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Summary Introduction: Feronia limonia (synonyms: Feronia elephantum, Hesperethusa crenulata, Limonia acidissima Linn, Schinus limonia) is a member of Rutaceae family. F. limonia is an aesthetically pleasing plant with various medicinal and nutraceutical properties. Objective: The primary objective of this research was to determine the flavonoid from F. limonia. Methods: Different solvents have been soxhleted to the roots of F. limonia powder. Column chromatography was performed using silica gel, a yellow amorphous solid was obtained from ethyl acetate extract after elution with hexane: ethyl acetate (4:8). Results: We have successfully isolated a unique geranyl flavanone from the roots of F. limonia. The structure was verified as 8-(2′′,3′′-epoxy-3′′-methyl butyl)-4′-prenyloxy flavanone-7-O-6′′′′-acetyl β-D-glucopyranoside. Conclusion: According to the findings based upon spectroscopic analysis, a hitherto unknown flavanone was isolated in the F. limonia.

An extracellular pectinase from a mixed consortium of Bacillus sp. (BSP) was immobilized onto graphene oxide/chitosan composite (GO/CS) through covalent binding to enhance its recycling and operational stability features. Different parameters were optimized, including cross-linker concentration (%), time, pH, and GO/CS-pectinase ratios. GO/CS-pectinase was further characterized by FT-IR and XRD. The activity of GO/CS-pectinase was reached up to 804 μmolmin

Considering the importance of acetylcholine esterase (AChE, BchE) and α-glucosidase in the treatment of Alzheimer's disease and diabetes mellitus, the synthesis of novel azinane triazole-based derivatives as effective acetylcholinesterase (AchE), α-glucosidase, urease, lipoxygenase (LOX), and butyrylcholinesterase (BChE) inhibitors is described. Azinane analogue (

The present study focuses on iron nanoparticles (Fe NPs) biosynthesis, characterization and photocatalytic activity (PCA) appraisal for methylene blue dye degradation. A green rapid biogenic synthesis route was employed for synthesis of Fe NPs using banana peel extract. The synthesized Fe NPs was characterized by XRD (X-ray diffraction), SEM (scanning electron microscopy) and EDX (energy dispersive X-ray) techniques. These analysis confirmed the synthesis of zero valent Fe NPs with high crystallinity, purity and semi spherical in shape. The photocatalytic activity was assessed under ultra violet irradiation and under optimum conditions, 87% degradation of MB dye was obtained for 72 min of irradiation, which revealed promising catalytic efficiency of the Fe NPs. The result shows that photocatalytic activity of Fe NPs is promising and could possibly be used to treat dyes in industrial effluents and the use of green synthetic protocol is suggested due to its ecofriendly nature.

This work investigates the effects of double ion substitution on the ferroelectric, electrochemical, dielectric and photocatalytic properties of Gd and Fe doped La1-yGdyNi1-xFexO3 nanoparticles (NPs). La1-yGdyNi1-xFexO3 was fabricated by facile micro-emulsion path and its properties were studied by thermogravimetric analysis (TGA), X-ray diffraction (XRD), scanning electron microscopy (SEM), Raman scattering, Fourier Transform of Infrared (FTIR), energy dispersive x-rays (EDX) techniques. It has a distorted rhombohedral shape with crystallite size within the range of 17–23 nm. The doped material has a spherical heterogeneous morphology, and its surface area increased with increased doping. The electrochemical (CV, EIS, and I-V), conductivity and dielectric (dielectric constant and low dielectric & tangent loss) properties of La1-yGdyNi1-xFexO3 were dependent on the contents of the dopants (Gd and Fe). The doped material had improved specific capacitance compared to the undoped LaNiO3 due to the synergistic effect of Gd and Fe on the doped materials. The conductivity of Gd and Fe doped LaNiO3 5.16 × 104 Sm−1 was enhanced compared to the undoped LaNiO3 3.52 × 10−2 Sm1. Furthermore, hysteresis loop was used to investigate the coercivity (Hc), saturation magnetization (Ms) and remanence (Mr) of the material. The Ms and Mr values were enhanced with the content of the dopants. The photocatalytic activity (PCA) of the material in degrading malachite green (MG) dye was studied. La1-yGdyNi1-xFexO3 NPs was able to degrade up to 96.4% of the dye under visible light irradiation in 50 min. La1-yGdyNi1-xFexO3 has remarkable dielectric, electrochemical, ferroelectric and photo-catalytic properties and have potential applications in microwave, electrical, electronic, energy storage devices. It is also an active photo-catalyst material for the removal/oxidation of toxic pollutants from the environment.

