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14 results on '"Semmler, Georg"'

1. Etiological cure prevents further decompensation and mortality in cirrhotic patients with ascites as the single first decompensating event

Author

Tonon, Marta, Balcar, Lorenz, Semmler, Georg, Calvino, Valeria, Scheiner, Bernhard, Incicco, Simone, Barone, Anna, Paternostro, Rafael, Gambino, Carmine Gabriele, Bauer, David Josef Maria, Accetta, Antonio, Hartl, Lukas, Brocca, Alessandra, Jachs, Mattias, Trauner, Michael, Mandorfer, Mattias, Angeli, Paolo, Reiberger, Thomas, and Piano, Salvatore

Subjects
Hepatology
Published
2023
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3. The rs429358 Locus in Apolipoprotein E Is Associated With Hepatocellular Carcinoma in Patients With Cirrhosis

Author

Innes, Hamish, Nischalke, Hans Dieter, Guha, Indra Neil, Weiss, Karl Heinz, Irving, Will, Gotthardt, Daniel, Barnes, Eleanor, Fischer, Janett, Ansari, M. Azim, Rosendahl, Jonas, Lin, Shang‐Kuan, Marot, Astrid, Pedergnana, Vincent, Casper, Markus, Benselin, Jennifer, Lammert, Frank, McLauchlan, John, Lutz, Philip L., Hamill, Victoria, Mueller, Sebastian, Morling, Joanne R., Semmler, Georg, Eyer, Florian, von Felden, Johann, Link, Alexander, Vogel, Arndt, Marquardt, Jens U., Sulk, Stefan, Trebicka, Jonel, Valenti, Luca, Datz, Christian, Reiberger, Thomas, Schafmayer, Clemens, Berg, Thomas, Deltenre, Pierre, Hampe, Jochen, Stickel, Felix, Buch, Stephan, UCL - SSS/IREC/MONT - Pôle Mont Godinne, and UCL - (MGD) Service de gastro-entérologie

Subjects
Liver Cirrhosis, Carcinoma, Hepatocellular, Hepatology, Liver Neoplasms, Membrane Proteins, SNP, Genomics, Hepatitis C, Polymorphism, Single Nucleotide, digestive system diseases, ddc, Chronic Liver Disease, Apolipoproteins E, Cirrhosis, Genetics, Humans, Genetic Predisposition to Disease, Liver cancer
Abstract

The host genetic background for hepatocellular carcinoma (HCC) is incompletely understood. We aimed to determine if four germline genetic polymorphisms, rs429358 in apolipoprotein E (APOE), rs2642438 in mitochondrial amidoxime reducing component 1 (MARC1), rs2792751 in glycerol‐3‐phosphate acyltransferase (GPAM), and rs187429064 in transmembrane 6 superfamily member 2 (TM6SF2), previously associated with progressive alcohol‐related and nonalcoholic fatty liver disease, are also associated with HCC. Four HCC case‐control data sets were constructed, including two mixed etiology data sets (UK Biobank and FinnGen); one hepatitis C virus (HCV) cohort (STOP‐HCV), and one alcohol‐related HCC cohort (Dresden HCC). The frequency of each variant was compared between HCC cases and cirrhosis controls (i.e., patients with cirrhosis without HCC). Population controls were also considered. Odds ratios (ORs) associations were calculated using logistic regression, adjusting for age, sex, and principal components of genetic ancestry. Fixed‐effect meta‐analysis was used to determine the pooled effect size across all data sets. Across four case‐control data sets, 2,070 HCC cases, 4,121 cirrhosis controls, and 525,779 population controls were included. The rs429358:C allele (APOE) was significantly less frequent in HCC cases versus cirrhosis controls (OR, 0.71; 95% confidence interval [CI], 0.61‐0.84; P = 2.9 × 10−5). Rs187429064:G (TM6SF2) was significantly more common in HCC cases versus cirrhosis controls and exhibited the strongest effect size (OR, 2.03; 95% CI, 1.45‐2.86; P = 3.1 × 10−6). In contrast, rs2792751:T (GPAM) was not associated with HCC (OR, 1.01; 95% CI, 0.90‐1.13; P = 0.89), whereas rs2642438:A (MARC1) narrowly missed statistical significance (OR, 0.91; 95% CI, 0.84‐1.00; P = 0.043). Conclusion: This study associates carriage of rs429358:C (APOE) with a reduced risk of HCC in patients with cirrhosis. Conversely, carriage of rs187429064:G in TM6SF2 is associated with an increased risk of HCC in patients with cirrhosis.

