in the beam direction, and during this irradiation the scintillation of the plate was imaged using a cooled charge-coupled device (CCD) camera. In the imaging, Li-6 in the Li-ZnS(Ag) plate captures neutrons and converts them to alpha particles (He-4) and tritium (H-3), while ZnS(Ag) in the Li-ZnS(Ag) plate produces scintillation light in the plate. We also conducted Monte Carlo simulation and compared its results with the experimental results.The image of the emitted light from the Li-ZnS(Ag) plate was clearly obtained with an imaging time of 0.5 s. The depth and lateral profiles of the measured image using the Li-ZnS(Ag) plate showed the same shapes as the neutron distributions measured with gold foil, within a difference of 8%. The destructive effect of neutrons on the CCD camera increased approximately three times, but the unit was still working after the measurement.The optical imaging of neutrons in water is possible, and it has the potential to be a new method for efficient QA as well as for research on neutrons.

Although luminescence imaging of water during irradiation by particle ions is a promising method for dose estimation, it has only been tried for static images in which temporal information is not included. In addition to the positional distribution of the beam, temporal information is also important because the beams from a synchrotron-based therapy system have short pulse shapes called spills. The temporal information is also important for high dose rate, short-time radiotherapy, or so-called FLASH radiotherapy. To measure the particle ion beam distributions with precise temporal information, we conducted short time sequential luminescence imaging of protons. First, we measured short time sequential luminescence images during irradiation of a water phantom by 150-MeV protons using a cooled charge-coupled device (CCD) camera at 0.143-s intervals. With this imaging, the images showed beam distributions, but the shapes of the spill were not precisely evaluated in time intensity curves due to the insufficient sampling rate of the imaging. Then we measured short time sequential optical images with 0.053-s intervals. With this imaging, the images showed that the beam distributions in the spill shape could be measured, but the image and depth profiles evaluated from the images were noisy due to the insufficient light intensity. Consequently, we measured short time sequential luminescence images during irradiation of fluorescein (FS) water by 150-MeV protons. Since FS water produced ∼10 times higher luminescence, we could obtain high-intensity images enabling us to evaluate the time intensity curves based on the shape of the spills during measurement with 0.053-s intervals. The depth profiles of the beam were also obtained from the measured images. With these results, we confirmed that time sequential luminescence imaging was possible and, in such cases, FS water images measured at 0.053-s intervals are most promising to measure the short time sequential luminescence images during irradiation of protons.

Vitamin B2 (V-B2) is a material that converts shorter-wavelength light such as ultraviolet (UV) light to longer-wavelength light. However, it is not clear whether longer-wavelength light is produced by the irradiation of alpha particles. Because UV light such as Cherenkov light is required to produce longer-wavelength light for V-B2 and alpha particles do not produce Cherenkov light in a material, no light is expected to be emitted in V-B2 by the irradiation of alpha particles. However, we irradiated alpha particles to a V-B2 plate and measured the produced light in the plate. During irradiation of alpha particles, a significant amount of longer-wavelength light was observed from the V-B2 plate. The luminescence intensity of the V-B2 plate during irradiation of alpha particles was ∼1/6 of that of the plastic scintillator. The spectrum of luminescence from the V-B2 plate during this irradiation was the same as that emitted by the irradiation of ultraviolet (UV) light, which possibly indicates UV or shorter-wavelength light production in the V-B2 plate by the irradiation of alpha particles. This longer-wavelength light is not attributed to the UV light from the air scintillation by the alpha particles but to the direct irradiation of alpha particles to the V-B2 plate. From these results, we conclude that the luminescence of the V-B2 plate was the scintillation by the irradiation of alpha particles, or other phenomenon that was; UV as well as shorter-wavelength visible light was produced in the V-B2 plate by the irradiation of alpha particles and that the longer-wavelength light was produced from this light. The UV light was produced from the light generated by the dipole interaction of moving secondary electrons with V-B2 or binder molecules and then converted to the longer-wavelength light with a slower decay of the V-B2 in the plate that had high intensity due to the decreased simultaneity of the light emission.