Furan-oxadiazole structural hybrids belong to the most promising and biologically active classes of oxygen and nitrogen containing five member heterocycles which have expanded therapeutic scope and potential in the fields of pharmacology, medicinal chemistry and pharmaceutics. A novel series 5a–j of benzofuran-oxadiazole molecules incorporating S-alkylated amide linkage have been synthesized using ultrasonic irradiation and screened for bacterial tyrosinase inhibition activity. Most of the synthesized furan-oxadiazole structural motifs exhibited significant tyrosinase inhibition activity in the micromolar range, with one of the derivatives being more potent than the standard drug ascorbic acid. Among the tested compounds, the scaffold 5a displayed more tyrosinase inhibition efficacy IC50 (11 ± 0.25 μM) than the ascorbic acid IC50 (11.5 ± 0.1 μM). Compounds 5b, 5c and 5d efficiently inhibited bacterial tyrosinase with IC50 values in the range of 12.4 ± 0.0–15.5 ± 0.0 μM. The 2-fluorophenylacetamide containing furan-oxadiazole compound 5a may be considered as a potential lead for tyrosinase inhibition with lesser side effects as a skin whitening and malignant melanoma anticancer agent.

In the present investigation, La1-xCoxCr1-yFeyO3 (x,y = 0.0, 0.12, 0.36, 0.60) perovskite was fabricated via a facile micro-emulsion route. The synthesized perovskites were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) techniques to examine the effect of Co and Fe ions on the physico-chemical properties. The ferroelectric, dielectric, and magnetic properties of La1-xCoxCr1-yFeyO3 were changed significantly as a function of dopants contents (Co and Fe ions). Outcomes revealed that the dielectric, ferroelectric and magnetic properties of LaCrO3 perovskite can be tuned significantly via Co and Fe doping and La0.40Co0.60Cr0.40Fe0.60O3 have potential for photocatalytic dye removal under (visible) light expoure. The photocatalytic activity (PCA) of the pristine LaCrO3 and La0.40Co0.60Cr0.40Fe0.60O3 photocatalyst was evaluated under (visible) light irradiation for crystal violet (CV) dye. Experimental results revealed that La0.40Co0.60Cr0.40Fe0.60O3 photocatalyst degrdae almost 77.21% CV dye with the rate constant value of 0.01475 min−1. In the presence of isopropyl alcohol (IPA) scavenger, the PCA of the La0.40Co0.60Cr0.40Fe0.60O3 photocatalyst and rate constant value of the photocatalytic reaction decreased to 32.5% and 0.00491 min−1, suggesting the superoxide as main active specie. Results revealed that Co and Fe doping doped material is efficient for photocatalytic presentations under solar light expoure.

