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Supplemental material, sj-docx-1-wmr-10.1177_0734242X221081667 for Carbon material produced by hydrothermal carbonisation of food waste as an electrode material for supercapacitor application: A circular economy approach by Saikrishna Venna, Hari Bhakta Sharma, Debabrata Mandal, Hari Prasad Reddy, Shamik Chowdhury, Amreesh Chandra and Brajesh K Dubey in Waste Management & Research

Supplemental material for Effect of Medicaid Expansion on Health Insurance for Low-Income Nursing Home Aides by Lili Xu and Hari Sharma in Journal of Applied Gerontology

Supplemental material, sj-docx-1-wmr-10.1177_0734242X221081667 for Carbon material produced by hydrothermal carbonisation of food waste as an electrode material for supercapacitor application: A circular economy approach by Saikrishna Venna, Hari Bhakta Sharma, Debabrata Mandal, Hari Prasad Reddy, Shamik Chowdhury, Amreesh Chandra and Brajesh K Dubey in Waste Management & Research

Additional file 2: Supplementary Table 1. Proteins commonly expressed in all treatments yet differentially expressed across S. bicolor genotypes upon C. partellus infestation and at steady state (Pattern 3 and Pattern 4). Supplementary Table 2. List of differentially abundant proteins in S. bicolor infested with pest C. partellus (A, C, E) and in S. bicolor at steady state (B, D, F) treatments. These proteins signify how the resistant genotypes of S. bicolor ICSV700 and IS2205 manifest their resistance to insect pests and the susceptible genotype Swarna cannot. Supplementary Table 3. Gene-specific primers used for the qRT-PCR analysis of selected candidate genes of S. bicolor plants induced by wounding and C. partellus extract. The gene expression analysis focuses on the early response (3 h to 24 h) by S. bicolor to the inductions.

Additional file 1: Supplementary Figure 1. PCA plot across different treatment groups in S. bicolor - C. partellus interaction proteomics| The PCA score plot shows the variation amongst different treatments and biological and technical replicates. Supplementary Figure 2. GO analysis of proteins commonly expressed across resistant & susceptible S. bicolor upon C. partellus infestation| Proteins down-regulated in infested samples (highlighted in blue) and up-regulated in control samples are included in Pattern1whereas Pattern2 indicates proteins that are up-regulated in infested samples (highlighted in red) and down-regulated in control samples. GO of proteins displaying Pattern1 (38) and Pattern2 (19) are indicated molecular function (A) biological processes (B) cellular component (C). Supplementary Figure 3. GO biological process analysis of differentially expressed proteins across treatments in S. bicolor genotypes| Commonly present yet differential abundance proteins were classified into patterns based on their expression across S. bicolor genotypes. (A) Pattern3 listed proteins (11) generally down-regulated in S. bicolor upon C. partellus infestation, where one of the S. bicolor genotypes displayed a contrasting expression as indicated in the insets (difference in A/B; C/D or E/F) (B) Pattern4 listed proteins (25) generally up-regulated in S. bicolor upon C. partellus infestation, where one of the S. bicolor genotypes displayed a contrasting expression as indicated in the insets (difference in A/B; C/D or E/F). ‘Difference in A/B’ demonstrates a contradictory pattern in ICSV700, similarly ‘Difference in C/D’ represents in IS2205 and ‘Difference in E/F’ represents in Swarna respectively.

Supplemental material, SUPPLEMENTARY_MATERIAL for Medicaid and Nursing Home Choice: Why Do Duals End Up in Low-Quality Facilities? by Hari Sharma, Marcelo Coca Perraillon, Rachel M. Werner, David C. Grabowski and R. Tamara Konetzka in Journal of Applied Gerontology

ObjectivesNerve regeneration after peripheral nerve injury is a slow process with a limited degree of functional recovery, resulting in a high disability rate. Thus, accelerating the rate of nerve regeneration and improving the degree of nerve repair is a clinical challenge. This study aimed to investigate the role of growth factor gel combined with small-gap nerve anastomosis in the regeneration of sciatic nerve injury in rats. This was achieved by injecting nerve growth factor (NGF) and basic fibroblast growth factor (bFGF) gel into a silicon chamber that bridged the transection of the nerve.MethodsIn 27 randomly chosen Sprague Dawley rats, a sharp blade was used to transect the right hind leg sciatic nerve. The rats were divided into 3 groups: in groups A and B, silicon tubes containing NGF and bFGF gel or saline, respectively, were used to bridge the nerve proximal and distal ends (3-mm gap), and in group C, the nerve proximal and distal ends were directly sutured. Eight weeks after surgery, the sciat...