Imaging of positrons induced by nuclear reactions with a proton beam is a possible method for observing the beam shape from outside the subject. However, such imaging of induced positrons has so far been conducted for solid materials. The induced positron distribution in liquid water has not been measured or reported. To clarify the distribution of induced positrons in liquid water, we conducted Cherenkov-light imaging after irradiation by protons to a water phantom. After irradiation by a 117-MeV proton beam to a phantom containing liquid water, Cherenkov-light imaging of the induced positrons was conducted using a cooled charge-coupled device (CCD) camera following the decay of the positrons. We also imaged the luminescence of water during irradiation by the proton beam to compare the distributions. We could measure the distribution of Cherenkov-light from the induced positrons in liquid water. Positron distributions kept their beam shapes in water but were different from that of the luminescence image; positron distribution was wider in the deep area of the beams in the lateral as well as depth direction. The distributions' shapes were only slightly changed with time. We conclude that Cherenkov-light imaging from the induced positrons after irradiation by a proton beam in water was possible, and we found that the induced positrons kept their beam shape in water with different shape from that of dose. These findings may provide new insights for imaging in particle therapy.

Astatine-211 (At-211) is a promising alpha particle emitter for targeted radionuclide therapy. Since its daughter isotope (polonium-211(Po-211)) emits characteristic X-rays of about 80 keV, the distribution of At-211 in the body can be imaged by detecting the X-rays with a scintillation camera. However, the isotopes also emit high-energy gamma photons that are collimated with difficulty for a parallel-hole collimator of a clinical scintillation camera system, and thus the selection of a collimator is important. In this study, we compared the performances of low-energy high-resolution (LEHR), low-energy all-purpose (LEAP), medium-energy (ME), and high-energy (HE) parallel-hole collimators for At-211 using Monte Carlo simulation. We simulated a clinical scintillation camera system with the collimators using the Geant4 toolkit. The energy spectra, sensitivities, and spatial resolutions for the point source of At-211 were evaluated. Moreover, we simulated imaging of six sphere sources of At-211 in a 1-cm-thick cylindrical phantom filled with At-211 solution to evaluate image contrast. All of the results in this study are simulation data. The spatial resolution with LEHR was 7.6 mm full width at half maximum (FWHM) and the highest between collimators, while the sensitivity with LEAP was 85 cps/MBq and the highest. The image contrast acquired with the ME collimator was superior to those with the other collimators. We concluded that the LEHR, LEAP, and ME collimators had their advantages, so an optimum collimator should be selected depending on the purpose of imaging of At-211, although there was no advantage in using the HE collimator for the imaging of At-211.

Reactive hydroxyl radicals (·OH) play important roles in the biological effects of radiation exposure or radiation therapy, and the distribution of ·OH in water during irradiation is of interest to researchers. However, real-time ·OH distribution measurement during irradiation has so far not been achieved due to the difficulty of detecting ·OH. To make these distribution measurements possible, we attempted the imaging of light emitted from luminol water during irradiation with low-energy X-rays. Imaging of the light emitted from luminol water was conducted using a cooled charge-coupled device (CCD) camera during X-ray irradiation to luminol water at lower energy than the Cherenkov-light threshold. The light emission of luminol water was 25 times higher than that of water, and clear images of light distributions were measured for the luminol water. By carrying out the imaging of luminol water with the addition of a radical scavenger to the luminol water, we could confirm that the emitted light was from ·OH produced in water. With this addition of the radical scavenger, the light intensity decreased as the weight of the scavenger increased. With these results, we confirmed that the detected light distribution in luminol water could be attributed to the ·OH produced by the X-ray irradiation.

In the development of new scintillators for X-ray imaging, a high-resolution and highly efficient system is required to evaluate the performance of the scintillator plates. For this purpose, we developed a high-resolution X-ray microscope system. The developed compact X-ray microscope system is based on a magnifying unit and a cooled charge-coupled device (CCD) camera, combined with a small industrial X-ray irradiation system. Using this system, we carried out imaging of three scintillator plates and evaluated their spatial resolution. Each scintillator plates was set in front of the lens of the objective, X-rays were irradiated to the scintillator plates, and transmission images of masks were acquired. The measured spatial resolution of the scintillator plates varied from 16 μm to 30 μm, depending on the type of scintillator plate. The focus size of the X-ray tube had an almost negligible effect on the spatial resolution of the images for the evaluated scintillator plates.