Proteases with alkaline nature and requisite catalytic characteristics have been the supreme interest of numerous industrial sectors. The present study was focused on justifying the following aims, i.e., (1) protease producing strain improvement via physical and chemical mutagenesis, (2) protease optimization, purification, and immobilization on chitosan beads, and (3) de-staining and goat skin dehairing potentialities of chitosan beads immobilized protease (ChitB-protease). Briefly, a protease produced by a UV mutant Bacillus sp. MS1 was purified and characterized to present its scope for detergent and leather sectors. Two-step purification resulted up to 4.1-fold purification and 41% yield of Bacillus sp. MS1 protease. The purified fraction was identified as a monomeric with an apparent molecular weight of 28 kDa on sodium dodecyl sulfate–polyacrylamide gel electrophoresis. The protease was entrapped in glutaraldehyde-activated chitosan beads to improve its stability and reusability. The ChitB-protease represented the highest activity and immobilization efficiency of 10.31 U/mL and 86.43 ± 1.15%, respectively. ChitB-protease exhibited better catalytic activity in a broader pH range and higher temperature than free enzyme. Moreover, a significant improvement in the thermal resistance was also recorded after immobilization. ChitB-protease retained 70.53% of its initial activity after seven washings. SEM morphological analysis further confirmed the recycling efficiency of ChitB-protease. Furthermore, a complete de-staining and dehairing were observed within the short incubation period. These results suggest that this protease is potentially useful in many industrial applications.

A series of Bi and Fe doped La1−x Bi x Cr1−y Fe y O3 (x = 0.00–0.10 and y = 0.02–0.12) perovskites were fabricated through a facile microemulsion method and were characterized by XRD, DC electrical-resistivity, dielectric, VSM, and UV–Visible measurements. Orthorhombic phase of synthesized substituted chromite nanocrystallite was confirmed by powdered XRD analysis with crystallite size in 47.8–32.9 nm range. DC electrical resistivity was observed to increase from 1.70–39.99 × 108 Ω-cm. Dielectric parameters analyzed in frequency range of 20 kHz–20 MHz were decreased, while magnetic parameters were observed to increase with the increase in dopant (Bi+3 and Fe+3) concentration. Whereas coercivity values was low (narrow hysteresis loop), which indicate the soft ferromagnetic of the prepared material materials which are quite useful to employ in storage devices and electronics. Moreover, La1−x Bi x Cr1−y Fe y O3 degraded 90.80% Rhodamine B dye under visible light irradiation within 55 min. The increase in electrical resistivity, while decrease in dielectric parameters was also observed with increase in dopant concentration, ferromagnetic nature and excellent photocatalytic properties make this material suitable for high frequency energy devices, microwave appliances as well as an excellent magnetically separable photocatalyst for the purification of contaminated wastewater.

La1-xGdxCr1-yNiyO3 nanoparticles were synthesized by micro-emulsion approach. The fabricated NPs were characterized by EDX, SEM, XRD, VSM and UV–Vis techniques. The X-ray diffraction analysis confirmed the successful substitution of Gd3+ and Ni3+ ions into the LaCrO3 structure with rhombohedral structure. The lattice parameters, i.e., bulk density, X-ray density, porosity and crystallite size were calculated for doped and undoped LaCrO3. Morphology of the synthesized NPs shows the aggregation of particles. The average crystallite size determined through XRD and SEM was in the range 30–45 nm. The optical band gaps energy calculated using Tauc plots for undoped and doped material was found to be 2.17 eV–2.03 eV. The Hysteresis study revealed that the magnetization saturation of Gd3+ and Ni3+doped LaCrO3 was greater than un-doped NPs showing the ferromagnetic properties of fabricated materials, which gradually increased by increasing the dopant Gd3+ and Ni3+ concentration. Investigation of dielectric properties for doped and undoped materials revealed that the dielectric constant and dielectric loss shows a decreasing trend at higher frequency due to the decrease in various types of polarization. Photocatalytic activities of as-synthesized La1-xGdxCr1-yNiyO3 NPs were evaluated by the degradation of crystal violet (CV) dye. It was observed that about 94.39% CV dye was degraded by as synthesized NPs in 45 min of UV light irradiation. The results revealed that doping of Gd3+ and Ni3+ in the crystal lattice of LaCrO3 NPs reduces the band gap energy and significantly improves the dielectric and magnetic properties, which make them promising candidates to be used as photo-catalyst for the degradations of toxic textile dyes effluent, and for electronic and microwave devices.