Published
2022
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6. Clinical course of cirrhotic patients developing ascites as the single first decompensation

Author

Balcar, Lorenz, Tonon, Marta, Semmler, Georg, Pomej, Katharina, Calvino, Valeria, Scheiner, Bernhard, Incicco, Simone, Rafael Paternostro, Gambino, Carmine Gabriele, Bauer, David J. M., Accetta, Antonio, Hartl, Lukas, Brocca, Alessandra, Jachs, Mathias, Angeli, Paolo, Trauner, Michael, Mandorfer, Mattias, Piano, Salvatore, and Reiberger, Thomas

Subjects
Hepatology
Published
2022
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9. The alpha-1 antitrypsin Pi*Z allele is an independent risk factor for liver transplantation/death in patients with advanced chronic liver disease

Author

Balcar, Lorenz, Scheiner, Bernhard, Urheu, Markus, Weinberger, Patrick, Rafael Paternostro, Simbrunner, Benedikt, Hartl, Lukas, Jachs, Mathias, Bauer, David Jm, Semmler, Georg, Willheim, Claudia, Pinter, Matthias, Ferenci, Peter, Trauner, Michael, Reiberger, Thomas, Staettermayer, Albert, and Mandorfer, Mattias

Subjects
Hepatology
Published
2022
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11. UEG900820 Supplemental Material - Supplemental material for Novel reliability criteria for controlled attenuation parameter assessments for non-invasive evaluation of hepatic steatosis

Author

Semmler, Georg, Wöran, Katharina, Scheiner, Bernhard, Unger, Lukas Walter, Paternostro, Rafael, Stift, Judith, Schwabl, Philipp, Bucsics, Theresa, Bauer, David, Simbrunner, Benedikt, Stättermayer, Albert Friedrich, Pinter, Matthias, Trauner, Michael, Reiberger, Thomas, and Mandorfer, Mattias

Subjects
FOS: Clinical medicine, FOS: Biological sciences, 111199 Nutrition and Dietetics not elsewhere classified, FOS: Health sciences, 110308 Geriatrics and Gerontology, 69999 Biological Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, UEG900820 Supplemental Material for Novel reliability criteria for controlled attenuation parameter assessments for non-invasive evaluation of hepatic steatosis by Georg Semmler, Katharina Wöran, Bernhard Scheiner, Lukas Walter Unger, Rafael Paternostro, Judith Stift, Philipp Schwabl, Theresa Bucsics, David Bauer, Benedikt Simbrunner, Albert Friedrich Stättermayer, Matthias Pinter, Michael Trauner, Thomas Reiberger and Mattias Mandorfer in United European Gastroenterology Journal

Published
2020
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14. Relationship between hepatic venous pressure gradient and presence of decompensation in non-alcoholic fatty liver disease

Author

Bassegoda, Octavi, Olivas, Pol, Turco, Laura, Mandorfer, Mattias, Burriel, Miquel Serra, Luis, Tellez, Kwanten, Wilhelmus, Laroyenne, Alexia, Nicoara-Farcau, Oana, Alvarado, Edilmar, Moga, Lucile, Vuille-Lessard, Elise, Fortea, Jose Ignacio, Ibanez, Luis, Tosetti, Giulia, Vanwolleghem, Thomas, Larrue, Helene, Burgos-Santamaria, Diego, Horia, Stefanescu, Rafael Paternostro, Cippitelli, Annalisa, Lens, Sabela, Augustin, Salvador, Llop, Elba, Laleman, Wim, Trebicka, Jonel, Johannes, Chang, Masnou, Helena, Zipprich, Alexander, Miceli, Francesca, Semmler, Georg, Forns, Xavier, Primignani, Massimo, Banares, Rafael, Puente, Angela, Berzigotti, Annalisa, Rautou, Pierre-Emmanuel, Villanueva, Candid, Gines, Pere, Garcia Pagan, Juan Carlos, Procopet, Bogdan, Bureau, Christophe, Albillos, Agustin, Francque, Sven, Reiberger, Thomas, Schepis, Filippo, Graupera, Isabel, and Hernandez-Gea, Virginia

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