Prompt secondary electron bremsstrahlung X-ray (prompt X-ray) imaging using a low-energy X-ray camera is a promising method for observing a beam shape from outside the subject. However, the images measured within short times suffer from statistical noise. Consequently, we performed prompt X-ray imaging with higher sensitivity using a larger-diameter pinhole collimator and compared the results with those of a conventional collimator. Prompt X-ray imaging was conducted during irradiation with pencil beams of 241.5-MeV/n carbon ions to a water phantom. A newly developed X-ray camera with a 4-mm diameter as well as conventional 1.5-mm-diameter pinhole collimators was used for the imaging in list mode, and we compared the prompt X-ray images, energy spectra, and time count rate curves between 1.5-mm-diameter and 4-mm-diameter pinhole collimators. The prompt X-ray images taken with the 4-mm-diameter pinhole collimators had ∼7 times higher sensitivity with 70 % lower offset fractions originating from the prompt gamma photons. Furthermore, the ranges were more precisely estimated with the 4-mm collimator than with the 1.5-mm collimator. The energy spectra showed less contamination by tungsten-characteristic X-rays for the 4-mm pinhole collimator. Even for images measured with 0.1-s intervals, the beam shapes and time count rate curves could be obtained with less statistical noise using the 4-mm-diameter pinhole collimators. The use of the 4-mm-diameter pinhole collimator attached to the X-ray camera had advantages for prompt X-ray imaging with high sensitivity and low background, enabling us to image the beams even with short-time measurements.

The imaging of the luminescence of water and Cherenkov-light with fluorescein during irradiation is a useful method to increase intensity; however, the magnitudes of the increase in intensity for Cherenkov-light and luminescence of water have been neither evaluated nor compared. Therefore, we measured the Cherenkov-light and luminescence of water with and without fluorescein during irradiation, and then we compared the magnitudes of the intensity increase with fluorescein. For 6 and 10 MV X-rays as well as 6 and 12 MeV electrons, the intensity of the Cherenkov-light images increased only 2 to 3 times with fluorescein water compared with that of water. Meanwhile, for 100 kV X-rays and 150 MeV protons, the intensity of the luminescence images increased more than 10 times with fluorescein water compared with that of water. The difference could probably be attributed to the difference in the light-emission mechanisms and coherency between Cherenkov-light and the luminescence of water.

Silver-doped zinc sulfide (ZnS(Ag)) is an opaque powder scintillator that is mainly used for detection or imaging of charged particles such as alpha particles. Since ZnS(Ag) is not transparent, the thickness of ZnS(Ag) was limited to ∼10 μm. If a thicker ZnS(Ag) scintillator could be developed, it would be useful for studies such as high-energy particle ion detection as well as beta particle or gamma photon detection. We developed a ZnS(Ag) fiber-structured scintillator using a capillary plate in which ZnS(Ag) powder was encapsulated in the capillaries. The thickness of the capillary plate was 400 μm, and the light produced in ZnS(Ag) escaped from the capillaries, spread through the transparent lead glass area, and reached the opposite side of the plate; consequently, the opaque character and absorption of light could be avoided. The amount of light emitted from the capillary plate based fiber-structured ZnS(Ag) was almost the same as that of a commercially available ZnS (Ag) film, but the detection efficiency was about 1/5 (∼ 20%). The amount of light emitted from beta particles and gamma photons per MeV was less than 1% of that from alpha particles. The spatial resolution of the developed capillary plate based fiber-structured ZnS(Ag) scintillator for 5.5 MeV alpha particles was ∼200 μm FWHM. Imaging of the slits and light spots from alpha particles could be achieved with the developed scintillator combined with an electron-multiplied charge-coupled device (EM-CCD) camera. The developed capillary plate based fiber-structured ZnS(Ag) will be useful for detecting high-energy particle ions.