Cobalt (Co) and chromium (Cr) doped lanthanum ortho-ferrite with a composition of La1-xCox Fe1-yCryO3 (x, y = 0.0, 0.15, 0.30, 0.45, 0.60, 0.75) were fabricated by micro-emulsion route. The effect of Co2+ and Cr3+ cation substitution on the structural and dielectric properties was explored by XRD, FTIR, AFM, magnetic analysis, dielectric and ferroelectric measurements, which showed orthorhombic geometry. Various parameters like lattice constant (a, b, c), bulk density (ρm), X-ray density (ρx), porosity (P) and crystalline size were determined. By increasing dopant contents, the saturation magnetization was also increased and exhibited ferromagnetic property and LaFeO3 exhibits anti-ferromagnetism. The maximum value of magnetic saturation (0.841 emu) and Mr (0.420 emu) was found for highly substituted La0.40Co0.60Fe0.40Cr0.60O3 form. Through polarization electric (P-E) loops, the ferroelectric nature of fabricated nanoparticles was confirmed. It was observed that the values of dielectric constant (ɛ ), dielectric loss (ɛ ) and loss tangent (tanᵟ) were decreased with increasing the frequency. In addition, the conductivity is continuously increased with increasing frequency as well as dopant concentration. Furthermore, photocatalytic efficiency was evaluated by degrading methyl orange (MO) dye under UV irradiation and it was found that most substituted nanomaterial La0.40 Co0.60Fe0.40Cr0.60O3 exhibited maximum degradation of 91.01% of MO dye. Results revealed that the lanthanum ortho-ferrite properties can be tuned by doping with Cr and Co for practical applications in different filed since the ferroelectric, magnetic and photocatalytic properties were changed as a function of dopant concentration.

Michael reaction is the nucleophilic addition of active methylene compounds to conjugated olefins, resultantly affording a variety of biologically active scaffolds with high enantiopurity. To improve the reaction yield, as well as enantioselectivity of the product, a variety of catalysts (amine-based catalysts, bifunctional L-proline amides, bifunctional squaramides, chiral ionic liquids, cinchona alkaloids, enzymes, indolinols, metal catalysts, peptide derived catalytic system, phase transfer catalysts, pyrrolidine based organocatalysts) have been investigated by a different era of chemists. Besides this, different methodologies have been developed to improve reaction yield and enantioselectivity of the targeted products with low catalyst loading. : This review article provides a concise overview of the catalysts applied recently by different scientists in the Michael addition reaction. Moreover, current strategies and potential applications of this reaction have also been illustrated in this review.

A green ultrasound assisted convenient approach has been reported for the ring opening of epoxides. As a result, a series of N-phenyl piperazine and morpholine based β-amino alcohols has been synthesized under ultrasound irradiation in DMSO for 60 minutes at 70°C. This methodology showed excellent tolerance with various epoxides and provided excellent yields upto 96%. All the synthetic derivatives (4a-e) (5c-d) significantly influence the catalytic activity of protease while 5d exhibited maximum (100%) inhibitory effect with a half-life of 40.76 minutes. Among the target derivatives, compound 4c exhibited significant antibacterial activity against Bacillus subtilis and Escherichia coli bacterial strains with zone of inhibition values 45 mm and 32 mm, respectively.

