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Background: The number of patients with breast cancer is increasing worldwide, resulting in a growing number of patients with chemotherapy-related cognitive impairment (CRCI), which seriously affects their quality of life. CRCI is associated with inflammatory factors and systemic inflammatory markers such as pan-immune-inflammation value (PIV) and monocyte-to-lymphocyte ratio (MLR), which can reflect the level of inflammation in the body. While the Managing Cancer and Living Meaningfully (CALM) intervention has been demonstrated to alleviate CRCI in patients with breast cancer, the specific mechanism remains unclear. Objective: This study evaluated the impact of the CALM intervention on systemic inflammation. Methods: Ninety patients with breast cancer with CRCI were enrolled and randomized into care as usual (CAU) and CALM intervention groups. All patients were assessed using the Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog), Mini-Mental State Exam (MMSE), and Functional Assessment of Cancer Therapy-Breast (FACT-B) before and after the CAU/CALM intervention. The blood levels of inflammatory markers were also analyzed before and after the intervention. Results: Compared to the CAU group, the CALM group showed significantly improved cognitive function and significantly decreased PIV ( P Conclusion: PIV is an important marker of inflammation. The CALM intervention may improve the cognitive function of patients by regulating the systemic inflammation marker PIV through the neuroimmune axis.

Chemotherapy-related cognitive impairment (CRCI) is a common but easily overlooked condition that markedly affects the quality of life (QOL) of patients with breast cancer. The rs671 is a common gene polymorphism of aldehyde dehydrogenase 2 (ALDH2) in Asia that is involved in aldehyde metabolism and may be closely related to CRCI. However, no study has yet summarised the association between ALDH2 and CRCI.This study enrolled one hundred and twenty-four patients diagnosed with breast cancer according to the pathology results, genotyped for ALDH2 single-nucleotide polymorphisms (SNP) to explore these. The mini-mental state exam (MMSE), verbal fluency test (VFT), and digit span test (DST) results were compared in these patients before and after chemotherapy (CT).We found that patients with ALDH2 gene genotypes of rs671_GG, rs886205_GG, rs4648328_CC, and rs4767944_TT polymorphisms were more likely to suffer from cognitive impairment during chemotherapy. A trend toward statistical significance was observed for rs671_GG of DST (z = 2.769, p = 0.006), VFT (t = 4.624, P0.001); rs886205_GG of DST (z = 3.663, P0.001); rs4648328_CC of DST (z = 2.850, p = 0.004), VFT (t = 3.477, p = 0.001); and rs4767944_TT of DST (z = 2.967, p = 0.003), VFT (t = 2.776, p = 0.008). The cognitive indicators of these patients significantly decreased after chemotherapy (p 0.05). The difference in ALDH2 rs671 was most obvious.Our results showed what kinds of ALDH2 genotyped patients that are more likely to develop CRCI. In the future, it may be possible to infer the risk of CRCI by detecting the single-nucleotide locus of ALDH2 that is conducive to strengthening clinical interventions for these patients and improving their QOL. More importantly, this study has important implications for Asian women with breast cancer as ALDH2 rs671 is a common polymorphism in Asians.

A numerical model of spray and its interaction with the gas exhaust flow and static mixer are developed to investigate the effects of the mixer on the selective catalytic reduction (SCR). The residence time of spray droplets in straight pipes with and without mixers and the interaction between spray droplets and the blades of mixers are investigated. The numerical results show that due to the improvement of evaporation rates of sprays and the ability to break droplets into smaller ones, static mixers can help SCR systems achieve better urea conversion efficiency. Furthermore, the using of mixers significantly improves the uniformity of the reducing agent in a pipe.

The development of automated NDT is more and more fast, in order to better serve the needs of NDT, we independently research robot system facing to the test, and achieve it's preliminary application. Basing on MOTOMAN-MH6 six degrees of freedom robot, this paper sets up “computer + PMAC + manipulation motor” motion control system, achieves to three closed-loop system in order to meet the exact requirements of the position control. Basing on D-H parameters, we set up robot coordinate system and kinematics model, research and write algorithm which is in line with the guidelines applicable to pieper six degrees of freedom serial robot. In addition to this, we call Pcommserver and Opencascade dynamic link library to design and write “motion control + motion simulation” interface in the host computer, which can meet the needs of human-computer interaction. Finally, the robot system facing to the testing is applied to parts of the NDT projects, and is preliminary proved it's feasibility and reliability.