Although optical imaging of electron beams and X-rays from medical linear accelerators (LINAC) is a possible method for dose distribution measurements, it has been limited to two-dimensional (2D) projection images. For the precise measurement of an optical image of electron beams and X-rays, three-dimensional (3D) imaging is desired. To measure 3D dose distributions, we conducted imaging of electron beams and X-rays using a plastic scintillator plate set in a water phantom. When this plate was immersed in the water phantom, irradiation with electron beams or X-rays was carried out from along the plate's sides. Optical images of the scintillator plate were acquired using a charge-coupled device (CCD) camera from the side during irradiation with electron beams and X-rays. Measurements were conducted at 6 MeV, 9 MeV and 12 MeV for electron beams and at 6 MV and 10 MV for X-rays. The imaging system was set on the bed of the LINAC and moved at 10-mm steps perpendicular to the beam direction to acquire a set of sliced optical images of the beams. A set of these sliced images were stacked and interpolated to form 3D optical images. For the 3D images, after the correction of the Cherenkov-light component in the images, the relative depth and lateral doses were evaluated. From the relative depth doses of electron beams, the half-value depths could be evaluated within an error of 1.3 mm. Lateral widths could be evaluated within an error of less than 2 mm parallel to the plastic scintillator and less than 6.5 mm perpendicular to it. From the relative depth doses of X-rays, the average difference between the measured value and that by a planning system was within an error of 2 %. Lateral widths could be evaluated within an error of less than 0.68 mm parallel to the plastic scintillator and less than 2.6 mm perpendicular to it. We confirmed that 3D imaging of electron beams and X-rays using plastic scintillator plate is feasible and is a promising method for measuring dose images at any position.

Positron emission tomography (PET) is a powerful tool because we can acquire functional information of tissue from the images with high sensitivity and relatively high spatial resolution. However, high-spatial-resolution PET imaging for high-energy positron emitters is difficult because the positrons have a long range and annihilation radiations are emitted at the endpoints of the positrons' trajectories. Along the trajectories, Cerenkov light (CL) is also emitted in advance of the emission of annihilation radiations. Hence, CL can be used for the imaging of high-energy positron emitters. Bremsstrahlung X-rays are also emitted along the trajectories of positrons, and imaging is possible. However, the differences in the spatial distributions of these three types of radiations are not obvious. Because CL and bremsstrahlung X-rays are produced before the endpoint of the positron, high-spatial-resolution imaging may be possible for high-energy positrons. In this study, to clarify this point, we simulated the spatial distribution of CL, bremsstrahlung X-rays, and annihilation radiations using Monte Carlo simulation and compared the distributions. The distributions of the bremsstrahlung X-rays and CL were smaller than those of the annihilation radiations in case of high energy positrons, and we found that the distributions of bremsstrahlung X-rays nearly matched those of CL for high-energy positron emitters. We concluded that CL and bremsstrahlung X-ray imaging have higher spatial resolution than annihilation radiation imaging for MeV ordered positron emitters, and thus they are promising for high-spatial-resolution imaging of high-energy positron emitters such as O-15 for ion therapy and Ga-68 for PET imaging.

Because the sensitivity of positron emission tomography (PET) system increases in proportion to the inverse of the diameter of the detector ring, brain PET systems are being planned and developed. However, count losses due to the dead-time of the detector blocks increases as the ring diameter decreases. Since the count losses decrease the noise equivalent count rate (NECR) of the system, the NECR of brain PET system may be lower than that of a whole-body PET system in clinical dose range. In this paper, we compared the NECRs of brain PET systems with that of a whole-body PET system using a Monte Carlo simulation. We simulated the PET system for a 27-cm-diameter detector ring, a 54-cm-diameter detector ring, and an 89-cm-diameter detector ring and evaluated the NECRs. In the clinical dose range, the NECR of the small-diameter brain PET system was lower than those of the whole-body PET system unless the electronics was advanced. We conclude that the small-diameter brain PET system with conventional electronics has not so much advantage except for the lower cost and the higher spatial resolution. However, advanced electronics can reduce degradation of NECR, so the small-diameter brain PET system with advanced electronics will be useful for clinical studies.

Measurements of three-dimensional (3D) dose distribution of electron-beams in water are important for high-energy electron beams from medical linear accelerators (LINAC). Although ionization chambers are commonly used for this purpose, measurements take a long time for precise 3D dose distribution. To solve the problem, we tried the measurements of the 3D dose distributions using a scintillator plate combined with a mirror. After we placed a 1 mm thick plastic scintillator plate at the upper inside of a black box, a water phantom was set above the plastic scintillator plate outside the black box, and electron beam was irradiated to the water phantom from the upper side. The attenuated electron-beam by the water in the phantom was detected by the plastic scintillator plate and the scintillation image was formed in the plate. The image was reflected by a surface mirror set below the plastic scintillator plate and detected by a cooled charge coupled device (CCD) camera from the side. We changed the depths of the water in the phantom, obtained the scintillation images, and calculated a 3D scintillation image using the measured images. Measurements were made for 9 MeV and 12 MeV electron-beams using the imaging system. From the images, we could successfully form 3D scintillation images. The depth profiles measured from the 3D images showed almost identical distribution with those calculated by the planning system within the difference of 5%. The lateral profiles also showed almost identical within the difference of the widths less than 2.5 mm. We conclude that the proposed method is promising for 3D dose distribution measurements of electron-beams.