Sirtuins (SIRT1-7) are distinct histone deacetylases (HDACs) whose activity is determined by cellular metabolic status andnicotinamide adenine dinucleotide (NAD

In this study, we have investigated ciprofloxacin-based acetanilides for their in-vitro inhibitory study against gram +ve, -ve bacteria and serine protease activity. The compounds 4e and 4g showed excellent antibacterial activity against Bacillus subtilis with a zone of inhibition (ZI) values of 40 ± 0.9 mm, 37 ± 1.4 mm and with MIC values of 4.0 ± 0.78 mg/mL, 3.0 ± 0.98 mg/ML respectively, while 4a and 4i were found most active against Escherichia coli, with ZI values 38 ± 0.1 mm, 46 ± 1.8 mm and with MIC values of 1.0 ± 0.25 mg/mL, 1.0 ± 0.23 mg/mL respectively. All derivatives (4a-j) significantly inhibited the catalytic activity of serine protease, while 4a exhibited a maximum (100%) inhibitory effect at 96 minutes having 22.50 minutes t12, and non-competitive inhibition with 0.1±0.00μM Ki. The IFD/MM-GBSA studies highlighted the binding mode of 4a for protease inhibition and indicated improved binding affinity with –107.62 kcal/mol of ΔGbind.

Angiotensinogen (AGT) is one of the most significant enzymes of the renin-angiotensin-aldosterone system (RAAS) which is involved in the regulation and maintenance of blood pressure. AGT is involved in the production of angiotensin I which is then converted into angiotensin II that leads to renal homeostasis. However, various genetic polymorphisms in AGT have been discovered in recent times which have shown an association with various diseases. Genetic polymorphism increases the level of circulating AGT in blood which exaggerates the effects produced by AGT. The associated diseases occur due to various effects produced by increased AGT levels. Several cardiovascular diseases including myocardial infarction, coronary heart disease, heart failure, hypertrophy, etc. are associated with AGT polymorphism. Other diseases such as depression, obesity, diabetic nephropathy, pre-eclampsia, and liver injury are also associated with some variants of AGT gene. The most common variants of AGT polymorphism are M235T and T174M. The two variants are associated with many diseases. Some other variants such as G-217A, A-6G, A-20C and G-152A, are also present but they are not as significant as that of M235T and T174M variants. These variants increase the level of circulating AGT and are associated with prevalence of different diseases. These diseases occur through various pathological pathways, but the initial reason remains the same, i.e., increased level of AGT in the blood. In this article, we have majorly focused on how genetic polymorphism of different variants of AGT gene is associated with the prevalence of different diseases.

In this study graphene oxide (GO) reinforced polyvinyl alcohol (PVA) composites hydrogels were synthesized and used as efficient adsorbents for Drimarene Brilliant Blue K-4BL. GO nanoparticles (NPs) were synthesized by modified Hummer’s method. The composites were characterized by Fourier transform infrared spectroscopy (FT-IR), Thermo-gravimetric analysis (TGA), Scanning electron microscopy (SEM) and X-ray diffraction (XRD). The results showed homogeneous dispersion of reinforcement in the synthesized composites. Moreover thermal stability of the composites was significantly enhanced by the addition of graphene oxide nanoparticles. The synthesized composites were used for the removal of Drimarene brilliant Blue from model waste water. The effect of pH, content of GONPs and initial concentration of Drimarene Brilliant Blue K-4BL on the adsorption capacity of synthesized GO/PVA composites were investigated. The equilibrium isothermal data were studied by applying Langmuir and Freundlich isotherm models. Results demonstrated that the adsorption process is well described by the Langmuir adsorption isotherm. According to the Langmuir model, maximum adsorption capacity i.e. 32mg/g was obtained at 0.7% GO/PVA composite. From the kinetic study it was concluded that pseudo-second-order model is the best fitted. Synthesized composites showed excellent reusability (almost 95 %) for the adsorption of Drimarene Brilliant Blue K-4BL after four successive cycles of adsorption and desorption. Thus, the GO/PVA composites demonstrated a great potential in terms of cost effectiveness, efficiency and reusability for the removal of Drimarene Brilliant Blue K-4BL dye.