An unusual and ambitious program constitutes Simon Fraser University's response to a 1987 initiative of the Chiefs of the Shuswap Nation Tribal Council and the Secwepemc Cultural Education Society to gain control over the education and training of their people. Offered as an extension program, it leads to a number of academic credentials and is specifically designed to enhance Native students' knowledge of their history, language, and culture, while providing a solid foundation in the social sciences. With a focus on the British Columbia Interior, the program is entirely offered in Kamloops, B.C., with some provision for distance education. As well as being a successful example of a collaboration between clients aware of their academic needs and objectives and a university capable of fulfilling them and willing to do so, the program is also an academic success in terms of its adaptability. Without sacrificing any of its scholarly requirements, it has adjusted to local circumstances and opportunities.

Investment decision-making problems are generally multi-objective in nature such as minimization of the risk and maximization of the expected return. These problems can be solved efficiently and effectively using multi-objective decision making (MODM) tools such as a lexicographic goal programming (LGP). This paper applies the LGP model for selecting an optimum mutual fund portfolio for an investor, while taking into account specific parameters including risk, return, expense ratio and others. Sensitivity analysis on the assigned weights in a priority structure of the goals identifies all possible solutions for decision-making. The Euclidean distance method is then used, to measure distances of all possible solutions from the identified ideal solution. The optimal solution is determined by the minimum distance between the ideal solution and other possible solutions of the problem. The associated weights with the optimal solution will be the most appropriate weights in a given priority structure. The effectiveness and applicability of the LGP model is demonstrated via a case example from broad categories of mutual funds.

To report 7 eyes of 7 patients who were diagnosed as the cases of endogenous endophthalmitis and proved by culture reports. Though in most of the previously published series, one or more predisposing factors were present in the patients of endogenous endophthalmitis, the authors are presenting a case series of culture-proven endogenous endophthalmitis in apparently healthy and immunocompetent individuals.Retrospective noncomparative case series. All patients were diagnosed as endogenous bacterial endophthalmitis with positive vitreal culture. Variables studied were demographic characteristics, microbiology, therapeutic interventions done, final visual and anatomical outcome.Streptococcus pneumoniae was the most frequent isolate 43% (3 out of 7 eyes) followed by Staphylococcus aureus and E. coli in equal frequency 29% (2 each out of 7 eyes). The median time between the onset of symptoms and presentation with features of endophthalmitis to hospital was 7 days. The presenting visual acuity was less than HM (hand motions) in all cases except one, which had VA of 20/200. No single underlying predisposing condition was identifiable in any of the cases. All the cases were given intravitreal therapeutic agents (one or more doses of antibiotics and steroid) and pars plana vitrectomy was performed in 2 cases. The final visual acuity was not better than presenting VA except in 1 case, which had final VA of 20/40. Intraocular pressure was on the lower side (mean IOP 7 mmHg compared to 12 mmHg in the fellow eye). No eye was enucleated or eviscerated.Though in most of the previously published literature endogenous endophthalmitis has been a metastatic ocular infection, the present study describes a series of endogenous bacterial endophthalmitis de novo in onset, without any identifiable predisposing factors. The overall age of presentation was in a younger population than in previously published series. The overall visual outcome was poor, probably due to the serious nature of disease itself and the relatively late presentation.

The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report AstraZeneca’s large drug combination dataset, consisting of 11,576 experiments from 910 combinations across 85 molecularly characterized cancer cell lines, and results of a DREAM Challenge to evaluate computational strategies for predicting synergistic drug pairs and biomarkers. 160 teams participated to provide a comprehensive methodological development and benchmarking. Winning methods incorporate prior knowledge of drug-target interactions. Synergy is predicted with an accuracy matching biological replicates for >60% of combinations. However, 20% of drug combinations are poorly predicted by all methods. Genomic rationale for synergy predictions are identified, including ADAM17 inhibitor antagonism when combined with PIK3CB/D inhibition contrasting to synergy when combined with other PI3K-pathway inhibitors in PIK3CA mutant cells.