Ce doped (Gd , La)2Si2O7 (LaGPS) is a new scintillator which has high light output and is a promising candidate for high resolution radiation imaging detectors. Thus we developed a radiation imaging detector using a LaGPS plate combined with a position sensitive photomultiplier tube (PSPMT) and evaluated the performance. We found that the decay times of LaGPS were different with the types of radiations and the separations of the images of the different types of radiations were possible using pulse shape discrimination. The spatial resolution for Am-241 alpha particles (5.5 MeV) was better than 0.31 mm FWHM and the energy resolution was 11 % FWHM. The spatial resolution for Sr–Y-90 beta particles was ∼ 0.6 mm FWHM and those for Co-57 gamma photons (122 keV) and Cs-137 X-ray ( ∼ 35 keV) were better than 0.6 mm FWHM and ∼ 0.8 mm FWHM, respectively. The decay times for alpha particles, beta particles, and gamma photons were 143 ns, 124 ns, and 119 ns, respectively. With these different decay times, the separation of alpha particles and gamma photons or beta particles was possible using the pulse shape discrimination. We conclude that the developed LaGPS imaging detector has high resolution for all types of radiations and is also capable of the simultaneous imaging and separating the different types of radiations.

Spatial resolution of a pixelated scintillator-based radiation-imaging detector is sometimes limited by the pixel size of the scintillators. We developed a small-size pixelated GAGG scintillator using a dicing method and combined it with a small channel-size Si-PM array for the development of an ultrahigh resolution radiation-imaging detector. The developed pixelated GAGG scintillator had a pixel size of 0.1 mm × 0.1 mm arranged in 0.15-mm separations. It was combined with a Si-PM array made of 1 mm × 1 mm channels to form a radiation-imaging detector. With the developed radiation imaging detectors, the 0.1 mm × 0.1 mm pixels could be resolved for Am-241 alpha particles (5.5 MeV). The spatial resolutions of this imaging detector were better than 0.31-mm FWHM for Am-241 alpha particles and Ca-45 (maximum energy: 0.257 MeV) beta particles. The spatial resolutions for Am-241 gamma photons (60 keV) and Cs-137 X-ray ( ∼ 32 keV) were better than 0.6-mm FWHM. Separation of the images of alpha particles and gamma photons was possible using the scintillation decay time difference of GAGG between alpha particles and gamma photons. The developed ultrahigh spatial resolution pixelated GAGG radiation-imaging detector is promising for the imaging of alpha particles, beta particles, low-energy gamma photons and X-ray.

A scintillator with a high light output is considered to be required for the development of high spatial resolution radiation imaging detectors. In contrast to this scientific consensus, we found that high spatial resolution images can be obtained using a medium light output scintillator comprising cerium-doped yttrium aluminum perovskite, YA1O3 (YAP(Ce)). We evaluated the performance of a radiation imaging detector comprising a 0.5 mm thick YAP(Ce) plate, which was optically coupled to a 25.4 mm (1-inch) square position-sensitive photomultiplier. The Anger principle was used to calculate the radiation positions. The spatial resolution and energy resolution for the imaging detector with 5.5 MeV alpha particles were 0.25 mm full width at half-maximum (FWHM) and 7.4% FWHM, respectively. The spatial resolutions for 60 keV gamma photons and ∼32 keV X-rays were ∼0.6 mm FWHM and ∼0.8 mm FWHM, respectively. The spatial resolution of the detector when imaging beta particles at a maximum energy of 254 keV was less than 0.6 mm FWHM. We conclude that YAP(Ce) is a promising scintillator for developing high spatial resolution and high energy resolution radiation detectors for imaging alpha particles, beta particles, and gamma photons.