In this era of technology, neurological disorders are the most prevalent disorders in growing population. Alzheimer's and Parkinson's diseases are the most common neurological disorders which are manifested by any abnormality in the structure and functions of neurons present in brain and spinal cord. Exposure to environmental pollution is a serious issue which is associated with high morbidity and mortality rate in the worldwide. Air pollutants are the major contributors to induce the inflammation in lungs and brain which ultimately impairs the normal functioning of CNS. Air pollution persuades CNS pathology by inducing the oxidative stress, activation of microglial cells, neuroinflammation and alteration in permeability of blood brain barrier. Similarly, exposure of heavy metals also exhibits the major and long-lasting effects on brain and causes cognitive dysfunction. Likewise, pesticides have also major influence on the etiology of neurological disorders. Pesticides such as paraquat and rotenone are involved in the pathogenesis of Parkinson's disease. Treatment strategy for environmental pollutants-induced neurological disorders is a challenging task because conventional therapeutics are effective but do not have optimum therapeutic efficacy against such type of disorders. This article addresses how the environmental pollutants are involved in the pathogenesis of neurological disorders and treatment strategies to reduce the occurrence of neurological disorders.

Iron oxide nanoparticles (Fe2O3 NPs) were fabricated through green route using pomegranate (Punica granatum) seeds extract. The Fe2O3 NPs were characterized by UV–vis, XRD, EDX, SEM and AFM techniques. The adopted green rout furnished semi spherical Fe2O3 NPs, uniformly distributed and particle size in the range of 25–55 nm. The LCMS/MS was performed for the identification of biomolecule present in the extract of pomegranate seeds and p-hydroxy benzoic acid, gallic acid, methyl gallate, catechin, kaempferol-3-O-sophoroside, 3-deoxyflavonoids, magnolol, ferulic acid, vanillic acid and pinocembrin along with other minor constituents were detected in the extracts using for Fe2O3 NPs. The synthesized Fe2O3 NPs showed excellent photocatalytic activity against reactive blue under UV light irradiation and maximum degradation of 95.08% was achieved with 56 min of reaction time. In view of promising activity, the Fe2O3 NPs could be used photocatalyst for the degradation of dyes in wastewater and pomegranate seeds extract can be applied as eco-benign and cost effective approach for Fe2O3 NPs synthesis. Keywords: Punica granatum, Green synthesis, Iron oxide nanoparticles, Photocatalysis, Dye degradation

Due to an increasing awareness of the harmful effects of synthetic dyes among the global community, the demand for natural dyes in the textile sector has increased. The current study has been conducted to explore coconut coir, that is, Cocos nucifera, as a new dye yielding plant for wool dyeing under ultrasonic (US) radiation. Unirradiated and US-irradiated extracts of coconut coir were utilized to dye unirradiated and US-irradiated wool fabrics. To make the process more sustainable, acacia, henna, turmeric and pomegranate extracts as biomordants were used to dye wool fabric at 65℃ for 45 min. It was found that a good color yield was achieved by dyeing US-treated wool with US-treated acidic methanolic extract at 65℃ for 45 min. It is found that biomordanting profoundly added value in coloration and also enhanced the fastness rating of the dyed wool fabrics. It is concluded that US rays have excellent efficacy for exploring the coloring wealth of plants for dyeing of natural fabrics.

Nanoparticles (NPs) of Gd1−xMxCrO3 (M = La, Co, Bi) were synthesized by microemulsion techniques, involving simultaneous single ion substitution philosophy. Structural, magnetic, dielectric properties, morphology, elemental analysis and distribution size of fabricated nano-crystalline were determined. The techniques employed for investigation are X-ray diffraction (XRD), vibrating sample magnetometer (VSM), dielectric measurement and scanning electron microscopy (SEM), energy dispersive X-ray (EDX), photoluminescence (PL) and atomic force microscopy (AFM), respectively. XRD pattern confirm that all the as-synthesized NPs have orthorhombic structure and successfully substituted of different metal ions into the regular crystal structure of GdCrO3. The lattice parameters X-ray density, bulk density, porosity and grain size were calculated from XRD pattern of Gd1−xMxCrO3 (M = La, Co, Bi) substituted and un-substituted GdCrO3. The magnetic hysteresis loop of fabricated product confirmed that the entire sample exhibits ferromagnetic behavior at room temperature. It was also found that the fabricated NPs show excellent photocatalytic activity (PCA) against Congo-red, about 78.24% after 55 min of incubation.