We previously developed a radiation detector using a ceramic scintillator made for X-ray computed tomography (CT), Gd3(GaAl)5O12:Ce (GGAG), combined with a position-sensitive photomultiplier tube (PSPMT) for the imaging of radiation. However, GGAG's scintillation wavelength is more suitable for silicon-based photodetectors than PSPMT, and so better performance is expected by combining it with a silicon-based photodetector. Therefore, here we combined a GGAG plate with silicon photomultiplier (Si-PM) arrays to develop a radiation-imaging detector. Our proposed Si-PM-based GGAG radiation-imaging detector consists of a 0.5-mm-thick GGAG plate, a light guide, and an 8 x 8 Si-PM array. The spatial resolutions of this imaging detector surpassed 0.31-mm FWHM for 5.5-MeV alpha particles. The spatial resolution of the Sr-Y-90 beta particles (maximum energy: 2.28 MeV) was ∼0.8 mm FWHM and 0.6-mm FWHM for Ca-45 (maximum energy: 0.24 MeV). The spatial resolutions for Co-57 (122 keV), Am-241 gamma photons (60 keV), and Cs-137 X-rays (∼35 keV) were 0.6-, 0.8-, and 1.0-mm FWHM, respectively. Since GGAG's scintillation decay curves for alpha particles are different from gamma photons or beta particles, we can use pulse-shape discrimination to separate the Am-241 alpha particles from the Cs-137 gamma photons as well as from the Sr-Y-90 beta particles.

Gd3(GaAl)5O12 :Ce (GGAG) is a ceramic scintillator originally developed for X-ray CT, and it was also an excellent material for the development of an event-by-event-based radiation imaging detector when it was combined with a position sensitive photomultiplier (PSPMT). With the developed GGAG imaging detector, we found that the decay times for alpha particles and gamma photons were different. Also, we found that the decay times for alpha particles and beta particles were different. These characteristics are advantageous for developing an imaging detector for the simultaneous imaging of different types of radiation using pulse shape discrimination. Thus, we tested the separation of the images of the alpha particles and gamma photons using pulse shape discrimination. Also, we evaluated the separation of the alpha and beta particle images. In the pulse shape spectra, we could separate the peaks of Am-241 alpha particles and Cs-137 gamma photons with a peak-to-valley ratio (P/V) of 3.5. We obtained clearly separated images for Am-241 alpha particles and Cs-137 gamma photons using pulse shape discrimination. We could also separate the peaks of Am-241 alpha particles and Sr–Y-90 beta particles with a P/V of 1.5 in the pulse shape spectrum. We obtained separated images for Am-241 alpha particles and Sr–Y-90 beta particles using pulse shape discrimination. In addition, we could separate electrostatically collected natural alpha particles, Po-218 and Po-214, from the environmental beta particles and gamma photons using pulse shape discrimination. We conclude that the GGAG imaging detector is promising for simultaneous imaging and separating the images of different types of radiation using pulse shape discrimination.

Although the luminescence of water at lower energy than the Cerenkov-light threshold during carbon-ion irradiation was found and imaging was possible, the temporal response has not been measured, and so the difference from Cerenkov-light remains unclear. To clarify this point, we measured the temporal response of the luminescence of water at lower energy than the Cerenkov-light threshold and compared it with that of Cerenkov-light. We used silicon photomultiplier (Si-PM) modules to measure the temporal response at the Bragg peak area of a water phantom during irradiation of the carbon ion where the Cerenkov-light was not included. We also measured the temporal response at the shallow depth of the water phantom where the Cerenkov-light was included. In both areas, we measured the temporal waveforms of the light produced by the irradiation of the carbon ions in which the ripples of spills were clearly observed. We found no difference in the waveforms between the Bragg peak and the shallow depths of water. Our results do not contradict the hypothesis that the luminescence of water and Cerenkov-light are produced by the same mechanism.

Living lab, where various stakeholders such as local residents, local governments and companies collaborate (cf. (European Networks of Living Labs. https://www.openlivinglabs.eu)), has been attracting attention as a design method for local community services. Running a living lab, however, requires the lab staff to have highly specialized skills, and ideation facilitation is one of the important skills required for successful Living Lab management. Supporting novice staff with information technologies is expected to contribute to the further spread and implementation of living labs. In this study, we conducted a preliminary study of interaction state estimation based on nonverbal and speech-event cues to support novice facilitators. The proposed method can serve as a basis for designing a supporting system for novice facilitators by detecting important interaction events.