The hydrated complexes 1, 3, 7 and 8 with the general formula (RCOO)2M.xH2O (where M = Zn & x = 6; M = Cu & x = 5,6) were synthesized by the reaction of sodium salt of 2,2`-diphenyl acetic acid or 2-(4-hydroxyphenyl)acetic acid (RCOONa) with Zn(NO3)2.6H2O or CuSO4.5H2O in an aqueous medium. The addition of methanolic solution of either bipyridine (bpy) or 1,10-phenanthroline (phen) to an aqueous suspension of 1, 3, 7 and 8 (produced in situ) result in the formation of mixed ligand products with the general formulae (RCOO)2M(bpy).xH2O (2, 4, 9 and 10) and (RCOO)2M(phen).xH2O (5 and 6). The complexes were characterized by microanalysis, FTIR and NMR (1H and 13C) spectroscopic techniques. The FTIR data suggested a bidentate coordination mode of the carboxylate ligand and complexes exhibited four/six-coordinated geometry in the solid state. The spectroscopic data also revealed the presence of coordinated water molecules in all complexes. 1H and 13C NMR data demonstrated the coordination between ligand and the metal in complex 1. The complexes were tested for their binding with salmon sperm DNA (SS-DNA). The DNA binding potential of the complexes owed to the presence of zinc metal and the nature of the incorporated ligand. The complexes showed a significant hypochromic effect and an intercalating mode of binding with SS-DNA. The complexes were screened against various bacterial and fungal strains to check their biological activity. All the complexes showed significant antibacterial activity but none of complex exhibit antifungal activity.

This work investigates the effects of double ion substitution on the ferroelectric, electrochemical, dielectric and photocatalytic properties of Gd and Fe doped La

Three carotenoids: zeaxanthin, meso-zeaxanthin and lutein uniquely concentrates into the human macula. Green leafy vegetables, orange and yellow fruits are the sources of zeaxanthin and lutein while meso-zeaxanthin is believed to be formed by ingested carotenoids metabolic transformation in macula. Large scale clinical trials and epidemiological studies have proved the positive association with ocular health and consumption of carotenoids through diets or supplements but little intake of carotenoids in developing countries is a matter of concern where deficiency leads to high eye disease and mortality rates. This chapter may serve as gestalt of food sources of carotenoids and role of carotenoids in vision & abnormalities of carotenoids. In this chapter, we first examine location of different carotenoids in different sections of internal macula, advantages of polyene chain, the chemistry, biochemistry, pharmacokinetics, interaction of carotenoids with other nutrients or drugs, commercially available synthetic carotenoids for eye protection and vision abnormalities with reference to carotenoid imbalance. Next, we turn to carotenoids as translational medicines and its role from infancy to old age and role of other carotenoids in visual cycle.

Claims of nanomaterials in environmental fortification have shaped the conditions to remediate environment and control pollution, which have brought about advances in environmental science and engineering. Using nanomaterials to resolve environmental matters will become an inevitable propensity in the future. Applications of nanomaterials in chemistry, degradation of organic pollutants, redressing of polluted soils or water, sensing and detection have been considered important. However, the potential risks of nanomaterials are not neglectable. The structure of nanomaterials imparts strong adsorption capacity of toxic heavy metals (copper, lead, mercury, cadmium, and others) in the soil, air, and water. These metals are considered highly toxic and can generate ROS, leading to multiple disorders including neurological disorders. Case studies related to neurotoxicity due to nanomaterials are discussed in the present chapter. The knowledge presented in this chapter will assist to envisage environmental hazards, evaluate impacts, and develop approaches to mitigate harm while encouraging advantageous practices involving nanomaterials.