To help second language (L2) learners acquire oral communication skills, dialogue-based computer-assisted language learning (DB-CALL) systems are attracting more interest than ever. When robot-assisted language learning (RALL) is used for realizing such systems, L2 learners are provided with a sense of reality and tension similar to that in a real L2 conversation. At the same time, there are increasing demands for remote learning, accelerated in part by the spread of the novel coronavirus. We have therefore developed a robot-avatar-assisted language learning system that simulates a trialogue in English with two robot avatars and a learner for remote learning. The conversation scenarios deal with various daily topics to keep the learner’s interest and the system prompts the learner to acquire oral skills by using specific syntactic forms in conversation. We conducted a six-day remote learning experiment with ten Japanese university students to evaluate the learning effect, using eye gaze as an index of the learners’ degree of concentration. Our findings demonstrated the effectiveness of our system for remote learning and showed that the learners’ eye gaze activities changed between question answering and repeating tasks.

Background: A majority of gastrointestinal tumors are adenocarcinoma. Rarely, there is also a type of tumors such as acinar cell carcinoma, which are often called pancreatic-type acinar cell carcinoma. Among those, some are differentiated into neuroendocrine components. A few of them can be called MiNENs. Case presentation: The patient was an 80-year old male who was referred to our hospital for treatments of a pedunculated gastric tumor. It was 5 cm in diameter and detected in the upper gastric body with upper GI endoscopy conducted for investigation of anemia. In the biopsy, although a kind of hyperplasia of gastric gland cell was pointed out, no tumor cells were found. Retrospectively, the diagnosis was turned out to be a misdiagnosis. An operation was arranged because bleeding from the tumor was suspected as a cause of anemia and because a surgical resection was considered to be desirable for accurate diagnosis. Hence, laparoscopy and endoscopy cooperative surgery was performed. In pathological examination, several types of epithelial cells which proliferated in the area between mucosa and deep inside the submucosa were observed. These consisted of acinar-glandular/trabecular patterns and solid pattern. A diagnosis of pancreatic-type acinar cell carcinoma of the stomach with NET G2 and G3 was made based on characteristic cellular findings and the result of immunostaining tests. Each of them consisted of more than 30% of the lesion; a diagnosis of pancreatic-type mixed acinar neuroendocrine carcinoma (pancreatic-type MiNEN) of the stomach, or a type of gastric MiNEN was obtained. Anemia was resolved after operation, and the patient was discharged from the hospital without perioperative complications. Conclusions: Pancreatic-type ACC of the stomach which is differentiated into neuroendocrine tumor is very rare. Hence, we report this case along with several literature reviews.

It is widely believed that light is not emitted in water during irradiation of radiation at energies lower than the Cherenkov light threshold. Contrary to this consensus, we discovered that light (luminescence) is emitted in water during irradiation of radiation, and imaging of this luminescence was possible. In this review, the author describes the optical images obtained for various types of radiation, their characteristics and origins, and potential applications of the luminescence of water during irradiation at a lower energy than the Cherenkov light threshold. The author also describes the luminescence of other transparent materials and future prospects of the discovered luminescence.

In alpha radionuclide therapy, an optical fiber-based alpha particle detector is a new tool that could possibly be employed for the direct detection of alpha particles in subjects. Thus, in the present study, we developed an optical fiber-based alpha particle detector. The alpha particle detector was made of a 1mm diameter, 10 cm long plastic double clad optical fiber drilled a 0.7 mm diameter, 2 mm depth open space at the one end of the fiber. Silver-doped zinc sulfide (ZnS (Ag)) was painted inside this open space to form a ZnS(Ag) small scintillation chamber. To conduct performance comparisons, we also developed a fiber detector using the same fiber in which a Ce-doped Lu1.8Y0·2SiO5 (LYSO(Ce)) scintillator with dimensions of 0.32 mm × 0.5 mm × 5 mm was inserted. Both fiber detectors were wrapped in aluminized Mylar and optically coupled to a position sensitive photomultiplier tube, before calculating the two-dimensional distributions, energy, and pulse shape spectra. For 5.5-MeV alpha particles, the ZnS(Ag) fiber detector produced ~ 5 times larger pulse heights and the count rate was ~2 times higher compared with those using the LYSO(Ce) fiber detector. For the maximum energy 2.28-MeV beta particles and 0.66-MeV gamma photons, the ZnS(Ag) fiber detector produced no counts, but it yielded small counts from natural alpha particles. Our results confirmed that the ZnS(Ag) fiber detector developed in this study could selectively detect alpha particles and it was insensitive to beta particles and gamma photons.